HUE060385T2 - Integrated continuous isolation of fluid streams from sterile process vessels - Google Patents

Integrated continuous isolation of fluid streams from sterile process vessels

Info

Publication number
HUE060385T2
HUE060385T2 HUE15791822A HUE15791822A HUE060385T2 HU E060385 T2 HUE060385 T2 HU E060385T2 HU E15791822 A HUE15791822 A HU E15791822A HU E15791822 A HUE15791822 A HU E15791822A HU E060385 T2 HUE060385 T2 HU E060385T2
Authority
HU
Hungary
Prior art keywords
fluid streams
integrated continuous
process vessels
sterile process
continuous isolation
Prior art date
Application number
HUE15791822A
Other languages
Hungarian (hu)
Inventor
Robert Snow
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of HUE060385T2 publication Critical patent/HUE060385T2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/12—Apparatus for enzymology or microbiology with sterilisation, filtration or dialysis means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/26—Inoculator or sampler
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/58—Reaction vessels connected in series or in parallel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/26—Conditioning fluids entering or exiting the reaction vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/02—Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/06—Means for testing the completeness of the sterilization
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
HUE15791822A 2014-10-24 2015-10-20 Integrated continuous isolation of fluid streams from sterile process vessels HUE060385T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462068181P 2014-10-24 2014-10-24

Publications (1)

Publication Number Publication Date
HUE060385T2 true HUE060385T2 (en) 2023-02-28

Family

ID=54478962

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE15791822A HUE060385T2 (en) 2014-10-24 2015-10-20 Integrated continuous isolation of fluid streams from sterile process vessels

Country Status (17)

Country Link
US (3) US20160115438A1 (en)
EP (1) EP3209765B1 (en)
JP (2) JP6672287B2 (en)
KR (1) KR102465762B1 (en)
CN (2) CN113105992A (en)
AU (1) AU2015336130B2 (en)
BR (1) BR112017008252B1 (en)
CA (1) CA2965478C (en)
DK (1) DK3209765T3 (en)
ES (1) ES2931455T3 (en)
HU (1) HUE060385T2 (en)
IL (1) IL251819B (en)
MX (1) MX2017005348A (en)
RU (1) RU2713126C2 (en)
SG (2) SG10201801943SA (en)
TW (2) TWI691342B (en)
WO (1) WO2016064846A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6672287B2 (en) * 2014-10-24 2020-03-25 ジェンザイム・コーポレーション Integrated continuous isolation of fluid streams from sterilization vessels
JP7325884B2 (en) 2017-10-31 2023-08-15 グローバル・ライフ・サイエンシズ・ソリューションズ・ユーエスエー・エルエルシー flexible bag
TWI747743B (en) * 2021-02-22 2021-11-21 全淨然興業股份有限公司 Amino acid enzyme automatic generation and activation equipment
CN114947113A (en) * 2021-02-24 2022-08-30 游家源 Method and equipment for preparing plant amino acid enzyme
EP4339274A1 (en) * 2022-09-13 2024-03-20 Sartorius Stedim Biotech GmbH Method for operating a bioprocess installation for production of a bioproduct
JP7422925B1 (en) 2023-07-19 2024-01-26 佐竹マルチミクス株式会社 Bioreactor culture method and bioreactor sterilization device

