HUE029406T2 - (1R,4R)-6'-fluor-N,N-dimetil-4-fenil-4',9'-dihidro-3'H-spiro-[ciklohexán-1,1'- pirano[3,4,B]indol]-4-amin-hidroklorid szilárd formái - Google Patents

Description

Description

FIELD OF THE INVENTION

[0001] The invention relates to solid forms of (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohex-ane-1,1’-pyrano[3,4,b]indol]-4-amine hydrochloride, in particular crystalline forms and/or amorphous forms thereof, pharmaceutical compositions and medicaments comprising these solid forms, the use of these solid forms as well as to a process for obtaining them.

BACKGROUND OF THE INVENTION

[0002] Pharmaceutically active drugs can exist in different solid forms. For example, a drug may exist in different crystalline forms which have different physical and chemical properties.

[0003] Different physical properties can cause different crystalline forms of the same drug to have largely different processing and storage performance. Such physical properties include, for example, thermodynamic stability, crystal morphology [form, shape, structure, particle size, particle size distribution, degree of crystallinity, color], ripple behavior, flowability, density, bulk density, powder density, apparent density, vibrated density, depletability, emptyability, hardness, deformability, grindability, compressability, compactability, brittleness, elasticity, caloric properties [particularly melting point], solubility [particularly equilibrium solubility, pH dependence of solubility], dissolution [particularly dissolution rate, intrinsic dissolution rate], reconstitutability, hygroscopicity, tackiness, adhesiveness, tendency to electrostatic charging, and the like.

[0004] In addition, different chemical properties can cause different crystalline forms of the same drug to have largely different performance properties. For example, a crystalline form having a low hygroscopicity (relative to other crystalline forms) can have superior chemical stability and longer shelf-life stability (cf. R. Hilfiker, Polymorphism, 2006 Wiley VCH, pp 235-242).

[0005] Further, different stereoisomers of one compound can form different crystalline forms. In some cases this difference can be exploited to allow separation of the stereoisomers from one another.

[0006] One particular drug that is of great interest for use in treating cancer pain (and other acute, visceral, neuropathic and chronic pain pain disorders) is (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,T-pyrano[3,4b]indol]-4-amine. This drug is depicted below as the compound of formula (I).

(I) (1r,4r)-6'-fluoro-/V,/V-dimethyl-4-phenyl-4',9'-dihydro-3'/-/-spiro[cyclohexane-1,1 '-pyrano[3,4-ù]indol]-4-amine [0007] The solid forms of (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclo-hexane-1,T-pyrano[3,4b]indol]-4-amine that are known so far are not satisfactory in every respect and there is a demand for advantageous solid forms.

[0008] It is an object of the invention to provide forms or modifications of (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano[3,4,b]indol]-4-amine that have advantages compared to the forms or modifications of the prior art.

[0009] This object has been achieved by the present invention.

[0010] It has been found that by converting (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohex-ane-1 ,T-pyrano[3,4b]indol]-4-amine into the hydrochloride salt, optionally in the form of a solvate thereof, the aqueous solubility of the compound may be improved.

[0011] It has surprisingly been found that converting (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cy- clohexane-1,1’-pyrano[3,4b]indol]-4-amine into the hydrochloride salt, optionally in the form of a solvate thereof, and subsequent crystallization purifies the compound.

[0012] Moreover, it has surprisingly been found that different crystalline forms of (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano[3,4b]indol]-4-amine hydrochloride, optionally in the form of solvates thereof, can be prepared which have fundamentally different properties. These inventive crystalline forms are described herein.

BRIEF DESCRIPTION OF THE DRAWINGS

[0013]

Figures 1 a-g show the PXRD patterns of crystalline forms A, B, C, D, E, F and G.

Figures 2a-g show the Raman spectra of crystalline forms A, B, C, D, E, F and G.

DETAILED DESCRIPTION

[0014] The compound according to general formula (I) can systematically be referred to as "1,1-(3-dimethylamino-3-phenylpentamethylene)-6-fluoro-1,3,4,9-tetrahydropyrano[3,4-b]indole (trans)" or as "(1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano[3,4,b]indol]-4-amine", respectively.

[0015] In the solid form according to the invention the compound according to general formula (I) is present in form of the hydrochloride. The definition of the hydrochloride of the compound according to general formula (I) as used herein includes salts, solvates, co-crystals, polymorphs, amorphous forms and multi-component complex forms. For the purpose of the specification, "hydrochloride" preferably means that the compound according to general formula (I) is present in form of the hydrochloric acid-addition salt. The most basicfunctional group of the compound according to general formula (I) is its Ν,Ν-dimethylamino moiety, which thus according to the invention is preferably protonated. Methods to determine whether a chemical substance is present as a salt, co-crystalline form, crystalline form or as the free base, optionally in each case in a solvated from thereof, are known to the skilled artisan such as 14N or 15N solid state NMR, X-ray diffraction, IR, DSC, TGA, Raman and XPS. 1H-NMR recorded in solution may also be used to consider the presence of protonation.

[0016] Unless explicitly stated otherwise, all 2Θ values refer to a X-ray diffractogram measured using CuKa radiation having a wavelength of 1.54060 A determined at 23 +/- 3°C.

[0017] One aspect of the present invention relates to a solid form of (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1 ,T-pyrano[3,4b]indol]-4-amine hydrochloride. The solid form according to the invention may be a crystalline form or an amorphous form, which may be in the form of an ansolvate or in the form of a solvate.

[0018] Mixtures of crystalline forms and/or amorphous forms are also included within the scope of the present invention.

[0019] In a preferred embodiment, the solid form according to the invention is an amorphous form.

[0020] Suitable methods for the preparation of amorphous forms are known to a person skilled in the art. For example, amorphous forms of or amorphous mixtures may be obtained by means of the following methods: i) precipitation from solution, ii) lyophilization, iii) spray drying, iv) melts extrusion, v) flash evaporation, vi) quench cooling of the melt, vii) grinding at ambient or liquid nitrogen temperatures, and/or viii) using capillary crystallization technology.

[0021] In a preferred embodiment, the solid form according to the invention is a crystalline form of (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,T-pyrano-[3,4b]indol]-4-amine hydrochloride.

[0022] In some preferred embodiments, the crystalline form according to the invention has an X-ray diffraction peak at 14.3 ±0.5 (20) and/or an X-ray diffraction peak at 17.1 ±0.5 (20) and/or an X-ray diffraction peak at 18.9 ±0.5 (20) and/or an X-ray diffraction peak at 19.6 ±0.5 (20). All 2Θ values refer to a X-ray diffractogram measured using CuKa radiation having a wavelength of 1.54060 A.

[0023] Preferably, said X-ray diffraction peak(s) exhibit(s) a relative intensity of at least 20%, more preferably of at least 25%, still more preferably of at least 30%, yet more preferably of at least 40%, most preferably of at least 45% and in particular, of at least 50%.

[0024] Preferably, the crystalline form according to the invention has at least two Raman peaks selected from the group consisting of 918±5 cm-1, 1299±5 cm"1, 1569±5 cnr1and at 1583±5 cm"1.

[0025] In a preferred embodiment, the crystalline form according to the invention has at least three Raman peaks selected from the group consisting of 918±5 cm'1, 1299±5 cm-1, 1569±5 cm'1 and at 1583±5 cm"1. In an especially preferred embodiment, the crystalline form according to the invention has all four peaks.

[0026] The solid form according to the invention may be an ansolvate or a solvate. Therefore, the crystalline form according to the invention may be an ansolvate or a solvate.

[0027] In a preferred embodiment, the crystalline form is an ansolvate.

[0028] In a preferred embodiment, the ansolvate form does not contain any solvent.

[0029] In another preferred embodiment, the ansolvate form may contain up to 1.5 wt.-% of water.

[0030] In another preferred embodiment, the ansolvate form does not contain any impurities.

[0031] Impurities in the sense of the present invention may be preferably understood as reagents or decomposition products thereof, which have been employed in the synthesis of the compound according to formula (I) and/or the synthesis of the inventive solid form thereof, or as decomposition or reaction products of (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano[3,4b]indol]-4-amine or hydrochloric acid or agent employed for the in-situ generation of hydrochloric acid.

[0032] In another preferred embodiment, the crystalline form is a solvate. Preferably, the solvate is selected from hydrates, solvates of 1,4-dioxane and solvates of pyridine, or mixtures thereof.

[0033] In a preferred embodiment, the solvate form does not contain any impurities.

[0034] Another aspect of the present invention relates to a process for the production of the solid form, in particular the crystalline form according to the invention.

[0035] In a preferred embodiment, the process comprises the step of (a-1) precipitating the hydrochloride salt of (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohex-ane-1,1’-pyrano[3,4,b]indol]-4-amine from a solution or suspension of the free base.

[0036] For the purpose of the specification, "free base" preferably means that the compound according to general formula (I) is not present in form of a salt, particularly not in form of an acid-addition salt.

[0037] Conventional solvents known to persons skilled in the art may be used as solvents in a solution or suspension of this type, such as water or organic solvents selected from the group consisting of alcohols such as methanol, ethanol, n-propanol, iso-propanol and n-butanol; esters such as ethyl acetate, n-propyl acetate, iso-propyl acetate, n-butyl acetate and iso-butyl acetate; ketones such as acetone, 2-butanone, pentan-2-one, pentan-3-one, hexan-2-one and hexan-3-one; ethers such as tert-butyl methyl ether, diethylether, tetrahydrofuran, diisopropylether and 1,4-dioxane; nitriles such as acetonitril; aromatic hydrocarbons such as toluene; saturated hydrocarbons such as n-pentane, n-hexane and n-heptane; chlorinated hydrocarbons such as dichloromethane and chloroform; and also N-methyl-2-pyrrolidone, dimethyl formamide and dimethyl sulfoxide; and mixtures thereof.

[0038] Step (a-1) may be carried out by the addition of hydrogen chloride.

[0039] In a preferred embodiment, the hydrogen chloride is added in form of hydrogen chloride gas.

[0040] In another preferred embodiment, the hydrogen chloride is produced in situ by means of a reaction, e.g. by the addition of trimethylsilyl chloride to an aqueous solution.

[0041] In still another preferred embodiment, the hydrogen chloride is in form of a solution.

[0042] In a preferred embodiment, the solution is a solution of hydrogen chloride in an aqueous solvent, hydrochloric acid is particularly preferred.

[0043] In another preferred embodiment, the solution is a solution of hydrogen chloride in an organic solvent, especially preferred are alcohols such as ethanol, isopropanol and n-butanol, and ethers such as diethylether, di-isopropylether, tetrahydrofurane, methyl-tetrahydrofurane 1,4-dioxane.

[0044] Preferably, the hydrogen-chloride containing solution and the solution of thefree base contain the same solvent.

[0045] Preferably, the solution contains the hydrogen chloride in a concentration within the range of from 0.01 mol/L to 15 mol/L, more preferably within the range of from 0.02 mol/L to 12.5 mol/L, still more preferably within the range of from 0.05 mol/L to 10 mol/L, yet more preferably within the range of from 0.1 mol/L to 7.5 mol/L, most preferably within the range of from 0.2 mol/L to 10 mol/L, and in particular within the range of from 0.3 mol/L to 5 mol/L.

[0046] Preferably, the hydrogen chloride is added to the solution or suspension of the free base in molar excess.

[0047] Preferably, in the process according to the invention, step (a-1) is carried out at a temperature below or at the boiling point of the respective solvent, preferably at a temperature not higher than 80 °C, more preferably not higher than 60°C, even more preferably not higher than 40°C, and in particular in a temperature range of 20-40 °C.

[0048] Preferably, in the process according to the invention, the suspension obtained in step (a-1) is stirred for a time period of at least 1 minute, preferably at least 2 minutes, more preferably at least 3 minutes, still more preferably at least 5 minutes, yet more preferably at least 10 minutes, most preferably at least 20 minutes, and in particular at least 30m inutes.

[0049] In a preferred embodiment, the suspension obtained in step (a-1) is stirred for a time period of at least 1 hour, preferably at least 4 hours, more preferably at least 6 hours, still more preferably at least 12 hours, yet more preferably at least 18 hours, most preferably at least 1 day, and in particular at least 2 days.

[0050] In another preferred embodiment, the suspension obtained in step (a-1) is stirred for a time period of at most 1 day, preferably at most 12 hours, more preferably at most 6 hours, still more preferably at most 2 hours, yet more preferably at most 60 minutes, and most preferably at most 45 minutes, and in particular at most 30 minutes.

[0051] Preferably, the process according to the invention further comprises the step (b-1) separating, preferably filtering off the solid obtained in step (a-1).

[0052] Preferably, the process according to the invention further comprises the step (c-1) drying of the solid obtained in step (b-1).

[0053] In a preferred embodiment, step (c-1) takes place under air, nitrogen flow or argon flow.

[0054] In another preferred embodiment, step (c-1) takes place under vacuum, more preferably at a vacuum of 0 to 900 mbar, even more preferably at a vacuum of 1 to 500 mbar, and in particular at a vacuum of 10 to 200 mbar.

[0055] Preferably, in the process according to the invention, step (c-1) takes place in a temperature range from 0 to 60 °C, preferably from 10°C to 50 °C more preferably from 20 to 40 °C.

[0056] In another preferred embodiment, the process comprises the step of (a-2) dissolving(1 r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano[3,4,b]in-dol]-4-amine hydrochloride in a solvent.

[0057] Conventional solvents known to persons skilled in the art may be used as solvents in a suspension of this type, in particular organic solvents selected from the group consisting of alcohols such as methanol, ethanol, n-propanol, isopropanol and n-butanol; esters such as ethyl acetate, n-propyl acetate, iso-propyl acetate, n-butyl acetate and iso-butyl acetate; ketones such as acetone, 2-butanone, pentan-2-one, pentan-3-one, hexan-2-one and hexan-3-one; ethers such as tert-butyl methyl ether, diethylether, tetrahydrofuran, diisopropyletherand 1,4-dioxane; nitriles such as acetonitril; aromatic hydrocarbons such as toluene; chlorinated hydrocarbons such as dichloromethane and chloroform; and also N-methyl-2-pyrrolidone, dimethyl formamide and dimethyl sulfoxide; and mixtures thereof. Saturated hydrocarbons, such as n-pentane, n-hexane and n-heptane, and water are less suitable, the compound (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano[3,4,b]indol]-4-amine hydrochloride being only poorly soluble in these substances.

[0058] Preferably, the solvent is selected from the group consisting of dichloromethane, N-methyl-2-pyrrolidone, methanol, dimethyl formamide, and mixtures thereof.

[0059] In an especially preferred embodiment, the organic solvent is a mixture of dichloromethane and methanol. Preferably, the ratio between dichloromethane and methanol is within the range of from 10:1 to 1:10, more preferably within the range of from 7:1 to 1:5, still more preferably within the range of from 6:1 to 1:3, yet more preferably within the range of from 5:1 to 1:1, most preferably within the range of from 4:1 to 2:1, and in particular within the range of from 3.5:1 to 2.5:1 (volume/volume).

[0060] Preferably, in the process according to the invention, step (a-2) is carried out at a temperature below or at the boiling point of the respective solvent or solvent mixture, more preferably at a temperature not higher than 80 °C, more preferably not higher than 60°C, even more preferably not higher than 40 °C, and in particular in a temperature range of 20-40 °C.

[0061] In a preferred embodiment, the process according to the invention further comprises the step (b-2) evaporating off the solvent of the solution obtained in step (a-2).

[0062] Suitable methods for evaporating off the solvent are known to a person skilled in the art. Preferably, in the process according to the invention, the solvent is evaporated off in air, air flow, or inert gas flow, in particular argon or nitrogen flow. However, evaporating off the solvent under vacuum, for example by means of a rotary evaporator, is also possible.

[0063] Preferably, in the process according to the invention, the solvent is evaporated off at room temperature.

[0064] In another preferred embodiment, the process further comprises the step of (b-2’) precipitating (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclo-hexane-1,1’- pyrano[3,4,b]indol]-4-aminehydrochloride from the solution obtained in step (a-2).

[0065] Suitable methods of precipitation are known to a person skilled in the art. In the process according to the invention, step (b-2’) may be carried out by reducing the volume of the solution obtained in step (a-2) and/or by cooling of the solution, preferably to a temperature of at most 15°C, more preferably at most 10°C, even more preferably at most 4-8°C and/or by cooling of the solution, preferably to a temperature of at least 10 °C, more preferably at least 30 °C, even more preferably at least 60 °C below the temperature according to step (a-2).

[0066] In a preferred embodiment, step (b-2’) is carried out by the addition of a medium in which (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano-[3,4,b]indol]-4-amine hydrochloride is only poorly soluble ("anti-solvent") to the solution obtained in step (a-2). Said medium is preferably selected from the group consisting of esters such as ethyl acetate, n-propyl acetate, iso-propyl acetate, n-butyl acetate and iso-butyl acetate; ethers such as tert-butyl methyl ether, diethyl ether and diisopropyl ether; ketones such as acetone, 2-butanone, pentan-2-one, pentan-3-one, hexan-2-one and hexan-3-one; nitriles such as acetonitril; pyridine, acetic acid and water.

[0067] The amount of the media in which (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano[3,4,b]indol]-4-amine hydrochloride is only poorly soluble, the precipitant or anti-solvent, is preferably selected in such a manner that upon its addition precipitation of the dissolved component begins.

[0068] The total amount of the media in which(1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohex-ane-1,1’-pyrano[3,4,b]indol]-4-amine hydrochloride is only poorly soluble may also be divided into several portions, preferably two or three portions. In this embodiment, the precipitation of the dissolved component preferably begins after the addition of the last portion.

[0069] The precipitation of the dissolved component preferably begins either immediately after the precipitant, preferably the total amount of the precipitant, has been added or alternatively with a delay of 2 seconds to 120 minutes. Preferably, the precipitation of the dissolved component begins within a time period of at most 90 minutes, more preferably at most 60 minutes, still more preferably at most 30 minutes, even more preferably at most 5 minutes, most preferably at most 60 seconds and in particular at most 10 seconds.

[0070] Furthermore, the amount of the media in which (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano[3,4,b]indol]-4-amine hydrochloride, is only poorly soluble, the precipitant or anti-solvent, is preferably selected in such a manner that the dissolved component is completely precipitated or at least up to 90% of the initial amount is precipitated within a time period of at most 90 minutes, more preferably at most 80 minutes, still more preferably at most 70 minutes, and most preferably at most 60 minutes after the anti-solvent has been completely added.

[0071] Step (b-2’) may also be carried out by exposing the solution obtained in step (a-2) to an atmosphere containing a solvent, in which (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,T-pyrano[3,4,b]indol]-4-amine hydrochloride is only poorly soluble, i. e. by a vapor diffusion crystallization technique.

[0072] In this embodiment, dichloromethane is preferably selected as solvent in step (a-2) and the solution obtained in step (a-2) is preferably exposed to an atmosphere containing hexane.

[0073] Preferably, in the process according to the invention, after step (b-2) or respectively (b-2’), all other steps are carried out at a temperature between 40 and 0 °C, preferably between 35 and 5°C, more preferably between 25 and 15°C.

[0074] Preferably, in the process according to the invention, the suspension obtained in step (b-2’) is stirred for a time period of at least 1 minute, preferably at least 2 minutes, more preferably at least 3 minutes, and most preferably at least 5 minutes.

[0075] Preferably, the process according to the invention further comprises the step (c-2’) separating, preferably filtering off the precipitate obtained in step (b-2’).

[0076] Preferably, the process according to the invention further comprises the step (d-2’) drying of the solid obtained in step (c-2’).

[0077] Preferably, in the process according to the invention, step (d-2’) takes place under air or inert gas flow, such as argon or nitrogen flow. However, depending on the crystalline form to be obtained evaporating off the solvent at an elevated temperature, e.g. within the range of from 20 °C to 60 °C, is also possible.

[0078] In still another preferred embodiment, the process comprises the step of (a-3) suspending (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclo-hexane-1,1’-pyrano[3,4,b]in-dol]-4-amine hydrochloride in a solvent.

[0079] Conventional solvents known to persons skilled in the art may be used as solvents in a suspension of this type, in particular water and organic solvents selected from the group consisting of alcohols such as methanol, ethanol, n-propanol, iso-propanol and n-butanol; esters such as ethyl acetate, n-propyl acetate, iso-propyl acetate, n-butyl acetate and iso-butyl acetate; ketones such as acetone, 2-butanone, pentan-2-one, pentan-3-one, hexan-2-one and hexan-3-one; ethers such as tert-butyl methyl ether, diethylether, tetrahydrofuran, diisopropylether and 1,4-dioxane; nitriles such as acetonitril; aromatic hydrocarbons such as toluene; saturated hydrocarbons such as n-pentane, n-hexane and n-heptane; chlorinated hydrocarbons such as dichloromethane and chloroform; and also N-methyl-2-pyrrolidone, dimethyl formamide and dimethyl sulfoxide; and mixtures thereof.

[0080] In a preferred embodiment, step (a-3) is carried out at a temperature below or at the boiling point of the respective solvent, preferably at a temperature not higher than 100°C, more preferably not higher than 90°C, still more preferably not higher than 80°C, yet more preferably not higher than 60°C, most preferably not higher than 40°C, and in particular in a temperature range of 15-35 °C.

[0081] In another preferred embodiment, step (a-3) is carried out in a temperature range of 100-40 °C, more preferably 90-50 °C, and most preferably 85-60°C.

[0082] Preferably, in the process according to the invention, the suspension obtained in step (a-3) is stirred for a time period of at least 2 h, preferably at least 4 h, more preferably at least 8 h, still more preferably at least 12 h, yet more preferably at least 16 h, most preferably at least 24 h, and in particular at least 2 days.

[0083] Preferably, the process according to the invention further comprises the step (b-3) separating, preferably filtering off the solid obtained in step (a-3).

[0084] Preferably, the process according to the invention further comprises the step (c-3) drying of the solid obtained in step (b-3).

[0085] In the process according to the invention, step (c-3) may take place under air or inert gas flow, such as argon or nitrogen flow. However, drying under vacuum, more preferably at a vacuum of 0 to 900 mbar, even more preferably at a vacuum of 1 to 500 mbar, and in particular at a vacuum of 10 to 200 mbar is preferred.

[0086] Preferably, in the process according to the invention, step (c-3) takes place in a temperature range from 0 to 60 °C, preferably from 10 °C to 50 °C more preferably from 20 to 40 °C.

[0087] A further aspect of the invention relates to a solid form, preferably a crystalline form of (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano-[3,4,b]indol]-4-amine hydrochloride that is obtainable by the process as described above.

[0088] In the following, any reference to a "crystalline form" refers to a crystalline form of (1 r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano[3,4,b]indol]-4-amine hydrochloride.

[0089] A further aspect of the present invention relates to a crystalline form A.

[0090] Preferably, the crystalline form A according to the invention has one or more X-ray diffraction peaks selected from the group consisting of 10.8 ±0.2 (20), 17.0 ±0.2 (20), 17.5 ±0.2 (20), 18.9 ±0.2 (20) and 25.5 ±0.2 (20). In some preferred embodiments, the crystalline form comprises X-ray difFraction peaks at 17.0 ±0.2 (20), 18.9 ±0.2 (20) and 25.5 ±0.2(20). In some preferred embodiments, the crystalline form comprises an X-ray diffraction peak at 25.5 ±0.2 (20).

[0091] In some preferred embodiments, crystalline form A comprises X-ray diffraction peaks at 10.8 ±0.2 (20), 17.0 ±0.2 (20), 18.9 ±0.2 (20), 25.5 ±0.2 (20) and optionally 17.5 ±0.2 (20).

[0092] The crystalline form A according to the invention may additionally have at least one X-ray diffraction peak selected from the group consisting of 8.4 ±0.2 (20), 20.0 ±0.2 (20), 20.7 ±0.2 (20), 24.1 ±0.2 (20), 27.9 ±0.2 (20), 30.2 ±0.2 (20), 30.8 ±0.2 (20) and 34.3 ±0.2 (20).

[0093] Further, the crystalline form A according to the invention may be characterised in that as well as one or more X-ray diffraction peaks selected from the group consisting of 10.8 ±0.2 (20), 17.0 ±0.2 (20), 17.5 ±0.2 (20), 18.9 ±0.2 (20) and 25.5 ±0.2 (20), and optionally one or more X-ray diffraction peaks selected from the group consisting of 8.4 ±0.2 (20), 20.0 ±0.2 (20), 20.7 ±0.2 (20), 24.1 ±0.2 (20), 27.9 ±0.2 (20), 30.2 ±0.2 (20), 30.8 ±0.2 (20) and 34.3 ±0.2 (20), it additionally has at least one X-ray diffraction peak selected from the group consisting of 21.6 ±0.2 (20), 22.3 ±0.2 (20), 23.6 ±0.2 (20), 26.3 ±0.2 (20), 28.4 ±0.2 (20), 33.7 ±0.2 (20), and 34.6 ±0.2 (20).

[0094] The crystalline form A according to the invention may further be characterised in that as well as one or more X-ray diffraction peaks selected from the group consisting of 10.8 ±0.2 (20), 17.0 ±0.2 (20), 17.5 ±0.2 (20), 18.9 ±0.2 (20) and 25.5 ±0.2 (20), and optionally one or more X-ray diffraction peaks selected from the group consisting of 8.4 ±0.2 (20), 20.0 ±0.2 (20), 20.7 ±0.2 (20), 24.1 ±0.2 (20), 27.9 ±0.2 (20), 30.2 ±0.2 (20), 30.8 ±0.2 (20) and 34.3 ±0.2 (20), and optionally one or more X-ray diffraction peaks selected from the group consisting of 21.6 ±0.2 (20), 22.3 ±0.2 (20), 23.6 ±0.2 (20), 26.3 ±0.2 (20), 28.4 ±0.2 (20), 33.7 ±0.2 (20), and 34.6 ±0.2 (20), it additionally has at least one X-ray diffraction peak selected from the group consisting of 12.3 ±0.2 (20), 13.1 ±0.2 (20), 22.6 ±0.2 (20), 23.3 ±0.2 (20), 26.8 ±0.2 (20), 29.2 ±0.2 (20), 31.5 ±0.2 (20) and 32.4 ±0.2 (20).

[0095] All 2Θ values refer to an X-ray diffractogram measured using CuKa radiation having a wavelength of 1.54060 A.

[0096] In DSC analyses, the crystalline form A according to the present invention preferably exhibits an endothermal event with a peak temperature at 258-268 °C, more preferably at 259-267 °C, still more preferably at 260-266 °C, yet more preferably at 261-265 °C and in particular at 262-265 °C.

[0097] Preferably, the crystalline form A according to the present invention further exhibits a further endothermal event, preferably within a temperature range of 210-275 °C.

[0098] The crystalline form A according to the present invention may further be characterized in that it has one or more Raman bands selected from the group consisting of 1003 ±2 cm-1, 1554 ±2 cm-1,2958 ±2 cm-1 and 3071 ±2 cm-1.

