HU9303218D0 - Application of atp-depended protease and its inhibitor for treatment of cachexy and amyotrophia - Google Patents
Application of atp-depended protease and its inhibitor for treatment of cachexy and amyotrophiaInfo
- Publication number
- HU9303218D0 HU9303218D0 HU9303218A HU9303218A HU9303218D0 HU 9303218 D0 HU9303218 D0 HU 9303218D0 HU 9303218 A HU9303218 A HU 9303218A HU 9303218 A HU9303218 A HU 9303218A HU 9303218 D0 HU9303218 D0 HU 9303218D0
- Authority
- HU
- Hungary
- Prior art keywords
- cachexy
- amyotrophia
- depended
- atp
- protease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96466—Cysteine endopeptidases (3.4.22)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/20—Screening for compounds of potential therapeutic value cell-free systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/699,184 US5340736A (en) | 1991-05-13 | 1991-05-13 | ATP-dependent protease and use of inhibitors for same in the treatment of cachexia and muscle wasting |
Publications (2)
Publication Number | Publication Date |
---|---|
HU9303218D0 true HU9303218D0 (en) | 1994-03-28 |
HUT66512A HUT66512A (en) | 1994-11-28 |
Family
ID=24808290
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9303218A HUT66512A (en) | 1991-05-13 | 1992-05-11 | Atp-dependent protease and use of inhibitors for same in the treatment of cachexia and muscle wasting |
Country Status (7)
Country | Link |
---|---|
US (4) | US5340736A (hu) |
EP (1) | EP0591316A1 (hu) |
JP (1) | JPH06507786A (hu) |
AU (1) | AU666854B2 (hu) |
CA (1) | CA2102195A1 (hu) |
HU (1) | HUT66512A (hu) |
WO (1) | WO1992020804A1 (hu) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5340736A (en) * | 1991-05-13 | 1994-08-23 | The President & Fellows Of Harvard College | ATP-dependent protease and use of inhibitors for same in the treatment of cachexia and muscle wasting |
EP0684829A4 (en) * | 1993-02-10 | 1997-05-21 | Harvard College | THE ROLE OF ATP-UBIQUITIN-DEPENDENT PROTEOLYSIS IN MHC-1 DEPENDENT ANTIGENT PRESENTATION AND RELATED INHIBITORS. |
US5847076A (en) * | 1993-05-20 | 1998-12-08 | Board Of Regents, The University Of Texas System | Regulators of the proteasome |
US5744343A (en) * | 1994-01-04 | 1998-04-28 | Mitotix, Inc. | Ubiquitin conjugating enzymes |
CA2179537A1 (en) * | 1994-01-04 | 1995-07-13 | Giulio Draetta | Ubiquitin conjugating enzymes |
US5981699A (en) * | 1994-01-04 | 1999-11-09 | Mitotix, Inc. | Human ubiquitin conjugating enzyme |
US5693617A (en) * | 1994-03-15 | 1997-12-02 | Proscript, Inc. | Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein |
US5550262A (en) * | 1994-11-14 | 1996-08-27 | Cephalon, Inc. | Multicatalytic protease inhibitors |
US5614649A (en) * | 1994-11-14 | 1997-03-25 | Cephalon, Inc. | Multicatalytic protease inhibitors |
US6838477B2 (en) | 1995-04-12 | 2005-01-04 | President And Fellows Of Harvard College | Lactacystin analogs |
US6335358B1 (en) | 1995-04-12 | 2002-01-01 | President And Fellows Of Harvard College | Lactacystin analogs |
US5726025A (en) * | 1995-04-20 | 1998-03-10 | President And Fellows Of Harvard College | Assay and reagents for detecting inhibitors of ubiquitin-dependent degradation of cell cycle regulatory proteins |
CA2229204C (en) | 1995-08-09 | 2012-10-09 | Alan D. D'andrea | Deubiquitinating enzymes that regulate cell growth |
