HU210667B - Process for producing n,n'-bis(dicarboxy-methyl)-1,4,10,13-tetraoxa-7,16-diaza-cyclooktadecane derivatives, salts and complexes thereof and pharmaceutical compositions containing them - Google Patents
Process for producing n,n'-bis(dicarboxy-methyl)-1,4,10,13-tetraoxa-7,16-diaza-cyclooktadecane derivatives, salts and complexes thereof and pharmaceutical compositions containing themInfo
- Publication number
- HU210667B HU210667B HU90145A HU14590A HU210667B HU 210667 B HU210667 B HU 210667B HU 90145 A HU90145 A HU 90145A HU 14590 A HU14590 A HU 14590A HU 210667 B HU210667 B HU 210667B
- Authority
- HU
- Hungary
- Prior art keywords
- tetraoxa
- diaza
- bis
- derivatives
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/08—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and more than one oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
A találmány tárgya eljárás új N,N'-bisz(dikarbőxi-metil)-1,4,10,13-tetraőxa-7,16-diaza-ciklőőktadekán és származékai (I) általánősképletű vízőldható sói és kőmplexei előállítására. A képletben R jelentése hidrőgénatőm, 1–5 szénatőmős egyenes vagy elágazó láncúalkilcsőpőrt vagy benzilcsőpőrt, M és N jelentése azőnős vagy különböző és lehet hidrőgén-atőm, alkálifém-vagy alkáliföldfém-atőm vagy ammóniűmiőn és Me jelentése átmeneti fém, előnyösen vas- vagy cinkatőm vagyalkáliföldfém-atőm, előnyösen magnéziűm- vagy kalciűmatőm m és n 1 vagy 2 p 1, 2 vagy 3 q 0 vagy 1, s és r 0, 1 vagy 2, azzal a megkötéssel, hőgy a hidrőgénatőmők száma 0, 1 vagy 2 és azzal a megkötéssel, hőgy ha q 1 akkőr s és r nem lehet egyszerre 0vagy 2, és azzal a megkötéssel, hőgy ha q 0, akkőr M és N nem lehetalkáliföldfém-atőm vagy ammóniűmiőn, tővábbá, ha q jelentése 0 ésmindkét R jelentése hidrőgénatőm, akkőr M és N nem lehet azőnősátriűm- vagy lítiűmatőm. A találmány tárgya tővábbá ezeket avegyületeket tartalmazó radiőaktív fémizőtópők kiürülését főkőzógyógyászati készítmények előállítása is. ŕThe present invention relates to a process for the preparation of novel N, N'-bis (dicarboxymethyl) -1,4,10,13-tetraoxa-7,16-diaza-cyclooctadecane and its derivatives (I) of the general formula. In the formula, R is hydrogen, C1-C5 straight or branched alkyl or benzyl, M and N are single or different and may be hydrogen, alkali or alkaline earth or ammonium, preferably iron or metal, and Me is , preferably magnesium or calcium, m and n 1 or 2 p 1, 2 or 3 q 0 or 1, s and r 0, 1 or 2, with the proviso that the number of hydrogen atoms is 0, 1 or 2 and with the proviso that q 1 then s and r cannot be 0 or 2 at the same time, and with the proviso that q 0, then M and N cannot be alkaline earth metal or ammonium, especially if q is 0 and both R are hydrogen, then M and N cannot be my mother tent or lithium mat. It is a further object of the present invention to provide major stoning pharmaceutical compositions for the depletion of radioactive metallization ponds containing these compounds. ŕ
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU90145A HU210667B (en) | 1990-01-16 | 1990-01-16 | Process for producing n,n'-bis(dicarboxy-methyl)-1,4,10,13-tetraoxa-7,16-diaza-cyclooktadecane derivatives, salts and complexes thereof and pharmaceutical compositions containing them |
HU9502769A HUT73493A (en) | 1990-01-16 | 1990-01-16 | Salts and complexes of n,n`-bis(dicarboxy-methyl)-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadekane derivatives, ad pharmaceutical compositions containing them |
