HUP0102612A2 - Modulators of protein tyrosine phosphatases - Google Patents

Modulators of protein tyrosine phosphatases

Info

Publication number
HUP0102612A2
HUP0102612A2 HU0102612A HUP0102612A HUP0102612A2 HU P0102612 A2 HUP0102612 A2 HU P0102612A2 HU 0102612 A HU0102612 A HU 0102612A HU P0102612 A HUP0102612 A HU P0102612A HU P0102612 A2 HUP0102612 A2 HU P0102612A2
Authority
HU
Hungary
Prior art keywords
diseases
protein tyrosine
tyrosine phosphatases
ptpases
compounds according
Prior art date
Application number
HU0102612A
Other languages
Hungarian (hu)
Inventor
Henrik Sune Andersen
Frank Urban Axe
Farid Bakir
Sven Branner
Yu Ge
Daniel Dale Holsworth
Lars Fogh Iversen
Claus Bekker Jeppesen
Lone Jeppesen
Todd Kevin Jones
Luke Milburn Judge
Niels Peter Hundahl Moller
Ole Hvilsted Olsen
Lutz Stefan Richter
Wiliam Charles Ripka
Jing Su
Roy Teruyuki Uyeda
Josef Vagner
Original Assignee
Novo Nordisk A/S
Ontogen Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S, Ontogen Corporation filed Critical Novo Nordisk A/S
Publication of HUP0102612A2 publication Critical patent/HUP0102612A2/en

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    • C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Abstract

A találmány tárgyát a fehérje-tirozinfoszfatázokat modulálóvegyületek, valamint ezeket tartalmazó gyógyászati készítményekképezik. A találmány szerinti vegyületek három kritériumnak felelnekmeg: (1) az (I) általános képlet alá tartozik, ahol a képletben R1, R2és R4 jelentése bármely kémiai csoport vagy ezek kombinációja; (2)foszfotirozin felismerő egység ligandumaként viselkedik, előnyösen SH2doménokat tartalmazó fehérjék vagy egy vagy több PTPázok inhibitoravagy modulátora; és (3) móltömege 2500 Dalton vagy ennél kisebb. Atalálmány szerinti vegyületek hatásosan modulálják vagy gátolják akülönböző PTPázokat, és ezért számos betegség kezelésére adhatók. Ezenbetegségek közül említik meg az I és II-típusú diabetest, az autoimmunbetegségeket, osteoporosist, a burjánzásos betegségeket, Alzheimer-kórt, skizofréniát, valamint a fertőzéses betegségeket. ÓThe subject of the invention is compounds that modulate protein tyrosine phosphatases, as well as medicinal preparations containing them. The compounds according to the invention meet three criteria: (1) belong to the general formula (I), where R1, R2 and R4 in the formula are any chemical group or their combination; (2) acts as a ligand for a phosphotyrosine recognition unit, preferably an inhibitor or modulator of proteins containing SH2 domains or one or more PTPases; and (3) has a molecular weight of 2500 Daltons or less. The compounds according to the invention effectively modulate or inhibit various PTPases and can therefore be used to treat many diseases. Among these diseases, type I and II diabetes, autoimmune diseases, osteoporosis, proliferative diseases, Alzheimer's disease, schizophrenia, and infectious diseases are mentioned. HE

HU0102612A 1998-03-12 1999-03-12 Modulators of protein tyrosine phosphatases HUP0102612A2 (en)

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DK47498 1998-04-03
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DK47298 1998-04-03
DK47698 1998-04-03
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US8291298P 1998-04-24 1998-04-24
DK66798 1998-05-15
US8811598P 1998-06-05 1998-06-05
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DKPA199800938 1998-07-15
DKPA199800940 1998-07-15
DKPA199801385 1998-10-28
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