[0099] The crystalline form A according to the present invention may further be characterized in that it has one or more Raman bands selected from the group consisting of 1003 ±2 cm-1, 1554 ±2 cm'1,2958 ±2 cm-1 and 3071 ±2 cm'1; and/or one or more Raman bands selected from the group consisting of 691 ±2 cm'1, 914 ±2 cm-1,926 ±2 cm'1, 1034 ±2 cm'1, 1156 ±2 cm'1, 1295 ±2 cm'1, 1316 ±2 cm'1, 1372 ±2 cm'1, 1441 ±2 cm'1, 1470 ±2 cm'1, 1582 ±2 cm'1, 2882 ±2 cm'1, 2907 ±2 cm'1, 2935 ±2 cm'1,2986 ±2 cm'1, 3020 ±2 cm'1 and 3041 ±2 cm'1.

[0100] The crystalline form A according to the present invention may further be characterized in that it has one or more Raman bands selected from the group consisting of 408 ±2 cm-1, 451 ±2 cm-1, 483 ±2 cm-1, 512 ±2 cm-1, 524 ±2 cm'1, 536 ±2 cm'1, 554 ±2 cm'1, 597 ±2 cm'1, 621 ±2 cm'1, 642 ±2 cm'1, 660 ±2 cm'1, 712 ±2 cm'1,789 ±2 cm'1, 824 ±2 cm'1, 842 ±2 cm'1, 869 ±2 cm'1, 885 ±2 cm'1, 965 ±2 cm'1, 1049 ±2 cm'1, 1061 ±2 cm'1, 1095 ±2 cm'1, 1112 ±2 cm1, 1128 ±2 cm'1, 1175 ±2 cm1, 1201 ±2 cm 1, 1208 ±2 cm'1, 1234 ±2 cm'1, 1268 ±2 cm'1, 1353 ±2 cm 1, 1600 ±2 cm'1, 1625 ±2 cm'1, 2542 ±2 cm1, 2811 ±2 cm'1, 2847 ±2 cm'1,2858 ±2 cm'1 and 3201 ±2 cm'1.

[0101] Another aspect of the present invention relates to a process for the production of the crystalline form A described above.

[0102] In a preferred embodiment, the process comprises the step of (a-1) precipitating the hydrochloride salt of (1 r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohex-ane-1,1’-pyrano[3,4,b]indol]-4-amine from a solution or suspension of the free base.

[0103] Conventional solvents known to persons skilled in the art may be used as solvents in a solution or suspension of this type, in particular water and organic solvents selected from the group consisting of alcohols such as methanol, ethanol, n-propanol, iso-propanol and n-butanol; esters such as ethyl acetate, n-propyl acetate, iso-propyl acetate, n-butyl acetate and iso-butyl acetate; ketones such as acetone, 2-butanone, pentan-2-one, pentan-3-one, hexan-2-one and hexan-3-one; ethers such as tert-butyl methyl ether, diethylether, tetrahydrofuran, diisopropylether and 1,4-dioxane; nitriles such as acetonitril; aromatic hydrocarbons such as toluene; saturated hydrocarbons such as n-pentane, n-hexane and n-heptane; chlorinated hydrocarbons such as dichloromethane and chloroform; and also N-methyl-2-pyrrolidone, dimethyl formamide and dimethyl sulfoxide; and mixtures thereof.

[0104] Preferably, the solvent is selected from the group consisting of alcohols such as methanol, ethanol, n-propanol, iso-propanol and n-butanol; ketones such as acetone, 2-butanone, pentan-2-one, pentan-3-one, hexan-2-one and hexan-3-one; etherssuch as tert-butyl methyl ether, diethylether, tetrahydrofuran, diisopropylether and 1,4-dioxane; chlorinated hydrocarbons such as dichloromethane and chloroform; and mixtures thereof.

[0105] Especially preferred are solvents selected from the group consisting of tetrahydrofuran, 1,4-dioxane, acetone, dichloromethane, methanol, ethanol, isopropanol, water, and mixtures thereof, in particular THF / water and acetone / water mixtures.

[0106] Step (a-1) may be carried out by the addition of hydrogen chloride.

[0107] In a preferred embodiment, the hydrogen chloride is added in form of hydrogen chloride gas.

[0108] In another preferred embodiment, the hydrogen chloride is produced In situ by means of a reaction, e.g. by the addition of trimethylsilyl chloride to an aqueous solution.

[0109] In still another preferred embodiment, the hydrogen chloride is in form of a solution.

[0110] In a preferred embodiment, the solution is a solution of hydrogen chloride in an aqueous solvent, hydrochloric acid is particularly preferred.

[0111] In another preferred embodiment, the solution is a solution of hydrogen chloride in an organic solvent, especially preferred are alcohols such as ethanol, isopropanol and n-butanol, and ethers such as diethylether, di-isopropylether, tetrahydrofurane, methyl-tetrahydrofurane 1,4-dioxane.

[0112] Preferably, the hydrogen-chloride containing solution and the solution of the free base contain the same solvent.

[0113] Preferably, the solution contains the hydrogen chloride in a concentration within the range of from 0.01 mol/L to 15 mol/L, more preferably within the range of from 0.02 mol/L to 12.5 mol/L, still more preferably within the range of from 0.05 mol/L to 10 mol/L, yet more preferably within the range of from 0.1 mol/L to 7.5 mol/L, most preferably within the range of from 0.2 mol/L to 10 mol/L, and in particular within the range of from 0.3 mol/L to 5 mol/L.

[0114] Preferably, the hydrogen chloride is added to the solution or suspension of the free base in molar excess.

[0115] Preferably, in the process according to the invention, step (a-1) is carried out at a temperature below or at the boiling point of the respective solvent, preferably at a temperature not higher than 80 °C, more preferably not higher than 60°C, even more preferably not higher than 40°C, and in particular in a temperature range of 20-40 °C.

[0116] Preferably, in the process according to the invention, the suspension obtained in step (a-1) is stirred for a time period of at least 1 minute, preferably at least 2 minutes, more preferably at least 3 minutes, still more preferably at least 5 minutes, yet more preferably at least 10 minutes, most preferably at Ieast20 minutes, and in particular at least 30 minutes.

[0117] In a preferred embodiment, the suspension obtained in step (a-1) is stirred for a time period of at least 1 hour, preferably at least 4 hours, more preferably at least 6 hours, still more preferably at least 12 hours, yet more preferably at least 18 hours, most preferably at least 1 day, and in particular at least 2 days.

[0118] In another preferred embodiment, the suspension obtained in step (a-1) is stirred for a time period of at most 1 day, preferably at most 12 hours, more preferably at most 6 hours, still more preferably at most 2 hours, yet more preferably at most 60 minutes, and most preferably at most 45 minutes, and in particular at most 30 minutes.

[0119] Preferably, the process according to the invention further comprises the step (b-1) separating, preferably filtering ofFthe solid obtained in step (a-1).

[0120] Preferably, the process according to the invention further comprises the step (c-1) drying of the solid obtained in step (b-1).

[0121] In a preferred embodiment, step (c-1) takes place under air or inert gas flow, such as argon or nitrogen flow.

[0122] In another preferred embodiment, step (c-1) takes place under vacuum, more preferably at a vacuum of 0 to 900 mbar, even more preferably at a vacuum of 1 to 500 mbar, and in particular at a vacuum of 10 to 200 mbar.

[0123] Preferably, in the process according to the invention, step (c-1) takes place in a temperature range from 0 to 60 °C, preferably from 10 °C to 50 °C more preferably from 20 to 40 °C.

[0124] In another preferred embodiment, the process comprises the step of (a-2) dissolving (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano[3,4,b]in-dol]-4-amine hydrochloride in a solvent.

[0125] Conventional solvents known to persons skilled in the art may be used as solvents in a suspension of this type, in particular organic solvents selected from the group consisting of alcohols such as methanol, ethanol, n-propanol, isopropanol and n-butanol; esters such as ethyl acetate, n-propyl acetate, iso-propyl acetate, n-butyl acetate and iso-butyl acetate; ketones such as acetone, 2-butanone, pentan-2-one, pentan-3-one, hexan-2-one and hexan-3-one; ethers such as tert-butyl methyl ether, diethylether, tetrahydrofuran, diisopropylether and 1,4-dioxane; nitriles such as acetonitril; aromatic hydrocarbons such as toluene; chlorinated hydrocarbons such as dichloromethane and chloroform; and also N-methyl-2-pyrrolidone, dimethyl formamide and dimethyl sulfoxide; and mixtures thereof. Saturated hydrocarbons, such as n-pentane, n-hexane and n-heptane, and water are less suitable, the compound (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano[3,4,b]indol]-4-amine hydrochloride being only poorly soluble in these substances.

[0126] Preferably, the solvent is selected from the group consisting of dichloromethane, N-methyl-2-pyrrolidone, methanol, dimethyl formamide, and mixtures thereof.

[0127] In an especially preferred embodiment, the organic solvent is a mixture of dichloromethane and methanol. Preferably, the ratio between dichloromethane and methanol is within the range of from 10:1 to 1:10, more preferably within the range of from 7:1 to 1:5, still more preferably within the range of from 6:1 to 1:3, yet more preferably within the range of from 5:1 to 1:1, most preferably within the range of from 4:1 to 2:1, and in particular within the range of from 3.5:1 to 2.5:1 (volume/volume).

[0128] Preferably, in the process according to the invention, step (a-2) is carried out at a temperature below or at the boiling point of the respective solvent, preferably at a temperature not higher than 80 °C, more preferably not higher than 60°C, even more preferably not higher than 40°C, and in particular in a temperature range of 20-40 °C.

[0129] In a preferred embodiment, the process according to the invention further comprises the step (b-2) evaporating off the solvent of the solution obtained in step (a-2).

[0130] Suitable methods for evaporating off the solvent are known to a person skilled in the art. Preferably, in the process according to the invention, the solvent is evaporated off in air, air flow, or inert gas flow, in particular argon or nitrogen flow. However, evaporating off the solvent under vacuum, for example by means of a rotary evaporator, is also possible.

[0131] Preferably, in the process according to the invention, the solvent is evaporated off at room temperature.

[0132] In another preferred embodiment, the process further comprises the step of (b-2’) precipitating (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclo-hexane-1,1 pyrano[3,4,b]indol]-4-amine hydrochloride from the solution obtained in step (a-2).

[0133] Suitable methods of precipitation are known to a person skilled in the art. In the process according to the invention, step (b-2’) may be carried out by reducing the volume of the solution obtained in step (a-2) and/or by cooling of the solution, preferably to a temperature of at most 15°C, more preferably at most 10°C, even more preferably at most 4-8°C and/or by cooling of the solution, preferably to a temperature of at least 10 °C, more preferably at least 30 °C, even more preferably at least 60 °C below the temperature according to step (a-2).

[0134] In a preferred embodiment, step (b-2’) is carried out by the addition of a medium in which (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano-[3,4,b]indol]-4-amine hydrochloride is only poorly soluble ("anti-solvent") to the solution obtained in step (a-2). Said medium is preferably selected from the group consisting of esters such as ethyl acetate, n-propyl acetate, iso-propyl acetate, n-butyl acetate and iso-butyl acetate; ethers such as tert-butyl methyl ether, diethyl ether and diisopropyl ether; ketones such as acetone, 2-butanone, pentan-2-one, pentan-3-one, hexan-2-one and hexan-3-one; nitriles such as acetonitril; pyridine, acetic acid and water. Especially preferred are ethyl acetate, acetonitril, acetone and diethyl ether.

[0135] The amount of the media in which (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano[3,4,b]indol]-4-amine hydrochloride is only poorly soluble, the precipitant or anti-solvent, is preferably selected in such a manner that upon its addition precipitation of the dissolved component begins.

[0136] The total amount ofthe media inwhich(1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohex-ane-1,1’-pyrano[3,4,b]indol]-4-amine hydrochloride is only poorly soluble may also be divided into several portions, preferably two or three portions. In this embodiment, the precipitation ofthe dissolved component preferably begins after the addition ofthe last portion.

[0137] The precipitation ofthe dissolved component preferably begins either immediately after the precipitant, preferably the total amount of the precipitant, has been added or alternatively with a delay of 2 seconds to 120 minutes.

[0138] Step (b-2’) may also be carried out by exposing the solution obtained in step (a-2) to an atmosphere containing a solvent, in which (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano[3,4,b]indol]- 4-amine hydrochloride is only poorly soluble.

[0139] Preferably, in the process according to the invention, after step (b-2) or respectively (b-2’), all other steps are carried out at a temperature between 40 and 0 °C, preferably between 35 and 5°C, more preferably between 25 and 15°C.

[0140] Preferably, in the process according to the invention, the suspension obtained in step (b-2’) is stirred fora time period of at least 1 minute, preferably at least 2 minutes, more preferably at least 3 minutes, and most preferably at least 5 minutes.

[0141] Preferably, the process according to the invention further comprises the step (c-2’) separating, preferably filtering off the precipitate obtained in step (b-2’).

[0142] Preferably, the process according to the invention further comprises the step (d-2’) drying ofthe solid obtained in step (c-2’).

[0143] Preferably, in the process according to the invention, step (d-2’) takes place under air or inert gas flow, such as argon or nitrogen flow.

[0144] In still another preferred embodiment, the process comprises the step of (a-3) suspending (1 r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclo-hexane-1,T-pyrano[3,4,b]in-dol]-4-amine hydrochloride in a solvent.

[0145] Conventional solvents known to persons skilled in the art may be used as solvents in a suspension of this type, in particular water and organic solvents selected from the group consisting of alcohols such as methanol, ethanol, n-propanol, iso-propanol and n-butanol; esters such as ethyl acetate, n-propyl acetate, iso-propyl acetate, n-butyl acetate and iso-butyl acetate; ketones such as acetone, 2-butanone, pentan-2-one, pentan-3-one, hexan-2-one and hexan-3-one; ethers such as tert-butyl methyl ether, diethylether, tetrahydrofuran, diisopropylether and 1,4-dioxane; nitriles such as acetonitril; aromatic hydrocarbons such as toluene; saturated hydrocarbons such as n-pentane, n-hexane and n-heptane; chlorinated hydrocarbons such as dichloromethane and chloroform; and also N-methyl-2-pyrrolidone, dimethyl formamide and dimethyl sulfoxide; and mixtures thereof.

[0146] Preferably, the solvent is water.

[0147] Preferably, in the process according to the invention, step (a-3) is carried out at a temperature below or at the boiling point of the respective solvent, preferably at a temperature not higher than 80 °C, more preferably not higher than 60°C, even more preferably not higher than 40°C, and in particular in a temperature range of 15-35 °C.

[0148] Preferably, in the process according to the invention, the suspension obtained in step (a-3) is stirred for a time period of at least 2 h, preferably at least 4 h, more preferably at least 8 h, still more preferably at least 12 h, yet more preferably at least 16 h, most preferably at least 24 h, and in particular at least 2 days.

[0149] Preferably, the process according to the invention further comprises the step (b-3) separating, preferably filtering off the solid obtained in step (a-3).

[0150] Preferably, the process according to the invention further comprises the step (c-3) drying of the solid obtained in step (b-3).

[0151] In the process according to the invention, step (c-3) may take place under air or inert gas flow, such as argon or nitrogen flow. However, drying under vacuum, more preferably at a vacuum of 0 to 900 mbar, even more preferably at a vacuum of 1 to 500 mbar, and in particular at a vacuum of 10 to 200 mbar is preferred.

[0152] Preferably, in the process according to the invention, step (c-3) takes place in a temperature range from 0 to 60 °C, preferably from 10°C to 50°C more preferably from 20 to 40 °C.

[0153] A further aspect of the invention relates to a crystalline form A that is obtainable by the process as described above.

[0154] A further aspect of the present invention relates to a crystalline form B.

[0155] Preferably, the crystalline form B according to the invention has one or more X-ray diffraction peaks selected from the group consisting of 10.6 ±0.2 (20), 17.2 ±0.2 (20), 18.6 ±0.2 (20), 19.3 ±0.2 (20), 22.2 ±0.2 (20), 26.7 ±0.2 (20) and 29.3 ±0.2 (20). In some preferred embodiments, the crystalline form comprises X-ray diffraction peaks at 18.6 ±0.2 (20) and 19.3 ±0.2 (20). In some preferred embodiments, the crystalline form comprises an X-ray diffraction peak at 18.6 ±0.2 (20).

[0156] In some preferred embodiments, crystalline form B comprises X-ray diffraction peaks at 10.6 ±0.2 (20), 17.2 ±0.2 (20), 18.6 ±0.2 (20), 19.3 ±0.2 (20), 26.7 ±0.2 (20), 29.3 ±0.2 (20) and optionally at 22.2 ±0.2 (20).

[0157] The crystalline form B according to the invention may additionally have at least one X-ray diffraction peak selected from the group consisting of 16.9 ±0.2 (20), 21.2 ±0.2 (20), 24.4 ±0.2 (20), 28.6 ±0.2 (20), 28.8 ±0.2 (20), 30.0 ±0.2 (20), 31.2 ±0.2 (20) and 31.7 ±0.2 (20).

[0158] Further, the crystalline form B according to the invention may be characterised in that as well as one or more X-ray diffraction peaks selected from the group consisting of 10.6 ±0.2 (20), 17.2 ±0.2 (20), 18.6 ±0.2 (20), 19.3 ±0.2 (20), 22.2 ±0.2 (20), 26.7 ±0.2 (20) and 29.3 ±0.2 (20), and optionally one or more X-ray diffraction peaks selected from the group consisting of 16.9 ±0.2 (20), 21.2 ±0.2 (20), 24.4 ±0.2 (20), 28.6 ±0.2 (20), 28.8 ±0.2 (20), 30.0 ±0.2 (20), 31.2 ±0.2 (20) and 31.7 ±0.2 (20), it additionally has at least one X-ray diffraction peak selected from the group consisting of 8.4 ±0.2 (20), 11.4 ±0.2 (20), 12.5 ±0.2(20), 15.5 ±0.2 (2Θ), 20.7 ±0.2 (20), 21.4 ±0.2(20), 25.4 ±0.2 (20), 27.9 ±0.2 (20) and 30.7 ±0.2 (20).

[0159] The crystalline form B according to the invention may further be characterised in that as well as one or more X-ray diffraction peaks selected from the group consisting of 10.6 ±0.2 (20), 17.2 ±0.2 (20), 18.6 ±0.2 (20), 19.3 ±0.2 (20), 22.2 ±0.2 (20), 26.7 ±0.2 (20) and 29.3 ±0.2 (20), and optionally one or more X-ray diffraction peaks selected from the group consisting of 16.9 ±0.2 (20), 21.2 ±0.2 (20), 24.4 ±0.2 (20), 28.6 ±0.2 (20), 28.8 ±0.2 (20), 30.0 ±0.2 (20), 31.2 ±0.2 (20) and 31.7 ±0.2 (20), and optionally one or more X-ray diffraction peaks selected from the group consisting of 8.4 ±0.2 (20), 11.4 ±0.2 (20), 12.5 ±0.2 (20), 15.5 ±0.2 (20), 20.7 ±0.2 (20), 21.4 ±0.2 (20), 25.4 ±0.2 (20), 27.9 ±0.2 (20) and 30.7 ±0.2 (20), it additionally has at least one X-ray diffraction peak selected from the group consisting of 14.2 ±0.2 (20), 27.1 ±0.2 (20), 28.3 ±0.2 (20), 32.9 ±0.2 (20), 33.4 ±0.2 (20), 33.8 ±0.2 (20) and 34.7 ±0.2 (20).

[0160] All 2Θ values refer to an X-ray diffractogram measured using CuKa radiation having a wavelength of 1.54060 A.

[0161] In DSC analyses, the crystalline form B according to the present invention preferably exhibits an endothermal event with a peak temperature at261-271 °C, more preferably at 262-270 °C, still more preferably at 263-269 °C, yet more preferably at 264-268 °C and in particular at 265-268 °C.

[0162] Preferably, the crystalline form B according to the present invention further exhibits an exothermal event, preferably within a temperature range of 210-265 °C.

[0163] The crystalline form B according to the present invention may further be characterized in that it has one or more Raman bands selected from the group consisting of 1300 ±2 cm-1, 1569 ±2 cm-1, 1583 ±2 cm-1 and 2992 ±2 cm-1.

[0164] The crystalline form B according to the present invention may further be characterized in that it has one or more Raman bands selected from the group consisting of 1300 ±2 cm"1, 1569 ±2 cm-1, 1583 ±2 cm'1 and 2992 ±2 cm-1; and/orone or more Raman bands selected from the group consisting of 183 ±2 cm-1, 919 ±2 cm"1,1001 ±2 cm"1, 3054 ±2 cm-1 and 3069 ±2 cm"1; and/orone or more Raman bands selected from the group consisting of 160 ±2 cm-1, 208 ±2 cm-1, 491 ±2 cm1,683 ±2 cm’1, 1120 ±2 cm1, 1374 ±2 cm’1, 1436 ±2 cm1, 1463 ±2 cm-1, 1481 ±2 cm-1, 2870 ±2 cm1, 2906 ±2 cm1, 2922 ±2 cm’1, 2931 ±2 cm1,2958 ±2 cm1 and 3034 ±2 cm1.

[0165] The crystalline form B according to the present invention may further be characterized in that it has one or more Raman bands selected from the group consisting of 255 ±2 cm-1, 279 ±2 cm-1, 371 ±2 cm-1, 397 ±2 cm-1, 430 ±2 cm1, 450 ±2 cm’1, 466 ±2 cm1, 518 ±2 cm-1, 540 ±2 cm1, 557 ±2 cm1, 568 ±2 cm1, 598 ±2 cnr1,606 ±2 cm1, 620 ±2 cm’1, 628 ±2 cnr1, 710 ±2 cnr1, 768 ±2 cnr1, 786 ±2 cm'1, 808 ±2 cm'1, 820 ±2 cnr1, 828 ±2 cnr1, 856 ±2 cm’1, 873 ±2 cnr1, 888 ±2 cm’1, 928 ±2 cnr1, 957 ±2 cnr1,984 ±2 cnr1,1028 ±2 cnr1,1035 ±2 cnr1,1047 ±2 cnr1, 1073 ±2 cnr1, 1136 ±2 cm-1, 1174 ±2 cnr1, 1199 ±2 cnr1, 1216 ±2 cm'1 1222 ±2 cm'1 1265 ±2 cm'1 1352 ±2 cm’1 1628 ±2 cnr1 and 2845 ±2 cm-1.

[0166] Another aspect of the present invention relates to a process for the production of the crystalline form B described above comprising the step of (a-1) precipitating the hydrochloride salt of (1 r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’IH-spiro[cyclohex-ane-1,1’-pyrano[3,4,b]indol]-4-amine from a solution or suspension of the free base.

[0167] Conventional solvents known to persons skilled in the art may be used as solvents in a solution or suspension of this type, in particular water and organic solvents selected from the group consisting of alcohols such as methanol, ethanol, n-propanol, iso-propanol and n-butanol; esters such as ethyl acetate, n-propyl acetate, iso-propyl acetate, n-butyl acetate and iso-butyl acetate; ketones such as acetone, 2-butanone, pentan-2-one, pentan-3-one, hexan-2-one and hexan-3-one; ethers such as tert-butyl methyl ether, diethylether, tetrahydrofuran, diisopropyletherand 1,4-dioxane; nitriles such as acetonitril; aromatic hydrocarbons such as toluene; saturated hydrocarbons such as n-pentane, n-hexane and n-heptane; chlorinated hydrocarbons such as dichloromethane and chloroform; and also N-methyl-2-pyrrolidone, dimethyl formamide and dimethyl sulfoxide; and mixtures thereof.

[0168] In an especially preferred embodiment, the organic solvent is a mixture of acetone and tetrahydrofuran. Preferably, the ratio between acetone and tetrahydrofuran is within the range of from 100:1 to 1:1, more preferably within the range of from 75:1 to 2:1, still more preferably within the range of from 50:1 to 5:1, yet more preferably within the range of from 40:1 to 10:1, most preferably within the range of from 35:1 to 15:1, and in particular within the range of from 30:1 to 15:1 (volume/volume).

[0169] Step (a-1) may be carried out by the addition of hydrogen chloride.

[0170] In a preferred embodiment, the hydrogen chloride is added in form of hydrogen chloride gas.

[0171] In another preferred embodiment, the hydrogen chloride is produced in situ by means of a reaction, e.g. by the addition of trimethylsilyl chloride to an aqueous solution.

[0172] In still another preferred embodiment, the hydrogen chloride is in form of a solution.

[0173] In a preferred embodiment, the solution is a solution of hydrogen chloride in an organic solvent, especially preferred are alcohols such as ethanol, isopropanol and n-butanol, and ethers such as diethylether, di-isopropylether, tetrahydrofurane, methyl-tetrahydrofurane 1,4-dioxane.

[0174] In an especially preferred embodiment, the solution is a solution of hydrogen chloride in an aqueous solvent, hydrochloric acid is particularly preferred.

[0175] Preferably, the hydrogen-chloride containing solution and the solution of the free base contain the same solvent.

[0176] Preferably, the solution contains the hydrogen chloride in a concentration within the range of from 0.01 mol/L to 15 mol/L, more preferably within the range of from 0.02 mol/L to 12.5 mol/L, still more preferably within the range of from 0.05 mol/L to 10 mol/L, yet more preferably within the range of from 0.1 mol/L to 7.5 mol/L, most preferably within the range of from 0.2 mol/L to 10 mol/L, and in particular within the range of from 0.3 mol/L to 5 mol/L.

[0177] Preferably, the hydrogen chloride is added to the solution or suspension of the free base in molar excess.

[0178] Preferably, in the process according to the invention, step (a-1) is carried out at a temperature below or at the boiling point of the respective solvent, preferably at a temperature not higher than 80°C, more preferably not higher than 60 °C, even more preferably not higher than 40°C, and in particular in a temperature range of 20-40 °C.

[0179] Preferably, in the process according to the invention, the suspension obtained in step (a-1) is stirred for a time period of at least 1 hour, preferably at least 4 hours, more preferably at least 6 hours, still more preferably at least 12 hours, yet more preferably at least 18 hours, most preferably at least 1 day, and in particular at least 2 days.

[0180] Preferably, the process according to the invention further comprises the step (b-1) separating, preferably filtering off the solid obtained in step (a-1).

[0181] Preferably, the process according to the invention further comprises the step (c-1) drying of the solid obtained in step (b-1).

[0182] In a preferred embodiment, step (c-1) takes place under air or inert gas flow, such as argon or nitrogen flow.

[0183] In another preferred embodiment, step (c-1) takes place under vacuum, more preferably at a vacuum of 0 to 900 mbar, even more preferably at a vacuum of 1 to 500 mbar, and in particular at a vacuum of 10 to 200 mbar.

[0184] Preferably, in the process according to the invention, step (c-1) takes place in a temperature range from 0 to 60°C, preferably from 10°C to 50°C more preferably from 20 to 40 °C.

[0185] In another preferred embodiment, the process comprises the step of (a-2) dissolving (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’l-l-spiro[cyclohexane-1,1’-pyrano[3,4,b]in-dol]-4-amine hydrochloride in a solvent.