US6001619A (en) * | 1995-10-04 | 1999-12-14 | Cold Spring Harbor Laboratory | Ubiquitin ligases, and uses related thereto |
WO1998023283A1 (en) * | 1996-11-25 | 1998-06-04 | The President And Fellows Of Harvard College | Methods of inhibiting protein degradation to combat muscle wasting |
US5935804A (en) * | 1997-03-21 | 1999-08-10 | Laine; Roger A. | Method for detecting eubacteria in biological samples with catalytically inactive murein binding enzymes |
US6747128B2 (en) | 1997-08-20 | 2004-06-08 | Gpc Biotech, Inc. | Components of ubiquitin ligase complexes, and uses related thereto |
US6096778A (en) * | 1997-10-07 | 2000-08-01 | Cephalon, Inc. | α-ketoamide multicatalytic protease inhibitors |
US20060105357A1 (en) * | 1998-02-18 | 2006-05-18 | Myomics, Inc. | Tissue sensor and uses thereof |
WO1999042604A1 (en) * | 1998-02-18 | 1999-08-26 | Cell Based Delivery | Methods of screening compounds for bioactivity in organized tissue |
AU3474199A (en) * | 1998-04-07 | 1999-10-25 | Regeneron Pharmaceuticals, Inc. | Method of identifying agents that block muscle atrophy |
US8197430B1 (en) | 1998-05-22 | 2012-06-12 | Biopheresis Technologies, Inc. | Method and system to remove cytokine inhibitor in patients |
US6620382B1 (en) | 1998-05-22 | 2003-09-16 | Biopheresis Technologies, Llc. | Method and compositions for treatment of cancers |
KR20010080267A (ko) * | 1998-10-20 | 2001-08-22 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 프로테아솜 억제제 약물 작용을 모니터링하는 방법 |
US6831099B1 (en) * | 1999-05-12 | 2004-12-14 | Yale University | Enzyme inhibition |
US20030077288A1 (en) * | 2001-01-16 | 2003-04-24 | Goldberg Alfred L. | Compositions and methods for treatment of muscle wasting |
US8198270B2 (en) * | 2004-04-15 | 2012-06-12 | Onyx Therapeutics, Inc. | Compounds for proteasome enzyme inhibition |
US7232818B2 (en) * | 2004-04-15 | 2007-06-19 | Proteolix, Inc. | Compounds for enzyme inhibition |
SG152239A1 (en) | 2004-04-15 | 2009-05-29 | Proteolix Inc | Compounds for proteasome enzyme inhibition |
US20050256324A1 (en) * | 2004-05-10 | 2005-11-17 | Proteolix, Inc. | Synthesis of amino acid keto-epoxides |
PT2030981E (pt) | 2004-05-10 | 2014-10-14 | Onyx Therapeutics Inc | Compostos para inibição da enzima proteassoma |
US20060088471A1 (en) | 2004-10-20 | 2006-04-27 | Proteolix, Inc. | Compounds for enzyme inhibition |
WO2006062732A2 (en) * | 2004-11-19 | 2006-06-15 | Synta Pharmaceuticals Corp. | Compounds acting at the centrosome |
JP4990155B2 (ja) | 2004-12-07 | 2012-08-01 | プロテオリックス, インコーポレイテッド | プロテアソームを阻害するための組成物 |
JP5311209B2 (ja) * | 2005-05-27 | 2013-10-09 | オニキス セラピューティクス, インク. | Rpn11酵素活性のための新規な基質 |
US20070015777A1 (en) * | 2005-07-14 | 2007-01-18 | Myogen, Inc. | Use of Inhibitors of the Ubiquitin Proteasome Pathway as a Method of Increasing Contractility of the Heart |
US7691896B2 (en) * | 2005-08-10 | 2010-04-06 | President And Fellows Of Harvard College | Analogs of salinosporamide A |
CN105237621A (zh) | 2005-11-09 | 2016-01-13 | 欧尼斯治疗公司 | 用于酶抑制的化合物 |
AR057227A1 (es) * | 2005-12-09 | 2007-11-21 | Centocor Inc | Metodo para usar antagonistas de il6 con inhibidores del proteasoma |
JP5137321B2 (ja) * | 2006-04-20 | 2013-02-06 | ルネサスエレクトロニクス株式会社 | 表示装置、lcdドライバ及び駆動方法 |
