HUE028425T2 - Nagyon gyors bõr-penetrációs sebességû aril- és heteroarilecetsavak pozitív töltésû vízoldható prodrugjai - Google Patents
Nagyon gyors bõr-penetrációs sebességû aril- és heteroarilecetsavak pozitív töltésû vízoldható prodrugjai Download PDFInfo
- Publication number
- HUE028425T2 HUE028425T2 HUE06795612A HUE06795612A HUE028425T2 HU E028425 T2 HUE028425 T2 HU E028425T2 HU E06795612 A HUE06795612 A HU E06795612A HU E06795612 A HUE06795612 A HU E06795612A HU E028425 T2 HUE028425 T2 HU E028425T2
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- HU
- Hungary
- Prior art keywords
- acoh
- diethylaminoethyl
- acetate
- drugs
- methyl
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/10—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to an acyclic carbon atom of a carbon skeleton containing rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Claims (3)
- Nagyem gpsrs bőr-penstrádós sebességű aril- és bsteroarîleceisavak podtrrtbltési vizoldbaiio prodregjai SZABADALMI IGÉN YPONTOK1. .Egy,,, s következő vegyüíeteket tanai mazó csoportból ki választott vegyidet; Dietílstót)0étil-1 Ap-kîôrbeozoil}~5~meioxi~2-meti]indob3“<xceïâl>AcDi:i D?éli!amiaöétlI-(Z)-d~Óáör'Z“déő]~I“|^~Métilsmí:Sííil)-léőiíMedIib|-lMAMléíi-3* aceiàLÂcOK. DIéi!ammöétlI-:l“meíií-SA4AaeÍ&^oÍB-ll-l<^liyéBI-acetát.Aá:ÖBr DieüiaininoetildA4''kIérbeiizoil}-'I,4'-dîai<;li!~i bl-p5rröId"a«etáí<-Ac(>H5 Dkíüaminoeükl ,8-dieiil-1,3,4,9-tetrahidropirancK3 AAyjindoM^ceíáUkcöM, DíetilamtenetilLAaró DÎetaanén0etii'A''amïa0dAA''brômdeRSK>îibbenzo!acetàt,AcOH, DietüamhiOetndAlór'dAS'propeniloxíj-byazolacctátAcO!!, DieíilaminoedblAZ^díklórfcwKB-bebz^laéötát.AcOB, Dioubminíadlbl~(d'IlárMaKöil~5~m0íők{"2»métiblB-Md©!d-aeeí0kíáceíábÁe:ÖBs Died:kmia0éti^4dd“k!őffe0Í:I}':2-lbai:b3:-bag0la®adt.AcÚ!-!v D;eiHaiTUTsoetil*3 4^MemI)4*Il!b$4 H-pírazoM-aceiát.AeOH, Dieti iamiiwet^í 4teozü-1 Uandazo]dAI}~oxi|-aeeiibA:dd!l Die«iammô#tîRiA»âoxiâ“2“j\ai'taUn“2-acetàLAcOH,è§ SiétiteiéüétibpAzebuű] lenit uvíáLÁcOR
- 2. Eljárás m 1. igiitygord szapsi vegydldtbk előállítására, áltól sav-balogemdeket vagy tolmeíin, aomeprae, etodoke, amíenac broraiénac, aicloienac, fencfofenac, acemetacin, Ébattazae, ibdometaéiá, Jő&fáe, lónazolsc, beadazac, ŐMNA vagy fcfeae vegyes abhldAdeketegy |33 áMársbs képleté vegyülettel reagáltatokaîîd a p ) általános képletben Es jelMiése ©tilesöpört, tU edlesoportet képvisel' X oxigeosiodoi jelent és n értéke 2. X Eljárás az L Igénypont szerinti végyileiek előállitásÉra, ahol tolinePni, zomepltácot. étodoiacób aféihnaeoi, fetóntimaeoi. afélofénaooh fénelofénaeob aeemeiadint, fénijazaeei, indometacint, suiindacop lonazolacot, bendazacot, 6MNA~í vagy íbutenacoi egy (3) általános képlóíS vegyöletlel kai^solá féagánsek aikalorazlsá oralleit rsagáltaíanlcahol a (3) általános képletben id jelentése éti lesöpört. :¾ etilcsoporiot képvisel; X oxigénatomot jelent és n értéke 2. 4. A 3. Igénypont szerinti eljárás, ahol a hapcsolonsmgensí az alábbi vegyüíeiekbél álló esopotiból választjuk.ki; NjM’-Dielklohexilkarbodliinld, M, N'-Onzöpropilkarbodiimid, 0^{ί50ηζ@*^0ί-.1:.4}}-foszíbniumbexafluribsziat.