[0186] Conventional solvents known to persons skilled in the art may be used as solvents in a suspension of this type, in particular organic solvents selected from the group consisting of alcohols such as methanol, ethanol, n-propanol, isopropanol and n-butanol; esters such as ethyl acetate, n-propyl acetate, iso-propyl acetate, n-butyl acetate and iso-butyl acetate; ketones such as acetone, 2-butanone, pentan-2-one, pentan-3-one, hexan-2-one and hexan-3-one; ethers such as tert-butyl methyl ether, diethylether, tetrahydrofuran, diisopropyletherand 1,4-dioxane; nitriles such as acetonitril; aromatic hydrocarbons such as toluene; chlorinated hydrocarbons such as dichloromethane and chloroform; and also N-methyl-2-pyrrolidone, dimethyl formamide and dimethyl sulfoxide; and mixtures thereof. Saturated hydrocarbons, such as n-pentane, n-hexane and n-heptane, and water are less suitable, the compound (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano[3,4,b]indol]-4-amine hydrochloride being only poorly soluble in these substances.

[0187] Preferably, the solvent is selected from dichloromethane and mixtures of dichloromethane and methanol.

[0188] In a preferred embodiment, the organic solvent is a mixture of dichloromethane and methanol. Preferably, the ratio between dichloromethane and methanol is within the range of from 10:1 to 1:10, more preferably within the range of from 7:1 to 1:5, still more preferably within the range of from 6:1 to 1:3, yet more preferably within the range of from 5:1 to 1:1, most preferably within the range of from 4:1 to 2:1, and in particular within the range of from 3.5:1 to 2.5:1 (volume/volume).

[0189] Preferably, in the process according to the invention, step (a-2) is carried out at a temperature below or at the boiling point of the respective solvent, preferably at a temperature not higher than 80°C, more preferably not higher than 60°C, even more preferably not higher than 40°C, and in particular in a temperature range of 20-40 °C.

[0190] In an especially preferred embodiment, the process according to the invention further comprises the step (b-2) evaporating off the solvent of the solution obtained in step (a-2).

[0191] Suitable methods for evaporating off the solvent are known to a person skilled in the art. Preferably, in the process according to the invention, the solvent is evaporated off in air, air flow, or inert gas flow, in particular argon or nitrogen flow. However, evaporating off the solvent under vacuum, for example by means of a rotary evaporator, is also possible.

[0192] Preferably, in the process according to the invention, the solvent is evaporated off at room temperature.

[0193] In another preferred embodiment, the process further comprises the step of (b-2’) precipitating (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclo-hexane-1,1’- pyrano[3,4,b]indol]-4-amine hydrochloride from the solution obtained in step (a-2).

[0194] Suitable methods of precipitation are known to a person skilled in the art. In the process according to the invention, step (b-2’) may be carried out by reducing the volume of the solution obtained in step (a-2) and/or by cooling of the solution, preferably to a temperature of at most 15°C, more preferably at most 10°C, even more preferably at most 4-8°C and/or by cooling of the solution, preferably to a temperature of at least 10 °C, more preferably at least 30 °C, even more preferably at least 60 °C below the temperature according to step (a-2).

[0195] In a preferred embodiment, step (b-2’) is carried out by the addition of a medium in which (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano-[3,4,b]indol]-4-amine hydrochloride is only poorly soluble ("anti-solvent") to the solution obtained in step (a-2). Said medium is preferably selected from the group consisting of esters such as ethyl acetate, n-propyl acetate, iso-propyl acetate, n-butyl acetate and iso-butyl acetate; ethers such as tert-butyl methyl ether, diethyl ether and diisopropyl ether; ketones such as acetone, 2-butanone, pentan-2-one, pentan-3-one, hexan-2-one and hexan-3-one; nitriles such as acetonitril; pyridine, acetic acid and water. Especially preferred media are ethyl acetate and acetonitril.

[0196] The amount of the media in which (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano[3,4,b]indol]-4-amine hydrochloride is only poorly soluble, the precipitant or anti-solvent, is preferably selected in such a manner that upon its addition precipitation of the dissolved component begins.

[0197] The total amount ofthe media inwhich(1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohex-ane-1 ,T-pyrano[3,4,b]indol]-4-amine hydrochloride is only poorly soluble may also be divided into several portions, preferably two or three portions. In this embodiment, the precipitation ofthe dissolved component preferably begins after the addition ofthe last portion.

[0198] The precipitation of the dissolved component preferably begins either immediately after the precipitant, preferably the total amount of the precipitant, has been added or alternatively with a delay of 2 seconds to 120 minutes. Preferably, the precipitation ofthe dissolved component begins within a time period of at most 90 minutes, more preferably at most 60 minutes, still more preferably at most 30 minutes, even more preferably at most 5 minutes, most preferably at most 60 seconds and in particular at most 10 seconds.

[0199] Preferably, in the process according to the invention, after step (b-2) or respectively (b-2’), all other steps are carried out at a temperature between 40 and 0°C, preferably between 35 and 5°C, more preferably between 25 and 15°C.

[0200] Preferably, in the process according to the invention, the suspension obtained in step (b-2’) is stirred for a time period of at least 1 minute, preferably at least 2 minutes, more preferably at least 3 minutes, and most preferably at least 5 minutes.

[0201] Preferably, the process according to the invention further comprises the step (c-2’) separating, preferably filtering off the precipitate obtained in step (b-2’).

[0202] Preferably, the process according to the invention further comprises the step (d-2’) drying ofthe solid obtained in step (c-2’).

[0203] Preferably, in the process according to the invention, step (d-2’) takes place under air or inert gas flow, such as argon or nitrogen flow.

[0204] In still another preferred embodiment, the process comprises the step of (a-3) suspending (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclo-hexane-1,T-pyrano[3,4,b]in-dol]-4-amine hydrochloride in a solvent.

[0205] Conventional solvents known to persons skilled in the art may be used as solvents in a suspension of this type, in particular water and organic solvents selected from the group consisting of alcohols such as methanol, ethanol, n-propanol, iso-propanol and n-butanol; esters such as ethyl acetate, n-propyl acetate, iso-propyl acetate, n-butyl acetate and iso-butyl acetate; ketones such as acetone, 2-butanone, pentan-2-one, pentan-3-one, hexan-2-one and hexan-3-one; ethers such as tert-butyl methyl ether, diethylether, tetrahydrofuran, diisopropylether and 1,4-dioxane; nitriles such as acetonitril; aromatic hydrocarbons such as toluene; saturated hydrocarbons such as n-pentane, n-hexane and n-heptane; chlorinated hydrocarbons such as dichloromethane and chloroform; and also N-methyl-2-pyrrolidone, dimethyl formamide and dimethyl sulfoxide; and mixtures thereof.

[0206] In a preferred embodiment, step (a-3) is carried out at a temperature not higher than 100°C, more preferably not higherthan 90°C, still more preferably not higherthan 80°C, yet more preferably not higherthan 60°C, most preferably not higher than 40°C, and in particular in a temperature range of 15-35 °C.

[0207] In another preferred embodiment, step (a-3) is carried out in a temperature range of 100-40 °C, more preferably 90-50 °C, and most preferably 85-60°C.

[0208] Preferably, in the process according to the invention, the suspension obtained in step (a-3) is stirred for a time period of at least 2 h, preferably at least 4 h, more preferably at least 8 h, still more preferably at least 12 h, yet more preferably at least 16 h, most preferably at least 24 h, and in particular at least 2 days.

[0209] Preferably, the process according to the invention further comprises the step (b-3) separating, preferably filtering off the solid obtained in step (a-3).

[0210] Preferably, the process according to the invention further comprises the step (c-3) drying ofthe solid obtained in step (b-3).

[0211] In the process according to the invention, step (c-3) may take place under air or inert gas flow, such as argon or nitrogen flow. However, drying under vacuum, more preferably at a vacuum of 0 to 900 mbar, even more preferably at a vacuum of 1 to 500 mbar, and in particular at a vacuum of 10 to 200 mbar is preferred.

[0212] Preferably, in the process according to the invention, step (c-3) takes place in a temperature range from 0 to 60°C, preferably from 10°C to 50°C more preferably from 20 to 40°C.

[0213] A further aspect of the invention relates to a crystalline form B that is obtainable by the process as described above.

[0214] A further aspect of the present invention relates to a crystalline form C.

[0215] Preferably, the crystalline form C according to the invention has one or more X-ray diffraction peaks selected from the group consisting of 9.1 ±0.2 (20), 11.2 ±0.2 (20), 18.2 ±0.2 (20), 18.8 ±0.2 (20), 19.1 ±0.2 (20), 19.3 ±0.2 (20), 24.0 ±0.2 (20), 27.5 ±0.2 (20) and 28.2 ±0.2 (20). In some preferred embodiments, the crystalline form comprises X-ray diffraction peaks at 11.2 ±0.2 (20), 18.2 ±0.2 (20) and 27.5 ±0.2 (20). In some preferred embodiments, the crystalline form comprises an X-ray diffraction peak at 18.2 ±0.2 (20).

[0216] In some preferred embodiments, crystalline form C comprises X-ray diffraction peaks at 9.1 ±0.2 (20), 11.2 ±0.2 (20), 18.2 ±0.2 (20), 18.8 ±0.2 (20), 19.3 ±0.2 (20), 24.0 ±0.2 (20), 27.4 ±0.2 (20), 28.2 ±0.2 (20) and optionally 19.1 ±0.2(20).

[0217] The crystalline form C according to the invention may additionally have at least one X-ray diffraction peak selected from the group consisting of 22.4 ±0.2 (20), 23.8 ±0.2 (20), 24.3 ±0.2 (20), 26.1 ±0.2 (20), 26.4 ±0.2 (20), 27.9 ±0.2 (20), 31.6 ±0.2 (20) and 34.1 ±0.2 (20).

[0218] Further, the crystalline form C according to the invention may be characterised in that as well as one or more X-ray diffraction peaks selected from the group consisting of 9.1 ±0.2 (20), 11.2 ±0.2 (20), 18.2 ±0.2 (20), 18.8 ±0.2 (20), 19.1 ±0.2 (20), 19.3 ±0.2 (20), 24.0 ±0.2 (20), 27.5 ±0.2 (20) and 28.2 ±0.2 (20), and optionally one or more X-ray diffraction peaks selected from the group consisting of 22.4 ±0.2 (20), 23.8 ±0.2 (20), 24.3 ±0.2 (20), 26.1 ±0.2 (20), 26.4 ±0.2 (20), 27.9 ±0.2 (20), 31.6 ±0.2 (20) and 34.1 ±0.2 (20), it additionally has at least one X-ray diffraction peak selected from the group consisting of 17.0 ±0.2 (20), 24.5 ±0.2 (20), 26.7 ±0.2 (20), 29.2 ±0.2 (20), 29.8 ±0.2 (20), 32.0 ±0.2 (20), 34.3 ±0.2 (20) and 34.8 ±0.2 (20).

[0219] The crystalline form C according to the invention may further be characterised in that as well as one or more X-ray diffraction peaks selected from the group consisting of 9.1 ±0.2 (20), 11.2 ±0.2 (20), 18.2 ±0.2 (20), 18.8 ±0.2 (20), 19.1 ±0.2(20), 19.3 ±0.2 (20), 24.0 ±0.2 (20), 27.5 ±0.2 (20) and 28.2 ±0.2(20), and optionally one or more X-ray diffraction peaks selected from the group consisting of 22.4 ±0.2 (20), 23.8 ±0.2 (20), 24.3 ±0.2 (20), 26.1 ±0.2 (20), 26.4 ±0.2 (20), 27.9 ±0.2 (20), 31.6 ±0.2 (20) and 34.1 ±0.2 (20), and optionally one or more X-ray diffraction peaks selected from the group consisting of 17.0 ±0.2 (20), 24.5 ±0.2 (20), 26.7 ±0.2 (20), 29.2 ±0.2 (20), 29.8 ±0.2 (20), 32.0 ±0.2 (20), 34.3 ±0.2 (20) and 34.8 ±0.2 (20), it additionally has at least one X-ray diffraction peak selected from the group consisting of 7.8 ±0.2 (20), 17.3 ±0.2(20), 21.7 ±0.2 (20) and 23.4 ±0.2 (20).

[0220] All 2Θ values refer to an X-ray diffractogram measured using CuKa radiation having a wavelength of 1.54060 A.

[0221] The crystalline form C according to the present invention may further be characterized in that it has one or more Raman bands selected from the group consisting of 177 ±2 cm-1, 1567 ±2 cm'1 and 1584 ±2 cm-1.

[0222] The crystalline form C according to the present invention may further be characterized in that it has one or more Raman bands selected from the group consisting of 177 ±2 cm-1, 1567 ±2 cm-1 and 1584 ±2 cm-1; and/or one or more Raman bands selected from the group consisting of 158 ±2 cm-1, 685 ±2 cm-1, 918 ±2 cm'1, 925 ±2 cm-1, 1000 ±2 cm-1, 1301 ±2 cnr1 and 3072 ±2 cnr1; and/or one or more Raman bands selected from the group consisting of 208 ±2 cm'1,253 ±2 cm'1, 266 ±2 cm'1, 370 ±2 cm'1,490 ±2 cm'1, 600 ±2 cm'1, 620 ±2 cm'1, 628 ±2 cm'1, 829 ±2 cm'1, 1028 ±2 cm'1, 1114 ±2 cm'1, 1219 ±2 cm'1, 1374 ±2 cm'1, 1432 ±2 cm'1, 1454 ±2 cm'1, 1464 ±2 cm'1, 1481 ±2 cm-1, 1600 ±2 cm"1 and 2959 ±2 cm"1.

[0223] The crystalline form C according to the present invention may further be characterized in that it has one or more Raman bands selected from the group consisting of 322 ±2 cm'1, 395 ±2 cm'1, 429 ±2 cm'1, 471 ±2 cm'1, 516 ±2 cm'1, 538 ±2 cm'1, 567 ±2 cm'1, 710 ±2 cm'1, 772 ±2 cm'1, 786 ±2 cm'1, 889 ±2 cm'1, 954 ±2 cm'1, 986 ±2 cm'1, 1055 ±2 cm'1, 1076 ±2 cm'1, 1136 ±2 cm'1, 1167 ±2 cm'1, 1200 ±2 cm'1, 1267 ±2 cm'1, 1359 ±2 cm'1, 1628 ±2 cm"1,2842 ±2 cm"1,2880 ±2 cm'1, 2901 ±2 cm"1,2927 ±2 cm'1,2994 ±2 cm'1, 3031 ±2 cm"1 and 3045 ±2 cm"1.

[0224] Another aspect of the present invention relates to a process for the production of the crystalline form C described above comprising the step of (a-1) precipitating the hydrochloride salt of (1 r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohex-ane-1,1’-pyrano[3,4,b]indol]-4-amine from a solution or suspension of the free base.

[0225] The solution or suspension preferably contains water. In this embodiment, the solution or suspension preferably further contains a water miscible organic solvent, such as acetone or tetrahydrofuran.

[0226] Especially preferred solvents that may be used as solvents for the solution or suspension are mixtures of tetrahydrofuran and water.

[0227] In an especially preferred embodiment, the organic solvent is a mixture of water and tetrahydrofuran. Preferably, the ratio between water and tetrahydrofuran is within the range of from 50:1 to 1:50, more preferably within the range of from 30:1 to 1:20, still more preferably within the range of from 20:1 to 1:10, yet more preferably within the range of from 15:1 to 1:5, most preferably within the range of from 10:1 to 1:2, and in particular within the range of from 8:1 to 1:1 (volume/volume).

[0228] Step (a-1) may be carried out by the addition of hydrogen chloride.

[0229] In a preferred embodiment, the hydrogen chloride is added in form of hydrogen chloride gas.

[0230] In another preferred embodiment, the hydrogen chloride is produced in situ by means of a reaction, e.g. by the addition of trimethylsilyl chloride to an aqueous solution.

[0231] In still another preferred embodiment, the hydrogen chloride is in form of a solution.

[0232] Preferably, the solution is a solution of hydrogen chloride in an aqueous solvent, hydrochloric acid is particularly preferred.

[0233] Preferably, the solution contains the hydrogen chloride in a concentration within the range of from 0.01 mol/L to 15 mol/L, more preferably within the range of from 0.02 mol/L to 12.5 mol/L, still more preferably within the range of from 0.05 mol/L to 10 mol/L, yet more preferably within the range of from 0.1 mol/L to 7.5 mol/L, most preferably within the range of from 0.2 mol/L to 10 mol/L, and in particular within the range of from 0.3 mol/L to 5 mol/L.

[0234] Preferably, the hydrogen chloride is added to the solution or suspension of the free base in molar excess.

[0235] Preferably, in the process according to the invention, step (a-1) is carried out at a temperature below or at the boiling point of the respective solvent, preferably at a temperature not higher than 80 °C, more preferably not higher than 60°C, even more preferably not higher than 40°C, and in particular in a temperature range of 20-40 °C.

[0236] Preferably, in the process according to the invention, the suspension obtained in step (a-1) is stirred for a time period of at least 1 hour, preferably at least 4 hours, more preferably at least 6 hours, still more preferably at least 12 hours, yet more preferably at least 18 hours, and most preferably at least 1 day.

[0237] Preferably, the process according to the invention further comprises the step (b-1) separating, preferably filtering off the solid obtained in step (a-1).

[0238] Preferably, the process according to the invention further comprises the step (c-1) drying of the solid obtained in step (b-1).

[0239] In a preferred embodiment, step (c-1) takes place at a relative humidity of at least 50%, more preferably at least 60%, still more preferably at least 70%, yet more preferably at least 75%, most preferably at least 79%, and in particular at least 85% or at least 95%.

[0240] In another preferred embodiment, step (c-1) takes place under vacuum, preferably at a vacuum of 0 to 900 mbar, even more preferably at a vacuum of 1 to 500 mbar, and in particular at a vacuum of 10 to 200 mbar. In this embodiment, the solid obtained in step (b-1) is exposed to the vacuum for at most 12 h, more preferably at most 8 h, still more preferably at most 6 h, yet more preferably at most 4 h, most preferably at most 2 h, and in particular at most 1 h.

[0241] A further aspect of the invention relates to a crystalline form C that is obtainable by the process as described above.

[0242] A further aspect of the present invention relates to a crystalline form D.

[0243] Preferably, the crystalline form D according to the invention has one or more X-ray diffraction peaks selected from the group consisting of 16.3 ±0.2 (20), 18.3 ±0.2 (20), 18.9 ±0.2 (20), 19.6 ±0.2 (20), 23.7 ±0.2 (20), 24.3 ±0.2 (20), 27.6 ±0.2 (20) and 28.9 ±0.2 (20). In some preferred embodiments, the crystalline form comprises X-ray diffraction peaks at 18.3 ±0.2 (20), 18.9 ±0.2 (20) and 19.6 ±0.2 (20). In some preferred embodiments, the crystalline form comprises an X-ray diffraction peak at 18.9 ±0.2 (20).

[0244] In some preferred embodiments, crystalline form D comprises X-ray diffraction peaks at 18.3 ±0.2 (20), 18.9 ±0.2 (20), 19.6 ±0.2 (20), 23.7 ±0.2 (20), 24.3 ±0.2 (20), 28.9 ±0.2 (20), optionally 16.3 ±0.2 (20) and optionally 27.6 ±0.2 (20).

[0245] The crystalline form D according to the invention may additionally have at least one X-ray diffraction peak selected from the group consisting of 12.9 ±0.2 (20), 16.9 ±0.2 (20), 20.2 ±0.2 (20), 21.6 ±0.2 (20), 22.0 ±0.2 (20), 23.3 ±0.2 (20), 24.7 ±0.2 (20), 28.6 ±0.2 (20), 31.3 ±0.2 (20) and 31.6 ±0.2 (20).

[0246] Further, the crystalline form D according to the invention may be characterised in that as well as one or more X-ray diffraction peaks selected from the group consisting of 16.3 ±0.2 (20), 18.3 ±0.2 (20), 18.9 ±0.2 (20), 19.6 ±0.2 (20), 23.7 ±0.2 (20), 24.3 ±0.2 (20), 27.6 ±0.2 (20) and 28.9 ±0.2 (20), and optionally one or more X-ray diffraction peaks selected from the group consisting of 12.9 ±0.2 (20), 16.9 ±0.2 (20), 20.2 ±0.2 (20), 21.6 ±0.2 (20), 22.0 ±0.2 (20), 23.3 ±0.2 (20), 24.7 ±0.2 (20), 28.6 ±0.2 (20), 31.3 ±0.2 (20) and 31.6 ±0.2 (20), it additionally has at least one X-ray diffraction peak selected from the group consisting of 12.6±0.2 (20), 15.6 ±0.2 (20), 25.8 ±0.2 (20), 26.4 ±0.2 (20), 29.6 ±0.2 (20), 30.0 ±0.2 (20) and 33.1 ±0.2 (20).

[0247] The crystalline form D according to the invention may further be characterised in that as well as one or more X-ray diffraction peaks selected from the group consisting of 16.3 ±0.2 (20), 18.3 ±0.2 (20), 18.9 ±0.2 (20), 19.6 ±0.2 (20), 23.7 ±0.2 (20), 24.3 ±0.2 (20), 27.6 ±0.2 (20) and 28.9 ±0.2 (20), and optionally one or more X-ray diffraction peaks selected from the group consisting of 12.9 ±0.2 (20), 16.9 ±0.2 (20), 20.2 ±0.2 (20), 21.6 ±0.2 (20), 22.0 ±0.2 (20), 23.3 ±0.2(20), 24.7 ±0.2 (20), 28.6 ±0.2(20), 31.3 ±0.2 (20) and 31.6 ±0.2 (20), and optionally one or moreX-ray diffraction peaks selected from the group consisting of 12.6 ±0.2 (20), 15.6 ±0.2 (20), 25.8 ±0.2 (20), 26.4 ±0.2 (20), 29.6 ±0.2 (20), 30.0 ±0.2 (20) and 33.1 ±0.2 (20), it additionally has at least one X-ray diffraction peak selected from the group consisting of 7.8 ±0.2(20), 9.1 ±0.2 (20), 9.5 ±0.2 (20), 10.8 ±0.2(20), 11.0 ±0.2 (20) and 14.1 ±0.2(20).

[0248] All 2Θ values refer to an X-ray diffractogram measured using CuKa radiation having a wavelength of 1.54060 A.

[0249] The crystalline form D according to the present invention may further be characterized in that it has one or more Raman bands selected from the group consisting of 161 ±2 cm-1, 172 ±2 cm"1, 180 ±2 cm'1, 686 ±2 cm"1, 919 ±2 cm"1, 1004 ±2 cm"1, 1299 ±2 cm"1, 1567 ±2 cm"1, 1573 ±2 cm"1,2912 ±2 cm'1, 2957 ±2 cm'1,2981 ±2 cm'1 and 3071 ±2 cm"1.

[0250] The crystalline form D according to the present invention may further be characterized in that it has one or more Raman bands selected from the group consisting of 161 ±2 cm-1, 172 ±2 cm'1, 180 ±2 cm'1, 686 ±2 cm'1, 919 ±2 cm'1, 1004 ±2 cm1, 1299 ±2 cm1, 1567 ±2 cm1, 1573 ±2 cm'1,2912 ±2 cm'1, 2957 ±2 cm'1,2981 ±2 cm'1 and 3071 ±2 cm"1; and/or one or more Raman bands selected from the group consisting of 206 ±2 cm"1, 252 ±2 cm"1,600 ±2 cm"1, 829 ±2 cm"1, 1308 ±2 cm"1, 1374 ±2 cm"1, 1443 ±2 cm"1, 1466 ±2 cm'1 and2875 ±2 cm'1; and/or one or more Raman bands selected from the group consisting of 278 ±2 cm-1, 370 ±2 cm'1, 392 ±2 cm-1, 429 ±2 cm-1, 490 ±2 cm"1, 517 ±2 cm1, 620 ±2 cm1, 629 ±2 cm1, 676 ±2 cm"1, 887 ±2 cm"1, 983 ±2 cm"1, 1028 ±2 cm"1, 1035 ±2 cm"1, 1045 ±2 cm"1, 1116 ±2 cm"1, 1161 ±2 cm"1, 1197 ±2 cm"1, 1217 ±2 cm"1, 1263 ±2 cm"1, 1355 ±2 cm"1, 1627 ±2 cm"1, 2845 ±2 cm"1 and 3038 ±2 cm"1.

[0251] The crystalline form D according to the present invention may further be characterized in that it has one or more Raman bands selected from the group consisting of 317 ±2 cm"1, 401 ±2 cm"1, 468 ±2 cm-1, 538 ±2 cm'1, 557 ±2 cm1, 569 ±2 cm1, 712 ±2 cm"1, 771 ±2 cm1, 787 ±2 cm"1, 869 ±2 cm"1, 953 ±2 cm"1, 1074 ±2 cm"1, 1134 ±2 cm"1, 1183 ±2 cm"1, 1250 ±2 cm"1 and 1339 ±2 cm"1.

[0252] Another aspect of the present invention relates to a process for the production of the crystalline form D described above comprising the step of (a-1) precipitating the hydrochloride salt of (1 r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’l-l-spiro[cyclohex-ane-1,1’-pyrano[3,4,b]indol]-4-amine from a solution or suspension of the free base.

[0253] Preferably, the solvent is selected from the group consisting of alcohols such as methanol, ethanol, n-propanol, iso-propanol and n-butanol; ketones such as acetone, 2-butanone, pentan-2-one, pentan-3-one, hexan-2-one and hexan-3-one; ethers such as tert-butyl methyl ether, diethylether, tetrahydrofuran, diisopropyletherand 1,4-dioxane; chlorinated hydrocarbons such as dichloromethane and chloroform; and mixtures thereof.

[0254] Preferably, the solvent does not contain water.

[0255] Especially preferred are solvents selected from the group consisting of toluene, ethanol, n-propanol, isopropanol, n-butanol and 2-butanone.

[0256] Step (a-1) may be carried out by the addition of hydrogen chloride.

[0257] In a preferred embodiment, the hydrogen chloride is added in form of hydrogen chloride gas.

[0258] In another preferred embodiment, the hydrogen chloride is produced in situ by means of a reaction, e.g. by the addition of trimethylsilyl chloride to an aqueous solution.

[0259] In still another preferred embodiment, the hydrogen chloride is in form of a solution.

[0260] Preferably, the solution is a solution of hydrogen chloride in an organic solvent, especially preferred are alcohols such as ethanol, isopropanol and n-butanol.

[0261] Preferably, the solution contains the hydrogen chloride in a concentration within the range of from 0.01 mol/L to 15 mol/L, more preferably within the range of from 0.02 mol/L to 12.5 mol/L, still more preferably within the range of from 0.05 mol/L to 10 mol/L, yet more preferably within the range of from 0.1 mol/L to 7.5 mol/L, most preferably within the range of from 0.2 mol/L to 10 mol/L, and in particular within the range of from 0.3 mol/L to 5 mol/L.

[0262] Preferably, the hydrogen chloride is added to the solution or suspension of the free base in molar excess.

