HU227123B1 - Pharmaceutical combination comprising amlodipine and lisinopril and it's use for the treatment of certain cardiovascular disorders - Google Patents
Pharmaceutical combination comprising amlodipine and lisinopril and it's use for the treatment of certain cardiovascular disorders Download PDFInfo
- Publication number
- HU227123B1 HU227123B1 HU0202416A HU020246A HU227123B1 HU 227123 B1 HU227123 B1 HU 227123B1 HU 0202416 A HU0202416 A HU 0202416A HU 020246 A HU020246 A HU 020246A HU 227123 B1 HU227123 B1 HU 227123B1
- Authority
- HU
- Hungary
- Prior art keywords
- amlodipine
- lysinopril
- treatment
- lisinopril
- hypertension
- Prior art date
Links
- RLAWWYSOJDYHDC-BZSNNMDCSA-N lisinopril Chemical compound C([C@H](N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 RLAWWYSOJDYHDC-BZSNNMDCSA-N 0.000 title claims abstract description 30
- HTIQEAQVCYTUBX-UHFFFAOYSA-N amlodipine Chemical compound CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl HTIQEAQVCYTUBX-UHFFFAOYSA-N 0.000 title claims abstract description 28
- 229960000528 amlodipine Drugs 0.000 title claims abstract description 22
- 238000011282 treatment Methods 0.000 title claims abstract description 18
- 108010007859 Lisinopril Proteins 0.000 title claims description 31
- 229960002394 lisinopril Drugs 0.000 title claims description 16
- 208000024172 Cardiovascular disease Diseases 0.000 title claims description 3
- 206010020772 Hypertension Diseases 0.000 claims abstract description 25
- 239000000203 mixture Substances 0.000 claims description 11
- 239000003826 tablet Substances 0.000 claims description 10
- 230000035488 systolic blood pressure Effects 0.000 claims description 7
- ZPBWCRDSRKPIDG-UHFFFAOYSA-N amlodipine benzenesulfonate Chemical compound OS(=O)(=O)C1=CC=CC=C1.CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1Cl ZPBWCRDSRKPIDG-UHFFFAOYSA-N 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 229960004005 amlodipine besylate Drugs 0.000 claims description 5
- 238000009472 formulation Methods 0.000 claims description 5
- -1 lysinopril dihydrate Chemical class 0.000 claims description 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 230000004043 responsiveness Effects 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 239000007909 solid dosage form Substances 0.000 claims description 3
- 239000008188 pellet Substances 0.000 claims description 2
- 229940124531 pharmaceutical excipient Drugs 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 3
- 201000010099 disease Diseases 0.000 abstract description 2
- 230000004044 response Effects 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 16
- 230000036772 blood pressure Effects 0.000 description 11
- 239000003814 drug Substances 0.000 description 10
- 229940079593 drug Drugs 0.000 description 9
- 230000009467 reduction Effects 0.000 description 6
- 230000001631 hypertensive effect Effects 0.000 description 5
- 238000009097 single-agent therapy Methods 0.000 description 5
- 206010019280 Heart failures Diseases 0.000 description 4
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 4
- 238000011260 co-administration Methods 0.000 description 4
- 230000035487 diastolic blood pressure Effects 0.000 description 4
- 230000003205 diastolic effect Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 230000002411 adverse Effects 0.000 description 3
- 238000011284 combination treatment Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 2
- 239000002876 beta blocker Substances 0.000 description 2
- 229940097320 beta blocking agent Drugs 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000002648 combination therapy Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000002934 diuretic Substances 0.000 description 2
- 229940030606 diuretics Drugs 0.000 description 2
- 230000002526 effect on cardiovascular system Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000007634 remodeling Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- 239000005541 ACE inhibitor Substances 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- XPCFTKFZXHTYIP-PMACEKPBSA-N Benazepril Chemical compound C([C@@H](C(=O)OCC)N[C@@H]1C(N(CC(O)=O)C2=CC=CC=C2CC1)=O)CC1=CC=CC=C1 XPCFTKFZXHTYIP-PMACEKPBSA-N 0.000 description 1
- 229940127291 Calcium channel antagonist Drugs 0.000 description 1
- 206010007572 Cardiac hypertrophy Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010014418 Electrolyte imbalance Diseases 0.000 description 1
- 208000007530 Essential hypertension Diseases 0.000 description 1
- 206010029412 Nightmare Diseases 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000002730 additional effect Effects 0.000 description 1
- 229940030600 antihypertensive agent Drugs 0.000 description 1
- 239000002220 antihypertensive agent Substances 0.000 description 1
- 229960004530 benazepril Drugs 0.000 description 1
- 238000009530 blood pressure measurement Methods 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000000480 calcium channel blocker Substances 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 238000002565 electrocardiography Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 229940126601 medicinal product Drugs 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 230000010503 organ complication Effects 0.000 description 1
- 230000008816 organ damage Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000010972 statistical evaluation Methods 0.000 description 1
- 210000002820 sympathetic nervous system Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0202416A HUP0202416A3 (en) | 2002-07-24 | 2002-07-24 | Novel pharmaceutical combination and it's use for the treatment of certain cardiovascular disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HU227123B1 true HU227123B1 (en) | 2010-07-28 |
Family
ID=89980644
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0202416A HU227123B1 (en) | 2002-07-24 | 2002-07-24 | Pharmaceutical combination comprising amlodipine and lisinopril and it's use for the treatment of certain cardiovascular disorders |
| HU0202416A HUP0202416A3 (en) | 2002-07-24 | 2002-07-24 | Novel pharmaceutical combination and it's use for the treatment of certain cardiovascular disorders |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0202416A HUP0202416A3 (en) | 2002-07-24 | 2002-07-24 | Novel pharmaceutical combination and it's use for the treatment of certain cardiovascular disorders |
Country Status (1)
| Country | Link |
|---|---|
| HU (2) | HU227123B1 (OSRAM) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0401170A2 (en) | 2004-06-10 | 2006-09-28 | Richter Gedeon Vegyeszet | Pharmaceutical composition comprising amlodipine besilate and lisinopril dihydrate and process for |
-
2002
- 2002-07-24 HU HU0202416A patent/HU227123B1/hu unknown
- 2002-07-24 HU HU0202416A patent/HUP0202416A3/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0202416A2 (hu) | 2004-04-28 |
| HUP0202416A3 (en) | 2006-01-30 |
| HU0202416D0 (OSRAM) | 2002-09-28 |
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