EP2041158B1 (en) * | 2006-06-19 | 2013-04-17 | Onyx Therapeutics, Inc. | Peptide epoxyketones for proteasome inhibition |
US8097596B2 (en) * | 2006-06-30 | 2012-01-17 | Lakewood-Amedex, Inc. | Compositions and methods for the treatment of muscle wasting |
US20080118940A1 (en) * | 2006-11-22 | 2008-05-22 | Maher Albitar | Proteasomal peptidase activity and the use thereof in clinical applications |
CL2008002966A1 (es) | 2007-10-04 | 2010-06-25 | Onyx Therapeutics Inc | Compuesto tetrapeptido ceto-epoxido cristalino; sal citrato cristalina del compuesto; metodos de preparacion; compuesto intermediario cristalino; metodo de preparacion; y uso para tratar cancer, enfermedad autoinmune, afeccion relacionada con trasplante, enfermedad neurodegenerativa, afeccion asociada con fibrosis, entre otros. |
EA035100B1 (ru) | 2008-10-21 | 2020-04-28 | Оникс Терапьютикс, Инк. | Комбинированная терапия с применением пептид эпоксикетонов |
TWI504598B (zh) | 2009-03-20 | 2015-10-21 | Onyx Therapeutics Inc | 結晶性三肽環氧酮蛋白酶抑制劑 |
US20110053197A1 (en) * | 2009-08-25 | 2011-03-03 | Quest Diagnostics Investments Incorporated | Ubiquitin proteasome system profiling and the use thereof in clinical applications for cancer diagnosis |
US20110053199A1 (en) * | 2009-08-25 | 2011-03-03 | Quest Diagnostics Investments Incorporated | Ubiquitin proteasome system profiling and the use thereof in clinical applications for cancer diagnosis |
US20110053198A1 (en) * | 2009-08-25 | 2011-03-03 | Quest Diagnostics Investments Incorporated | Ubiquitin proteasome system profiling and the use thereof in clinical applications for proliferative hematological disorders |
WO2011060179A1 (en) | 2009-11-13 | 2011-05-19 | Onyx Therapeutics, Inc | Use of peptide epoxyketones for metastasis suppression |
US9359398B2 (en) | 2010-03-01 | 2016-06-07 | Onyx Therapeutics, Inc. | Compounds for immunoproteasome inhibition |
BR112012025264A2 (pt) | 2010-04-07 | 2019-09-24 | Onyx Therapeutics Inc | inibidor de imunoproteassoma de e´poxicetona peptídica cristalina. |
UY34897A (es) | 2012-07-09 | 2014-01-31 | Onyx Therapeutics Inc | Profarmacos de inhibidores peptidicos de expoxi cetona proteasa |
CA2879139C (en) | 2012-07-18 | 2021-05-11 | Onyx Therapeutics, Inc. | Liposomal compositions of epoxyketone-based proteasome inhibitors |
AR095426A1 (es) | 2013-03-14 | 2015-10-14 | Onyx Therapeutics Inc | Inhibidores tripeptídicos de la epoxicetona proteasa |
EA030957B1 (ru) | 2013-03-14 | 2018-10-31 | Оникс Терапьютикс, Инк. | Дипептидные и трипептидные эпоксикетонные ингибиторы протеазы |
AR108919A1 (es) | 2016-06-29 | 2018-10-10 | Kezar Life Sciences | Proceso de preparación del inhibidor de inmunoproteasoma de péptido epoxicetona, y sus precursores |
BR112018077390A2 (pt) | 2016-06-29 | 2019-04-09 | Kezar Life Sciences | sais cristalinos de peptídeo epoxicentona inibidor de imunoproteassoma |
WO2021142359A1 (en) | 2020-01-10 | 2021-07-15 | Amgen Inc. | Stable cyclodextrin free carfilzomib formulation |
WO2021142360A1 (en) | 2020-01-10 | 2021-07-15 | Amgen Inc. | Stable cyclodextrin free carfilzomib formulation |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5340736A (en) * | 1991-05-13 | 1994-08-23 | The President & Fellows Of Harvard College | ATP-dependent protease and use of inhibitors for same in the treatment of cachexia and muscle wasting |