- 5, Eljárás az 1. igénypont szerinti vegyületek előállítására, ahol tolmeiín, zonteptMC, eíodolae, amiénac, bromíenac, alclofenae, fénclofénae, acemetacm, féntlazae Jadömetaeio, sullndao, ionazolac. bendazac, éMNA, sbuíenac vagy rokon vegyületek fém sóit, szerves bázíkus sóit vagy tmmobíltzált bázjkus sóit a (4) általános képiéin vegyöleítel. reagáltatjuk.ahol a (4) általános képletben jelentése hidrogénatom, R-( etilesoporíoi képvisel; R4 etilcsoportot jelem; 2 jeknfose bafógéoáfbnr vágy p-toíuülsápiíbnilcsppöri, A” jelentése bármely negativ ion., és n értéke 2. & Kompozíció» .tJely legalább tgyym, L igénypont szerinti vegyüfotéf tarialmaz, 7. M. 1. ipnypoot szerinti vegyidet vagy a 6, igénypont széftó kompozíció emberbe« vagy állatok barn a fogfájás, iejfoiás és arthritis és más gyulladásos fájdalmak, láz, rák, dysmenorrhea, sigárzás okozta hányás, diabefikits nepfopáia és alM migrénes fejfájás, hemoflliás artropátia, csontvesztés., és napégés csoportból tlválasáfoh nem-'S^tereid gyulladás gátié szerrel (TéSAIÁ) kezdMtó állapotok kezelésére szolgáié dljÉÉsIsá vsáé tdWmasám $. Â 7. igénypont szerinti alkalmazásra szolgáló vegyüiet vagy kompozíció, ahol az említett: alkálfoazÉs tartalmazza a. vegyüiet vagy kompozíció tramzdennáiis beadását a. test bármely részébe, a vcg> ùles. gyógyászatilag hatásos plazma szintjének felszabadítására. R. A 7. igénypont szerinti alkalmazásra szolgáló vegyüiet vágy kompozíció* ahol az biSAíA-kezelhető állapot nhyAtó' fogfájás, és IzOmfájdalmál,, és arfferytis és más gyuiadákós fajdalmisk csoporihőlvan kiválasztva, és ítmMImazza a vegyüiet vagyjmmpozmld gyógyászatiág: hatásos mennyiségének beadását a gyitladr tertlletbe, 10, A 7, Igénypont: szerinti alteteazásra szolgáld vegyfiet vagy bj.mjpz|sà#¥.^àî kezdhető állapot alom, napégés vágy más bor rendel lenességek csoportból van kiválasztva, ahol á vegyüiet Vagy kompozfdé transzdortnáliaan van beadva és OldM, spray, foinn, balzsam, emulzió vagy gél formában van, kl, A 7. igénypont szerinti alkalmazásra szolgáié vegyüiet vagy kompozíció, ahol az NSAIA-kezethéti állapot az asztma, ahol.1 a vegyüld vagy kompozícié a sz^on vagy orron át vagy a test mis részeim porlasztással van beadva, 12, A 7. igénypont szerinti alkalmazásra szolgáló vegyidet vagy kompozíció, ahol az NSAIÁ-kezdhető állapot a gytjllaáásöS. szembetegségek, szaruhártya műtét nMfo szemfoidalom, glauMma, és- Mgpfcfe és/vagy ipälmas iifeegségek (otitis) espportböi v® kiválasztva. i l aifeÀmâsI mtàszêr, mely Í©pttl&$iy*az I, igérsyganl szerkó hatóanyagként, NSAlÀ-kezelhefé állapotok kezéléslbetz valá alkalma*® emberben vagy ál latokban. M. AII- Igénypont szerinti teaszàemïllls gyôgyâszaîi alkalmazási mndszen ahol aréndszer egy kötés vagy tapasz, mely egy hatóanyagot tartalmazó .mátrix réteget, és egy ÍBiprmeáblik vèdiiréteget4art»lmaz¥ vagy ahol: a mzdázer egy iaíáaayag tartály, mely a bér felé permeibíiis fenékrésszel rendelkezik.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2006/052732 WO2008017903A1 (en) | 2006-08-08 | 2006-08-08 | Positively charged water-soluble prodrugs of aryl- and heteroarylacetic acids with very fast skin penetration rate |
