HUP0000920A2 - PDE4 inhibítor hatású izokinolinilidénszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

PDE4 inhibítor hatású izokinolinilidénszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0000920A2
HUP0000920A2 HU0000920A HUP0000920A HUP0000920A2 HU P0000920 A2 HUP0000920 A2 HU P0000920A2 HU 0000920 A HU0000920 A HU 0000920A HU P0000920 A HUP0000920 A HU P0000920A HU P0000920 A2 HUP0000920 A2 HU P0000920A2
Authority
HU
Hungary
Prior art keywords
isoquinolinylidene
derivatives
preparation
pde4 inhibitor
medicaments containing
Prior art date
Application number
HU0000920A
Other languages
English (en)
Inventor
Gyuláné Kiss
Zoltán Kapui
Endre Mikus
Ágnes Behr
Éva Boronkay
Sándor Bátori
István Hermecz
Katalin Takács
Attila Baranyi
Marc Pascal
Szabó Katalin Urbán
Erzsébet Fejér
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Priority to HU0000920A priority Critical patent/HUP0000920A3/hu
Publication of HU0000920D0 publication Critical patent/HU0000920D0/hu
Priority to AU2001240939A priority patent/AU2001240939A1/en
Priority to PCT/HU2001/000024 priority patent/WO2001064647A1/en
Publication of HUP0000920A2 publication Critical patent/HUP0000920A2/hu
Publication of HUP0000920A3 publication Critical patent/HUP0000920A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HU0000920A 2000-02-28 2000-02-28 Pde4 inhibitor isoquinolinylidene derivatives, process for their preparation and medicaments containing them HUP0000920A3 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
HU0000920A HUP0000920A3 (en) 2000-02-28 2000-02-28 Pde4 inhibitor isoquinolinylidene derivatives, process for their preparation and medicaments containing them
AU2001240939A AU2001240939A1 (en) 2000-02-28 2001-02-27 Isoquinoline derivatives as pde4 inhibitors
PCT/HU2001/000024 WO2001064647A1 (en) 2000-02-28 2001-02-27 Isoquinoline derivatives as pde4 inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0000920A HUP0000920A3 (en) 2000-02-28 2000-02-28 Pde4 inhibitor isoquinolinylidene derivatives, process for their preparation and medicaments containing them

Publications (3)

Publication Number Publication Date
HU0000920D0 HU0000920D0 (en) 2000-04-28
HUP0000920A2 true HUP0000920A2 (hu) 2002-02-28
HUP0000920A3 HUP0000920A3 (en) 2002-03-28

Family

ID=89978126

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0000920A HUP0000920A3 (en) 2000-02-28 2000-02-28 Pde4 inhibitor isoquinolinylidene derivatives, process for their preparation and medicaments containing them

Country Status (3)

Country Link
AU (1) AU2001240939A1 (hu)
HU (1) HUP0000920A3 (hu)
WO (1) WO2001064647A1 (hu)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1972684A (zh) * 2004-04-23 2007-05-30 细胞基因公司 用于治疗和控制肺高血压的含有pde4调节剂的组合物以及其使用方法
EP2555773A1 (de) * 2010-04-08 2013-02-13 Boehringer Ingelheim International GmbH Arzneimittelkombinationen enthaltend pde4-inhibitoren und ep4-rezeptor-antagonisten
CN110117271A (zh) * 2018-02-06 2019-08-13 中国科学院上海药物研究所 四氢异喹啉类化合物、其制备方法、包含此类化合物的药物组合物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4062850A (en) * 1973-05-30 1977-12-13 Chinoin Pharmaceutical And Chemical Works Ltd. Thiazoloisoquinolines with coronary and respiratory effects
HU178454B (en) * 1979-07-02 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing new isoquinoline derivatives containing sulphur
HU209930B (en) * 1990-11-14 1994-12-28 Chinoin Gyogyszer Es Vegyeszet Process for producing of 2-mercapto-2-(1-isoquinolylidene)-acetonitrile derivatives and pharmaceutical compositions comprising them
GB9406137D0 (en) * 1994-03-28 1994-05-18 Erba Carlo Spa N-substituted beta-aryl- and betaheteroaryl-alpha-cyanoacrylamide derivatives and process for their preparation

Also Published As

Publication number Publication date
HUP0000920A3 (en) 2002-03-28
HU0000920D0 (en) 2000-04-28
AU2001240939A1 (en) 2001-09-12
WO2001064647A1 (en) 2001-09-07

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