[0263] Preferably, in the process according to the invention, step (a-1) is carried out at a temperature below or at the boiling point of the respective solvent, preferably at a temperature not higher than 80 °C, more preferably not higher than 60°C, even more preferably not higher than 40°C, and in particular in a temperature range of 20-40 °C. Preferably, in the process according to the invention, the suspension obtained in step (a-1) is stirred for a time period of at least 1 minute, preferably at least 2 minutes, more preferably at least 3 minutes, still more preferably at least 5 minutes, yet more preferably at least 10 minutes, most preferably at least 20 minutes, and in particular at least 30 minutes.

[0264] In another preferred embodiment, the suspension obtained in step (a-1) is stirred for a time period of at most 1 day, preferably at most 12 hours, more preferably at most 6 hours, still more preferably at most 2 hours, yet more preferably at most 60 minutes, and most preferably at most 45 minutes, and in particular at most 30 minutes.

[0265] Preferably, the process according to the invention further comprises the step (b-1) separating, preferably filtering off the solid obtained in step (a-1).

[0266] Preferably, the process according to the invention further comprises the step (c-1) drying of the solid obtained in step (b-1).

[0267] In a preferred embodiment, step (c-1) takes place under air or inert gas flow, such as argon or nitrogen flow.

[0268] In another preferred embodiment, step (c-1) takes place under vacuum, more preferably at a vacuum of 0 to 900 mbar, even more preferably at a vacuum of 1 to 500 mbar, and in particular at a vacuum of 10 to 200 mbar.

[0269] Preferably, in the process according to the invention, step (c-1) takes place in a temperature range from 0 to 60 °C, preferably from 10 °C to 50 °C more preferably from 20 to 40 °C.

[0270] In another preferred embodiment, the process comprises the step of (a-2) dissolving (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano[3,4,b]in-dol]-4-amine hydrochloride in a solvent.

[0271] Preferably, the solvent is selected from the group consisting of dichloromethane, N-methyl-2-pyrrolidone, methanol, dimethyl formamide, and mixtures thereof.

[0272] In an especially preferred embodiment, the organic solvent is a mixture of dichloromethane and methanol. Preferably, the ratio between dichloromethane and methanol is within the range of from 10:1 to 1:10, more preferably within the range of from 7:1 to 1:5, still more preferably within the range of from 6:1 to 1:3, yet more preferably within the range of from 5:1 to 1:1, most preferably within the range of from 4:1 to 2:1, and in particular within the range of from 3.5:1 to 2.5:1 (volume/volume).

[0273] Preferably, in the process according to the invention, step (a-2) is carried out at a temperature below or at the boiling point of the respective solvent, preferably at a temperature not higher than 80 °C, more preferably not higher than 60°C, even more preferably not higher than 40°C, and in particular in a temperature range of 20-40 °C.

[0274] In a preferred embodiment, the process according to the invention further comprises the step (b-2) evaporating off the solvent of the solution obtained in step (a-2).

[0275] Suitable methods for evaporating off the solvent are known to a person skilled in the art. Preferably, in the process according to the invention, the solvent is evaporated off in air, air flow, or inert gas flow, in particular argon or nitrogen flow. However, evaporating off the solvent under vacuum, for example by means of a rotary evaporator, is also possible.

[0276] Preferably, in the process according to the invention, the solvent is evaporated off at room temperature.

[0277] In another preferred embodiment, the process further comprises the step of (b-2’) precipitating (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclo-hexane-1,T- pyrano[3,4,b]indol]-4-amine hydrochloride from the solution obtained in step (a-2).

[0278] Suitable methods of precipitation are known to a person skilled in the art. In the process according to the invention, step (b-2’) may be carried out by reducing the volume of the solution obtained in step (a-2) and/or by cooling of the solution, preferably to a temperature of at most 15°C, more preferably at most 10°C, even more preferably at most 4-8°C and/or by cooling of the solution, preferably to a temperature of at least 10 °C, more preferably at least 30 °C, even more preferably at least 60 °C below the temperature according to step (a-2).

[0279] In a preferred embodiment, step (b-2’) is carried out by the addition of a medium in which (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano-[3,4,b]indol]-4-amine hydrochloride is only poorly soluble ("anti-solvent") to the solution obtained in step (a-2). Said medium is preferably selected from the group consisting of esters such as ethyl acetate, n-propyl acetate, iso-propyl acetate, n-butyl acetate and iso-butyl acetate; ethers such as tert-butyl methyl ether, diethyl ether and diisopropyl ether; ketones such as acetone, 2-butanone, pentan-2-one, pentan-3-one, hexan-2-one and hexan-3-one; nitriles such as acetonitril; pyridine, acetic acid and water.

[0280] Especially preferred are tert-butyl methyl ether and diethyl ether.

[0281] The amount of the media in which (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1 ,T-pyrano[3,4,b]indol]-4-amine hydrochloride is only poorly soluble, the precipitant or anti-solvent, is preferably selected in such a manner that upon its addition precipitation of the dissolved component begins.

[0282] The total amount ofthe media inwhich(1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohex-ane-1,1’-pyrano[3,4,b]indol]-4-amine hydrochloride is only poorly soluble may also be divided into several portions, preferably two or three portions. In this embodiment, the precipitation ofthe dissolved component preferably begins after the addition ofthe last portion.

[0283] The precipitation of the dissolved component preferably begins either immediately after the precipitant, pref- erably the total amount of the precipitant, has been added or alternatively with a delay of 2 seconds to 120 minutes. Preferably, the precipitation of the dissolved component begins within a time period of at most 60 minutes, more preferably at most 30 minutes, still more preferably at most 20 minutes, yet more preferably at most 10 minutes, most preferably at most 5 minutes, and in particular at most 3 minutes.

[0284] Preferably, in the process according to the invention, after step (b-2) or respectively (b-2’), all other steps are carried out at a temperature between 40 and 0 °C, preferably between 35 and 5°C, more preferably between 25 and 15°C.

[0285] Preferably, in the process according to the invention, the suspension obtained in step (b-2’) is stirred for a time period of at least 1 minute, preferably at least 2 minutes, more preferably at least 3 minutes, and most preferably at least 5 minutes.

[0286] Preferably, the process according to the invention further comprises the step (c-2’) separating, preferably filtering off the precipitate obtained in step (b-2’).

[0287] Preferably, the process according to the invention further comprises the step (d-2’) drying of the solid obtained in step (c-2’).

[0288] In a preferred embodiment, step (d-2’) takes place under air or inert gas flow, such as argon or nitrogen flow.

[0289] In another preferred embodiment, step (c-1) takes place under vacuum, more preferably at a vacuum of 0 to 900 mbar, even more preferably at a vacuum of 1 to 500 mbar, and in particular at a vacuum of 10 to 200 mbar.

[0290] A further aspect of the invention relates to a crystalline form D that is obtainable by the process as described above.

[0291] A further aspect of the present invention relates to a crystalline form E (polymorph E).

[0292] Preferably, the crystalline form E according to the invention has one or more X-ray diffraction peaks selected from the group consisting of 9.1 ±0.2 (20), 17.1 ±0.2 (20), 17.7 ±0.2 (20), 19.6 ±0.2 (20), 21.3 ±0.2 (20), 22.5 ±0.2 (20), 23.6 ±0.2 (20), 24.6 ±0.2 (20) and 28.8 ±0.2 (20). In some preferred embodiments, the crystalline form comprises X-ray diffraction peaks at 17.1 ±0.2 (20), 17.7 ±0.2 (20) and 19.6 ±0.2 (20). In some preferred embodiments, the crystalline form comprises an X-ray diffraction peak at 19.6 ±0.2 (20).

[0293] In some preferred embodiments, crystalline form E comprises X-ray diffraction peaks at 9.1 ±0.2 (20), 17.1 ±0.2 (20), 17.7 ±0.2 (20), 19.6 ±0.2 (20), 21.3 ±0.2 (20), 22.5 ±0.2 (20), 23.6 ±0.2 (20), 24.6 ±0.2 (20) and optionally 28.8 ±0.2(20).

[0294] The crystalline form E according to the invention may additionally have at least one X-ray diffraction peak selected from the group consisting of 18.3 ±0.2 (20), 23.4 ±0.2 (20), 24.1 ±0.2 (20), 26.2 ±0.2 (20), 26.8 ±0.2 (20), 30.5 ±0.2 (20) and 31.7 ±0.2 (20).

[0295] Further, the crystalline form E according to the invention may be characterised in that as well as one or more X-ray diffraction peaks selected from the group consisting of 9.1 ±0.2 (20), 17.1 ±0.2 (20), 17.7 ±0.2 (20), 19.6 ±0.2 (20), 21.3 ±0.2(20), 22.5 ±0.2 (20), 23.6 ±0.2(20), 24.6 ±0.2 (20) and 28.8 ±0.2(20), and optionally one or more X-ray diffraction peaks selected from the group consisting of 18.3 ±0.2 (20), 23.4 ±0.2 (20), 24.1 ±0.2 (20), 26.2 ±0.2 (20), 26.8 ±0.2 (20), 30.5 ±0.2 (20) and 31.7 ±0.2 (20), it additionally has at least one X-ray diffraction peak selected from the group consisting of 15.7 ±0.2 (20), 18.9 ±0.2 (20), 20.7 ±0.2 (20), 25.1 ±0.2 (20), 27.8 ±0.2 (20), 30.2 ±0.2 (20) and 34.8 ±0.2 (20).

[0296] The crystalline form E according to the invention may further be characterised in that as well as one or more X-ray diffraction peaks selected from the group consisting of 9.1 ±0.2 (20), 17.1 ±0.2 (20), 17.7 ±0.2 (20), 19.6 ±0.2 (20), 21.3 ±0.2 (20), 22.5 ±0.2 (20), 23.6 ±0.2 (20), 24.6 ±0.2 (20) and 28.8 ±0.2 (20), and optionally one or more X-ray diffraction peaks selected from the group consisting of 18.3 ±0.2 (20), 23.4 ±0.2 (20), 24.1 ±0.2 (20), 26.2 ±0.2 (20), 26.8 ±0.2 (20), 30.5 ±0.2 (20) and 31.7 ±0.2 (20), and optionally one or more X-ray diffraction peaks selected from the group consisting of 15.7 ±0.2 (20), 18.9 ±0.2 (20), 20.7 ±0.2 (20), 25.1 ±0.2 (20), 27.8 ±0.2 (20), 30.2 ±0.2 (20) and 34.8 ±0.2 (20), it additionally has at least one X-ray diffraction peak selected from the group consisting of 8.1 ±0.2 (20), 10.6 ±0.2 (20), 11.2 ±0.2 (20), 11.6 ±0.2 (20)and 13.3 ±0.2 (20).

[0297] All 2Θ values refer to an X-ray diffractogram measured using CuKa radiation having a wavelength of 1.54060 A.

[0298] The crystalline form E according to the present invention may further be characterized in that it has one or more Raman bands selected from the group consisting of 1569 ±2 cm-1, 2963 ±2 cm-1 and 3069 ±2 cm-1.

[0299] The crystalline form E according to the present invention may further be characterized in that it has one or more Raman bands selected from the group consisting of 1569 ±2 cm-1,2963 ±2 cm-1 and 3069 ±2 cm-1; and/or one or more Raman bands selected from the group consisting of 160 ±2 cm-1, 176 ±2 cm'1, 686 ±2 cm"1, 836 ±2 cm-1, 917 ±2 cm-1, 1003 ±2 cm"1, 1299 ±2 cm-1, 1308 ±2 cm'1 and 1582 ±2 cm'1; and/or one or more Raman bands selected from the group consisting of 211 ±2 cm-1, 253 ±2 cm"1, 369 ±2 cm-1, 491 ±2 cm"1, 599 ±2 cm'1, 1029 ±2 cm-1, 1200 ±2 cm"1, 1220 ±2 cm"1, 1376 ±2 cm"1, 1441 ±2 cm"1, 1465 ±2 cm"1, 2855 ±2 cm"1, 2873 ±2 cm"1, 2889 ±2 cm"1, 2986 ±2 cm"1 and 3048 ±2 cm-1.

[0300] The crystalline form E according to the present invention may further be characterized in that it has one or more Raman bands selected from the group consisting of 287 ±2 cm-1, 317 ±2 cm-1, 395 ±2 cm-1, 433 ±2 cm'1, 471 ±2 cm-1, 517 ±2 cm-1, 538 ±2 cm-1, 558 ±2 cm-1, 568 ±2 cm-1, 619 ±2 cm-1, 629 ±2 cm-1, 676 ±2 cm-1,713 ±2 cm-1, 786 ±2 cm"1, 854 ±2 cm"1, 870 ±2 cm"1, 889 ±2 cm1, 952 ±2 cm"1, 983 ±2 cm"1, 993 ±2 cm"1, 1019 ±2 cm'1, 1047 ±2 cm"1, 1076 ±2 cm'1, 1107 ±2 cm'1, 1117 ±2 cm1, 1133 ±2 cm'1, 1142 ±2 cm'1, 1166 ±2 cm'1, 1267 ±2 cm1, 1353 ±2 cm-1, 1494 ±2 cm-1, 1630 ±2 cm-1 and 3031 ±2 cm1.

[0301] Another aspect of the present invention relates to a process for the production of the crystalline form E described above comprising the step of (a-1) precipitating the hydrochloride salt of (1 r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohex-ane-1,1’-pyrano[3,4,b]indol]-4-amine from a solution or suspension of the free base.

[0302] The solution or suspension preferably comprises 1,4-dioxane. Preferably, the solution or suspension comprises1,4-dioxane in an amount of at least 5 Vol.-%, more preferably at least 30 Vol.-%, still more preferably at least 50 Vol.-%, yet more preferably at least 80 Vol.-%, most preferably at least 90 Vol.-%, and in particular at least 95 Vol.-%, based on the total volume of solvents contained in the solution or suspension. In particular, the solution or suspension contains 1,4-dioxane as the only solvent.

[0303] Step (a-1) may be carried out by the addition of hydrogen chloride.

[0304] In a preferred embodiment, the hydrogen chloride is added in form of hydrogen chloride gas.

[0305] In another preferred embodiment, the hydrogen chloride is produced in situ by means of a reaction, e.g. by the addition of trimethylsilyl chloride to an aqueous solution.

[0306] In still another preferred embodiment, the hydrogen chloride is in form of a solution. Preferably, the solution is a solution of hydrogen chloride in an organic solvent, especially preferred is 1,4-dioxane.

[0307] Preferably, the solution contains the hydrogen chloride in a concentration within the range of from 0.01 mol/L to 15 mol/L, more preferably within the range of from 0.02 mol/L to 12.5 mol/L, still more preferably within the range of from 0.05 mol/L to 10 mol/L, yet more preferably within the range of from 0.1 mol/L to 7.5 mol/L, most preferably within the range of from 0.2 mol/L to 10 mol/L, and in particular within the range of from 0.3 mol/L to 5 mol/L.

[0308] Preferably, the hydrogen chloride is added to the solution or suspension of the free base in molar excess.

[0309] Preferably, in the process according to the invention, step (a-1) is carried out at a temperature below or at the boiling point of the respective solvent, preferably at a temperature not higher than 80 °C, more preferably not higher than 60°C, even more preferably not higher than 40°C, and in particular in a temperature range of 20-40 °C.

[0310] Preferably, the suspension obtained in step (a-1) is then stirred for a time period of preferably at most 1 day, preferably at most4 hours, more preferably at most 60 minutes, still more preferably at most 30 minutes, yet more preferably at most 20 minutes, and most preferably at most 15 minutes, and in particular at most 10 minutes.

[0311] Preferably, the process according to the invention further comprises the step (b-1) separating, preferably filtering off the solid obtained in step (a-1).

[0312] Preferably, the process according to the invention further comprises the step (c-1) drying of the solid obtained in step (b-1).

[0313] Preferably, step (c-1) takes place under air or inert gas flow, such as argon or nitrogen flow.

[0314] A further aspect of the invention relates to a crystalline form E that is obtainable by the process as described above.

[0315] A further aspect of the present invention relates to a crystalline form F.

[0316] Preferably, the crystalline form F according to the invention has one or more X-ray diffraction peaks selected from the group consisting of 11.5 ±0.2 (20), 14.5 ±0.2 (20), 18.5 ±0.2 (20), 19.3 ±0.2 (20), 27.3 ±0.2 (20) and 29.1 ±0.2 (20). In some preferred embodiments, the crystalline form comprises X-ray diffraction peaks at 19.3 ±0.2 (20) and 29.1 ±0.2(20). In some preferred embodiments, the crystalline form comprises an X-ray diffraction peak at 19.3 ±0.2(20).

[0317] In some preferred embodiments, crystalline form F comprises X-ray diffraction peaks at 14.5 ±0.2 (20), 18.5 ±0.2 (20), 19.3 ±0.2 (20), 27.3 ±0.2 (20), 29.1 ±0.2 (20) and optionally 11.5 ±0.2 (20).

[0318] The crystalline form F according to the invention may additionally have at least one X-ray diffraction peak selected from the group consisting of 21.2 ±0.2 (20),22.0 ±0.2 (20), 27.5 ±0.2(20), 30.3 ±0.2 (20) and 31.7 ±0.2 (20).

[0319] Further, the crystalline form F according to the invention may be characterised in that as well as one or more X-ray diffraction peaks selected from the group consisting of 11.5 ±0.2 (20), 14.5 ±0.2 (20), 18.5 ±0.2 (20), 19.3 ±0.2 (20), 27.3 ±0.2 (20) and 29.1 ±0.2 (20), and optionally one or more X-ray diffraction peaks selected from the group consisting of 21.2 ±0.2 (20), 22.0 ±0.2 (20), 27.5 ±0.2 (20), 30.3 ±0.2 (20) and 31.7 ±0.2 (20), it additionally has at least one X-ray diffraction peak selected from the group consisting of 16.1 ±0.2 (20), 16.6 ±0.2 (20), 19.9 ±0.2 (20), 20.5 ±0.2 (20), 23.2 ±0.2 (20), 26.1 ±0.2 (20), 26.5 ±0.2 (20), and 30.7 ±0.2 (20).

[0320] The crystalline form F according to the invention may further be characterised in that as well as one or more X-ray diffraction peaks selected from the group consisting of 11.5 ±0.2 (20), 14.5 ±0.2 (20), 18.5 ±0.2 (20), 19.3 ±0.2 (20), 27.3 ±0.2 (20) and 29.1 ±0.2 (20), and optionally one or more X-ray diffraction peaks selected from the group consisting of 21.2 ±0.2 (20), 22.0 ±0.2 (20), 27.5 ±0.2 (20), 30.3 ±0.2 (20) and 31.7 ±0.2 (20), and optionally one or more X-ray difFraction peaks selected from the group consisting of 16.1 ±0.2 (20), 16.6 ±0.2 (20), 19.9 ±0.2 (20), 20.5 ±0.2 (20), 23.2 ±0.2 (20), 26.1 ±0.2 (20), 26.5 ±0.2 (20), and 30.7 ±0.2 (20), it additionally has at least one X-ray diffraction peak selected from the group consisting of 9.9 ±0.2 (20), 10.5 ±0.2 (20), 17.4 ±0.2 (20), 24.5 ±0.2 (20), 28.2 ±0.2 (20), 32.0 ±0.2 (20), 33.0 ±0.2 (20) and 34.6 ±0.2 (20).

[0321] All 2Θ values refer to an X-ray difFractogram measured using CuKa radiation having a wavelength of 1.54060 A.

[0322] The crystalline form F according to the present invention may further be characterized in that it has one or more Raman bands selected from the group consisting of 160 ±2 cm"1, 1295 ±2 cm'1, 1573 ±2 cm-1, 1585 ±2 cm"1, 2979 ±2 cm"1 and 3070 ±2 cm-1.

[0323] The crystalline form F according to the present invention may further be characterized in that it has one or more Raman bands selected from the group consisting of 160 ±2 cm'1, 1295 ±2 cm'1, 1573 ±2 cm1, 1585 ±2 cm"1, 2979 ±2 cm"1 and 3070 ±2 cm1; and/or one or more Raman bands selected from the group consisting of 174 ±2 cm'1, 206 ±2 cm'1, 917 ±2 cm 1, 1003 ±2 cm"1 and 2954 ±2 cm"1; and/or one or more Raman bands selected from the group consisting of 254 ±2 cm"1, 598 ±2 cm"1, 683 ±2 cm"1,1030 ±2 cm"1,1110±2cm"1 1217 ±2 cm"1, 1434 ±2 cm"1, 1458 ±2 cm"1, 1468 ±2 cm"1, 2895 ±2 cm"1, 2942 ±2 cm"1 and 3029 ±2 cm"1.

[0324] The crystalline form F according to the present invention may further be characterized in that it has one or more Raman bands selected from the group consisting of 273 ±2 cm'1, 367 ±2 cm'1, 390 ±2 cm1, 436 ±2 cm"1, 488 ±2 cm1, 515 ±2 cm'1, 538 ±2 cm'1, 568 ±2 cm'1, 620 ±2 cm'1 707 ±2 cm'1, 769 ±2 cm1, 786 ±2 cm1, 829 ±2 cm'1, 888 ±2 cm'1 980 ±2 cm'1, 1047 ±2 cm'1, 1132 ±2 cm'1, 1170 ±2 cm'1, 1201 ±2 cm'1, 1264 ±2 cm'1, 1368 ±2 cm'1, 1486 ±2 cm'1, 1629 ±2 cm'1 and 2840 ±2 cm'1.

[0325] Another aspect of the present invention relates to a process for the production of the crystalline form F described above comprising the step of (a-1) precipitating the hydrochloride salt of (1 r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohex-ane-1,1’-pyrano[3,4,b]indol]-4-amine from a solution or suspension of the free base.

[0326] Preferably, the solvent is selected from the group consisting of alcohols such as methanol, ethanol, n-propanol, iso-propanol and n-butanol; ketones such as acetone, 2-butanone, pentan-2-one, pentan-3-one, hexan-2-one and hexan-3-one; etherssuch astert-butyl methyl ether, diethylether, tetrahydrofuran, diisopropyletherand 1,4-dioxane; chlorinated hydrocarbons such as dichloromethane and chloroform; and mixtures thereof.

[0327] Preferably, the solvent does not contain water.

[0328] Step (a-1) may be carried out by the addition of hydrogen chloride.

[0329] In a preferred embodiment, the hydrogen chloride is added in form of hydrogen chloride gas.

[0330] In another preferred embodiment, the hydrogen chloride is produced In situ by means of a reaction, e.g. by the addition of trimethylsilyl chloride to an aqueous solution.

[0331] In still another preferred embodiment, the hydrogen chloride is in form of a solution.

[0332] Preferably, the solution is a solution of hydrogen chloride in an organic solvent, especially preferred are alcohols such as ethanol, isopropanol and n-butanol.

[0333] Preferably, the solution contains the hydrogen chloride in a concentration within the range of from 0.01 mol/L to 15 mol/L, more preferably within the range of from 0.02 mol/L to 12.5 mol/L, still more preferably within the range of from 0.05 mol/L to 10 mol/L, yet more preferably within the range of from 0.1 mol/L to 7.5 mol/L, most preferably within the range of from 0.2 mol/L to 10 mol/L, and in particular within the range of from 0.3 mol/L to 5 mol/L. Preferably, the hydrogen chloride is added to the solution or suspension of the free base in molar excess.

[0334] Preferably, in the process according to the invention, step (a-1) is carried out at a temperature below or at the boiling point of the respective solvent, preferably at a temperature not higher than 80 °C, more preferably not higher than 60°C, even more preferably not higher than 40°C, and in particular in a temperature range of 20-40 °C.

[0335] Preferably, in the process according to the invention, the suspension obtained in step (a-1) is stirred for a time period of at least 1 minute, preferably at least 2 minutes, more preferably at least 3 minutes, still more preferably at least 5 minutes, yet more preferably at least 10 minutes, most preferably at Ieast20 minutes, and in particularat least30 minutes.

[0336] In another preferred embodiment, the suspension obtained in step (a-1) is stirred for a time period of at most 1 day, preferably at most 12 hours, more preferably at most 6 hours, still more preferably at most 2 hours, yet more preferably at most 60 minutes, and most preferably at most 45 minutes, and in particular at most 30 minutes.

[0337] Preferably, the process according to the invention further comprises the step (b-1) separating, preferably filtering off the solid obtained in step (a-1).

[0338] Preferably, the process according to the invention further comprises the step (c-1) drying of the solid obtained in step (b-1).

[0339] In a preferred embodiment, step (c-1) takes place under air or inert gas flow, such as argon or nitrogen flow.

[0340] In another preferred embodiment, step (c-1) takes place under vacuum, more preferably at a vacuum of 0 to 900 mbar, even more preferably at a vacuum of 1 to 500 mbar, and in particular at a vacuum of 10 to 200 mbar.

[0341] Preferably, in the process according to the invention, step (c-1) takes place in a temperature range from 0 to 60 °C, preferably from 10 °C to 50 °C more preferably from 20 to 40 °C.

[0342] In another preferred embodiment, the process comprises the step of (a-2) dissolving (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano[3,4,b]in-dol]-4-amine hydrochloride in a solvent.

[0343] Preferably, the solvent is selected from the group consisting of dichloromethane, N-methyl-2-pyrrolidone, methanol, dimethyl formamide, and mixtures thereof.

[0344] In an especially preferred embodiment, the organic solvent is a mixture of dichloromethane and methanol. Preferably, the ratio between dichloromethane and methanol is within the range of from 10:1 to 1:10, more preferably within the range of from 7:1 to 1:5, still more preferably within the range of from 6:1 to 1:3, yet more preferably within the range of from 5:1 to 1:1, most preferably within the range of from 4:1 to 2:1, and in particular within the range of from 3.5:1 to 2.5:1 (volume/volume).

[0345] Preferably, in the process according to the invention, step (a-2) is carried out at a temperature below or at the boiling point of the respective solvent, preferably at a temperature not higher than 80 °C, more preferably not higher than 60°C, even more preferably not higher than 40°C, and in particular in a temperature range of 20-40 °C.

[0346] In a preferred embodiment, the process according to the invention further comprises the step (b-2) evaporating off the solvent of the solution obtained in step (a-2).

[0347] Suitable methods for evaporating off the solvent are known to a person skilled in the art. Preferably, in the process according to the invention, the solvent is evaporated off in air, air flow, or inert gas flow, in particular argon or nitrogen flow. However, evaporating off the solvent under vacuum, for example by means of a rotary evaporator, is also possible.

[0348] Preferably, in the process according to the invention, the solvent is evaporated off at room temperature.

[0349] In another preferred embodiment, the process further comprises the step of (b-2’) precipitating (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclo-hexane-1,1’- pyrano[3,4,b]indol]-4-amine hydrochloride from the solution obtained in step (a-2).

[0350] Suitable methods of precipitation are known to a person skilled in the art. In the process according to the invention, step (b-2’) may be carried out by reducing the volume of the solution obtained in step (a-2) and/or by cooling of the solution, preferably to a temperature of at most 15°C, more preferably at most 10°C, even more preferably at most 4-8°C and/or by cooling of the solution, preferably to a temperature of at least 10 °C, more preferably at least 30 °C, even more preferably at least 60 °C below the temperature according to step (a-2).

