AU2001240939A1 - Isoquinoline derivatives as pde4 inhibitors - Google Patents

Isoquinoline derivatives as pde4 inhibitors

Info

Publication number
AU2001240939A1
AU2001240939A1 AU2001240939A AU4093901A AU2001240939A1 AU 2001240939 A1 AU2001240939 A1 AU 2001240939A1 AU 2001240939 A AU2001240939 A AU 2001240939A AU 4093901 A AU4093901 A AU 4093901A AU 2001240939 A1 AU2001240939 A1 AU 2001240939A1
Authority
AU
Australia
Prior art keywords
pde4 inhibitors
isoquinoline derivatives
isoquinoline
derivatives
pde4
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001240939A
Inventor
Agnes Behr
Eva Boronkay
Erzsebet Fejer
Istvan Hermecz
Zoltan Kapui
Gyulane Kiss
Endre Mikus
Marc Pascal
Kalman Takacs
Katalin Urban Szabo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Publication of AU2001240939A1 publication Critical patent/AU2001240939A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2001240939A 2000-02-28 2001-02-27 Isoquinoline derivatives as pde4 inhibitors Abandoned AU2001240939A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0000920A HUP0000920A3 (en) 2000-02-28 2000-02-28 Pde4 inhibitor isoquinolinylidene derivatives, process for their preparation and medicaments containing them
HU0000920 2000-02-28
PCT/HU2001/000024 WO2001064647A1 (en) 2000-02-28 2001-02-27 Isoquinoline derivatives as pde4 inhibitors

Publications (1)

Publication Number Publication Date
AU2001240939A1 true AU2001240939A1 (en) 2001-09-12

Family

ID=89978126

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001240939A Abandoned AU2001240939A1 (en) 2000-02-28 2001-02-27 Isoquinoline derivatives as pde4 inhibitors

Country Status (3)

Country Link
AU (1) AU2001240939A1 (en)
HU (1) HUP0000920A3 (en)
WO (1) WO2001064647A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2005234783A1 (en) * 2004-04-23 2005-11-03 Celgene Corporation Methods of using and compositions comprising PDE4 modulators for the treatment and management of pulmonary hypertension
WO2011124524A1 (en) * 2010-04-08 2011-10-13 Boehringer Ingelheim International Gmbh Combinations of medicaments, containing pde4 inhibitors and ep4 receptor antagonists
CN110117271A (en) * 2018-02-06 2019-08-13 中国科学院上海药物研究所 Tetrahydroisoquinolicompounds compounds, preparation method, the medical composition and its use comprising such compound

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4062850A (en) * 1973-05-30 1977-12-13 Chinoin Pharmaceutical And Chemical Works Ltd. Thiazoloisoquinolines with coronary and respiratory effects
HU178454B (en) * 1979-07-02 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing new isoquinoline derivatives containing sulphur
HU209930B (en) * 1990-11-14 1994-12-28 Chinoin Gyogyszer Es Vegyeszet Process for producing of 2-mercapto-2-(1-isoquinolylidene)-acetonitrile derivatives and pharmaceutical compositions comprising them
GB9406137D0 (en) * 1994-03-28 1994-05-18 Erba Carlo Spa N-substituted beta-aryl- and betaheteroaryl-alpha-cyanoacrylamide derivatives and process for their preparation

Also Published As

Publication number Publication date
HUP0000920A2 (en) 2002-02-28
HU0000920D0 (en) 2000-04-28
WO2001064647A1 (en) 2001-09-07
HUP0000920A3 (en) 2002-03-28

Similar Documents

Publication Publication Date Title
AU2001258771A1 (en) -secretase inhibitors
IL181957A0 (en) Pyrimidine-4-one derivatives as ldl-pla2 inhibitors
AU2002221827A1 (en) Novel lactame-substituted pyrazolopyridine derivatives
AU2002216028A1 (en) Novel carbamate-substituted pyrazolopyridine derivatives
AU2001280099A1 (en) 4-acylaminopyrazole derivatives
AU2001230584A1 (en) 1h-imidazopyridine derivatives
AU2001237041A1 (en) Kinase inhibitors
AU2002250394A1 (en) Rho-kinase inhibitors
AU2002245709A1 (en) Rho-kinase inhibitors
AU2001295992A1 (en) Imidazopyridine derivatives
AU2002220241A1 (en) Parb inhibitors
AU2001230537A1 (en) Pyridoxazine derivatives
AU2001281802A1 (en) 6-phenylpyrrolopyrimidinedione derivatives
AU2001278790A1 (en) 1h-imidazopyridine derivatives
AU2954102A (en) (dihydro)isoquinoline derivatives as phosphodiesterase inhibitors
AU4217201A (en) Tri-aryl-substituted-ethane pde4 inhibitors
AU2001292137A1 (en) Quinazoline derivatives
HK1047276A1 (en) Tetrahydrothiopy ranphthalazinone derivatives as pde4 inhibitors
AU2002213978A1 (en) Substituted C-cyclohexylmethylamine derivatives
AU2002222627A1 (en) Tak1 inhibitors
AU2002212301A1 (en) Diazacycloalkanedione derivatives
AU2002212959A1 (en) Cycloalkylfluorosulfonamide derivatives
AU2002215212A1 (en) 1-methylcarbapenem derivatives
AU2001289937A1 (en) Substituted 1-aminobutan-3-ol derivatives
AU2001254661A1 (en) Aminosulfonylbiphenyl derivatives