HUP0004294A2 - Indole derivatives, pharmaceutical compositions containing them and process for producing them - Google Patents

Indole derivatives, pharmaceutical compositions containing them and process for producing them

Info

Publication number
HUP0004294A2
HUP0004294A2 HU0004294A HUP0004294A HUP0004294A2 HU P0004294 A2 HUP0004294 A2 HU P0004294A2 HU 0004294 A HU0004294 A HU 0004294A HU P0004294 A HUP0004294 A HU P0004294A HU P0004294 A2 HUP0004294 A2 HU P0004294A2
Authority
HU
Hungary
Prior art keywords
producing
pharmaceutical compositions
compositions containing
indole derivatives
general formula
Prior art date
Application number
HU0004294A
Other languages
Hungarian (hu)
Inventor
Holger Bang
Kay Brune
Holger Deppe
Bernhard Kutscher
Hildegard Poppe
Gerhard Quinkert
Dietmar Reichert
Stefan Szelenyi
Original Assignee
Asta Medica Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Aktiengesellschaft filed Critical Asta Medica Aktiengesellschaft
Publication of HUP0004294A2 publication Critical patent/HUP0004294A2/en
Publication of HUP0004294A3 publication Critical patent/HUP0004294A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)

Abstract

A találmány új, (I) általános képletű immuno-filin-ligandokra vonatkozik, amelyek asztmaellenes, allergiaellenes,reumaellenes, gyulladásellenes, pszoriázisellenes, immunszuppresszívés neuroprotektív hatásokkal rendelkeznek, és ezáltal alkalmasakgyógyszerkészítmények előállítására. A találmány továbbá az (I)általános képletű vegyületek fiziológiailag elfogadható sóira és az(I) általános képletű vegyületek előállítási eljárására és gyógyászatialkalmazására is vonatkozik. ÓThe invention relates to new immunophilin ligands of general formula (I), which have anti-asthmatic, anti-allergic, anti-rheumatic, anti-inflammatory, anti-psoriasis, immunosuppressive and neuroprotective effects, and are therefore suitable for the production of pharmaceutical preparations. The invention also relates to the physiologically acceptable salts of the compounds of the general formula (I) and to the production process and medicinal application of the compounds of the general formula (I). HE

HU0004294A 1997-09-25 1998-08-20 Indole derivatives, pharmaceutical compositions containing them and process for producing them HUP0004294A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19742263A DE19742263A1 (en) 1997-09-25 1997-09-25 New specific immunophilin ligands as anti-asthmatic, anti-allergic, anti-rheumatic, immunosuppressive, anti-psoriatic, neuroprotective
PCT/EP1998/005300 WO1999015501A1 (en) 1997-09-25 1998-08-20 Specific immunophilin ligands useful as anti-asthmatic, anti-allergic, anti-rheumatic, immunosuppressive, antipsoriatic and neuroprotective agents

Publications (2)

Publication Number Publication Date
HUP0004294A2 true HUP0004294A2 (en) 2001-05-28
HUP0004294A3 HUP0004294A3 (en) 2001-11-28

Family

ID=7843549

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004294A HUP0004294A3 (en) 1997-09-25 1998-08-20 Indole derivatives, pharmaceutical compositions containing them and process for producing them

Country Status (12)

Country Link
EP (1) EP1017673A1 (en)
JP (1) JP2001517653A (en)
KR (1) KR20010040253A (en)
AU (1) AU9345098A (en)
BR (1) BR9813226A (en)
CA (1) CA2304451A1 (en)
DE (1) DE19742263A1 (en)
HU (1) HUP0004294A3 (en)
IL (1) IL133246A0 (en)
NO (1) NO20001510L (en)
WO (1) WO1999015501A1 (en)
ZA (1) ZA987819B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9815882A (en) 1998-06-03 2002-09-17 Gpi Nil Holding Inc Sulfonamides linked by n of non-heterocyclic carboxylic acids or isosters of carboxylic acids
US6300341B1 (en) * 1998-09-30 2001-10-09 The Procter & Gamble Co. 2-substituted heterocyclic sulfonamides
US6417189B1 (en) 1999-11-12 2002-07-09 Gpi Nil Holdings, Inc. AZA compounds, pharmaceutical compositions and methods of use
US7253169B2 (en) 1999-11-12 2007-08-07 Gliamed, Inc. Aza compounds, pharmaceutical compositions and methods of use
DE60026568D1 (en) 1999-12-21 2006-05-04 Mgi Gp Inc HYDANTOINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHOD FOR THEIR USE
AU2005254783A1 (en) * 2004-06-18 2005-12-29 Biolipox Ab Indoles useful in the treatment of inflammation
ES2315877T3 (en) 2004-06-18 2009-04-01 Biolipox Ab USEFUL INDOLES IN THE TREATMENT OF INFLAMMATIONS.
CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
WO2006077366A1 (en) 2005-01-19 2006-07-27 Biolipox Ab Indoles useful in the treatment of inflammation
US10266490B2 (en) * 2012-03-16 2019-04-23 Georgetown University Radioprotector compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192773A (en) * 1990-07-02 1993-03-09 Vertex Pharmaceuticals, Inc. Immunosuppressive compounds
MX9202466A (en) * 1991-05-24 1994-06-30 Vertex Pharma NOVELTY IMMUNOSUPPRESSIVE COMPOUNDS.
US5385918A (en) * 1993-02-09 1995-01-31 Miles Inc. Aminomethylene-peptides as immunosuppressants
US5859031A (en) * 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US5614547A (en) * 1995-06-07 1997-03-25 Guilford Pharmaceuticals Inc. Small molecule inhibitors of rotamase enzyme
US5795890A (en) * 1995-09-27 1998-08-18 Ono Pharmaceutical Co., Ltd. Sulfonamide derivatives
DE19542189A1 (en) * 1995-11-13 1997-05-15 Hoechst Ag New cyclic alpha-imino:hydroxamic acid derivatives
DE19616509A1 (en) * 1996-04-25 1998-01-15 Asta Medica Ag New specific immunophilin ligands as anti-asthmatics, immunosuppressants