[0351] In a preferred embodiment, step (b-2’) is carried out by the addition of a medium in which (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano-[3,4,b]indol]-4-amine hydrochloride is only poorly soluble ("anti-solvent") to the solution obtained in step (a-2). Said medium is preferably selected from the group consisting of esters such as ethyl acetate, n-propyl acetate, iso-propyl acetate, n-butyl acetate and iso-butyl acetate; ethers such as tert-butyl methyl ether, diethyl ether and diisopropyl ether; ketones such as acetone, 2-butanone, pentan-2-one, pentan-3-one, hexan-2-one and hexan-3-one; nitriles such as acetonitril; pyridine, acetic acid and water.

[0352] Especially preferred are iso-butyl acetate and diethyl ether.

[0353] The amount of the media in which (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano[3,4,b]indol]-4-amine hydrochloride is only poorly soluble, the precipitant or anti-solvent, is preferably selected in such a manner that upon its addition precipitation of the dissolved component begins.

[0354] The total amount of the media in which(1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohex-ane-1,1’-pyrano[3,4,b]indol]-4-amine hydrochloride is only poorly soluble may also be divided into several portions, preferably two or three portions. In this embodiment, the precipitation of the dissolved component preferably begins after the addition of the last portion.

[0355] The precipitation of the dissolved component preferably begins either immediately after the precipitant, preferably the total amount of the precipitant, has been added or alternatively with a delay of 2 seconds to 120 minutes. Preferably, the precipitation of the dissolved component begins within a time period of at most 60 minutes, more preferably at most 30 minutes, still more preferably at most 20 minutes, yet more preferably at most 10 minutes, most preferably at most 5 minutes, and in particular at most 3 minutes.

[0356] Preferably, in the process according to the invention, after step (b-2) or respectively (b-2’), all other steps are carried out at a temperature between 40 and 0 °C, preferably between 35 and 5°C, more preferably between 25 and 15°C.

[0357] Preferably, in the process according to the invention, the suspension obtained in step (b-2’) is stirred for a time period of at least 1 minute, preferably at least 2 minutes, more preferably at least 3 minutes, and most preferably at least 5 minutes.

[0358] Preferably, the process according to the invention further comprises the step (c-2’) separating, preferably filtering off the precipitate obtained in step (b-2’), [0359] Preferably, the process according to the invention further comprises the step (d-2’) drying of the solid obtained in step (c-2’).

[0360] In a preferred embodiment, step (d-2’) takes place under air or inert gas flow, such as argon or nitrogen flow.

[0361] In another preferred embodiment, step (c-1) takes place under vacuum, more preferably at a vacuum of 0 to 900 mbar, even more preferably at a vacuum of 1 to 500 mbar, and in particular at a vacuum of 10 to 200 mbar.

[0362] A further aspect of the invention relates to a crystalline form F that is obtainable by the process as described above.

[0363] A further aspect of the present invention relates to a crystalline form G.

[0364] Preferably, the crystalline form G according to the invention has one or more X-ray diffraction peaks selected from the group consisting of 21.4 ±0.2 (20), 24.5 ±0.2 (20), 25.2 ±0.2 (20), 26.8 ±0.2 (20), 30.5 ±0.2 (20), 31.8 ±0.2 (20) and 33.0 ±0.2 (20). In some preferred embodiments, the crystalline form comprises X-ray diffraction peaks at 21.4 ±0.2 (20) and 26.8 ±0.2 (20). In some preferred embodiments, the crystalline form comprises an X-ray diffraction peak at 26.8 ±0.2 (20).

[0365] The crystalline form G according to the invention may additionally have at least one X-ray diffraction peak selected from the group consisting of 13.3 ±0.2 (20), 14.2 ±0.2 (20), 21.8 ±0.2 (20), 28.6 ±0.2 (20), 30.0 ±0.2 (20) and 31.3 ±0.2 (20).

[0366] Further, the crystalline form G according to the invention may be characterised in that as well as one or more X-ray diffraction peaks selected from the group consisting of 21.4 ±0.2 (20), 24.5 ±0.2 (20), 25.2 ±0.2 (20), 26.8 ±0.2 (20), 30.5 ±0.2 (20), 31.8 ±0.2 (20) and 33.0 ±0.2 (20), and optionally one or more X-ray diffraction peaks selected from the group consisting of 13.3 ±0.2 (20), 14.2 ±0.2 (20), 21.8 ±0.2 (20), 28.6 ±0.2 (20), 30.0 ±0.2 (20) and 31.3 ±0.2 (20), it additionally has at least one X-ray diffraction peak selected from the group consisting of 18.6 ±0.2 (20), 26.2 ±0.2 (20), 27.4 ±0.2 (20), 34.2 ±0.2 (20) and 34.8 ±0.2 (20).

[0367] All 20 values refer to an X-ray diffractogram measured using CuKa radiation having a wavelength of 1.54060 A.

[0368] The crystalline form G according to the present invention may further be characterized in that it has one or more Raman bands selected from the group consisting of 274 ±2 cm"1; 642 ±2 cm-1,1028 ±2 cm'1,3053 ±2 cm-1 and 3077 ±2 cm'1.

[0369] The crystalline form G according to the present invention may further be characterized in that it has one or more Raman bands selected from the group consisting of 200 ±2 cm"1, 293 ±2 cm-1, 445 ±2 cm"1, 560 ±2 cm'1, 623 ±2 cm 1, 654 ±2 cm1, 700 ±2 cm 1, 774 ±2 cm'1, 835 ±2 cm'1, 846 ±2 cm1, 894 ±2 cm 1, 986 ±2 cm1, 1005 ±2 cm 1, 1070 ±2 cm1, 1146 ±2 cm1, 1193 ±2 cm'1, 1242 ±2 cm'1, 1304 ±2 cm1 1361 ±2 cm'1, 1422 ±2 cm'1 1446 ±2 cm"1 1512 ±2 cm"1,1582 ±2 cm"1,1636 ±2 cm"1, 2986 ±2 cm"1, 3006 ±2 cm"1, 3019 ±2 cm"1, 3089 ±2 cm"1 and 3164 ±2 cm"1.

[0370] Another aspect of the present invention relates to a process for the production of the crystalline form G described above comprising the step of (a-2) dissolving (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano[3,4,b]in-dol]-4-amine hydrochloride in a solvent.

[0371] Preferably, the solvent is selected from the group consisting of dichloromethane, N-methyl-2-pyrrolidone, methanol, dimethyl formamide, and mixtures thereof.

[0372] In an especially preferred embodiment, the organic solvent is a mixture of dichloromethane and methanol.

Preferably, the ratio between dichloromethane and methanol is within the range of from 10:1 to 1:10, more preferably within the range of from 7:1 to 1:5, still more preferably within the range of from 6:1 to 1:3, yet more preferably within the range of from 5:1 to 1:1, most preferably within the range of from 4:1 to 2:1, and in particular within the range of from 3.5:1 to 2.5:1 (volume/volume).

[0373] Preferably, in the process according to the invention, step (a-2) is carried out at a temperature below or at the boiling point of the respective solvent, preferably at a temperature not higher than 80 °C, more preferably not higher than 60°C, even more preferably not higher than 40°C, and in particular in a temperature range of 20-40 °C.

[0374] Preferably, the process further comprises the step of (b-2’) precipitating (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’l-l-spiro[cyclo-hexane-1,1’- pyrano[3,4,b]indol]-4-amine hydrochloride from the solution obtained in step (a-2).

[0375] Suitable methods of precipitation are known to a person skilled in the art. In the process according to the invention, step (b-2’) may be carried out by reducing the volume of the solution obtained in step (a-2) and/or by cooling of the solution, preferably to a temperature of at most 15°C, more preferably at most 10°C, even more preferably at most 4-8°C and/or by cooling of the solution, preferably to a temperature of at least 10 °C, more preferably at least 30 °C, even more preferably at least 60 °C below the temperature according to step (a-2).

[0376] In a preferred embodiment, step (b-2’) is carried out by the addition of a medium in which (1 r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano-[3,4,b]indol]-4-amine hydrochloride is only poorly soluble (anti-solvent) to the solution obtained in step (a-2).

[0377] Preferably, said medium is pyridine.

[0378] The amount of the media in which (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano[3,4,b]indol]-4-amine hydrochloride is only poorly soluble, the precipitant or anti-solvent, is preferably selected in such a manner that within a time period of up to 2 days, preferably up to one day, precipitation of the dissolved component begins.

[0379] The total amount of the media in which (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohex-ane-1,1’-pyrano[3,4,b]indol]-4-amine hydrochloride is only poorly soluble may also be divided into several portions, preferably two or three portions. In this embodiment, the precipitation of the dissolved component preferably begins after the addition of the last portion.

[0380] Preferably, in the process according to the invention, after step (b-2) or respectively (b-2’), all other steps are carried out at a temperature between 40 and 0 °C, preferably between 35 and 5°C, more preferably between 25 and 15°C.

[0381] Preferably, the process according to the invention further comprises the step (c-2’) separating, preferably filtering off the precipitate obtained in step (b-2’).

[0382] Preferably, the process according to the invention further comprises the step (d-2’) drying of the solid obtained in step (c-2’).

[0383] Preferably, in the process according to the invention, step (d-2’) takes place under air or inert gas flow, such as argon or nitrogen flow.

[0384] A further aspect of the invention relates to a crystalline form G that is obtainable by the process as described above.

[0385] In some embodiments, the solid forms of the present invention make it possible to obtain (1 r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano-[3,4,b]indol]-4-amine in form of the hydrochloride with high yields and purity. These forms are further distinguished in that they have fundamentally different properties, which may provide advantages.

[0386] In some embodiments, the solid forms of the present invention are characterized by higher ease-of-handling and allow for more precise (or even exact) metering of the active ingredient.

[0387] In some embodiments, it has been surprisingly found that (1 r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano[3,4,b]indol]-4-amine hydrochloride is capable of forming four ansolvate forms (crystalline forms A, B, D and F), a hydrate (crystalline form C) and two different solvates with organic solvents (crystalline forms E and G).

[0388] In some embodiments, it has been surprisingly found that crystalline forms A, D and E or mixtures thereof are obtained by crystallization techniques with short equilibration times. In some embodiments, it has been surprisingly found that crystalline form A represents the most dominant form obtainable by these fast crystallization techniques.

[0389] In some embodiments, it has been found that crystalline form A is not hygroscopic. In some embodiments, it has been found that crystalline form A may be obtained from crystalline form C by drying.

[0390] In some embodiments, it has been found that crystalline form B is obtained by slower crystallization techniques, such as suspension equilibration. In some embodiments, it has surprisingly been found that crystalline forms A, B, C, D and F may be converted into crystalline form B by these slower crystallization techniques. In some embodiments, it has been found that crystalline form B represents the thermodynamically most stable form at room temperature.

[0391] Mixtures of the crystalline forms A, B, C, D, E, F and G, preferably mixtures of two or three of these crystalline forms, are also included within the scope of the present invention.

[0392] For example, mixtures of crystalline forms A and C may be obtained from crystalline form C by a partial loss of hydrate water or mixtures of crystalline forms A and B may be obtained from suspensions containing crystalline form A by partial suspension equilibration.

[0393] In a preferred embodiment, the crystalline form according to the invention is subsequently converted into an amorphous form.

[0394] In another aspect the present invention relates to a solid form, in particular a crystalline form and/or an amorphous formas described herein for use in the treatment of pain.

[0395] In another aspect the present invention relates to methods of treating pain, comprising administering a solid form as described herein to a patient in need thereof (for example, a patient who has been diagnosed with a pain disorder).

[0396] In another aspect the present invention relates to methods of treating pain, comprising administering a pharmaceutical composition that comprises a solid form as described herein to a patient in need thereof (for example, a patient who has been diagnosed with a pain disorder).

[0397] The term pain as used herein preferably includes but is not limited to pain selected from the group consisting of inflammatory pain, postoperative pain, neuropathic pain, diabetic neuropathic pain, acute pain, chronic pain, visceral pain, migraine pain and cancer pain.

[0398] In some preferred embodiments, the solid form, in particular the crystalline form and/or the amorphous form according to the invention is for use in the treatment of acute, visceral, neuropathic or chronic pain (cf. WO 2008/040481).

[0399] In another aspect the present invention relates to a pharmaceutical composition comprising a solid form, in particular a crystalline form and/or an amorphous form as described herein and optionally one or more suitable additives and/or adjuvants such as described below.

[0400] In some preferred embodiments, the pharmaceutical composition comprises between about 0.001 % by weight and about 40% by weight of one or more of the solid forms, in particular crystalline forms and/or amorphous forms described herein. In some preferred embodiments, the pharmaceutical composition comprises between about 0.001% by weight and about 20% by weight of one or more of the solid forms, in particular crystalline forms and/or amorphous forms described herein. In some preferred embodiments, the pharmaceutical composition comprises between about 0.001% by weight and about 10% by weight of one or more of the solid forms, in particular crystalline forms and/or amorphous forms described herein. In some preferred embodiments, the pharmaceutical composition comprises between about 0.001 % by weight and about 5% by weight of one or more of the solid forms, in particular crystalline forms and/or amorphous forms described herein. In some preferred embodiments, the pharmaceutical composition comprises between about 0.001% by weight and about 1% by weight of one or more of the solid forms, in particular crystalline forms and/or amorphous forms described herein. In some preferred embodiments, the pharmaceutical composition comprises between about 0.01 % by weight and about 1 % by weight of one or more of the solid forms, in particular crystalline forms and/or amorphous forms described herein.

[0401] Suitable methods for determining the content of the hydrochloric acid salt of (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,T-pyrano[3,4,b]indol]-4-amine are known to those skilled in the art and include e.g. XRPD, elemental analysis, Raman spectroscopy, infrared spectroscopy, chromatographic methods, NMR spectroscopy, thermal analysis, electrophoresis, atom absorption spectroscopy, energy dispersive X-ray spectroscopy thermal methods comprise, among others, e.g. DSC.TGA, modulated temperature DSC, high-speed DSC, melting point, hot-stage XRPD, hot-stage microscopy, heat of solution, microthermal analysis, calorimetry, micro-calorimetry.

[0402] Preferably said pharmaceutical composition may be used for the treatment of pain.

[0403] In still another aspect the present invention relates to a medicament comprising a solid form, in particular a crystalline form and/or an amorphous form as described herein. In a preferred embodiment, the medicament is a solid drug form. The medicament is preferably manufactured for oral administration. However, other forms of administration are also possible, e.g. for buccal, sublingual, transmucosal, rectal, intralumbal, intraperitoneal, transdermal, intravenous, intramuscular, intragluteal, intracutaneous and subcutaneous application.

[0404] Depending on the configuration, the medicament (dosage form) preferably contains suitable additives and/or adjuvants. Suitable additives and/or adjuvants in the sense of the invention are all substances known to a person skilled in the art for the formation of galenic formulations. The choice of these adjuvants and also the quantities to be used are dependent on how the medication is to be administered, i.e. orally, intravenously, intraperitoneally, intradermally, intramuscularly, intranasally, buccally or locally.

[0405] In some preferred embodiments, the dosage form comprises 40 ± 35 μς, more preferably 40 ± 30 μg, still more preferably 40 ± 25 μg, yet more preferably 40 ± 20 μς, even more preferably 40 ± 15 μς, most preferably 40 ± 10 μς, and in particular 40 ± 5 μς of one or more of the crystalline forms described herein. In some other preferred embodiments, the dosage form comprises 400 ± 375 μς or 400 ± 350 μς, more preferably 400 ± 300 μς, still more preferably 400 ± 250 μς, yet more preferably 400 ± 200 μς, even more preferably 400 ±150 μς, most preferably 40 ± 100 μς, and in particular 400 ± 50 μς of one or more of the crystalline forms described herein.

[0406] Preparations suitable for oral administration are those in the form of tablets, chewable tablets, lozenges, capsules, granules, drops, liquids or syrups, and those suitable for parenteral, topical and inhalatory administration are solutions, suspensions, easily reconstituted dry preparations and sprays. A further possibility is suppositories for rectal administration. The application in a depot in dissolved form, a patch or a plaster, possibly with the addition of agents promoting skin penetration, are examples of suitable percutaneous forms of application.

[0407] Examples of adjuvants and additives for oral forms of application are disintegrants, lubricants, binders, fillers, mould release agents, possibly solvents, flavourings, sugar, in particular carriers, diluents, colouring agents, antioxidants etc.

[0408] Waxes or fatty acid esters, amongst others, can be used forsuppositories and carrier substances, preservatives, suspension aids etc. can be used for parenteral forms of application.

[0409] Adjuvants can be, for example: water, ethanol, 2-propanol, glycerine, ethylene glycol, propylene glycol, polyethylene glycol, polypropylene glycol, glucose, fructose, lactose, saccharose, dextrose, molasses, starch, modified starch, gelatine, sorbitol, inositol, mannitol, microcrystalline cellulose, methyl cellulose, carboxymethyl-cellulose, cellulose acetate, shellac, cetyl alcohol, polyvinylpyrrolidone, paraffins, waxes, natural and synthetic rubbers, acacia gum, alginates, dextran, saturated and unsaturated fatty acids, stearic acid, magnesium stearate, zinc stearate, glyceryl stearate, sodium lauryl sulphate, edible oils, sesame oil, coconut oil, peanut oil, soybean oil, lecithin, sodium lactate, polyoxyethylene and propylene fatty acid esters, sorbitane fatty acid esters, sorbic acid, benzoic acid, citric acid, ascorbic acid, tannic acid, sodium chloride, potassium chloride, magnesium chloride, calcium chloride, magnesium oxide, zinc oxide, silicon dioxide, titanium oxide, titanium dioxide, magnesium sulphate, zinc sulphate, calcium sulphate, potash, calcium phosphate, dicalcium phosphate, potassium bromide, potassium iodide, talc, kaolin, pectin, crospovidon, agar and bentonite.

[0410] The production of these medicaments and pharmaceutical compositions is conducted using means, devices, methods and processes that are well known in the art of pharmaceutical technology, as described, for example, in 'Remington’s Pharmaceutical Sciences", A.R. Gennaro, 17th ed., Mack Publishing Company, Easton, Pa. (1985), in particular in part 8, chapters 76 to 93.

[0411] Thus, for example, for a solid formulation such as a tablet, the active substance of the drug can be granulated with a pharmaceutical carrier substance, e.g. conventional tablet constituents such as cornstarch, lactose, saccharose, sorbitol, talc, magnesium stearate, dicalcium phosphate or pharmaceutically acceptable rubbers, and pharmaceutical diluents such as water, for example, in order to form a solid composition that contains the active substance in a homogenous dispersion. Homogenous dispersion is understood hereto mean that the active substances are uniformly dispersed throughout the composition, so that this can be readily divided into identically effective standard dosage forms such as tablets, capsules, lozenges. The solid composition is then divided into standard dosage forms. The tablets or pills can also be coated or otherwise compounded to prepare a slow release dosage form. Suitable coating agents include polymeric acids and mixtures of polymeric acids with materials such as shellac, cetyl alcohol and/or cellulose acetate, for example.

[0412] In one embodiment of the present invention the solid form, in particularthe crystalline form and/or the amorphous formas described herein is present in immediate release form.

[0413] In another embodiment of the present invention the solid form, in particular the crystalline form and/or the amorphous form as described herein is at least partially present in controlled-release form. In particular, the active ingredient can be released slowly from preparations that can be applied orally, rectally or percutaneously.

[0414] The medicament can preferably be manufactured for administration once daily, twice daily (bid), or three times daily, the once daily or twice daily administration (bid) being preferred.

[0415] The term controlled release as used herein refers to any type of release other than immediate release such as delayed release, sustained release, slow release, extended release and the like. These terms are well known to any person skilled in the art as are the means, devices, methods and processes for obtaining such type of release.

[0416] In another embodiment of the present invention • the medicament is manufactured for oral administration; and/or • the medicament is a solid and/or compressed and/or film-coated drug form; and/or • the medicament releases the solid form, in particular the crystalline form and/or the amorphous form as described herein slowly from a matrix; and/or • the medicament contains the solid form, in particular the crystalline form and/or the amorphous form in a quantity of 0.001 to 99.999% by wt., more preferred 0.1 to 99.9% by wt., still more preferred 1.0 to 99.0% by wt., even more preferred 2.5 to 80% by wt., most preferred 5.0 to 50% by wt. and in particular 7.5 to 40% by wt., based on the total weight of the medicament; and/or • the medicament contains a pharmaceutically compatible carrier and/or pharmaceutically compatible adjuvants; and/or • the medicament has a total mass in the range of 25 to 2000 mg, more preferred 50 to 1800 mg, still more preferred 60 to 1600 mg, more preferred 70 to 1400 mg, most preferred 80 to 1200 mg and in particular 100 to 1000 mg; and/or • the medicament is selected from the group comprising tablets, capsules, pellets and granules.

[0417] The medicament can be provided as a simple tablet and as a coated tablet (e.g. as film-coated tablet or lozenge). The tablets are usually round and biconvex, but oblong forms are also possible. Granules, spheres, pellets or microcapsules, which are contained in sachets or capsules or are compressed to form disintegrating tablets, are also possible.

[0418] In yet another one of its aspects, the present invention relates to the use of the solid form, in particular the crystalline form and/or the amorphous form as described herein for the production of a medicament. Preferably said medicament is suitable for the treatment of pain.

[0419] In still another one of its aspects, the present invention relates to the use of the solid form, in particular the crystalline form and/or the amorphous form as described herein for the treatment of pain.

[0420] Furthermore, the present invention relates to a method for treating pain in a patient, preferably in a mammal, which comprises administering an effective amount of a solid form, in particular a crystalline form and/or an amorphous form as described herein to a patient.

EXAMPLES

[0421] The following examples serve to explain the invention in more detail, but should not be interpreted as restrictive.

[0422] The following abbreviations are used in the examples: iBuOAc iso-butyl acetate 1BuOH n-butanol (1-butanol) DMSO dimethylsulfoxid

EtOAc ethyl acetate

EtOH ethanol h hour(s) IPE diisopropyl ether

MeCN acetonitril MEK 2-butanone

MeOH methanol min minute(s) NMP N-methyl-2-pyrrolidone 1PrOH n-propanol (1-propanol) 2PrOH iso-propanol (2-propanol)

RT room temperature, preferably 20-25°C sec seconds TBME tert-butyl methyl ether THF tetra hydrofu ran NMR nuclear magnetic resonance spectroscopy PXRD powder x-ray diffraction XRPD x-ray powder diffraction SCXRD single crystal x-ray diffraction FT Raman Fourier-Transform Raman spectroscopy TG-FTIR thermogravimetry coupled with Fourier-Transform infrared spectroscopy DSC differential scanning calorimetry DVS dynamic vapour sorption [0423] Unless otherwise specified, solvent mixtures are always volume/volume.

[0424] Synthesis of (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano[3,4,b]in-dol]-4-amine [0425] (4-(dimethylamino)-4-phenylcyclohexanone (3 g, 13.82 mmol), 2-(5-fluoro-1H-indol-3-yl)ethanol (2.47 g, 13.82 mmol) and 150 mL dichloromethane were charged to a flask at 0°C. A solution of trifluoromethane sulfonic acid trimeth-ylsilylester (3 mL, 15.5 mmol) in 3 mL dichloromethane were added quickly. The reaction mixture changed color to violet and the temperature rose to 10°C. The reaction mixture was cooled in an ice bath and stirred for 20 min. Meanwhile a solid precipitated. The ice bath was removed and the reaction mixture was stirred for 3 to 3.5 hours at room temperature. Subsequently 50 mL of NaOH (1 N) were added and the reaction mixture was stirred further 10 min. The colour changed to yellow and a solid precipitated. In order to complete the precipitation the reaction mixture (two liquid phases) was stirred for further 20 min while cooled in an ice bath. Eventually the solid was filtered off. The resulting solid (4.2 g) was subsequently recrystallized in 800 mL 2-Propanol. Yield: 3.5g.

[0426] To enhance the yield, the liquid (Water and Dichloromethane) filtrate was separated. The aqueous solution with extracted 3 times with 20 mL Dichloromethane. The organic phases were united and dried with MgS04 and subsequently the solvent was stripped off until dryness. The resulting solid (1,7 g) was subsequently recrystallized under reflux in 800 mL 2-Propanol.

A) Synthesis of crystalline form A

[0427] 303 mg (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano[3,4,b]indol]-4-amine were dissolved in 50 mL acetone and 2 mL THF. 1.6 mL of hydrochloric acid (0.5 M in H20 was added. The salt precipitated out after short time of stirring. The resulting suspension was stirred for 1 day at RT. The resulting solids were filtered off and dried in air. A crystalline solid of crystalline form A was obtained and characterized by NMR, PXRD, FT Raman, TG-FTIR, DSC, elemental analysis and DVS (cf. Section "Analysis").

B) Synthesis of crystalline form B

[0428] 3.07 g (1 r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano[3,4,b]indol]-4-amine were suspended in 520 mL acetone/THF 25:1 (v/v). Only a small amount of solid remained. 18 mL of hydrochloric acid (0.5 M in H20 were slowly added and the formation of further precipitate was observed. The suspension was stirred for 5 days at RT. The resulting solids were filtered off and dried for 1.5 h under vacuum.A crystalline solid (2.35 g, 70%) of crystalline form B was obtained and characterized by NMR, PXRD, FT Raman, TG-FTIR, DSC, elemental analysis and DVS (cf. Section "Analysis").

[0429] The purity of the compound was determined by HPLC and was found to be > 99.9%. The impurity peak that typically is present in the HPLC spectrum of the free base was found to be below the detection limit in this sample. Therefore, converting the free base into the hydrochloric acid addition salt and subsequent crystallization of the resulting hydrochloride salt apparently purifies the compound.

Example 1

Acid-base reaction experiments [0430] (1 r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano-[3,4,b]indol]-4-amine (in form of the free base) was dissolved or suspended in different solvents at RT. In case that a turbid solution was obtained, the solution was filtered.Then hydrochloric acid was added to the solution. The resulting suspension was stirred at RT for different times. The resulting solids were filtered off, dried under different conditions (vacuum, nitrogen flow or at different relative humidities) and characterized by PXRD and/or FT Raman.

[0431] The detailed experimental conditions and results are summarized in the table here below. For characterization details of the obtained forms see Section "Analysis".

