HU212680B - Process for producing ointment for quick healing scarf-skinless surfaces containing zincoxyd, salicylic acid, oleum jecoris caselli and sulfur - Google Patents

Abstract

The present invention relates to a method for producing a medicated cream comprising zinc oxide, salicylic acid and cod liver oil and sulfur. The cream is prepared by treating 1-5% by weight of salicylic acid, 1-10% by weight of zinc oxide, 5-50% by weight of sulfur milk. 1-5% by weight of cod liver oil and 100% by weight of base cream, which may optionally contain other, conventional ointment additives, and may be converted into a cream suitable for rapid healing of epithelial skin surfaces. EN 212 680 B Scope of the description: 4 pages

Description

The present invention relates to a process for the preparation of a medicated cream. The cream of the invention contains, inter alia, zinc oxide, salicylic acid and cod liver oil, as well as sulfur.

Due to the drying effect of zinc oxide, it is a constituent of many skin protection and healing ointments and creams. No. 181,367. For example, U.S. Patent No. 4,123,198 to Henderson et al. relates to ointment for the treatment of goldfish lumps, in which zinc oxide is a major component. Salicylic acid is also used in many formulations because of its antiseptic effect (German Patent Application No. 3 704 214). Finally, cod liver oil is one of the most popular substances in the field of skin and skin care; WO 91/16914; International Patent Publication No. 4,198,119 discloses a number of preparations containing fish oil, which also contain a deodorant to eliminate the unpleasant odor of fish oil.

It is a common experience that skin discontinuities and wounds of different origins do not heal in the same way. If the child scratches his skin during play and does not become infected, he usually scratches after 1-2 days. In contrast, burns, for example, heal very badly, although burns of a second degree may occur, even though every two days, the doctor does not heal for several weeks. Finally, there are wounds for which there is practically no effective remedy today; such as lying wounds, which develop over a prolonged period on the skin of a helpless lying patient, become larger and very painful.

Our goal was to develop an ointment that would heal the aforementioned difficult-to-heal wounds in a short period of time. We have found that the above goal can be achieved with a cream which

1-5% by weight of salicylic acid,

1-10% by weight of zinc oxide,

5-50% by weight sulfur milk,

1-5% by weight of cod liver oil and

It contains up to 100% by weight of base cream, while the base cream may optionally contain other additives known and customary for curative ointment.

A preferred embodiment of the cream according to the invention is characterized in that the weight ratio of its active compounds, i.e. salicylic acid, zinc oxide, sulfur milk and cod liver oil is 1: 2: 5: 1.

The components of the above composition have been used separately for similar purposes, e.g. drying zinc ointment, the use of cod liver oil in cosmetics, and the use of sulfur milk (finely divided elemental sulfur) in a shaking mixture, e.g. against fungal fungus. It should be noted, however, that the cream containing all of the above ingredients in the above-mentioned amounts is not included in the NO-FO book or other pharmaceutical literature and is therefore considered to be novel. Quantitative ratio can play a very important role here. According to the experiments carried out so far, the effect of the cream according to the invention will be illustrated below in the individual cases.

The ingredients of the cream are easy to obtain and inexpensive. Salicylic acid is also known as a commercially available chemical, zinc oxide. Cod liver oil (Oleum jecoris aselli) is available from all pharmacies; It belongs to the semi-drying oils, contains vitamin A and D and glycerides of acellic acid, jecoric acid and therapeutic acid in addition to oleic acid glyceride. Fine sulfur is also known and commercially available.

A base lotion for good distribution of the components and lubricity can be any of the base or base lotions used for such purposes. Recipes can be found in the Hungarian Pharmacopoeia and the Handbook of the Cosmetic Industry. (ed. by Dr. Imre Hajdú, Technical Publishing House Budapest, 1962, pp. 260-268). Base creams may also contain various known additives. We have made the above claim regarding the possible addition of the base cream in order to include in the patented composition of the invention a composition identical to ours, but additionally e.g. It also contains the fatty extract of calendula (Calendula officinalis), which has long been used for the treatment of difficult to heal wounds.