Also Published As

Publication number Publication date
HUP0004294A3 (en) 2001-11-28
JP2001517653A (en) 2001-10-09
AU9345098A (en) 1999-04-12
WO1999015501A1 (en) 1999-04-01
IL133246A0 (en) 2001-04-30
NO20001510D0 (en) 2000-03-23
EP1017673A1 (en) 2000-07-12
BR9813226A (en) 2000-08-29
KR20010040253A (en) 2001-05-15
CA2304451A1 (en) 1999-04-01
DE19742263A1 (en) 1999-04-01
NO20001510L (en) 2000-05-22
ZA987819B (en) 1999-04-07

Similar Documents

Publication Publication Date Title
HUP0001802A2 (en) Pyrazine derivatives, process for producing them and pharmaceutical compositions containing them
HUP9902056A2 (en) Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use
ATE286032T1 (en) HETEROCYCLIC COMPOUNDS AND THEIR USE IN MEDICINAL PRODUCTS, PROCESS FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
HUP0102084A2 (en) Quinoline derivatives, process for producing them and pharmaceutical compositions containing them
RO115522B1 (en) Indoline derivatives, process for their preparation, pharmaceutical compositions containing them and method of treatment
HUP0004024A2 (en) Azabenzimidazole-based compounds, process for their preparation and pharmaceutical composition thereof
HUP0203257A2 (en) Polymorphic forms of atorvastatin calcium, process for their preparations and pharmaceutical compositions containing them
HUT68357A (en) Heterocyclic-cyclic-amine derivatives, pharmaceutical compositions containing them and process for their production
HUP0003309A2 (en) Imidazolyl-cyclic acetals, process for producing them and pharmaceutical compositions containing the same
HUP0401009A2 (en) 1-aryl-or 1-alkylsulfonylbenzole derivatives as 5-hydroxytryptamine-6 ligands, process for their preparation and pharmaceutical compositions containing them
HUP9701265A2 (en) Imidazoline derivatives, process for producing them and pharmaceutical compositions containing them
ATE182333T1 (en) HETEROCYCLIC COMPOUNDS, THEIR PRODUCTION AND USE
HUP9802762A2 (en) Diphenylmethylene piperidine derivatives, pharmaceutical compositions containing them, process for producing them and their use
HUP0200580A2 (en) Polymorphic crystalline forms of celecoxib, process their preparation and pharmaceutical compositions containing them
HUP0004294A2 (en) Indole derivatives, pharmaceutical compositions containing them and process for producing them
HUP0003413A2 (en) New fused pyridine derivatives, process for their preparation and pharmaceutical compositions containing them
HUP0401080A2 (en) Novel anziconvulsant derivative salts, process for their preparation and pharmaceutical compositions containing them
HUP9802121A2 (en) Imidazoline derivatives, process for producing them and pharmaceutical compositions containing them
MXPA02009643A (en) Shortened synthesis of 3,3-diarylpropylamine derivatives.
AU7215987A (en) 1,4-disubstituted piperazine derivatives, pharmaceutical compositions containing them and process for preparing same
YU9502A (en) Torsemide polymorphs
HUP0204154A2 (en) Novel benzothiadiazine derivatives, preparation method and pharmaceutical compositions containing same
HUP9701660A2 (en) 10,13,15-trioxatricyclo[9.2.1.1.9.6]pentadekanon derivatives, process for producing them, and pharmaceutical compositions containing them
GEP20032924B (en) Novel Furan Diarylmethylidene Derivatives, Method for Their Preparation and Pharmaceutical Composition
HUP9701479A2 (en) N-benzylazolium derivatives containing hydrolysing group, process for their preparation and pharmaceutical compositions containing them