BR9813226A - Immunophilin binders specific as antiasthmatics, antiallergics, antirheumatics, immunosuppressants, antipsoriatics, neuroprotectors - Google Patents

Immunophilin binders specific as antiasthmatics, antiallergics, antirheumatics, immunosuppressants, antipsoriatics, neuroprotectors

Info

Publication number
BR9813226A
BR9813226A BR9813226-1A BR9813226A BR9813226A BR 9813226 A BR9813226 A BR 9813226A BR 9813226 A BR9813226 A BR 9813226A BR 9813226 A BR9813226 A BR 9813226A
Authority
BR
Brazil
Prior art keywords
neuroprotectors
antipsoriatics
immunophilin
antirheumatics
antiasthmatics
Prior art date
Application number
BR9813226-1A
Other languages
Portuguese (pt)
Inventor
Dietmar Reichert
Bernhard Kutscher
Stefan Szelenyi
Hildegard Poppe
Gerhard Quinkert
Kay Brune
Holger Bang
Holger Deppe
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of BR9813226A publication Critical patent/BR9813226A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Patente de Invenção: <B>"LIGANTES DE IMUNOFILINA ESPECìFICOS COMO ANTIASMáTICOS, ANTIALéRGICOS, ANTIREUMáTICOS, IMUNOSSUPRESSORES, ANTIPSORIáTICOS, NEUROPROTETORES"<D>. Os novos ligantes imunofilina específicos da fórmula geral (I) possuem efeito antiasmático, antialérgico, antireumático, antiinflamatório, imunossupressor, antipsoriático e neuroprotetor e prestam-se para a preparação de medicamentos.Invention Patent: <B> "SPECIFIC IMMUNOPHYLINE BINDERS AS ANTIASMATICS, ANTI-ALLERGIC, ANTIREUMATICS, IMMUNOSUPPRESSORS, ANTIPSORIATICS, NEUROPROTECTORS" <D>. The new specific immunophilin binders of the general formula (I) have an anti-asthmatic, anti-allergic, anti-inflammatory, anti-inflammatory, immunosuppressive, antipsoriatic and neuroprotective effect and are suitable for the preparation of medicines.

BR9813226-1A 1997-09-25 1998-08-20 Immunophilin binders specific as antiasthmatics, antiallergics, antirheumatics, immunosuppressants, antipsoriatics, neuroprotectors BR9813226A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19742263A DE19742263A1 (en) 1997-09-25 1997-09-25 New specific immunophilin ligands as anti-asthmatic, anti-allergic, anti-rheumatic, immunosuppressive, anti-psoriatic, neuroprotective
PCT/EP1998/005300 WO1999015501A1 (en) 1997-09-25 1998-08-20 Specific immunophilin ligands useful as anti-asthmatic, anti-allergic, anti-rheumatic, immunosuppressive, antipsoriatic and neuroprotective agents

Publications (1)

Publication Number Publication Date
BR9813226A true BR9813226A (en) 2000-08-29

Family

ID=7843549

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9813226-1A BR9813226A (en) 1997-09-25 1998-08-20 Immunophilin binders specific as antiasthmatics, antiallergics, antirheumatics, immunosuppressants, antipsoriatics, neuroprotectors

Country Status (12)

Country Link
EP (1) EP1017673A1 (en)
JP (1) JP2001517653A (en)
KR (1) KR20010040253A (en)
AU (1) AU9345098A (en)
BR (1) BR9813226A (en)
CA (1) CA2304451A1 (en)
DE (1) DE19742263A1 (en)
HU (1) HUP0004294A3 (en)
IL (1) IL133246A0 (en)
NO (1) NO20001510L (en)
WO (1) WO1999015501A1 (en)
ZA (1) ZA987819B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999062880A1 (en) 1998-06-03 1999-12-09 Gpi Nil Holdings, Inc. N-linked sulfonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres
US6300341B1 (en) 1998-09-30 2001-10-09 The Procter & Gamble Co. 2-substituted heterocyclic sulfonamides
US6417189B1 (en) 1999-11-12 2002-07-09 Gpi Nil Holdings, Inc. AZA compounds, pharmaceutical compositions and methods of use
US7253169B2 (en) 1999-11-12 2007-08-07 Gliamed, Inc. Aza compounds, pharmaceutical compositions and methods of use
ATE319712T1 (en) 1999-12-21 2006-03-15 Mgi Gp Inc HYDANTOIN DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE THEREOF
CN101006054A (en) * 2004-06-18 2007-07-25 比奥里波克斯公司 Indoles useful in the treatment of inflammation
ES2315877T3 (en) 2004-06-18 2009-04-01 Biolipox Ab USEFUL INDOLES IN THE TREATMENT OF INFLAMMATIONS.
CA2571710A1 (en) 2004-06-24 2006-11-02 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
US8097623B2 (en) 2005-01-19 2012-01-17 Biolipox Ab Indoles useful in the treatment of inflammation
WO2013138600A1 (en) * 2012-03-16 2013-09-19 Rosen Eliot M Radioprotector compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192773A (en) * 1990-07-02 1993-03-09 Vertex Pharmaceuticals, Inc. Immunosuppressive compounds
MX9202466A (en) * 1991-05-24 1994-06-30 Vertex Pharma NOVELTY IMMUNOSUPPRESSIVE COMPOUNDS.
US5385918A (en) * 1993-02-09 1995-01-31 Miles Inc. Aminomethylene-peptides as immunosuppressants
US5859031A (en) * 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US5614547A (en) * 1995-06-07 1997-03-25 Guilford Pharmaceuticals Inc. Small molecule inhibitors of rotamase enzyme
KR100266467B1 (en) * 1995-09-27 2000-10-02 우에노 도시오 Sulfonamide derivatives
DE19542189A1 (en) * 1995-11-13 1997-05-15 Hoechst Ag New cyclic alpha-imino:hydroxamic acid derivatives
DE19616509A1 (en) * 1996-04-25 1998-01-15 Asta Medica Ag New specific immunophilin ligands as anti-asthmatics, immunosuppressants

Also Published As

Publication number Publication date
NO20001510L (en) 2000-05-22
NO20001510D0 (en) 2000-03-23
DE19742263A1 (en) 1999-04-01
ZA987819B (en) 1999-04-07
EP1017673A1 (en) 2000-07-12
WO1999015501A1 (en) 1999-04-01
AU9345098A (en) 1999-04-12
JP2001517653A (en) 2001-10-09
CA2304451A1 (en) 1999-04-01
HUP0004294A2 (en) 2001-05-28
HUP0004294A3 (en) 2001-11-28
KR20010040253A (en) 2001-05-15
IL133246A0 (en) 2001-04-30

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 4A,5A,6A,7A,8A E 9A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1910 DE 14/08/2007.