UA5001786A UA35547C2 (en) | 1990-01-16 | 1990-11-07 | 1,4,10,13-TETRAOXA-7,16-DIAZACYCLOOCTADECANE DERIVATIVES, DISODIUM SALT OF N,N1-BIS(DICARBOMETHYL)-1,4,10,13-TETRAOXA -7,16-DIAZACYCLOOCTADECANE -CALCIUM COMPLEX AND COMPOSITIONS ON THEIR BASIS for elimination of metal ions in living organism |
CA002048627A CA2048627A1 (en) | 1990-01-16 | 1990-11-07 | 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane derivatives, pharmaceutical compositions containing them and their use for the removal of toxic metal ions and radioactive isotopes from the living organism |
AU67116/90A AU645507B2 (en) | 1990-01-16 | 1990-11-07 | 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane derivatives, pharmaceutical compositions containing them and their use for the removal of toxic metal ions and radioactive isotopes from the living organism |
KR1019910701044A KR970009042B1 (en) | 1990-01-16 | 1990-11-07 | 1.4.10.13 - tetraoxa -7.16-diazacycloactadecane derivatives and pharmaceutical compositions containing them |
EP90916523A EP0463123A1 (en) | 1990-01-16 | 1990-11-07 | 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane derivatives, pharmaceutical compositions containing them and their use for the removal of toxic metal ions and radioactive isotopes from the living organism |
JP2515439A JPH04505626A (en) | 1990-01-16 | 1990-11-07 | 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane derivatives, pharmaceutical compositions containing them and their use for the removal of toxic metal ions and radioisotopes from living organisms |
SU905001786A RU2060256C1 (en) | 1990-01-16 | 1990-11-07 | Derivatives of 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane showing capability to eliminate radioactive isotopes from the living organism, and pharmaceutical composition for elimination of radioactive isotopes from organism |
PCT/HU1990/000070 WO1991010655A1 (en) | 1990-01-16 | 1990-11-07 | 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane derivatives, pharmaceutical compositions containing them and their use for the removal of toxic metal ions and radioactive isotopes from the living organism |
IN943/MAS/90A IN171733B (en) | 1990-01-16 | 1990-11-22 | |
US08/102,955 US5440031A (en) | 1990-01-16 | 1993-08-06 | 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane derivatives, pharmaceutical compositions containing them and their use for the removal of toxic metal ions and radioactive isotopes from living organism |
HU95P/P00244P HU211923A9 (en) | 1990-01-16 | 1995-06-19 | 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane derivatives, pharmaceutical compositions containing them and their use for the removal of toxic metal ions and radioactive isotopes from the living organism |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU90145A HU210667B (en) | 1990-01-16 | 1990-01-16 | Process for producing n,n'-bis(dicarboxy-methyl)-1,4,10,13-tetraoxa-7,16-diaza-cyclooktadecane derivatives, salts and complexes thereof and pharmaceutical compositions containing them |
Publications (2)
Publication Number | Publication Date |
---|---|
HU900145D0 HU900145D0 (en) | 1990-03-28 |
HU210667B true HU210667B (en) | 1998-03-30 |
Family
ID=10948158
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9502769A HUT73493A (en) | 1990-01-16 | 1990-01-16 | Salts and complexes of n,n`-bis(dicarboxy-methyl)-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadekane derivatives, ad pharmaceutical compositions containing them |
