HUP0101731A2 - Eljárás érrendszeri betegségek kezelésére és megelőzésére - Google Patents

Eljárás érrendszeri betegségek kezelésére és megelőzésére

Info

Publication number
HUP0101731A2
HUP0101731A2 HU0101731A HUP0101731A HUP0101731A2 HU P0101731 A2 HUP0101731 A2 HU P0101731A2 HU 0101731 A HU0101731 A HU 0101731A HU P0101731 A HUP0101731 A HU P0101731A HU P0101731 A2 HUP0101731 A2 HU P0101731A2
Authority
HU
Hungary
Prior art keywords
prevention
treatment
vascular disease
polypeptide
nucleic acid
Prior art date
Application number
HU0101731A
Other languages
English (en)
Inventor
Brian William Grinnell
Laura Jean Myers
Mark Alan Richardson
Original Assignee
Eli Lilly And Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Co. filed Critical Eli Lilly And Co.
Publication of HUP0101731A2 publication Critical patent/HUP0101731A2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány tárgya a TGF-<-nak speciális sejtfelszíni receptorokhoztörténő kötődésével kapcsolatos intracelluláris jelátvitelt közvetítőpolipeptid és az ezt kódoló nukleinsav molekula. A találmány tárgyatovábbá, az említett polipeptid aktivitását módosító polipeptid és azezt kódoló nukleinsav molekula. Ó
HU0101731A 1998-03-27 1999-03-25 Eljárás érrendszeri betegségek kezelésére és megelőzésére HUP0101731A2 (hu)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7968198P 1998-03-27 1998-03-27
PCT/US1999/006595 WO1999050296A1 (en) 1998-03-27 1999-03-25 Treatment and prevention of vascular disease

Publications (1)

Publication Number Publication Date
HUP0101731A2 true HUP0101731A2 (hu) 2001-09-28

Family

ID=22152123

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0101731A HUP0101731A2 (hu) 1998-03-27 1999-03-25 Eljárás érrendszeri betegségek kezelésére és megelőzésére

Country Status (7)

Country Link
EP (1) EP1066323A1 (hu)
JP (1) JP2002509711A (hu)
AU (1) AU3365299A (hu)
CA (1) CA2324476A1 (hu)
HU (1) HUP0101731A2 (hu)
IL (1) IL138692A0 (hu)
WO (1) WO1999050296A1 (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6566131B1 (en) 2000-10-04 2003-05-20 Isis Pharmaceuticals, Inc. Antisense modulation of Smad6 expression
AU7627700A (en) * 1999-08-04 2001-03-05 Uab Research Foundation The interaction of smad6 with hox proteins and uses thereof
US6159697A (en) * 2000-01-19 2000-12-12 Isis Pharmaceuticals, Inc. Antisense modulation of Smad7 expression
ITRM20030149A1 (it) 2003-04-02 2004-10-03 Giuliani Spa Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico
ES2526705T3 (es) 2005-10-25 2015-01-14 The Johns Hopkins University Métodos y composiciones para el tratamiento de síndrome de Marfan y trastornos asociados
US8454952B2 (en) 2006-03-13 2013-06-04 The Johns Hopkins University Augmentation of endothelial thromboresistance
US9084746B2 (en) 2010-09-22 2015-07-21 The Regents Of The University Of Colorado, A Body Corporate Therapeutic applications of SMAD7
CA2823154A1 (en) 2010-12-27 2012-07-05 Lsip, Llc Ips cells and method for generating same
US20150044178A1 (en) 2011-12-28 2015-02-12 Kyoto Prefectural Public University Corporation Normalization of culture of corneal endothelial cells
KR101359886B1 (ko) * 2011-12-28 2014-02-12 성균관대학교산학협력단 스매드 6번(Ｓｍａｄ６)으로부터 유래된 펩타이드를 유효성분으로 포함하는 패혈증 또는 패혈성 쇼크의 치료용 조성물
CN105358704B (zh) 2013-03-08 2020-01-03 科罗拉多大学董事会 Ptd-smad7治疗剂
JPWO2015064768A1 (ja) 2013-10-31 2017-03-09 京都府公立大学法人 角膜内皮の小胞体細胞死関連疾患治療薬
US10882903B2 (en) 2015-05-18 2021-01-05 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods and compositions for treating an alphavirus infection

Also Published As

Publication number Publication date
CA2324476A1 (en) 1999-10-07
AU3365299A (en) 1999-10-18
JP2002509711A (ja) 2002-04-02
EP1066323A1 (en) 2001-01-10
IL138692A0 (en) 2001-10-31
WO1999050296A1 (en) 1999-10-07

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