-
1991
- 1991-05-13 US US07/699,184 patent/US5340736A/en not_active Expired - Lifetime
-
1992
- 1992-05-11 EP EP92913050A patent/EP0591316A1/en not_active Withdrawn
- 1992-05-11 WO PCT/US1992/003914 patent/WO1992020804A1/en not_active Application Discontinuation
- 1992-05-11 AU AU20275/92A patent/AU666854B2/en not_active Ceased
- 1992-05-11 HU HU9303218A patent/HUT66512A/hu unknown
- 1992-05-11 CA CA002102195A patent/CA2102195A1/en not_active Abandoned
- 1992-05-11 JP JP5500127A patent/JPH06507786A/ja active Pending
-
1994
- 1994-06-20 US US08/262,497 patent/US5565351A/en not_active Expired - Lifetime
-
1996
- 1996-10-11 US US08/730,310 patent/US5786329A/en not_active Expired - Fee Related
-
1997
- 1997-12-02 US US08/982,295 patent/US5972636A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5340736A (en) | 1994-08-23 |
US5565351A (en) | 1996-10-15 |
HUT66512A (en) | 1994-11-28 |
CA2102195A1 (en) | 1992-11-14 |
AU666854B2 (en) | 1996-02-29 |
US5786329A (en) | 1998-07-28 |
WO1992020804A1 (en) | 1992-11-26 |
EP0591316A1 (en) | 1994-04-13 |
JPH06507786A (ja) | 1994-09-08 |
AU2027592A (en) | 1992-12-30 |
US5972636A (en) | 1999-10-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HU9303218D0 (en) | Application of atp-depended protease and its inhibitor for treatment of cachexy and amyotrophia | |
IL110525A0 (en) | Identification and use of protease inhibitors | |
HU9202842D0 (en) | Climotripsine-type proteases and inhibitors | |
EP0715619A4 (en) | INHIBITORS OF TNF-ALPHA SECRETION | |
IL104324A0 (en) | Variant of human kunitz-type protease inhibitor | |
PL307858A1 (en) | Sulphonamidic inhibitors of aspartilic hiv protease | |
PL313871A1 (en) | Inhibitors of hiv protease | |
IL105521A0 (en) | The use of inhibitors of plasminogen activators for the treatment of inflammations and wounds | |
EP0580402A3 (en) | Aminediol protease inhibitors | |
ZA939285B (en) | Inhibitors of aspartyl protease | |
EP0581581A3 (en) | Bioadhesive treatment compositions and methods of use | |
HU9500919D0 (en) | Peptide inhibitors of mitogenesis and motogenesis | |
NZ248332A (en) | Hiv protease inhibitor and its use | |
AU2251892A (en) | Inhibitors of picornavirus proteases | |
EP0727990A4 (en) | CONNECTIONS, PREPARATIONS AND TREATMENT OF ALLERGIES AND IGNITIONS | |
ZA944772B (en) | Treatment of fluids | |
PL311300A1 (en) | 4-arylo-4-hydroxy-tetrahydropyranes and 3-arylo-3-hydroxy-tetrahydrofuranes as inhibitors of 5-lipoxygenase | |
EP0713496A4 (en) | THROMBINE INHIBITORS TARGETED ON FIBRIN | |
AU2299592A (en) | Treatment of periodontal disease with protease inhibitors | |
GB9317943D0 (en) | Treatment of laminitis | |
HU9402312D0 (en) | Identification and use of protease inhibitors | |
GB9405905D0 (en) | Inhibitors of isoprenylated protein endoprotease | |
EP0502470A3 (en) | Compounds for the treatment of inflammation and allergy | |
GB9321679D0 (en) | Treatment of substrates | |
ZA946331B (en) | Pyran-4-ylmethyl-substituted arylalkylaryl- arylalkenylylaryl- and arylalkynylarylurea inhibitors of 5-lipoxygenase |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
DFD9 | Temporary prot. cancelled due to non-payment of fee |