HU90145A HU210667B (en) | 1990-01-16 | 1990-01-16 | Process for producing n,n'-bis(dicarboxy-methyl)-1,4,10,13-tetraoxa-7,16-diaza-cyclooktadecane derivatives, salts and complexes thereof and pharmaceutical compositions containing them |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU9502769A HUT73493A (en) | 1990-01-16 | 1990-01-16 | Salts and complexes of n,n`-bis(dicarboxy-methyl)-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadekane derivatives, ad pharmaceutical compositions containing them |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0463123A1 (en) |
JP (1) | JPH04505626A (en) |
KR (1) | KR970009042B1 (en) |
AU (1) | AU645507B2 (en) |
CA (1) | CA2048627A1 (en) |
HU (2) | HUT73493A (en) |
IN (1) | IN171733B (en) |
RU (1) | RU2060256C1 (en) |
UA (1) | UA35547C2 (en) |
WO (1) | WO1991010655A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0554358A4 (en) * | 1990-09-27 | 1995-09-06 | Brunswick Corp | Chelating agents |
HUP1100731A2 (en) * | 2011-12-30 | 2013-06-28 | Stratoxer S Kft | Complex forming compounds |
EA019079B1 (en) * | 2012-06-19 | 2013-12-30 | Елена Владимировна ОРЛОВА | BIOSAFETY NANOCOMPOSITE POLYMER SORBENT FOR SELECTIVE BINDING OF Sr AND Cs ISOTOPES FROM LIQUID MEDIUMS AND RAW MIX FOR PRODUCING SAME |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4190462A (en) * | 1978-07-04 | 1980-02-26 | Shell Oil Company | Dissolving barium sulfate scale with aqueous solutions of salts of carboxymethyl monocyclic macrocyclic polyamines |
US4597903A (en) * | 1984-08-21 | 1986-07-01 | University Of Maryland | Process for the direct preparation of N,N-disubstituted derivatives for 4,13-diaza-18-crown-6 |
JPS61263964A (en) * | 1985-05-17 | 1986-11-21 | Terumo Corp | Novel crown (thio)ether and production thereof |
-
1990
- 1990-01-16 HU HU9502769A patent/HUT73493A/en unknown
- 1990-01-16 HU HU90145A patent/HU210667B/en not_active IP Right Cessation
- 1990-11-07 UA UA5001786A patent/UA35547C2/en unknown
- 1990-11-07 AU AU67116/90A patent/AU645507B2/en not_active Ceased
- 1990-11-07 RU SU905001786A patent/RU2060256C1/en active
- 1990-11-07 CA CA002048627A patent/CA2048627A1/en not_active Abandoned
- 1990-11-07 EP EP90916523A patent/EP0463123A1/en not_active Withdrawn
- 1990-11-07 JP JP2515439A patent/JPH04505626A/en active Pending
- 1990-11-07 KR KR1019910701044A patent/KR970009042B1/en active IP Right Grant
- 1990-11-07 WO PCT/HU1990/000070 patent/WO1991010655A1/en not_active Application Discontinuation
- 1990-11-22 IN IN943/MAS/90A patent/IN171733B/en unknown
Also Published As
Publication number | Publication date |
---|---|
HU9502769D0 (en) | 1995-11-28 |
HU900145D0 (en) | 1990-03-28 |
UA35547C2 (en) | 2001-04-16 |
KR920701184A (en) | 1992-08-11 |
AU645507B2 (en) | 1994-01-20 |
RU2060256C1 (en) | 1996-05-20 |
CA2048627A1 (en) | 1991-07-17 |
IN171733B (en) | 1992-12-26 |
KR970009042B1 (en) | 1997-06-03 |
AU6711690A (en) | 1991-08-05 |
WO1991010655A1 (en) | 1991-07-25 |
EP0463123A1 (en) | 1992-01-02 |
JPH04505626A (en) | 1992-10-01 |
HUT73493A (en) | 1996-08-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HMM4 | Cancellation of final prot. due to non-payment of fee | ||
HPC4 | Succession in title of patentee |
Owner name: NUCLETECH KUTATO-FEJLESZTOE, EGESZSEGUEGYI ES KERE |
|
HMM4 | Cancellation of final prot. due to non-payment of fee | ||
HMM4 | Cancellation of final prot. due to non-payment of fee |