Table 1

Ex. solvent(s) amount free HCI solution stirring drying outcome1) remarks base/ time (crystall. amount form) solvent

1-1 acetone/THF 3.07 g / 520 0.5MinH2O, 5 days vacuum B

25:1 (v/v) mL 18 mL

1-2 acetone/THF 205 mg / 36 0.5MinH2O, 1h vacuum A, B

17:1 (v/v) mL 0.94 mL 1-3 acetone/THF 202 mg / 36 0.5MinH2O, 6 days vacuum B after 1 h: A; after

17:1 (v/v) mL 1.07 mL 6 days: B 1-4 THF/H20 1:1 206mg/14.5 0.5MinH2O, 1h vacuum "H" mixture

(v/v) mL 1.1 mL containing C (continued)

Ex. solvent(s) amount free HCI solution stirring drying outcome1) remarks base/ time (crystall. amount form) solvent

1-5 1,4-dioxane 197mg/14.5 0.5MinH2O, 0.5 h vacuum A, B

mL 1.1 mL

1-6 THF 80mg/7mL 0.5MinH2O, 3 min N2flow A

0.49 mL

1-7 CH2CI2 83 mg/25 1.25 Min 1h N2flow A mL EtOH, 0.21

mL

1-8 toluene 56 mg/37 1.25 Min 10 min N2flow D mL EtOH,

0.14mL

1-9 1BuOH 89 mg/35 3 M in 1h N2flow D mL 1BuOH,

0.09mL

1-10 MEK 108 mg/21 3 M in 5 min N2flow D mL 1BuOH,

0.11mL 1-11 1,4-dioxane 83mg/8mL 4 M in 5 min N2flow,then E converts to E, A, dioxane,0.07 vacuum D upon drying

mL

1-12 MeOH 106 mg/35 1.25 Min 1h N2flow A mL EtOH,

0.26mL

1-13 THF / H202) 102 mg/16 0.5MinH2O, 1h vacuum C (wet), converts to A 1:1.1 (v/v) mL 0.62 mL thenA(dry) upon drying

1-14 THF/H202) 202 mg/32 0.5MinH2O, 2 days at97%r.h., C (wet), A 1:1.1 (v/v) mL 1.2mL then vacuum (dry)

1-15 THF/ 196 mg/32 0.5MinH2O, 2 days at75.5%r.h. A, C

H202)02) mL 1.2 mL 1:1.1 (v/v)

1-16 THF/H202) 80 mg/39.3 0.5MinH2O, 2 days at79.5%r.h. C, A

1:7.4 (v/v) mL 0.48 mL

1-17 THF/H202) 79 mg/39.3 0.5MinH2O, 2 days at54.5%r.h. A, C

1:7.4 (v/v) mL 0.48 mL

1-18 2PrOH 202 mg/10 1.25 Min 4 days N2flow A mL 2PrOH,

0.49mL 1-19 2PrOH 490 mg/10 1.25 Min 2.5 h vacuum mixture of known forms or new mL 2PrOH, 1.2 form

mL

1-20 THF 415 mg/35 0.5MinH2O, 0.5 h vacuum A

mL 2.51 mL 1) determined by PXRD and/or FT Raman; bold: main component in mixture 2) the sample was dissolved in THF and a small amount of H20, then the rest of the H20 was added as precipitant [0432] It becomes evident from the above table that in experiments with long suspension equilibration times, mainly form B was obtained, whereas forms A, D and E were found in experiments with short equilibration times. Form C is probably a hydrate and was only found in experiments containing substantial amounts of water. It converts to crystalline form A upon drying. The amorphous form was not observed.

Example 2

Fast precipitation experiments [0433] Three stock solutions were prepared as follows:

Stock solution a: 110 mg crystalline form B was suspended in 40 mL NMP. The suspension was stirred for 2 h. The remaining small amount of precipitate was removed by filtration.

Stock solution b: 254 mg crystalline form B was suspended in 40 mL CH2CI2/ MeOH 3:1 (v/v). The suspension was stirred for 1 day. The remaining small amount of precipitate was removed by filtration.

Stock solution c: 246 mg crystalline form B was suspended in 40 mL CF^CI^ MeOH 3:1 (v/v). The suspension was stirred for 3 days. The remaining small amount of precipitate was removed by filtration.

[0434] In each precipitation experiment 10 mL of stock solution were quickly added to 10 mL of an anti-solvent. In some cases another portion of anti-solvent (20 mL) was added subsequently. The resulting suspension was stirred at RT for a while. The resulting solid was filtered off, dried (at air or nitrogen flow) and characterized by PXRD and/or FT Raman.

[0435] The detailed experimental conditions and results are summarized in the table here below. For characterization details of the obtained forms see Section "Analysis".

Table 2:

Ex. stock solution anti-solvent stirring time drying outcome1) (crystall. form) 2-1 a water (10mL) 15 min, then stored in - not enough precipitate for the fridge for 2 weeks analysis

2-2 a EtOAc, (10 mL) 15 min, then stored in air A the fridge for 1 month

2-3 b EtOAc (10 mL + 20 10 min N2flow F, B mL)

2-4 b MeCN (10 mL + 20 1h N2flow A, B mL)

2-5 b acetone (10mL + 20 1 h N2flow A mL)

2-6 b TBME (10 mL + 20 5 min N2flow D mL) 2-7 c diethyl ether (10 mL 5 min N2flow D, F (and A) + 20 mL)

2-8 c iBuOAc (10 mL + 20 5 min N2flow F mL) 2-9 c aceticacid (10 mL + 1 day, then stored in - noprecipitation 20 mL) the fridge for 15 days (solutionslightlyturbid)

2-10 c pyridine (10 mL + 20 1 day N2flow G mL) 1)bold: main component in mixture [0436] It becomes evident from the above table that by means of the fast precipitation technique mainly forms A, D, F and G were obtained. In some samples small amounts of form B were found in mixture with A or F. The amorphous form was not observed.

Example 3

Suspension Equilibration experiments [0437] The following experiments were designed to identify(thermodynamically) more stable polymorphs. In each suspension equilibration experiment the starting material was suspended in the solvent and stirred for several days. The resulting solid was filtered off, dried (under vacuumor at air) and characterized by PXRD and/or FT Raman.

[0438] The detailed experimental conditions and results are summarized in the table here below. For characterization details of the obtained forms see Section "Analysis".

Table 3

Ex. starting solvent(s) amount starting stirring time, drying outcome material: material/ amount T / °C (crystall. form) form solvent

3-1 A H20 200 mg / 2 mL 7 days, RT vacuum A

3-2 B NMP 71mg/3mL 4 days, RT vacuum B

3-3 B CFi2CI2 55 mg /3 mL 4 days, RT air B

3-4 B NMP/water 1:1 64 mg/3 mL 4 days, RT vacuum B (v/v)

3-5 B NMP/water 3:1 64 mg/3 mL 4 days, RT vacuum B (v/v)

3-6 B NMP 88 mg / 3 mL 1 day, 80°C vacuum B

3-7 B EtOFI 93 mg / 3 mL 3 days, 70°C vacuum B

3-8 B DMSO 170 mg/5 mL 4 days, RT vacuum B

3-9 A, B acetone / TFIF / 150 mg / 3 mL/120 4 days, RT vacuum B water μί/108 μί

3-10 A, B,C, D, F CH2CI2/MeOH (60/60/40/40/ 10) 4 days, RT vacuum B 3:1 (v/v) mg/3 mL1)

3-11 A, B,C, D, F acetone/ THF (45/80/40/30/10)mg 4 days, RT vacuum B 17:1 (v/v) / 3 mL1)

3-12 B H20 product of exp. 3-11 /3 9 days, RT air B

mL 1) The solvent mixture was saturated with crystalline form B prior to adding to the mixture of the other polymorphs [0439] It becomes evidentfrom the above table that, with one exception, always crystalline form B was obtained. Even mixtures of crystalline forms A, B, C, D and F converted to crystalline form B, indicating that crystalline form B is the most stable ansolvateform at RT. Only a suspension of crystalline form Ain water did not convert to another form within 7 days. This is probably because the solubility of crystalline form A in water is very low (1.21 mg/L), i. e. the equilibration time is very long.

Example 4

Vapor Diffusion experiments [0440] These experiments were designed to grow single crystals of the forms suitable for SCXRD. In each experiment, an undersaturated solution of crystalline form B was prepared and exposed to an atmosphere containing the antisolvent. The diffusion processes lower the solubility and subsequent crystallization occurs.

[0441] Two solvent/anti-solvent systems at two different temperatures were used.

[0442] Preparation of a stock solution for experiments 4-1 ) and 4-2): 110 mg crystalline form B was suspended in 40 mL NMP. The resulting suspension was stirred for 2 hours at RT and the remaining small amount of solid was removed by filtration (0.20 μΓη).

[0443] Preparation of a stock solution for experiments 4-3) and 4-4): 29 mg crystalline form B was suspended in 20 mL CH2CI2. The resulting suspension was stirred for 2 hours at RT and the remaining large amount of solid was removed by filtration (0.20 μ(η).

[0444] In each vapor diffusion experiment, 10 mL of the respective stock solution were exposed to an atmosphere containing the anti-solvent at different temperatures (RT or 4°C) for different times. The resulting solids were analyzed by SCXRD. From the SCXRD data the corresponding PXRD pattern was calculated and compared to the measured PXRD spectra of the different crystalline forms (as obtained from the other experiments).

[0445] The detailed experimental conditions and results are summarized in the table here below. For characterization details of the obtained forms see Section "Analysis".

Table 4

Ex. starting solvent/anti- T/°C time outcome crystalline form1) material: form solvent 4-1 B NMP / EtOFI RT weeks no precipitation 4-2 B NMP / EtOH 4 °C weeks no precipitation

4-3 B CH2CI2 / RT days precipitationofawhitesolidafter A hexane 1 day 4-4 B CH2CI2 / 4°C weeks precipitation after 2 weeks D2) hexane 1)as determined by comparison of the calculated PXRD spectrum with measured PXRD spectra of the crystalline forms (as obtained from other experiments); 2) see comment below.

[0446] The sample of experiment 4-3) most likely corresponds to crystalline form A. The calculated PXRD pattern of sample 4-4) resembles the measured PXRD pattern of crystalline form D. Flowever, due to the fact that the SCXRD and PXRD experiment were performed at different temperatures, it is not possible to say with high certainty that this sample indeed corresponds to crystalline form D.

Example 5

Evaporation experiment [0447] An undersaturated solution of crystalline form B was prepared by dissolving 46 mg crystalline form B in 40 mL Chl2CI2. The solvent was evaporated under vacuum in 45 minutes. The remaining solid was dried for 2 hours under vacuum. Crystalline form B was obtained.

Example 6 [0448] The effect of mechanical stress from grinding with an agate mortar was analyzed.

[0449] 6-1) A sample of crystalline form A was grinded in an agate mortar for 10 min. The resulting solid was characterized by PXRD. Except for a slightly increased background signal probably due to the higher bulk density after grinding, no significant difference compared to the PXRD spectrum before grinding was observed. No additional peaks were observed after grinding, i. e. crystalline form A does not convert to another form upon grinding for 10 minutes to a significant extent.

[0450] 6-2) A sample of crystalline form B was grinded in an agate mortar for 10 min. The resulting solid was characterized by PXRD. Except for a slightly increased background signal probably due to the higher bulk density after grinding and a slightly broadening of the peaks probably due to a reduction of the crystallite size upon grinding, no significant difference compared to the PXRD spectrum before grinding was observed. No additional peaks were observed after grinding, i. e. crystalline form B does not convert to another form upon grinding for 10 minutes to a significant extent.

Analysis - NMR

[0451] The 1H-NMR spectra of crystalline forms A, B and C complied with the structure of (1 r,4r)-6’-fluoro-N,N-dimethyl- 4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1 ,T-pyrano[3,4,b]indol]-4-amine hydrochloride. The 1H-NMR spectra show peak shifts compared to the spectrum of the free base, also indicating the salt formation.

Analysis - elemental analysis

Form A

[0452] The result of the elemental composition analysis is given in Table 5. It confirms the salt formation.

Table 5

Element Found Calculated C 69.05 69.47 H 6.82 6.80 N 6.69 6.75 O 4.23 3.86

Cl 8.53 8.54 F 4.70 4.58

Form B

[0453] The result of the elemental composition analysis is given in Table 6. It confirms the salt formation.

Table 6

Element Found Calculated1) Calculated2) C 68.37 69.47 69.16 H 6.66 6.80 6.82 N 6.60 6.75 6.72 O 3.92 3.86 4.23

Cl 9.21 8.54 8.51 F 4.62 4.58 4.56 1) Calculated assuming no water is present; 2) Calculated assuming 0.44% water is present.

Form C

[0454] Elemental composition analysis was performed with a sample of Ex. 1-4, i.e. on a mixture containing mainly C and something else. The result of the elemental composition analysis is given in Table 7. It does not comply with the assumed stoichiometry. However, the sample lost weight during the experiment, i.e. an exact weighting out for the elemental analysis was not possible.

Table 7

Element Found Calculated1) Calculated2) C 54.21 69.47 46.16 H 7.25 6.80 8.27 N 5.25 6.75 4.49 O 18.21 3.86 32.37

Cl 6.93 8.54 5.68 F 3.42 4.58 3.04 1) Calculated assuming no water is present; 2) Calculated assuming 33.56% water is present.

Analysis - XRPD (X-Ray Powder Diffraction) [0455] XRPD analyses were carried out in transmission geometry with a Philips X’pert PW 3040 X-ray powder diffractometer, monochromatised CuKa radiation being used by means of a germanium monochrystal. d-distances were calculated from the 2Θ values, the wavelength of 1.54060 À being taken as basis. The d-value analysis was performed with the software EVA version 10, 0, 0, 0. The CuKa2 was removed by the software and only lines up to 35° 28 were listed. In general, the 2Θ values have an error rate of ±0.2° in 2Θ. The experimental error in the d-distance values is therefore dependent on the location of the peak. D-distance values can be calculated from 2Θ values using Bragg’s law.

[0456] The samples were measured without any special treatment other than the application of slight pressure to get a flat surface. An ambient air atmosphere was used. To avoid contamination of the equipment, the samples were sealed with capton foil.

Crystalline form A

[0457] Figure 1 a shows the PXRD pattern of crystalline form A. Table 8 shows the peak list for crystalline form A. The uncertainty in the 2Θ values is ±0.2° in 2Θ; rel. I is the relative intensity of the respective peaks. Maximum relative intensity is 100.

Table 8 2Θ d value Á Intensity Cps rel. I % 8.4 10.5 505 46 10.8 8.2 782 72 12.3 7.2 54 5 13.1 6.8 76 7 17.0 5.2 955 87 17.5 5.1 592 54 18.9 4.7 942 86 20.0 4.4 347 32 20.7 4.3 437 40 21.6 4.1 262 24 22.3 4.0 185 17 22.6 3.9 158 14 23.3 3.8 151 14 23.6 3.8 161 15 24.1 3.7 270 25 25.5 3.5 1094 100 26.3 3.4 223 20 26.8 3.3 151 14 27.9 3.2 311 29 28.4 3.1 238 22 29.2 3.1 150 14 30.2 3.0 290 27 30.8 2.9 302 28 31.5 2.8 86 8 32.4 2.8 158 14 33.7 2.7 194 18 34.3 2.6 430 39 34.6 2.6 261 24

Crystalline form B

[0458] Figure 1 b shows the PXRD pattern of crystalline form B. Table 9 shows the peak list for crystalline form B. The uncertainty in the 2Θ values is ±0.2° in 2Θ; rel. I is the relative intensity of the respective peaks. Maximum relative intensity is 100.

Table 9 2Θ d value À Intensity Cps rel. I % 8.4 10.5 177 6 10.6 8.4 535 17 (continued) 2Θ d value À Intensity Cps rel. I % ~1ÏÂ 7T8 Ï83 6 12.5 7.1 182 6 14.2 6.2 168 5 15.5 5.7 208 7 16.9 5.2 311 10 17.2 5.2 609 19 18.6 4.8 3206 100 19.3 4.6 732 23 20.7 4.3 245 8 21.2 4.2 335 10 21.4 4.1 181 6 22.2 4.0 470 15 24.4 3.7 318 10 25.4 3.5 186 6 26.7 3.3 618 19 27.1 3.3 154 5 27.9 3.2 197 6 28.3 3.2 156 5 28.6 3.1 360 11 28.8 3.1 390 12 29.3 3.0 580 18 30.0 3.0 308 10 30.7 2.9 243 8 31.2 2.9 405 13 31.7 2.8 386 12 32.9 2.7 162 5 33.4 2.7 129 4 33.8 2.7 117 4 34.7 2.6 170 5

Crystalline form C

[0459] Figure 1 c shows the PXRD pattern of crystalline form C. Table 10 shows the peak list for crystalline form C. The uncertainty in the 2Θ values is ±0.2° in 2Θ; rel. I is the relative intensity of the respective peaks. Maximum relative intensity is 100.

Table 10 2Θ d value À Intensity Cps rel. I % 7.8 11.3 147 8 9.1 9.7 967 52 11.2 7.9 1521 82 17.0 5.2 265 14 17.3 5.1 107 6 18.2 4.9 1867 100 18.8 4.7 785 42 19.1 4.7 469 25 19.3 4.6 565 30 21.7 4.1 132 7 22.4 4.0 369 20 (continued) 2Θ d value À Intensity Cps rel. I % ~23A 3^8 Ï6Ô 9 23.8 3.7 292 16 24.0 3.7 500 27 24.3 3.7 278 15 24.5 3.6 221 12 26.1 3.4 291 16 26.4 3.4 315 17 26.7 3.3 253 14 27.5 3.3 1283 69 27.9 3.2 310 17 28.2 3.2 644 35 29.2 3.1 266 14 29.8 3.0 220 12 31.6 2.8 395 21 32.0 2.8 249 13 34.1 2.6 346 19 34.3 2.6 265 14 34.8 2.6 225 12

Crystalline form D

[0460] Figure 1d shows the PXRD pattern of crystalline form D. Table 11 shows the peak list for crystalline form D. The uncertainty in the 2Θ values is ±0.2° in 2Θ; rel. I is the relative intensity of the respective peaks. Maximum relative intensity is 100.

Table 11 2Θ d value À Intensity Cps rel. I % 7.8 11.3 72 9 9.1 9.7 75 10 9.5 9.3 75 10 10.8 8.2 55 7 11.0 8.0 51 7 12.6 7.0 128 17 12.9 6.9 186 24 14.1 6.3 72 9 15.6 5.7 93 12 16.3 5.4 232 30 16.9 5.3 181 24 18.3 4.8 422 55 18.9 4.7 772 100 19.6 4.5 561 73 20.2 4.4 185 24 21.6 4.1 177 23 22.0 4.0 185 24 23.3 3.8 169 22 23.7 3.8 313 41 24.3 3.7 248 32 24.7 3.6 169 22 25.8 3.5 141 18 (continued) 2Θ d value À Intensity Cps rel. I % ~26Λ 3Λ Ï48 19 27.6 3.2 233 30 28.6 3.1 176 23 28.9 3.1 242 31 29.6 3.0 112 15 30.0 3.0 127 16 31.3 2.9 175 23 31.6 2.8 162 21 33.1 2.7 110 14

Crystalline form E

[0461] Figure 1e shows the PXRD pattern of crystalline form E. Table 12 shows the peak list for crystalline form E. The uncertainty in the 2Θ values is ±0.2° in 2Θ; rel. I is the relative intensity of the respective peaks. Maximum relative intensity is 100.

Table 12 2Θ d value À Intensity Cps rel. I % 8.1 10.9 66 7 9.1 9.7 267 29 10.6 8.3 41 4 11.2 7.9 91 10 11.6 7.6 52 6 13.3 6.6 123 13 15.7 5.7 159 17 17.1 5.2 508 55 17.7 5.0 649 70 18.3 4.9 190 21 18.9 4.7 154 17 19.6 4.5 926 100 20.7 4.3 158 17 21.3 4.2 288 31 22.5 4.0 277 30 23.4 3.8 191 21 23.6 3.8 306 33 24.1 3.7 206 22 24.6 3.6 312 34 25.1 3.5 160 17 26.2 3.4 198 21 26.8 3.3 182 20 27.8 3.2 150 16 28.8 3.1 244 26 30.2 3.0 141 15 30.5 2.9 198 21 31.7 2.8 194 21 34.8 2.6 174 19

Crystalline form F

[0462] Figure 1f shows the PXRD pattern of crystalline form F. Table 13 shows the peak list for crystalline form F. The uncertainty in the 2Θ values is ±0.2° in29; rel. I is the relative intensity of the respective peaks. Maximum relative intensity is 100.

Table 13 2Θ d value À Intensity Cps rel. I % 9.9 8.9 130 9 10.5 8.4 44 3 11.5 7.7 390 26 14.5 6.1 444 29 16.1 5.5 190 12 16.6 5.3 182 12 17.4 5.1 104 7 18.5 4.8 495 32 19.3 4.6 1529 100 19.9 4.5 164 11 20.5 4.3 203 13 21.2 4.2 225 15 22.0 4.1 262 17 23.2 3.8 189 12 24.5 3.6 141 9 26.1 3.4 186 12 26.5 3.4 195 13 27.3 3.3 421 28 27.5 3.2 257 17 28.2 3.2 115 8 29.1 3.1 630 41 30.3 3.0 228 15 30.7 2.9 162 11 31.7 2.8 328 22 32.0 2.8 105 7 33.0 2.7 100 7 34.6 2.6 92 6

Crystalline form G

[0463] Figure 1g shows the PXRD pattern of crystalline form G. Table 14 shows the peak list for crystalline form G. The uncertainty in the 2Θ values is ±0.2° in 2Θ; rel. I is the relative intensity of the respective peaks. Maximum relative intensity is 100.

Table 14 2Θ d value À Intensity Cps rel. I % 13.3 6.6 151 16 14.2 6.2 138 15 18.6 4.8 131 14 21.4 4.2 637 67 21.8 4.1 215 23 24.5 3.6 299 31 25.2 3.5 235 25 26.2 3.4 119 12 (continued) 2Θ d value À Intensity Cps rel. I % ~2βϋ S3 955 ÍÖÖ 27.4 3.3 60 6 28.6 3.1 140 15 30.0 3.0 215 23 30.5 2.9 274 29 31.3 2.9 181 19 31.8 2.8 244 26 33.0 2.7 271 28 34.2 2.6 57 6 34.8 2.6 93 10

Analysis - FT Raman Spectroscopy (Fourier-Transform Raman Spectroscopy) [0464] FT Raman spectra were recorded on a Bruker RFS100 Raman spectrometer (Nd-YAG 100 mW laser, excitation 1064 nm, laser power 100 mW, Ge detector, 64 scans, 25-3500 cm-1, resolution 2 cm-1).

Figure 2a shows the Raman spectra of crystalline form A.

Figure 2b shows the Raman spectra of crystalline form B.

Figure 2c shows the Raman spectra of crystalline form C.

Figure 2d shows the Raman spectra of crystalline form D.

Figure 2e shows the Raman spectra of crystalline form E.

Figure 2f shows the Raman spectra of crystalline form F.

Figure 2g shows the Raman spectra of crystalline form G.

[0465] Raman peak tables were generated using the software OPUS, version 3.1, build: 3, 0, 17 (20010216). The sensitivity of the peak picking function was chosen in a way that most of the peaks were found (typically between 0.5% to 3%). Features which were accidentally attributed to peaks and which were obviously noise, were removed by hand. Peaks are listed in a spectral region between 3200 cm’1 and 150 cm’1. For the intensity classification, the absolute intensity was used and the most intense peak was scaled to 100%. The classification is as follow: very strong (vs): I >80%; strong (s): 80% > I >60%; medium (m): 60% > I > 40%; weak (w): 40% > l>20%; and very weak (vw): 20% > I.

Crystalline form A

[0466] 3201 (vw); 3071 (m); 3041 (w); 3020 (vw); 2986 (w); 2958 (s); 2935 (w); 2907 (w); 2882 (w); 2858 (vw); 2847 (vw); 2811 (vw); 2542 (vw); 1625 (vw); 1600 (vw); 1582 (w); 1554 (vs); 1470 (w); 1441 (w); 1372 (w); 1353 (vw); 1316 (w); 1295 (w); 1268 (vw); 1234 (vw); 1208 (vw); 1201 (vw); 1175 (vw); 1156 (w); 1128(vw); 1112(vw); 1095 (vw); 1061 (vw); 1049 (vw); 1034 (w); 1003 (m); 965 (vw); 926 (w); 914 (w); 885 (vw); 869 (vw); 842 (vw); 824 (vw); 789 (vw); 712 (vw); 691 (w); 660 (vw); 642 (vw); 621 (vw); 597 (vw); 554 (vw); 536 (vw); 524 (vw); 512 (vw); 483 (vw); 451 (vw); 408 (vw).

Crystalline form B

[0467] 3069 (m); 3054 (m); 3034 (w); 2992 (s); 2958 (w); 2931 (w); 2922 (w); 2906 (w); 2870(w); 2845 (vw); 1628 (vw); 1583 (s); 1569 (vs); 1481 (w); 1463 (w); 1436 (w); 1374 (w); 1352(vw); 1300 (s); 1265 (vw); 1222 (vw); 1216 (vw); 1199 (vw); 1174 (vw); 1136 (vw); 1120 (w); 1073 (vw); 1047 (vw); 1035 (vw); 1028 (vw); 1001 (m); 984 (vw); 957 (vw); 928 (vw); 919 (m); 888 (vw); 873 (vw); 856 (vw); 828 (vw); 820 (vw); 808 (vw); 786 (vw); 768 (vw); 710 (vw); 683 (w); 628 (vw); 620 (vw); 606 (vw); 598 (vw); 568 (vw); 557 (vw); 540 (vw); 518 (vw); 491 (w);466 (vw); 450 (vw); 430 (vw); 397 (vw); 371 (vw); 279 (vw); 255 (vw); 208 (w); 183 (m); 160 (w).

Crystalline form C

[0468] 3072 (m); 3045 (vw); 3031 (vw); 2994 (vw); 2959 (w); 2927 (vw); 2901 (vw); 2880 (vw); 2842 (vw); 1628 (vw); 1600 (w); 1584 (s); 1567 (vs); 1481 (w); 1464 (w); 1454 (w); 1432(w); 1374 (w); 1359 (vw); 1301 (m); 1267 (vw); 1219 (w); 1200 (vw); 1167 (vw); 1136 (vw); 1114 (w); 1076 (vw); 1055 (vw); 1028 (w); 1000 (m); 986 (vw); 954 (vw); 925 (m); 918 (m); 889 (vw);829 (w); 786 (vw); 772 (vw); 710 (vw); 685 (m); 628 (w); 620 (w); 600 (w); 567 (vw); 538 (vw); 516 (vw); 490 (w); 471 (vw); 429 (vw); 395 (vw); 370 (w); 322 (vw); 266 (w); 253 (w); 208 (w); 177 (s); 158 (m).

Crystalline form D

[0469] 3071 (vs); 3038 (w); 2981 (s); 2957 (vs); 2912 (s); 2875 (m); 2845 (w); 1627 (w); 1573(vs); 1567 (vs); 1466 (m); 1443 (m); 1374 (m); 1355 (w); 1339 (vw); 1308 (m); 1299 (s); 1263 (w); 1250 (vw); 1217 (w); 1197 (w); 1183 (vw); 1161 (w); 1134 (vw); 1116 (w); 1074 (vw); 1045 (w);1035 (w); 1028 (w); 1004 (s); 983 (w); 953 (vw); 919 (s); 887 (w); 869 (vw); 829 (m); 787 (vw);771 (vw); 712 (vw); 686 (s); 676 (w); 629 (w); 620 (w); 600 (m); 569 (vw); 557 (vw); 538 (vw);517 (w); 490 (w); 468 (vw); 429 (w); 401 (vw); 392 (w); 370 (w); 317 (vw); 278 (w); 252 (m); 206(m); 180 (vs); 172 (vs); 161 (vs).