The cream according to the invention is prepared by simply mixing the ingredients and homogenizing the mixture, so that the necessary equipment is very simple: a mixer, a dispenser and then a tube or a brick filling apparatus are required.

Based on the experimental data available to date, the uses of the cream include, but are not limited to, the following: treatment of ulcer wounds; healing of abrasive, bruised, broken skin (shoes, limb prosthesis, lack of epithelium due to sportswear); for quick healing of deep cuts directly after disinfection after application to the wound (deep wounds which are difficult to disinfect, eg soil, fish, meat broths do not burn); treating burned skin if the burn has already caused injuries to the back; for the treatment of yeast fungus (feet, scalp, body covered with diaper); daily injuries to children (including bicycle falls, slides, rough concrete, crushed wounds); topical treatment of acne and blackheads; it is also recommended to apply the cream to surgical wounds immediately after surgery.

The application details so far, and the experiences in the individual case descriptions, have been gained by testing the cream for ourselves, our family members, direct friends, acquaintances and coworkers, and for the Budapest Association for the Disabled to try the cream.

The composition of the preparation prevents the infection of the injured skin surface, and skin nourishing agents promote rapid epithelial formation. The elastic wound surface heals without complaints, the var can be easily removed, and the wound-itching feeling typical of wound healing is absent. The dressing does not stick to the wound and other preparations for dressing change are no longer required. The wound is healing2

EN 212 680 Β healing time is reduced by 1 to 3 days. During the healing process, the sensation of pain is significantly reduced.

Because the composition is very firm, after regular cleaning and disinfection of the wound area, the cream should be applied lightly to the injured area so that the cream covers the entire wound surface. It is enough to do the treatment once a day. All you have to do is wipe off the cream you apply before you apply it again, with a light touch. There is no need to remove the wound dressing. When dressing, the wound surface should, as far as possible, only be covered with a thin gauze blade to ventilate the wound.

The following exemplary embodiment of the cream is provided without limitation.

Example

1000 g of cream

29,410 g of salicylic acid,

58,820 g of zinc oxide,

147,000 grams of sulfur milk and

29,410 g of cod liver oil

735.250 g of base cream are mixed and the mixture is well homogenized. Composition of base cream used (% by weight):

12% stearin monoglyceride

1.0% sodium alginate

1.5% isopropyl myristate

14.6% glycerol

70.9% water.

The preparation thus obtained was used in the following cases.

1. Managing a Bed

X. X. An older man had a wound on his back during a long hospital stay that had not responded to any other treatment for 2 months. The wound, which became larger in size and finally palm-sized, was lightly peeled after 3-4 days with the cream of the invention and healed after 10 days.

2. Surgical wound care

Our little boy had to sew his face twice. The first time the wound was glued, we couldn't use the cream. The healing was slow, the wound remaining ugly for years.

Years after the first accident, the boy fell so unfortunate that the wound could not be glued (he bitten the flesh under his mouth) and could not be bandaged, but the depth of the wound and possible contamination during meals made him very concerned. We were able to use the cream, and by the time the order for sutures was taken 7 days later, the var had fallen out of the healed wound, and the sutures had no purpose at all to the surprise of the surgeon.

PATENT CLAIMS

Claims (2)

PATIENT INDIVIDUAL POINTS A method of producing a medicated cream comprising zinc oxide, salicylic acid, and cod liver oil, and sulfur, characterized in that: 1-5% by weight salicylic acid, 1-10% zinc oxide, 5-50% by weight of sulfur milk, 1-5% by weight of cod liver oil and In a quantity of up to 100% by weight, the base cream, which may optionally contain other additives known in the art for ointment, is mixed and converted into a cream suitable for the rapid treatment of epithelial skin surfaces. Process according to claim 1, characterized in that the active ingredients of the cream, i.e. salicylic acid, zinc oxide, sulfur milk and cod liver oil, are used in a weight ratio of 1: 2: 5: 1.