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2603805A1 (en) * 1986-09-16 1988-03-18 Transfusion Sanguine Assoc Rgl PROCESS FOR THE INACTIVATION BY OZONOLYSIS OF CONTAMINANT MICROORGANISMS PRESENT IN ESSENTIALLY PROTECTED BIOLOGICAL MATERIALS, THE PRODUCTS OBTAINED AND THEIR BIOLOGICAL AND ANALYTICAL APPLICATIONS
US5409841A (en) * 1991-03-14 1995-04-25 Chow; Timothy Ultraviolet light sterilized sampling device and method of sampling
EP0629135B1 (en) 1992-03-02 2000-07-26 Bioeng, Inc. Viral inactivation method
US5626767A (en) * 1993-07-02 1997-05-06 Sonosep Biotech Inc. Acoustic filter for separating and recycling suspended particles
DE9421778U1 (en) * 1994-09-13 1996-11-14 Thomae Gmbh Dr K New sampling system for bioprocess analysis
DE4432599C2 (en) * 1994-09-13 1996-10-31 Thomae Gmbh Dr K Sampling procedure for bioprocess analysis
US6197573B1 (en) * 1998-11-17 2001-03-06 Biocon India Limited Solid state fermentation
US20040204379A1 (en) * 2000-06-19 2004-10-14 Cheng Seng H. Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases
EP1498475A1 (en) * 2003-07-18 2005-01-19 Meristem Therapeutics S.A. Continuous plant cell bioreactor and method for continuous plant cell culture
US7255332B2 (en) * 2004-05-25 2007-08-14 The Board Of Trustees Of The University Of Arkansas System and method for dissolving gases in liquids
TWM283863U (en) * 2004-12-17 2005-12-21 Jia-Ching Shie Device for treating and recycling, circulating and re-using domestic sewage
US8920645B2 (en) * 2005-12-07 2014-12-30 Tarpon Biosystems Inc. Disposable chromatography valves and system
CN100389193C (en) * 2006-01-12 2008-05-21 上海交通大学 Method for safe continuous enclosed cell culture, virus production/ inactivation
WO2007124503A2 (en) * 2006-04-23 2007-11-01 Michael Charles Fahrenthold Methods, apparatus, products and compositions useful for processing fermentation waste streams
WO2008033573A2 (en) * 2006-09-13 2008-03-20 Petroalgae, Llc Tubular microbial growth system
WO2008157181A1 (en) * 2007-06-16 2008-12-24 Advanced Technology Materials, Inc. Bioreactor probe connection system
CN101182465A (en) * 2007-11-20 2008-05-21 沈佳特 Vacuum thin film filtration and microbial cultivation device
CN101200691B (en) * 2007-12-21 2011-05-11 清华大学 White rot fungi reactor capable of controlling mixed fungi pollution and controlling method therefor
JP4883067B2 (en) * 2008-09-29 2012-02-22 株式会社日立プラントテクノロジー Culture apparatus and culture method
EP2216395A1 (en) * 2009-02-09 2010-08-11 Lonza Biologics plc. Bioreactor for the cultivation of mammalian cells
WO2010120514A2 (en) 2009-03-31 2010-10-21 The Trustees Of The University Of Pennsylvania Antigen-binding proteins comprising recombinant protein scaffolds
GB0906836D0 (en) * 2009-04-21 2009-06-03 Cymtox Ltd Consumable component kit
WO2011038008A2 (en) * 2009-09-23 2011-03-31 Groton Biosystems, Llc Method and apparatus for sterile sampling for gmp reactor applications
RU102618U1 (en) 2010-08-03 2011-03-10 Учреждение Российской академии наук Институт биологического приборостроения с опытным производством РАН INSTALLATION FOR COMBINED CULTIVATION OF MICROORGANISMS
RU109275U1 (en) * 2011-04-08 2011-10-10 Общество с ограниченной ответственностью "Инновационные биотехнологии" (ООО "Инновационные биотехнологии") GAS-AIR FLOW NORMALIZATION UNIT
US8668886B2 (en) * 2011-04-24 2014-03-11 Therapeutic Proteins International, LLC Separative bioreactor
US10421939B2 (en) * 2011-10-24 2019-09-24 Bend Research, Inc. Systems and methods for producing bioproducts
US8501475B2 (en) * 2011-12-21 2013-08-06 Heliae Development Llc Systems and methods for contaminant removal from a microalgae culture
EP2682168A1 (en) 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
US20140154726A1 (en) * 2012-10-23 2014-06-05 Genzyme Corporation Perfusion Culturing Methods and Uses Thereof
US9428287B2 (en) * 2012-10-31 2016-08-30 BIOMéRIEUX, INC. Methods of fabricating test sample containers by applying barrier coatings after sealed container sterilization
US9322749B2 (en) * 2012-11-05 2016-04-26 Bend Research, Inc. Automatic sampling system for sampling from enclosed containers
IL274646B (en) * 2013-03-08 2022-09-01 Genzyme Corp Integrated continuous manufacturing of therapeutic protein drug substances
DK3047013T3 (en) * 2013-09-16 2021-11-15 Genzyme Corp METHODS AND SYSTEMS FOR PROCESSING A CELL CULTURE
CN203513669U (en) * 2013-10-08 2014-04-02 武汉大学 Generation device of ozonation cell culture fluid
JP6672287B2 (en) 2014-10-24 2020-03-25 ジェンザイム・コーポレーション Integrated continuous isolation of fluid streams from sterilization vessels
CN112206847A (en) * 2020-10-04 2021-01-12 夏喜明 Detection device for physics experiments

Also Published As

Publication number Publication date
US20220081669A1 (en) 2022-03-17
TW202026016A (en) 2020-07-16
SG10201801943SA (en) 2018-05-30
EP3209765A1 (en) 2017-08-30
TWI740417B (en) 2021-09-21
RU2020102925A3 (en) 2022-02-16
US11920120B2 (en) 2024-03-05
RU2713126C2 (en) 2020-02-03
JP2020103307A (en) 2020-07-09
CN107109322A (en) 2017-08-29
SG11201703265XA (en) 2017-05-30
MX2017005348A (en) 2017-07-28
US20160115438A1 (en) 2016-04-28
KR20170072932A (en) 2017-06-27
CA2965478A1 (en) 2016-04-28
RU2020102925A (en) 2021-07-26
KR102465762B1 (en) 2022-11-09
RU2017115655A3 (en) 2019-08-07
TW201625318A (en) 2016-07-16
WO2016064846A1 (en) 2016-04-28
CN113105992A (en) 2021-07-13
IL251819B (en) 2020-11-30
IL251819A0 (en) 2017-06-29
CN107109322B (en) 2021-04-06
TWI691342B (en) 2020-04-21
JP6672287B2 (en) 2020-03-25
CA2965478C (en) 2023-03-14
EP3209765B1 (en) 2022-09-07
DK3209765T3 (en) 2022-11-28
AU2015336130B2 (en) 2020-07-09
JP6994526B2 (en) 2022-02-21
JP2017531444A (en) 2017-10-26
BR112017008252B1 (en) 2022-03-03
US20210002601A1 (en) 2021-01-07
AU2015336130A1 (en) 2017-06-08
BR112017008252A2 (en) 2017-12-26
RU2017115655A (en) 2018-11-26
ES2931455T3 (en) 2022-12-29

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