Crystalline form E

[0470] 3069 (vs); 3048 (w); 3031 (vw); 2986 (w); 2963 (s); 2889 (w); 2873 (w); 2855 (w); 1630 (vw); 1582 (m); 1569 (vs); 1494 (vw); 1465 (w); 1441 (w); 1376 (w); 1353 (vw); 1308 (m); 1299 (m); 1267 (vw); 1220 (w); 1200 (w); 1166 (vw); 1142 (vw); 1133 (vw); 1117 (vw); 1107 (vw);1076 (vw); 1047 (vw); 1029 (w); 1019 (vw); 1003 (m); 993 (vw); 983 (vw); 952 (vw); 917 (m); 889 (vw); 870 (vw); 854 (vw); 836 (m); 786 (vw); 713 (vw); 686 (m); 676 (vw); 629 (vw); 619 (vw);599 (w); 568 (vw); 558 (vw); 538 (vw); 517 (vw); 491 (w); 471 (vw); 433 (vw); 395 (vw); 369 (w); 317 (vw); 287 (vw); 253 (w); 211 (w); 176 (m); 160 (m).

Crystalline form F

[0471] 3070 (vs), 3029 (w), 2979 (s), 2954 (m), 2942 (w), 2895 (w), 2840 (vw), 1629 (vw), 1585 (vs), 1573 (s), 1486 (vw), 1468 (w), 1458 (w), 1434 (w), 1368 (vw), 1295 (s), 1264 (vw), 1217 (w), 1201 (vw), 1170 (vw), 1132 (vw), 1110 (w), 1047 (vw), 1030 (w), 1003 (m), 980 (vw), 917 (m), 888 (vw), 829 (vw), 786 (vw), 769 (vw), 707 (vw), 683 (w), 620 (vw), 598 (w), 568 (vw), 538 (vw), 515 (vw), 488 (vw), 436 (vw), 390 (vw), 367 (vw), 273 (vw), 254 (w), 206 (m), 174 (m), 160 (s).

Crystalline form G

[0472] 3164 (vw); 3089 (vw); 3077 (vw); 3053 (w); 3019 (vw); 3006 (vw); 2986 (vw); 1636(vw); 1582 (vw); 1512 (vw); 1446 (vw); 1422 (vw); 1361 (vw); 1304 (vw); 1242 (vw); 1193 (vw);1146 (vw); 1070 (vw); 1028 (vs); 1005 (vw); 986 (vw); 894 (vw); 846 (vw); 835 (vw); 774 (vw); 700 (vw); 654 (vw); 642 (vw); 623 (vw); 560 (vw); 445 (vw); 293 (vw); 274 (w); 200 (vw).

Analysis - DSC

[0473] Differential Scanning Calorimetry (DSC): device reference Perkin Elmer DSC 7. Unless otherwise specified, the samples were weighed in a sealed gold crucible. The measurement took place in a nitrogen flow in a temperature range from -50°C up to 350°C with a heating rate of 10°C./min. The temperatures specified in relation to DSC analyses are, unless otherwise specified, the temperatures of the peak maxima.

[0474] In the following tables, "ΔΗ" means "specific heat", and "peak" means that a thermal event was observed at the temperature with the given peak temperature.

Table 15 DSC

Crystalline form A broad event: 239°C, ΔΗ =32 J/g peak, 263°C, ΔΗ =188 J/g

Crystalline form B event (broad), >210°C, ΔΗ = -51 J/g, overlapping with: peak,266°C,AH = 153 J/g

Analysis - TG-FTIR

[0475] Thermogravimetric analysis coupled with Fourier transform infrared spectra (TG-FTIR) were recorded with a Netzsch Thermo-Microwaage TG 209 and a Bruker FT-IR spectrometer Vector 22 (aluminium crucible (open or with micro-aperture), nitrogen atmosphere, heating rate 10 °C/min, 25 up to 350 °C).

[0476] TG-FTIR analyses performed with a sample of crystalline form A showed no significant weight loss (-0.06%) within the temperature range from 50°C to250°C indicating that crystalline form Adoes not contain any enclosed solvent (i e. is an ansolvate).

[0477] TG-FTIR analyses performed with a sample of crystalline form B showed a weight loss of about 0.5% within the temperature range from RT to 250°C. The weight loss is attributable to water. Decomposition was observed above 270°C. Based on these measurements crystalline form B is an ansolvate.

[0478] TG-FTIR analyses performed with a sample of crystalline form C showed a weight loss of 24.7%. The weight loss was strongest at around 115°C and attributable to water (heptahydrate: 23.3%; octahydrate: 25.8%). Decomposition was observed above 270°C. Based on these measurements crystalline form C is a hydrate.

[0479] TG-FTIR analyses performed with samples of crystalline form D showed a weight loss of 1.1-1.4% within the temperature range from RT to 240°C. The weight loss is attributable to water. Decomposition was observed above 270 °C. Based on these measurements crystalline form D is an ansolvate.

[0480] TG-FTIR analyses performed with a sample of crystalline form E showed a weight loss of 15.1% within the temperature range from RT to200°C. The weight loss is strongest at 110°C and is attributable to dioxane (monosolvate: 17.5%). Decomposition was observed above 270°C.

[0481] TG-FTIR analyses performed with a sample of crystalline form F showed a weight loss of about 0.2% within the temperature range from RT to 250°C. The weight loss is attributable to water. Decomposition was observed above 270°C. Based on these measurements crystalline form F is an ansolvate.

[0482] TG-FTIR analyses performed with a sample of crystalline form G showed a weight loss of 7.4% within the temperature range from 70°C to 200°C. The weight loss is strongest at around 170°C and is attributable to water. A sharp, stepwise weight loss of 45.2% was observed at around 280°C and is attributable to pyridine. This step is well above the boiling point of pyridine (115°C) indicating that the pyridine is strongly bound. No decomposition is observed up to 350 °C.

Analysis - Dynamic Vapour Sorption (DVS) [0483] Crystalline forms A and B were characterized by dynamic vapour sorption (DVS) using a Projekt Messtechnik SPS 11-100n multi sample vapour sorption analyzer. For the DVS analysis, each sample was placed in a AI crucible and allowed to equilibrate at 50% r.h. (relative humidity) before starting a pre-defined humidity program during which the change in weight of the sample is determined.

[0484] Although hygroscopicity was measured in a slightly different manner, it was classified according to the European Pharmacopoeia as follows: very hygroscopic (vh): increase of the mass > 15 %; hygroscopic (h): increase of the mass is less than 15 % and equal or greater than 2 %; slightly hygroscopic (sh): increase of the mass is less than 2 % and equal or greater than 0.2 %; not hygroscopic (nh): increase of the mass is less than 0.2 %; deliquescent (d): sufficient water is absorbed to form a liquid.

Crystalline form A

[0485] DVS with two cycles was performed on a sample of crystalline form A according to the following program: 2 h at 50 % r.h.; 50 % r. h. -> 0 % r.h. (10 %/h); 5 h at 0% r.h.; 0 -> 95 % r.h. (5 %/h); 3 h at 95 % r.h.; 95 -> 50 % (10 %/h), and 2 h at 50 % r.h.

[0486] The DVS showed two reversible cycles with no significant mass changes (Am <0.2%).

[0487] Another sample of crystalline form A was stored at RT and 85% r. h. for 24 h for hygroscopicity testing. The sample was found to be not hygroscopic (Am = 0%).

Crystalline form B

[0488] DVS was performed on a sample of crystalline form B according to the following program: 2 h at 50 % r.h.; 50 %r. h.—>0%r.h.(2.5%/h); 10hat0%r.h.;0—>95%r.h.(2.5%/h); 10hat95%r.h.;95—>50%(2.5%/h),and2hat50%r.h.

[0489] The sample showed a strong (and stepwise) water uptake above 74% r.h (up to a water content of approx. 15.4%). Lowering the humidity led to a complete loss of water, which was completed at about 50% r.h., i.e. a hysteresis was observed, indicating hydrate formation.

[0490] To further elucidate this, a suspension equilibration experiment of crystalline form B in water was performed.

[0491] A sample of crystalline form B was suspended for several days in water at RT and a Raman spectrum was measured in the wet state. Surprisingly no conversion of crystalline form B was observed.

[0492] In two control experiments, crystalline form B was stored for more than 2 weeks at 75.5% r.h. at RT and at 97% r.h. at RT, respectively, and the samples were analyzed by FT-Raman spectroscopy. No conversion was observed. Consequently, the DVS measurement was repeated.The data were in agreement with the first DVS experiment. The sample was checked before and after the DVS measurement by FT-Raman spectroscopy. No conversion was observed.

[0493] Hence an experiment was performed where a sample of crystalline form B was stored for about 3 weeks at 97% r.h. at RT and FT-Raman and TGFT-IR measurements were performed at the same time. FT-Raman showed no conversion, whereas TG-FTIR showed a water content of about 19% water and about 3% DMSO (the DMSO comes from the initial preparation of the sample). These results show that crystalline form B indeed takes upwater above 75% r.h., but that this water uptake is not detectable by means of Raman spectroscopy.

Analysis - Solubility in Water [0494] The aqueous solubility was determined in bidest H20 from saturated solutions (24 h equilibration time, RT). The concentration was measured by HPLC and the pH of the saturated solutions was determined.

Table 16

solubility [mg/L] resulting pH free base < 0.30 8.4 hydrochloride 1.21 2.7 [0495] It becomes evident from the solubility data that formation of the hydrochloride salt improves the aqueous solubility of the compound.

Analysis - Physical and Chemical Stability [0496] In this experiment the physical and chemical stability of (1 r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1 ,T-pyrano[3,4,b]indol]-4-amine hydrochloride(in the form of crystalline form A) was compared to that of the free base.

[0497] The stability tests were performed under two conditions. The samples were stored for four weeks at 75% r.h. at 40°C in open vials and one week at 80°C in closed vials. The purity was determined by HPLC. The results are summarized in Table 17.

Table 17

[0498] The hydrochloride salt showed no significant degradation after stability testing, whereas the free base showed clearly changes.

Analysis - single crystal diffraction [0499] Measurements were realized using MoKa-radiation(X = 0.71073 A) and a BrukerAXS D8-Goniometer equipped with a SMART APEX-CCD detector at 100 K.

[0500] Crystal data of crystalline forms A and D are summarized in the following tables 18-31.

Crystalline form A

[0501]

Table 18: Crystal data and structure refinement for crystalline form A.

(continued)

Table 19: Atomic coordinates (x 104) (i.e. (X 10M)) and equivalent isotropic displacement parameters (2X 103) (i.e. ( Λ2 X 10Λ3)) for crystalline form A. U(eq) is defined as one third of the trace of the orthogonalized Uij tensor.

(continued)

Table 20A: Bond lengths [À] and angles [deg] for crystalline form A.

(continued)

Table 20B: (Table 20A continued) Bond lengths [Λ] and angles [deg] for crystalline form A.

(continued)

Table 21: Hydrogen coordinates (x 104) (i.e. (x 10Λ4)) and isotropic displacement parameters (2x 103) (i.e. ( Λ2 x 10Λ3)) for crystalline form A.

Table 22: Anisotropie displacement parameters (2x 103) (i.e. ( Λ2 x 10Λ3)) for crystalline form A. The anisotropic displacement factor exponent takes the form: -2 piA2 hA2 a*A2 U11 +...+ 2hka*b* U12].

Table 23: Conformation of crystalline form A.

Table 24: Geometry of hydrogen bonds of crystalline form A.

Crystalline form D

[0502]

Table 25: Crystal data and structure refinement for crystalline form D.

Table 26: Atomic coordinates (x 104) (i.e. ( x 10Λ4)) and equivalent isotropic displacement parameters (2x 103) (i.e. ( Λ2 x 10Λ3)) for crystalline form D. U(eq) is defined as one third of the trace of the orthogonalized Uij tensor.

(continued)

Table 27A: Bond lenaths ΓΑ1 and anales ideal for crystalline form D.

(continued)

Table 27B: (Table 27A continued) Bond lengths [A] and angles [deg] for crystalline form D.

(continued)

(continued)

(continued)

[0503] Symmetry transformations used to generate equivalent atoms:

Table 28: Hydrogen coordinates (x 104) (i.e. ( x 10Λ4)) and isotropic displacement parameters (2x 103) (i.e. ( Λ2 x 10Λ3)) for crystalline form D.

(continued)

Table 29: Anisotropic displacement parameters (2 x 103) (i.e. ( Λ2 x 10Λ3)) for crystalline form D. The anisotropic displacement factor exponent takes the form: -2 ρίΛ2 [ hA2 a*A2 U11 +...+2hka*b*U12],

(continued)

(continued)

Table 30: Conformation of crystalline form D.

Table 31: Geometry of hydrogen bonds of crystalline form D.

Claims 1. A solid form of (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclo-hexane-1,T-pyrano[3,4,b]in-dol]-4-amine hydrochloride. 2. The solid form according to claim 1, which is a crystalline form or an amorphous form. 3. The crystalline form according to claim 2, which has one or more X-ray diffraction peaks (CuKa radiation) selected from the group consisting of 14.3 ±0.5 (20), 17.1 ±0.5 (20), 18.9 ±0.5 (20) and 19.6 ±0.5 (20) and/or at least two

Raman peaks selected from the group consisting of 918±5 cm"1,1299±5cnv1,1569±5cnr1 and at 1583±5 cm'1. 4. The crystalline form according to claim 2 or 3, which is an ansolvate or a solvate. 5. The crystalline form according to any of the preceding claims 2 to 4, which has A: an X-ray diffraction peak (CuKa radiation) at 25.5 ±0.2 (2Θ); or B: X-ray diffraction peaks (CuKa radiation) at 10.6 ±0.2 (2Θ), 17.2 ±0.2 (20), 18.6 ±0.2 (20), 19.3 ±0.2 (20), 22.2 ±0.2 (2Θ), 26.7 ±0.2 (2Θ) and 29.3 ±0.2 (20); or C: X-ray diffraction peaks (CuKa radiation) 11.2 ±0.2 (20), 18.2 ±0.2 (20), and 27.5 ±0.2 (20); or D: X-ray diffraction peaks (CuKa radiation) at16.3 ±0.2 (20), 18.3 ±0.2 (20), 18.9 ±0.2 (20), 19.6 ±0.2 (20), 23.7 ±0.2 (20), 24.3 ±0.2 (20), 27.6 ±0.2 (20) and 28.9 ±0.2 (20); or E: X-ray diffraction peaks (CuKa radiation) at 17.1 ±0.2 (20), 17.7 ±0.2 (20) and 19.6 ±0.2 (20); or F: X-ray diffraction peaks (CuKa radiation) at 11.5 ±0.2 (20), 14.5 ±0.2 (20), 18.5 ±0.2 (20), 19.3 ±0.2 (20), 27.3 ±0.2 (20) and 29.1 ±0.2 (20); or G: X-ray diffraction peaks (CuKa radiation) at 21.4 ±0.2 (20) and 26.8 ±0.2 (20). 6. The crystalline form A according to claims 5, which in DSC analysis exhibits an endothermal event with an onset temperature or a peak temperature in the range of 258-268 °C. 7. The crystalline form B according to claim 5, which in DSC analysis exhibits an endothermal event with an onset temperature or a peak temperature in the range of 262-270 °C. 8. A pharmaceutical composition comprising the solid form according to claim 1 or 2 or at least one crystalline form according to any of claims 3 to 7. 9. A process for obtaining a solid form, preferably a crystalline form of (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyrano[3,4,b]indol]-4-amine hydrochloride according to any of claims 1 to 8, comprising the steps of (a-1) precipitating the hydrochloride salt of (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cy-clohexane-1 ,T-pyrano[3,4,b]indol]-4-amine from a solution or suspension of the free base; and b-1) separating the solid; or a-2) dissolving (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro-[cyclohexane-1,1 ’- pyrano[3,4,b]indol]-4-amine hydrochloride in a solvent; and b-2) evaporating off the solvent from the solution, or b-2’) precipitating (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro-[cyclohexane-1 ,T- pyrano[3,4,b]indol]-4-amine hydrochloride from the solution, preferably by the addition of a precipitant; or (a-3) suspending (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro-[cyclohexane-1 ,T- pyrano[3,4,b]indol]-4-amine hydrochloride in a solvent, and stirring the resulting suspension; and (b-3) separating the solid. 10. A crystalline form of (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro-[cyclohexane-1 ,T- pyrano[3,4,b]indol]-4-amine hydrochloride according to claim 2 having a X-ray powder diffraction pattern (CuKa radiation) comprising characteristic peaks at 10.8 ±0.2 (20), 17.0 ±0.2 (20), 18.9 ±0.2 (20), 25.5 ±0.2 (20) and optionally 17.5 ±0.2 (20). 11. The crystalline form of claim 10, wherein the crystalline form has an endothermal event with a peak temperature at about 258-268 °C, as determined by DSC. 12. A crystalline form of (1r,4r)-6’-fluoro-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro-[cyclohexane-1,T- pyrano[3,4,b]indol]-4-amine hydrochloride according to claim 2 having a X-ray powder diffraction pattern (CuKa radiation) comprising characteristic peaks at 10.6 ±0.2 (20), 17.2 ±0.2 (20), 18.6 ±0.2 (20), 19.3 ±0.2 (20), 26.7 ±0.2 (20), 29.3 ±0.2 (20) and optionally at 22.2 ±0.2 (20). 13. The crystalline form of claim 12, wherein the crystalline form has an endothermal event with a peak temperature at about 262-270 °C, as determined by DSC. 14. A pharmaceutical composition comprising the crystalline form according to any of claims 10 to 13. 15. The pharmaceutical composition of claim 14, which comprises between about 0.001% by weight and about 20% by weight of the crystalline form. 16. The crystalline form according to any of the preceding claims 2 to 4, which has: A: X-ray diffraction peaks (CuKa radiation) at 10.8 ±0.2 (2Θ), 17.0 ±0.2 (2Θ); 18.9 ±0.2 (2Θ); 25.5 ±0.2 (2Θ) and optionally 17.5 ±0.2 (2Θ); and/or Raman peaks at 1003 ±0.2 (2Θ); 1554 ±2 cnv1, 2958 ±0.2 (2Θ) and 3071 ±0.2 (2Θ); or B: X-ray diffraction peaks (CuKa radiation) 10.6 ±0.2 (2Θ); 17.2 ±0.2 (2Θ); 18.6 (2Θ); 19.3 ±0.2 (20); 26.7 ±0.2 (20), 29.3 ±0.2 (2Θ) and optionally at 22.2 ±0.2 (2Θ) and/or Raman peaks at 1300 ±2 cm'1, 1583 ±2 cm-1 and 2992 ±2 cm"1; or C: X-ray diffraction peaks (CuKa radiation) at 9.1 ±0.2 (20); 11.2 ±0.2 (2Θ), 18.2 ±0.2 (2Θ), 18.8 ±0.2 (2Θ), 19.3 ±0.2 (2Θ), 24.0 ±0.2 (2Θ), 27.4 ±0.2 (2Θ), 28.2 ±0.2 (2Θ) and optionally 19.1 ±0.2 (2Θ); and/or Raman peaks at 177 ±2 cm-1, 1567 ±2 cm-1, and 1584 ±2 cm'1; or D: X-ray diffraction peaks (CuKa radiation) at 18.3 ±0.2 (2Θ), 18.9 ±0.2 (20); 19.6 ±0.2 (2Θ), 23.7 ±0.2 (2Θ); 24.3 ±0.2 (2Θ), 28.9 ±0.2 (20), and optionally 16.3 ±0.2 (2Θ) and optionally 27.6 ±0.2 (2Θ); and/or Raman peaks at 161 ±2 cm-1, 172 ±2 cm"1, 180 ±2 cm"1, 686 ±2 cm"1, 919 ±2 cnr1, 1004 ±2 cm"1, 1299 ±2 cnr1, 1567 ±2 cm"1, 1573 ±2 crrr1,2912 ±2 cnr1, 2957±2 cnr1,2981 ±2 cnr1, and 3017 cm-1; or E: X-ray diffraction peaks (CuKa radiation) at 9.1 ±0.2 (2Θ); 17.1 ±0.2 (2Θ); 17.7 ±0.2 (2Θ); 19.6 ±0.2 (2Θ); 21.3 ±0.2 (2Θ); 22.5 ±0.2 (2Θ); 23.6 ±0.2 (2Θ); 24.6 ±0.2 (2Θ) and optionally 28.8 ±0.2 (2Θ); and/or Raman peaks at 1569 ±2 cm"1,2963 ±2 cm-1 and 3069 ±2 cm-1; or F : X-ray diffraction peaks (CuKa radiation) at 14.5 ±0.2(20), 18.5 ±0.2(20); 19.3 ±0.2 (20),27.3 ±0.2(20), 29.1 ±0.2 (20) and optionally 11.5 ±0.2 (20) and/or Raman peaks at 160 ±2 cnr1, 1295 ±2 cnr1, 1573 ±2 cm-1, 1585 ±2 cm"1, 2979 ±2 cm-1, and 3070 ±2 cm-1; or G: X-ray diffraction peaks (CuKa radiation) at 21.4 ±0.2 (20), 24.5 ±0.2 (20), 25.2 ±0.2 (20), 26.8 ±0.2 (20), 30.5 ±0.2(20), 31.8 ±0.2(20) and 33.0 ±0.2 (20); and/or Raman peaks at 274 ±2 cnr1, 642 ±2 cnr1, 1028 ±2 cm-1, 3053 ±2 cnr1, and 3077 ±2 cm-1.

Patentansprüche 1. Feste Formen von (1r,4r)-6’-Fluor-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexan-1,1’-pyrano[ 3,4b]indol]-4-aminhydrochlorid. 2. Feste Form nach Anspruch 1, die eine kristalline Form oder eine amorphe Form ist. 3. Kristalline Form nach Anspruch 2, die ein oder mehr Röntgendiffraktionsmaxima (CuKa-Strahlung) hat, ausgewählt aus der Gruppe, bestehend aus 14,3 ±0,5 (20), 17,1 ±0,5 (20), 18,9 ±0,5 (20) und 19,6 ±0,5 (20) und/oder mindestens zwei Raman-Maxima, ausgewählt aus der Gruppe, bestehend aus 918±5 cnr1,1299±5 cnr1,1569±5 cm'1 und 1583±5 cm"1. 4. Kristalline Form nach Anspruch 2 oder 3, die ein Ansolvat oder ein Solvat ist. 5. Kristalline Form nach einem der vorstehenden Ansprüche 2 bis 4, umfassend A: ein Röntgendiffraktionsmaximum (CuKa-Strahlung) bei 25,5 ±0,2 (20); oder B: Röntgendiffraktionsmaxima (CuKa-Strahlung) bei 10,6 ±0,2 (20), 17,2 ±0,2 (20), 18,6 ±0,2 (20), 19,3 ±0,2 (20), 22,2 ±0,2 (20), 26,7 ±0,2 (20) und 29,3 ±0,2 (20); oder C: Röntgendiffraktionsmaxima (CuKa-Strahlung) bei 11,2 ±0,2 (20), 18,2 ±0,2 (20) und 27,5 ±0,2 (20); oder D: Röntgendiffraktionsmaxima (CuKa-Strahlung) bei 16,3 ±0,2 (20), 18,3 ±0,2 (20), 18,9 ±0,2 (20), 19,6 ±0,2 (20), 23,7 ±0,2 (20), 24,3 ±0,2 (20), 27,6 ±0,2 (20) und 28,9 ±0,2 (20); oder E: Röntgendiffraktionsmaxima (CuKa-Strahlung) bei 17,1 ±0,2 (20), 17,7 ±0,2 (20) und 19,6 ±0,2 (20); oder F: Röntgendiffraktionsmaxima (CuKa-Strahlung) bei 11,5 ±0,2 (20), 14,5 ±0,2 (20), 18,5 ±0,2 (20), 19,3 ±0,2 (20), 27,3 ±0,2 (20) und 29,1 ±0,2 (20); oder G: Röntgendiffraktionsmaxima (CuKa-Strahlung) bei 21,4 ±0,2 (20) und 26,8 ±0,2 (20). 6. Kristalline Form A nach Anspruch 5, die in der DDK-Analyse ein endothermales Ereignis bei einer Anfangstemperatur oder einer Spitzentemperatur im Bereich von 258-268 °C zeigt. 7. Kristalline Form B nach Anspruch 5, die in der DDK-Analyse ein endothermales Ereignis bei einer Anfangstemperatur oder einer Spitzentemperatur im Bereich von 262-270°C zeigt. 8. Pharmazeutische Zusammensetzung umfassend die feste Form nach Anspruch 1 oder 2 oder mindestens eine kristalline Form nach einem der Ansprüche 3 bis 7. 9. Verfahren zum Gewinnen einer festen Form, bevorzugt einer kristallinen Form von (1r,4r)-6’-Fluor-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexan-1,1’-pyrano[ 3,4,b]indol]-4-aminhydrochlorid nach einem der Ansprüche 1 bis 8, umfassend die Schritte des (a-1) Präzipitierens des Hydrochloridsalzes von (1r,4r)-6’-Fluor-N,N-dimethyl-4-phenyl4’,9’-dihydro-3’H-spi-ro[cyclohexan-1,1’-pyrano[3 ,4,b]indol]-4-amin aus einer Lösung oder Suspension der freien Base; und (b-1) Trennens des Feststoffs; oder (a-2) Lösens von (1r,4r)-6’-Fluor-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro[cyclohexan-1 ,T-pyrano[ 3,4,b]indol]-4-aminhydrochlorid in einem Lösungsmittel; und (b-2) Verdampfens des Lösungsmittels aus der Lösung, oder (b-2’) Präzipitierens von (1r,4r)-6’-Fluor-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro [cyclohexan-1 ,T-pyrano[ 3,4,b]indol]-4-aminhydrochlorid aus der Lösung, bevorzugt durch Hinzufügen eines Fällungsmittels; oder (a-3) Suspendierens von (1r,4r)-6’-Fluor-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro-[cyclohexan-1 ,T-pyrano[ 3,4,b]indol]-4-aminhydrochlorid in einem Lösungsmittel, und Rührens der resultierenden Suspension; und (b-3) Trennens des Feststoffs. 10. Kristalline Form von (1r,4r)-6’-Fluor-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro-[cyclohexan-1,T-pyrano [3,4,b]indol]-4-aminhydrochlorid nach Anspruch 2 mit einem Röntgenpulverdiffraktionsmuster (CuKa-Strahlung) umfassend charakteristische Maxima bei 10,8 ±0,2 (20), 17,0 ±0,2 (20), 18,9 ±0,2 (20), 25,5 ±0,2 (20) und optional bei 17,5 ±0,2 (20). 11. Kristalline Form nach Anspruch 10, wobei die kristalline Form ein endothermales Ereignis mit einer Höchsttemperatur von rund 258-268 °C hat, wie durch DDKbestimmt wurde. 12. Kristalline Form von (1r,4r)-6’-Fluor-N,N-dimethyl-4-phenyl-4’,9’-dihydro-3’H-spiro-[cyclohexan-1,T-pyrano [3,4,b]indol]-4-aminhydrochlorid nach Anspruch 2 mit einem Röntgenpulverdiffraktionsmuster (CuKa-Strahlung) umfassend charakteristische Maxima bei 10,6 ±0,2 (20), 17,2 ±0,2 (20), 18,6 ±0,2 (20), 19,3 ±0,2 (20), 26,7 ±0,2 (20), 29,3 ±0,2 (20) und optional bei 22,2 ±0,2 (20). 13. Kristalline Form nach Anspruch 12, wobei die kristalline Form, wie durch die DDK gezeigt, ein endothermales Ereignis bei einer Spitzentemperatur bei rund 262-270 °C hat. 14. Pharmazeutische Zusammensetzung umfassend die kristalline Form nach einem der Ansprüche 10 bis 13. 15. Pharmazeutische Zusammensetzung nach Anspruch 14, die bevorzugt zwischen rund 0,001 Gewichtsprozent und rund 20 Gewichtsprozent der kristallinen Form umfasst. 16. Kristalline Form nach einem der vorstehenden Ansprüche 2 bis 4, umfassend: A: Röntgendiffraktionsmaxima (CuKa-Strahlung) bei 10,8 ±0,2 (20), 17,0 ±0,2 (20); 18,9 ±0,2 (20); 25,5 ±0,2 (20) und optional 17,5 ±0,2 (20); und/oder Raman-Maxima bei 1003 ±0,2 (20); 1554 ±2 cm"1, 2958 ±0,2 (20) und 3071 ±0,2(20); oder B: Röntgendiffraktionsmaxima (CuKa-Strahlung) bei 10,6 ±0,2 (20); 17,2 ±0,2 (20); 18,6 (20); 19,3 ±0,2 (20); 26,7 ±0,2 (20), 29,3 ±0,2 (20) und optional bei 22,2 ±0,2 (20) und/oder Raman-Maxima bei 1300 ±2 cm'1, 1583 ±2 cm"1 und 2992 ±2 cm"1; oder C: Röntgendiffraktionsmaxima (CuKa-Strahlung) 9,1 ±0,2 (20); 11,2 ±0,2(20), 18,2 ±0,2(20), 18,8 ±0,2 (20), 19,3 ±0,2 (20), 24,0 ±0,2 (20), 27,4 ±0,2 (20), 28,2 ±0,2 (20) und optional 19,1 ±0,2 (20); und/oder Raman-Maxima bei 177 ±2 cm'1, 1567 ±2 cm'1 und 1584 ±2 cm'1; oder D: Röntgendiffraktionsmaxima (CuKa-Strahlung) bei 18,3 ±0,2 (20), 18,9 ±0,2 (2Θ); 19,6 ±0,2 (20), 23,7 ±0,2 (20); 24,3 ±0,2 (20), 28,9 ±0,2 (20), und optional 16,3 ±0,2 (20) und optional 27,6 ±0,2 (20); und/oder Raman-Maxima bei 161 ±2 cnr1, 172 ±2 crrr1, 180 ±2 cnr1, 686 ±2 cnr1, 919 ±2 crrr1, 1004 ±2 crrr1, 1299 ±2 cm-1, 1567 ±2 crrr1, 1573 ±2 cm-1, 2912 ±2 cnr1, 2957±2 cm"1, 2981 ±2 cm"1 und 3017 cm“1; oder E: Röntgendiffraktionsmaxima (CuKa-Strahlung) bei 9,1 ±0,2 (20); 17,1 ±0,2 (20); 17,7 ±0,2 (20); 19,6 ±0,2 (20); 21,3 ±0,2 (20); 22,5 ±0,2 (20); 23,6 ±0,2 (20); 24,6 ±0,2 (20) und optional 28,8 ±0,2 (20); und/oder Raman-Maxima bei 1569 ±2 cm"1, 2963 ±2 cm"1 und 3069 ±2 cm-1; oder F: Röntgendiffraktionsmaxima (CuKa-Strahlung) bei 14,5 ±0,2 (20), 18,5 ±0,2 (20); 19,3 ±0,2 (20), 27,3 ±0,2 (20), 29,1 ±0,2 (20) und optional 11,5 ±0,2 (20) und/oder Raman-Maxima bei 160 ±2 cm"1, 1295±2 cm"1, 1573 ±2 cm"1, 1585 ±2 cm"1,2979 ±2 cm-1 und 3070 ±2 cm"1; oder G: Röntgendiffraktionsmaxima (CuKa-Strahlung) bei 21,4 ±0,2 (20), 24,5 ±0,2 (20), 25,2 ±0,2 (20), 26,8 ±0,2 (20), 30,5 ±0,2 (20), 31,8 ±0,2 (20) und 33,0 ±0,2 (20); und/oder Raman-Maxima bei 274 ±2 cnr1, 642 ±2 cm"1, 1028 ±2 cm"1, 3053 ±2 cnr1 und 3077 ±2 cm-1.

