HUP0002442A3 - N-linked ureas and carbamates of heterocyclic thioesters and pharmaceutical compositions containing them - Google Patents
N-linked ureas and carbamates of heterocyclic thioesters and pharmaceutical compositions containing themInfo
- Publication number
- HUP0002442A3 HUP0002442A3 HU0002442A HUP0002442A HUP0002442A3 HU P0002442 A3 HUP0002442 A3 HU P0002442A3 HU 0002442 A HU0002442 A HU 0002442A HU P0002442 A HUP0002442 A HU P0002442A HU P0002442 A3 HUP0002442 A3 HU P0002442A3
- Authority
- HU
- Hungary
- Prior art keywords
- carbamates
- pharmaceutical compositions
- compositions containing
- heterocyclic thioesters
- linked ureas
- Prior art date
Links
- 150000004657 carbamic acid derivatives Chemical class 0.000 title 1
- 235000013877 carbamide Nutrition 0.000 title 1
- -1 heterocyclic thioesters Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003672 ureas Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/775,585 US5935989A (en) | 1996-12-31 | 1996-12-31 | N-linked ureas and carbamates of heterocyclic thioesters |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0002442A2 HUP0002442A2 (hu) | 2000-12-28 |
| HUP0002442A3 true HUP0002442A3 (en) | 2001-01-29 |
Family
ID=25104858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0002442A HUP0002442A3 (en) | 1996-12-31 | 1997-12-23 | N-linked ureas and carbamates of heterocyclic thioesters and pharmaceutical compositions containing them |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US5935989A (hu) |
| KR (1) | KR20000057488A (hu) |
| AR (1) | AR013909A1 (hu) |
| AU (1) | AU721572B2 (hu) |
| BG (1) | BG103408A (hu) |
| BR (1) | BR9714092A (hu) |
| CA (1) | CA2239781A1 (hu) |
| CZ (1) | CZ154699A3 (hu) |
| GT (1) | GT199800014A (hu) |
| HU (1) | HUP0002442A3 (hu) |
| IL (1) | IL129696A0 (hu) |
| PA (1) | PA8444001A1 (hu) |
| PL (1) | PL334372A1 (hu) |
| WO (1) | WO1998029117A1 (hu) |
| ZA (1) | ZA9711704B (hu) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6242468B1 (en) * | 1997-02-27 | 2001-06-05 | Jia-He Li | Carbamate and urea compositions and neurotrophic uses |
| AU764073B2 (en) * | 1997-06-04 | 2003-08-07 | Gpi Nil Holdings, Inc. | N-linked urea or carbamate of heterocyclic thioester hair growth compositions and uses |
| KR20010052502A (ko) * | 1998-06-03 | 2001-06-25 | 다니엘 피. 맥컬럼 | Ｎ-헤테로사이클릭 카복실산 및 카복실산 등입체의 요소및 카르밤산염 |
| ATE268772T1 (de) | 1998-07-17 | 2004-06-15 | Agouron Pharma | Verbindungen und zusammensetzungen um neurales wachstum und streckung zu stimulieren |
| US6399648B1 (en) * | 1998-08-14 | 2002-06-04 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders |
| US6506788B1 (en) * | 1998-08-14 | 2003-01-14 | Gpi Nil Holdings, Inc. | N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders |
| US6337340B1 (en) * | 1998-08-14 | 2002-01-08 | Gpi Nil Holdings, Inc. | Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders |
| US7265150B1 (en) * | 1998-08-14 | 2007-09-04 | Gpi Nil Holdings Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds for vision and memory disorders |
| US6228872B1 (en) | 1998-11-12 | 2001-05-08 | Bristol-Myers Squibb Company | Neurotrophic diamide and carbamate agents |