Publications (1)
Publication Number | Publication Date |
---|---|
HUE028425T2 true HUE028425T2 (hu) | 2016-12-28 |
Family
ID=39032656
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HUE06795612A HUE028425T2 (hu) | 2006-08-08 | 2006-08-08 | Nagyon gyors bõr-penetrációs sebességû aril- és heteroarilecetsavak pozitív töltésû vízoldható prodrugjai |
Country Status (8)
Country | Link |
---|---|
EP (2) | EP2990402A1 (hu) |
CN (1) | CN101506160A (hu) |
DK (1) | DK2049482T3 (hu) |
ES (1) | ES2559781T3 (hu) |
HU (1) | HUE028425T2 (hu) |
PL (1) | PL2049482T3 (hu) |
PT (1) | PT2049482E (hu) |
WO (1) | WO2008017903A1 (hu) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
EP2084124B9 (en) | 2006-10-02 | 2015-07-01 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of prostaglandins and related compounds with very high skin penetration rates |
CN101541743A (zh) | 2006-11-08 | 2009-09-23 | 于崇曦 | 多肽及相关化合物的透皮给药系统 |
EP2656879B1 (en) | 2006-12-10 | 2017-06-28 | Chongxi Yu | Transdermal delivery systems of beta-lactam antibiotics |
PL2125697T3 (pl) | 2007-01-15 | 2017-01-31 | Yu | Dodatnio naładowane, rozpuszczalne w wodzie proleki retinoidów i związków podobnych do retinoidów o bardzo wysokich współczynnikach przenikania przez skórę |
JP5389668B2 (ja) | 2007-01-31 | 2014-01-15 | チョンシー ユー | 皮膚浸透率の非常に高い1H−イミダゾ[4,5−c]キノリン−4−アミン及び関連化合物の正に荷電した水溶性プロドラッグ |
KR20190091378A (ko) * | 2007-06-04 | 2019-08-05 | 테크필즈 인크 | 매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(nsaia) 약물전구체 및 이들의 새로운 의약적 용도 |
KR20210123406A (ko) | 2008-12-04 | 2021-10-13 | 충시 위 | 고투과력을 가진 조성물 및 이의 적용 |
PL2427475T3 (pl) | 2009-05-08 | 2021-07-19 | Techfields Biochem Co., Ltd. | Kompozycje proleku o wysokim przenikaniu peptydów i związków powiązanych z peptydami |
US9969751B2 (en) | 2009-06-10 | 2018-05-15 | Techfields Pharma Co., Ltd. | High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds |
CN102557976B (zh) * | 2010-12-15 | 2015-06-10 | 辽宁盛京制药有限公司 | 溴芬酸有机盐及其制备方法、其组合物及用途 |
KR102443057B1 (ko) | 2012-01-18 | 2022-09-14 | 테크필즈 파마 코., 엘티디. | 폐 병태의 치료를 위한 고침투 전구약물 조성물 및 그의 약제학적 조성물 |
WO2014139161A1 (en) | 2013-03-15 | 2014-09-18 | Techfields Pharma Co., Ltd. | Novel high penetration drugs and their compositions thereof for treatment of parkinson diseases |
JP5997658B2 (ja) * | 2013-05-08 | 2016-09-28 | テックフィールズ インコーポレイテッド | 非常に速い皮膚及び膜浸透速度を有するnsaiaプロドラッグ及びその新規医薬使用 |
US20160168108A1 (en) | 2014-12-16 | 2016-06-16 | Adt Pharmaceuticals, Inc. | Method of treating or preventing ras-mediated diseases |
US9862698B2 (en) | 2014-12-16 | 2018-01-09 | Adt Pharmaceuticals, Inc. | Indenyl compounds, pharmaceutical compositions, and medical uses thereof |
CN117417281A (zh) * | 2017-09-28 | 2024-01-19 | 麦迪康制药公司 | 抗炎、抗癌和抗血管生成化合物,药物组合物及其制备和使用方法 |
US11186596B2 (en) | 2018-04-26 | 2021-11-30 | Adt Pharmaceuticals, Llc | Anticancer indenes, indanes, azaindenes, azaindanes, pharmaceutical compositions and uses |
