HUE028389T2 - Tiokarbont védõ csoportok RNSS szintéziséhez - Google Patents

Tiokarbont védõ csoportok RNSS szintéziséhez Download PDF

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Publication number
HUE028389T2
HUE028389T2 HUE12163999A HUE12163999A HUE028389T2 HU E028389 T2 HUE028389 T2 HU E028389T2 HU E12163999 A HUE12163999 A HU E12163999A HU E12163999 A HUE12163999 A HU E12163999A HU E028389 T2 HUE028389 T2 HU E028389T2
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HU
Hungary
Prior art keywords
group
rna
protected
groups
hydroxyl
Prior art date
Application number
HUE12163999A
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English (en)
Inventor
Douglas J Dellinger
Agnieska Sierzchala
John Turner
Joel Myerson
Zoltan Kupihar
Fernando Ferreira
Marvin H Caruthers
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Agilent Technologies Inc
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Filing date
Publication date
Application filed by Agilent Technologies Inc filed Critical Agilent Technologies Inc
Publication of HUE028389T2 publication Critical patent/HUE028389T2/hu

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Saccharide Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (5)

;.·:Ρ 2 476 689 BS Szabadalmi igdpyponmk
1. Vegyidet amely M alábbi cso^bMl· megválasztott szerkezetei brr:
ahol: a képletekbe» Beetetése vödéit vagy mm vétkb fceíeroci'ldiasos Mais; és R5 és R'' JeksiSése egymástól ilggeífcaöi bkktígés. «gy védfeöpott vagy agy fos?.t<Hami«hí csoport közül vas megválasztva,
2. Az 1. Igèsyppm szedmi vegyület az alábbi sxerkemkl:
3. Nukleinsavaz alábbi szerkezettel:
IX ahol a képletből B·' jelentése védést vagy pe® vétkét alkogéfítartalstá bázis; Q jelentése egy, ax 1. vagy 2. igénypontban ddmiak tk4;arbon*véd<>csoport: Ri;: jefcntése líidrogén, smtÉúÉio^náí, helyettesített széíéiáraiéoelc, artksoportok «s tfolyip-teshetr ári lesöpörtök alkotbi csoportból vas megválasztva, és m étske l~nél nagyobb «gesz sxs»
4- Eljárás «gy nukkinsav előállítására, amelynek során aj bixtoslamk egy nem védett Itidroxilcsoponol bíró tnâiec maradékot és egy. a T-helyxetbep védett rsaklsotid monomert, ahol a 2'~ltety?.eibcn védeti nakleoliá monomer ίβ:!. vagy 2. igénypontban definiált? szer*· feezæiô; és b; ax smitten nukkozid maradékot ax oatlfett' tnMeoíjcl olyan Mtitoényefc között. amelyek elegendőek az említed noktezid maradéknak m éíöfte n«k;i^4:asötáyn^«Z'^a'lé kovalens kötethez és az említett mtkletraav elóÉföásáiMtz:
5. Λ 4. igénypont szerinti eljín% amely *««$&amp;$. foglalja járulékosan az kkemukleotíd kmés egy oxidáld szernek vagy egy véc|ggsojKiri skáv<d:Msám :sxolgÍd szernek való kitételéi. 4 A 4. vagy 5* Igénypont: sxemiti eljárás, átósly megába foglalja jándéfcosan ax mltístt émtkeíSstósi lépég legalább «gysxm.assgb’mètîêsét. 7, Λ 4 - b, tgényf öntök: bármelyike szériád «prás,: amely magába foglalja iámlékósán m etnlsteti 2«helyxetii hídröxkvédöesöpört. eltávolítását b. A4- ?. igénypontok Mmtelyife; szerinti eljárás, ahol ax endRetg nem :v$lejs IbidÄilcI^sisttS fcfek naklsogld mambók egy szilárd iioídoxpbpx kotM. $ Λ 1 igénypont szerinti «bárás, az ^nälS^:.t«tkid»s»«ssk aren#- tett ;sxi tárd nmrdoxbréj való lehaskását sxsbadaukkimav elöállMsára.
HUE12163999A 2007-05-10 2008-05-09 Tiokarbont védõ csoportok RNSS szintéziséhez HUE028389T2 (hu)

Applications Claiming Priority (1)

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US92872207P 2007-05-10 2007-05-10

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HUE12163999A HUE028389T2 (hu) 2007-05-10 2008-05-09 Tiokarbont védõ csoportok RNSS szintéziséhez

Country Status (9)

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US (2) US8202983B2 (hu)
EP (2) EP2476689B1 (hu)
JP (1) JP5520818B2 (hu)
KR (1) KR101625363B1 (hu)
CN (1) CN101784556B (hu)
DK (1) DK2476689T3 (hu)
HU (1) HUE028389T2 (hu)
PL (1) PL2476689T3 (hu)
WO (1) WO2008141248A2 (hu)

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US20090209479A1 (en) 2009-08-20
WO2008141248A2 (en) 2008-11-20
JP2010526835A (ja) 2010-08-05
JP5520818B2 (ja) 2014-06-11
CN101784556A (zh) 2010-07-21
KR101625363B1 (ko) 2016-05-30
EP2476689B1 (en) 2015-10-21
US9067961B2 (en) 2015-06-30
EP2476689A1 (en) 2012-07-18
EP2160396B1 (en) 2018-11-21
EP2160396A2 (en) 2010-03-10
KR20100017733A (ko) 2010-02-16
WO2008141248A3 (en) 2009-03-19
CN101784556B (zh) 2014-07-09
US8202983B2 (en) 2012-06-19
US20120238737A1 (en) 2012-09-20

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