| AU5606400A (en) | 1999-07-09 | 2001-01-30 | Ortho-Mcneil Pharmaceutical, Inc. | Neurotrophic tetrahydroisoquinolines and tetrahydrothienopyridines, and related compositions and methods |
| AU5483500A (en) | 1999-07-09 | 2001-01-30 | Ortho-Mcneil Pharmaceutical, Inc. | Neurotrophic 2-azetidinecarboxylic acid derivatives, and related compositions and methods |
| BR0012327A (pt) * | 1999-07-09 | 2002-07-02 | Ortho Mcneil Pharm Inc | Pirrolidinas e piperidinas neurotróficas, e composições e métodos relacionados |
| US7253169B2 (en) | 1999-11-12 | 2007-08-07 | Gliamed, Inc. | Aza compounds, pharmaceutical compositions and methods of use |
| US6417189B1 (en) | 1999-11-12 | 2002-07-09 | Gpi Nil Holdings, Inc. | AZA compounds, pharmaceutical compositions and methods of use |
| CO5261615A1 (es) | 1999-12-01 | 2003-03-31 | Agouron Pharma | Compuestos, composiciones y metodos para estimular el crecimiento y elongacion de neuronas |
| US6818643B1 (en) | 1999-12-08 | 2004-11-16 | Bristol-Myers Squibb Company | Neurotrophic bicyclic diamides |
| ATE319712T1 (de) | 1999-12-21 | 2006-03-15 | Mgi Gp Inc | Hydantoin derivate, pharmazeutische zusammensetzungen und verfahren zu ihrer verwendung |
| KR20200089219A (ko) * | 2019-01-15 | 2020-07-24 | 보로노이 주식회사 | 아릴 또는 헤테로아릴 유도체, 및 이를 유효성분으로 포함하는 키나아제 관련 질환 치료용 약학적 조성물 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4310461A (en) * | 1980-06-23 | 1982-01-12 | E. R. Squibb & Sons, Inc. | Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
| US4578474A (en) * | 1980-06-23 | 1986-03-25 | E. R. Squibb & Sons, Inc. | Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
| US4390695A (en) * | 1980-06-23 | 1983-06-28 | E. R. Squibb & Sons, Inc. | Imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids |
| US4596819A (en) * | 1984-01-23 | 1986-06-24 | Warner-Lambert Company | Modified tripeptides |
| US4593102A (en) * | 1984-04-10 | 1986-06-03 | A. H. Robins Company, Inc. | N-[(amino)alkyl]-1-pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides (and thiocarboxamides) with sulfur linked substitution in the 2, 3 or 4-position |
| GB2182938B (en) * | 1985-11-13 | 1989-11-08 | Otsuka Pharma Co Ltd | Antihypertensive proline peptides |
| US5001142A (en) * | 1989-07-19 | 1991-03-19 | American Cyanamid Company | 1-substituted-2-(3-amino-1-propynyl)pyrrolidine derivatives |
| US5192773A (en) * | 1990-07-02 | 1993-03-09 | Vertex Pharmaceuticals, Inc. | Immunosuppressive compounds |
| ATE183178T1 (de) * | 1991-05-09 | 1999-08-15 | Vertex Pharma | Neue immunsuppressive verbindungen |
| MX9202466A (es) * | 1991-05-24 | 1994-06-30 | Vertex Pharma | Compuestos inmunosupresores novedosos. |
| HU211101B (en) * | 1992-03-13 | 1995-10-30 | Egyt Gyogyszervegyeszeti Gyar | Process for preparing 1-[/2s/-methyl-3-mercapto-propionyl]-pyrrolidine-/2s/-carboxylic acid |
| IS2334B (is) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| NZ314207A (en) * | 1992-09-28 | 2000-12-22 | Vertex Pharma | 1-(2-Oxoacetyl)-piperidine-2-carboxylic acid derivatives as multi drug resistant cancer cell sensitizers |
| US5385918A (en) * | 1993-02-09 | 1995-01-31 | Miles Inc. | Aminomethylene-peptides as immunosuppressants |
| US5798355A (en) | 1995-06-07 | 1998-08-25 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity |