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FR1593024A (hu) * | 1968-09-18 | 1970-05-25 | ||
IT1090782B (it) * | 1977-11-30 | 1985-06-26 | Menarini Sas | 2 4 bifenilil 2 dietilamino alchil propionamide suoi sali e procedimenti di fabbricazione relativi |
US5192753A (en) | 1991-04-23 | 1993-03-09 | Mcgeer Patrick L | Anti-rheumatoid arthritic drugs in the treatment of dementia |
US5654337A (en) | 1995-03-24 | 1997-08-05 | II William Scott Snyder | Topical formulation for local delivery of a pharmaceutically active agent |
AUPN531195A0 (en) | 1995-09-11 | 1995-10-05 | J.W. Broadbent Nominees Pty. Ltd. | Lipid extract having anti-inflamatory activity |
KR100213465B1 (ko) | 1996-11-01 | 1999-08-02 | 최좌진 | 케토프로펜 패취 조성물 |
US5885597A (en) | 1997-10-01 | 1999-03-23 | Medical Research Industries,Inc. | Topical composition for the relief of pain |
DE69939019D1 (de) | 1998-07-07 | 2008-08-14 | Transdermal Technologies Inc | Zusammensetzungen für die schnelle und nicht-irritierende transdermale verabreichung von pharmazeutika and verfahren zur formuliering davon und ihren verabreichung |
IT1317826B1 (it) * | 2000-02-11 | 2003-07-15 | Dompe Spa | Ammidi, utili nell'inibizione della chemiotassi dei neutrofiliindotta da il-8. |
US6416772B1 (en) | 2001-01-12 | 2002-07-09 | H. Wayne Van Engelen | Topical dermal anaesthetic |
US6528040B1 (en) | 2001-01-18 | 2003-03-04 | Maurine Pearson | EMU oil-based formulations for use as an analgesic, anesthetic and antipruritic |
ITMI20010395A1 (it) * | 2001-02-27 | 2002-08-27 | Dompe Spa | Omega-amminoalchilammidi di acidi r-2-aril-propionici come inibitori della chemiotassi di cellule polimorfonucleate e mononucleate |
ITMI20012025A1 (it) * | 2001-09-28 | 2003-03-28 | Dompe Spa | Sali di ammonio quaternari di omega-amminoalchilammidi di acidi r 2-aril-propionici e composizioni farmaceutiche che li contengono |
US7052715B2 (en) | 2003-04-11 | 2006-05-30 | All Natural Fmg, Inc. | Alcohol-free transdermal analgesic composition and processes for manufacture and use thereof |
-
2006
- 2006-08-08 DK DK06795612.8T patent/DK2049482T3/en active
- 2006-08-08 PT PT67956128T patent/PT2049482E/pt unknown
- 2006-08-08 PL PL06795612T patent/PL2049482T3/pl unknown
- 2006-08-08 WO PCT/IB2006/052732 patent/WO2008017903A1/en active Application Filing
- 2006-08-08 EP EP15190570.0A patent/EP2990402A1/en active Pending
- 2006-08-08 CN CNA2006800555598A patent/CN101506160A/zh active Pending
- 2006-08-08 EP EP06795612.8A patent/EP2049482B1/en not_active Not-in-force
- 2006-08-08 ES ES06795612.8T patent/ES2559781T3/es active Active
- 2006-08-08 HU HUE06795612A patent/HUE028425T2/hu unknown
Also Published As
Publication number | Publication date |
---|---|
EP2049482B1 (en) | 2015-10-21 |
ES2559781T3 (es) | 2016-02-15 |
EP2990402A1 (en) | 2016-03-02 |
EP2049482A4 (en) | 2010-05-26 |
EP2049482A1 (en) | 2009-04-22 |
PL2049482T3 (pl) | 2016-04-29 |
PT2049482E (pt) | 2016-02-24 |
DK2049482T3 (en) | 2016-02-01 |
CN101506160A (zh) | 2009-08-12 |
WO2008017903A1 (en) | 2008-02-14 |
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