Revendications 1. Forme de solide de chlorhydrate de (1r,4r)-6’-fluoro-N,N-diméthyl-4-phényl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyranno[3,4,b]indole]-4-amine. 2. Forme solide suivant la revendication 1, qui est une forme cristalline ou un forme amorphe. 3. Forme cristalline suivant la revendication 2, qui a un ou plusieurs pics de diffraction des rayons X (rayonnement de CuKa) choisis dans le groupe consistant en 14,3 ± 0,5 (2 0), 17,1 ± 0,5 (2 0), 18,9 ±0,5 (2 0) et 19,6 ± 0,5 (2 0) et/ou au moins deux pic Raman choisis dans le groupe consistant en 918 ± 5 cm'1, 1299 ± 5 cm-1, 1569 ± 5 cm-1 et à 1583 ± 5 cnr1 4. Forme cristalline suivant la revendication 2 ou 3, qui est un produit de non-solvatation ou un produit de solvatation. 5. Forme cristalline suivant l’une quelconque des revendications 2 à 4 précédentes, qui a : A : un pic de diffraction de rayons X (rayonnement de CuKa) à 25,02 ± 0,2 (2 0); ou B : des pics de diffraction des rayons X (rayonnement de CuKa) à 10,6 ± 0,2 (2 0), 17,2 ± 0,2 (2 0), 18,6 ± 0,2 (2 0), 19,3 ± 0,2 (2 0), 22,2 ± 0,2 (2 0), 26,7 ± 0,2 (2 0), et 29,3 ± 0,2 (2 0); ou C : des pics de diffraction des rayons X (rayonnement de CuKa) à 11,2 ± 0,2 (2 0), 18,2 ± 0,2 (2 0) et 27, 5 ± 0,2 (2 0); ou D : des pics de diffraction des rayons X (rayonnement de CuKa) à 16,3 ± 0,2 (2 0), 18,3 ± 0,2 (2 0), 18,9 ± 0,2 (2 0), 19,6 ± 0,2 (2 0), 23,7 ± 0,2 (2 0), 24,3 ± 0,2 (2 0), 27,6 ± 0,2 (2 0) et 28,9 ± 0,2 (2 0); ou E : des pics de diffraction des rayons X (rayonnement de CuKa) à 17,1 ± 0,2 (2 0), 17,7 ±0,2 (2 0), et 19,6 ± 0,2 (2 0); ou F : des pics de diffraction des rayons X (rayonnement de CuKa) à 11,5 ± 0,2 (2 0), 14,5 ± 0,2 (2 0), 18,5 ± 0,2(2 0), 19,3 ± 0,2 (2 0), 27,3 ± 0,2 (2 0) et 29,1 ± 0,2 (2 0); ou G : des pics de diffraction des rayons X (rayonnement de CuKa) à 21,4 ± 0,2 (2 0) et 26,8 ± 0,2 (2 0). 6. Forme cristalline Asuivant la revendication 5, qui, dans une analyse par DSC, présente un événement endothermique à une température de départ ou une température maximale dans l’intervalle de 258 à 268°C. 7. Forme cristalline B suivant la revendication 5, qui, dans une analyse par DSC, présente un événement endothermique à une température de départ ou une température maximale dans l’intervalle de 262 à 270°C. 8. Composition pharmaceutique comprenant la forme solide suivant la revendication 1 ou 2 ou au moins une forme cristalline suivant l’une quelconque des revendications 3 à 7. 9. Procédé pour obtenir une forme solide, de préférence une forme cristalline, de chlorhydrate de (1r,4r)-6’-fluoro-N,N-diméthyl-4-phényl-4’,9’-dihydro-3’H-spiro[cyclohexane-1,1’-pyranno[3,4,b]indole]-4-amine suivant l’une quelconque des revendications 1 à 8, comprenant les étapes de (a-1) précipitation du chlorhydrate de (1r,4r)-6’-fluoro-N,N-diméthyl-4-phényl-4’,9’-dihydro-3’H-spiro[cyclohexa-ne-1,1’-pyranno[3,4,b]indole]-4-amine à partir d’une solution ou suspension de la base libre ; et b-1) séparation de la substance solide ; ou a-2) dissolution du chlorhydrate de (1r,4r)-6’-fluoro-N,N-diméthyl-4-phényl-4’,9’-dihydro-3’H-spiro-[cyclohexa-ne-1,1’-pyranno[3,4,b]indole]-4-amine dans un solvant ; et b-2) évaporation du solvant de la solution ; ou b-2’) précipitation du chlorhydrate de (1r,4r)-6’-fluoro-N,N-diméthyl-4-phényl-4’,9’-dihydro-3’H-piro[cyclohexa-ne-1,1’-pyranno [3,4,b]indole]-4-amine à partir de la solution, de préférence par addition d’un agent précipitant ; ou (a-3) mise en suspension du chlorhydrate de (1r,4r)-6’-fluoro-N,N-diméthyl-4-phényl-4’,9’-dihydro-3’H-spiro[cy-clohexane-1,1’-pyranno[3,4,b]indole]-4-amine dans un solvant, et agitation de la suspension résultante ; et (b-3) séparation de la substance solide. 10. Forme cristalline de chlorhydrate de (1r,4r)-6’-fluoro-N,N-diméthyl-4-phényl-4’,9’-dihydro-3’H-spiro-[cyclohexane-1,1’-pyranno[3,4,b]indole]-4-amine suivant la revendication 2, ayant un diagramme de diffraction des rayons X sur poudre (rayonnement de Cu Ka) comprenant des pics caractéristiques à 10,8 ± 0,2 (2 Θ), 17,0 ± 0,2 (2 Θ), 18,9 ± 0,2 (2 Θ), 25,5 ± 0,2 (2 Θ) et éventuellement 17,5 ± 0,2 (2 Θ). 11. Forme cristalline suivant la revendication 10, ladite forme cristalline ayant un événement endothermique avec une température maximale à environ 258-268°C, de la manière déterminée par DSC. 12. Forme cristalline de chlorhydrate de (1r,4r)-6’-fluoro-N,N-diméthyl-4-phényl-4’,9’-dihydro-3’H-spiro-[cyclohexane-1,1’-pyranno[3,4,b]indole]-4-amine suivant la revendication 2, ayant un diagramme de diffraction des rayons X sur poudre (rayonnement de Cu Ka) comprenant des pics caractéristiques à 10,6 ± 0,2 (2 Θ), 17,2 ± 0,2 (2 Θ), 18,6 ± 0,2 (2 Θ), 19,3 ± 0,2 (2 0), 26,7 ± 0,2 (2 Θ), 29,3 ± 0,2 (2 Θ) et éventuellement à 22,2 ± 0,2 (2 Θ). 13. Forme cristalline suivant la revendication 12, ladite forme cristalline ayant un événement endothermique avec une température maximale à environ 262-270°C, de la manière déterminée par DSC. 14. Composition pharmaceutique comprenant la forme cristalline suivant l’une quelconque des revendications 10 à 13. 15. Composition pharmaceutique suivant la revendication 14, qui comprend environ 0,001 % en poids à environ 20 % en poids de la forme cristalline. 16. Forme cristalline suivant l’une quelconque des revendications 2 à 4 précédentes, qui a : A : des pics de diffraction des rayons X (rayonnement de CuKa) à 10,8 ± 0,2 (2 Θ), 17,0 ± 0,2 (2 0), 17,5 ± 0,2 (2 Θ), 18,9 ± 0,2 (2 Θ), 25,5 ± 0,2 (2 Θ) et éventuellement 17,5 ± 0,2 (2 Θ) ; et/ou des pics Raman à 1003 ± 2 (2 Θ), 1554 ± 2 cm'1, 2958 ±2(2 0) et 3071 ± 2 (2 Θ) ; ou B : des pics de diffraction des rayons X (rayonnement de CuKa) à 10,6 ± 0,2 (2 Θ), 17,2 ± 0,2 (2 0), 18,6 ± 0,2 (2 Θ), 19,3 ± 0,2 (2 Θ), 26,7 ± 0,2 (2 Θ), 29,3 ± 0,2 (2 0) et éventuellement à 22,2 ± 0,2 (2 Θ); et/ou des pics Raman à 1300 ± 2 cm"1, 1583 ± 2 cm-1 et 2992 ± 2 cm-1 ; ou C : des pics de diffraction des rayons X (rayonnement de CuKa) à 9,1 ± 0,2 (2 Θ), 11,2 ± 0,2 (2 Θ), 18,2 ± 0,2 (2 Θ), 18,8 ± 0,2(2 0), 19,3 ± 0,2(20), 24,0 ± 0,2(2 Θ), 27,4 ± 0,2 (2 0), 28,2 ± 0,2(2 0) et éventuellement à 19,1 ± 0,2 (2 0) ; et/ou des pics Raman à 177 ±2 cm'1, 1567 ± 2 cnr1 et 1584 ± 2 cm-1 ; ou D : des pics de diffraction des rayons X (rayonnement de CuKa) à 18,3 ± 0,2 (2 0), 18,9 ± 0,2 (2 0), 19,6 ± 0,2 (2 0), 23,7 ± 0,2 (2 0), 24,3 ± 0,2 (2 0), 28,9 ± 0,2 (2 0) et éventuellement à 27,6 ± 0,2 (2 0) ; et/ou des pics Raman à 161 ± 2 cm'1, 172 ± 2 cm'1, 180 ± 2 cm'1, 686 ± 2 cnr1, 919 ± 2 cm'1, 1004 ± 2 cnr1, 1299 ± 2 cm1, 1567 ± 2 cm'1, 1573 ± 2 cm'1,2912 ± 2 cm'1, 2957 ± 2 cnr1, 2981 ± 2 cm'1 et 3071 ± 2 cm'1 ; ou E : des pics de diffraction des rayons X (rayonnement de CuKa) à 9,1 ± 0,2 (2 0), 17,1 ± 0,2 (2 0), 17,7 ± 0,2(2 0), 19,6 ± 0,2 (2 0),21,3 ± 0,2 (2 0),22,5 ± 0,2 (2 0),23,6 ± 0,2 (2 0), 24,6 ± 0,2(20) et éventuellement à 28,8 ± 0,2 (2 Θ) ; et/ou des pics Raman à 1569 ± 2 cm-1,2963 ± 2 cm-1 et 3069 ± 2 cm-1 ; ou F : des pics de diffraction des rayons X (rayonnement de CuKa) à 14,5 ± 0,2 (2 Θ), 18,5 ± 0,2 (2 Θ), 19, 3 ± 0,2 (2 Θ), 27,3 ± 0,2 (2 Θ), 29,1 ± 0,2 (2 Θ) et éventuellement 11,5 ± 0,2 (2 Θ) ; et/ou des pics Raman à 160 ± 2 cm"1, 1295 ± 2 cm"1, 1573 ± 2 cm'1, 1585 ± 2 cm'1, 2979 ± 2 cm'1 et 3070 ± 2 cm'1 ; ou G : des pics de diffraction des rayons X (rayonnement de CuKa) à 21,4 ± 0, 2 (2 Θ), 24, 5 ± 0, 2 (2 Θ), 25, 2 ± 0, 2 (2 Θ), 26,8 ± 0,2 (2 Θ), 30,5 ± 0,2 (2 Θ), 31,8 ± 0,2 (2 Θ) et 33,0 ± 0,2 (2 Θ) ; et/ou des pics Raman à 274 ± 2 cm"1, 642 ± 2 crrr1, 1028 ± 2 crrr1, 3053 ± 2 crrr1 et 3077 ± 2 crrr1.

Claims (5)

1. Μ IF 2 : |1Τ §23 iajstr«Mmzàtmi «y répái szabadalom igénypontjainak magyar fdrdtflsm I* Pi^rH^Fluor-N.N-dimetíi^-íenií^’.S'-clihídro-S’H-apirxífciklohexán-l »1-pi'ranop^.bjindolj^-amin-hi^roklord szilárd formája, 2* Az 1- igénypont szinntí szilárd forrna, amely kristályos vagy amon ferma. 3> A 2 Igénypont szénné kristályos forma, amelynek egy vagy több a 14.3 ±0.6 (20), 17,1 11,2 ±0,5 (20) és a 19.8 ±0,5 {20} érték által alkotott csoportból yájaeztpíf röntgendlfírakciós csúcsa [CuKa sugárzás) és/vagy legalább két a 918*5 enf\ 1.209±f em4,1589±5 cm’5 és a 1583±S cm': érték általiilofetf csopirtból választóit Raman csucm: van. 4. A 2. vagy 3. igénypont szerinti kristályos forma, amely nermszoíváí vagy szólvit: &amp; Az előző 2-4. igénypontok bármelyike szerinti kristályos lárma, amelynek k röntgendiffrakciós csúcsa van (CuKa sugárzás) 25,6 ±i,2 (2i| irfiknél; vagy B: mntgendlÄkclÖs csúcsa van |CuKa suifeás) 10,6 ±0,2 (20), 17,2 ±0,2 (20), 18,6 ±0,2 (20), 19,3 ±0,2 (20), 22,2 00,2::120):, 28,7 értéknél; vagy C; rönlgébőiffrakclós csúcsa van (CuKu sugárzás) 11,2 ±0,2 (20), 18,2 ±0,2 (20), és 27,6 ±0,2 (20) értéknél; vagy D: röntgendiffrakciós csúcsa van (CuKa sugárzás) 18,3 ±0,2 (20), 18,3 ±0,2 (20), 18,9 ±0,2 (20). 19.6 ±0,2 (20), 23,7 ±0,2 (20), 24,3 ±0,2 (20), 27,8 ±0,2 (20) és 28,1 ±0,2 (20) irtiknél; vagy i; é§Öó$3 van (CuKct sugárzás) 17,1 ±0,2 (20), 17,7 ±0,2 (20) és 19,8 ±0,2 (20) értéknél; vagy IP; röntgendiffrakdós csúcsa van (CuKa sugárzás) 11,8 ±0,2 (20), 14,8 ±0,2 (20)^ 18,8 ±0,2 (20), 11,3 ±0,2 (20), 27,3 ±0,2 (20) és 29,1 ±0,2 (20) értéknél; vagy G; rőntgendlimköléi csúcsa « 21,4 ±0,2 (20) és 26,8 ±0,2 (20) értéknél. L· MM, iginpanf szerinti A kríslilps forma, amelynek DSC analízise endöterriáíié eseményt mutat egy kezdeti hőmérséklettel vagy csúcshőmérséklettel a 268~28f °C tartományban. I, fe δ. igénypont szerinti kristályos B forrna, amely a Dt|0 eseményt mutat egy kezdeti hőmérséklettel vagy csuoshimifoÉkléttej á 2ÍMf0 *Ü tartományain, tartalmazza m-i. vagy 2, igénypont szerinti szilárd féimiát vagy taríalmaz legalább egy a 3-7, Igénypontok bármelyike szerinti kristályos formái. 9, ittárás (irJr|#d|yoéiÇN"dliéi^^ plrarm|3,4:bpndoÍl'4'-imlrvhidroklorid 14L igénypontok birmelylte szerinti szilárd formájának, előnyösen kristályos formájának etőálltiaara,pme|y férfalmazza a kávefkező liipásekét ; (a«1} kicsapjuk az (1 r.4r}^6nfiipo-NfN-dimetil'-4áenil-4’,9:·<Ιίί^ο~3Ή·- spirö(dkiohexán-1, 1 ~p}rano[3,4,fe)lndoi|“4»amin hidrOkíoríd-sójái a szabad bázis oldatából vagy szuszpenziójából, és fof) alkCfibnlpk a szilárd anyagot;: vagy a~2) feloldjuk m. (1 r,4r)4l'4Buör*N ;N“dtmeik44eniM· .i'felbtdro-^Hnspro- [ctkíohaxán-1, 1 opiranop^jblindoil^-amimbidfekloridot oldótzifban; iá b-2) lep erőijük az oldószert az oldatból vagy b"2'} kicsapjuk az (ciklohexán- 1 , 1 ’-piranolS^^lindolJ-á-amfn-illdrekiondóf az oldatból, előnyösen kícsapószer hozzáadásával; vagy (a~3) szdszpendljjak az (1:r,Ar}474tueeÍ*Í*d|m^ [oiklnhexami, 1 'Oáfanoí3,4(b]indo0~4"amín4ydroklondot oldószerben, és kiverjük a képződött szuszpenzsot; és (b'3) elkülönítjük a szilárd anyagot,
2. 10, Az (1 r,4f)“8*4luor~N.N'dtmÄH^feb8^0i>ÄtiWdr^SfB^ptro^otkfeii^i^1<1‘-p ira no f 3 , 4, bj Irvf ο I j"4~am in~HÍdiOklorid 2. igénypont szerinti kristályos formája , amelynek rőntgenpordiafírakíogramja (Cd Ka sugárzás) tierniz jellemző csúcsokat 10.34» pi| 17p±0.2 (20). 18.9 ±0,2 (20), 26.3 ±0,2 (20) és adott esetben 17,5 ±0.2(24) érfeknll. ijft Iginypont szoinl kustilypsfomiiá, ahol a kristályos forma endotermális eseményt mutat körülbelül 258-288 °C csúcshőmérsékletnél a DSC segítségével történő méibatárözls szedni
3. 12. Az (1 r,4rH3'4kJor~N,N<!imetíi-44ePil-4i9:-dlhidrO''3!H“Spir(>Ícíklohexán-'1,1 psranop!4(b]i:pdol]-4mmln4iidroklorid 2, igénypont szerinti kristályos formája. teri-almaz |éïleo iZ# ^sucsD±nt 10,δ to,2 (20), 17,2 ±0,2 (20), 10>ΐ;;Λ2:ΡΙ), 19,3 ±0,2 (20|, 20,7 ^0,2 :|20)s 29,8 ±0,2 (20) és adott esetben 22J ±ö;2 (21) érteknél - 13, Λ12, igénypont szennö kristäyot^M^aÄ^älp^ famÊmk endotermills eseménye van körülbelül 262-270 °C csúcshőmérsékleten a DSC segítségével #gzeü meghatározás szedni
4. 14, Gyógyszerkészítmény,::amely tartalmaz d 10-13. igénypontok bármelyik# ázennfi kastély as fermât &amp; 1:4. igénypoot szérintl dyogyszefkéézltmehyv amely tartalmaz körülbelül 0,001 tomegól ét kófiibelybiö tömeg«»» mönnyMiü' kristályos fermât,
5. 10. Äz;efö2öl-4, igénypontok hirrielpke amelynek: /g reiii|éndBSrakcí^:S^eses\^ni!püÍ!&amp;.-Spg^i^eo| 10,6 ±0,2 (20), 1 / ,0 ±0,2 (20); 18,9 ±0,2 (29); 25,5 ±0,2 (20) és adott esetben 17,5 ±0,2 (20) értéknél; ésTvagy Raman csúcsa van 1(1)3 ±0,2 (20); 1564 ±2 cm!, 2058 ±0,2 (20) és 8071 ±0,2 (20) értiköél; vagy ii iíönigendrffrakciós csúcsa van (0yfesu§Éf2is) 10,6 ±0,2 (26¾ 17,2 ±0,2 (20); 48.6 (20); 19,3 ±0,2 (20); 26,7 ±0,2 (20), 29,3 ±0,2 (20) es ad« esetben 22,2 ±0,2 (20) értéknél Is/vagy Raman csúcsa van 1300 ±2 cm4, 1583 ±2 cm“1 is 2992 i:2 cm4 értéknél; vagy 0; römgendltfrakclós csúcsa van (CuKö sugárzás) 9,1 ±0,2 (20); 11,2 ±0,2 (29), 18.2 ±0,2 (20), 18,8 ±0,2 (20), 19,3 ±0,2 (20), 24,0 ±0,2 (20), 27,4 ±0,2 (2i), 28ß é|;2 (20) és adott esetben 19,1 ±0,2: (20) értéknél; és/vagy Raman csúcsa van 177 ±2 cm'!, 1587 ±2 cm4 és 1584 ±2 cm'1 értéknél; vagy D; röntgendllfakcíós csúcsa van (CuKa sugárzás) 18,3 ±0,2 (20), 18,9 ±0,2 (20); 19,8 ±0,2 (20), 23,7 ±0,2 (28); 24,3 ±0,2 (20), 28,9 ±0,2 (20); és adott esetben 18.3 à»:f2ô).Âadotoetben 27,6 ±0,2 (28) értéknél; és/vagy Raman esicsa van 181 ±2 ern“7 i72 ±2 .ént1» 100 ±2: cm k 688 ±2 cm"\ 919 ±2 cm“s, 1804 ±2 cm“·, 1299 ±2 cm4,1887 ±2 cm4,1573 ±2 cm4, 2912 ±2 cm 295? ±2 cm 2981 ±2 cm4, és 3017 cm4 értéknél; vagy E; röntgendlffraksiés csúcsa van (CuK^í sugárzás) 9,1 ±0,2(20); 17,1 ±0,2(20); 11.7 ±0,2 (20); 19,8 ±0,2 (28); 21,3 ±0,2 (20); 22,5 ±0,2 (20); 23,6 ±0,2 (28); 24,6 ±0,2 |20) és adott esetben 28,8 ±0,2 (20) értéknél; ÉM« iÄman csúcsa van 1669 ±2crP, 2ÍP ±2 cm * és 3069 ±2 cm " értéknél.;· vagy F; röntgend ïffrakclôs csúcsa van tCuK«.* sugaras) 14,5 ±0,2 (z.0), 1gs5 ±0v: (zb), 19.3 t0,2 (20), 27,3 ±0.2 (20), 29,1 ±0,2 (26) és adott esetben 11,5 ±0,2 (20) édebnél csOcse van 1É0 ±2 célΛ 1:296: ±2 cm *, 157c ±2 om . 1585 ±2 cm1, 2979 ±2 cm 1 és 5070 ±2 em'lirtékni!; w§y G: rönigendlffrakciós csúcsa van - (..-uKu sugárzás) 21,4 ±0,2 (20)» 24,5 3:0,2 p)), (20). 30,5 tO,2 (20),31,8 ±0,2 (20) és 33,0 ±0,2 (20) értéknél; és/vagy Raman csúcsa van 274 ±2 cm '5, 642 ±2 sm\ 1028 ±2 cm'1, 3051 Él cm'* és 3077 ±2 cní5 értéknél