| DE69512220T2 (de) * | 1994-03-07 | 2000-03-16 | Vertex Pharma | Sulfonamidderivate als aspartylprotease-inhibitoren |
| US5744485A (en) * | 1994-03-25 | 1998-04-28 | Vertex Pharmaceuticals Incorporated | Carbamates and ureas as modifiers of multi-drug resistance |
| US5463048A (en) * | 1994-06-14 | 1995-10-31 | American Home Products Corporation | Rapamycin amidino carbamates |
| US5726184A (en) * | 1995-05-19 | 1998-03-10 | Vertex Pharmaceuticals Incorporated | Tetralin compounds with improved MDR activity |
| US5696135A (en) | 1995-06-07 | 1997-12-09 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth |
| US5614547A (en) | 1995-06-07 | 1997-03-25 | Guilford Pharmaceuticals Inc. | Small molecule inhibitors of rotamase enzyme |
| US5859031A (en) | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
| US6037370A (en) * | 1995-06-08 | 2000-03-14 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
| US5801197A (en) | 1995-10-31 | 1998-09-01 | Gpi Nil Holdings, Inc. | Rotamase enzyme activity inhibitors |
| US5717092A (en) | 1996-03-29 | 1998-02-10 | Vertex Pharmaceuticals Inc. | Compounds with improved multi-drug resistance activity |
| US5786378A (en) | 1996-09-25 | 1998-07-28 | Gpi Nil Holdings, Inc. | Heterocyclic thioesters |
| US5801187A (en) | 1996-09-25 | 1998-09-01 | Gpi-Nil Holdings, Inc. | Heterocyclic esters and amides |
| US5721256A (en) | 1997-02-12 | 1998-02-24 | Gpi Nil Holdings, Inc. | Method of using neurotrophic sulfonamide compounds |
-
1996
- 1996-12-31 US US08/775,585 patent/US5935989A/en not_active Expired - Fee Related
-
1997
- 1997-12-23 IL IL12969697A patent/IL129696A0/xx unknown
- 1997-12-23 WO PCT/US1997/024070 patent/WO1998029117A1/en not_active Application Discontinuation
- 1997-12-23 AU AU57241/98A patent/AU721572B2/en not_active Ceased
- 1997-12-23 BR BR9714092-9A patent/BR9714092A/pt not_active IP Right Cessation
- 1997-12-23 KR KR1019990705162A patent/KR20000057488A/ko not_active Application Discontinuation
- 1997-12-23 HU HU0002442A patent/HUP0002442A3/hu unknown
- 1997-12-23 PL PL97334372A patent/PL334372A1/xx unknown
- 1997-12-23 CA CA002239781A patent/CA2239781A1/en not_active Withdrawn
- 1997-12-23 CZ CZ991546A patent/CZ154699A3/cs unknown
- 1997-12-30 ZA ZA9711704A patent/ZA9711704B/xx unknown
- 1997-12-31 PA PA19978444001A patent/PA8444001A1/es unknown
-
1998
- 1998-01-02 AR ARP980100005A patent/AR013909A1/es not_active Application Discontinuation
- 1998-01-19 GT GT199800014A patent/GT199800014A/es unknown
- 1998-10-02 US US09/165,372 patent/US6184243B1/en not_active Expired - Fee Related
-
1999
- 1999-09-17 BG BG103408A patent/BG103408A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20000057488A (ko) | 2000-09-15 |
| BG103408A (en) | 2000-01-31 |
| AU5724198A (en) | 1998-07-31 |
| AR013909A1 (es) | 2001-01-31 |
| ZA9711704B (en) | 1998-09-23 |
| GT199800014A (es) | 1999-07-13 |
| BR9714092A (pt) | 2000-05-09 |
| AU721572B2 (en) | 2000-07-06 |
| CZ154699A3 (cs) | 1999-11-17 |
| HUP0002442A2 (hu) | 2000-12-28 |
| PL334372A1 (en) | 2000-02-28 |
| CA2239781A1 (en) | 1998-06-30 |
| IL129696A0 (en) | 2000-02-29 |
| US6184243B1 (en) | 2001-02-06 |
| US5935989A (en) | 1999-08-10 |
| WO1998029117A1 (en) | 1998-07-09 |
| PA8444001A1 (es) | 2000-05-24 |
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