HU210667B - Process for producing n,n'-bis(dicarboxy-methyl)-1,4,10,13-tetraoxa-7,16-diaza-cyclooktadecane derivatives, salts and complexes thereof and pharmaceutical compositions containing them - Google Patents

Process for producing n,n'-bis(dicarboxy-methyl)-1,4,10,13-tetraoxa-7,16-diaza-cyclooktadecane derivatives, salts and complexes thereof and pharmaceutical compositions containing them

Info

Publication number
HU210667B
HU210667B HU90145A HU14590A HU210667B HU 210667 B HU210667 B HU 210667B HU 90145 A HU90145 A HU 90145A HU 14590 A HU14590 A HU 14590A HU 210667 B HU210667 B HU 210667B
Authority
HU
Hungary
Prior art keywords
tetraoxa
diaza
bis
derivatives
hydrogen
Prior art date
Application number
HU90145A
Other languages
Hungarian (hu)
Other versions
HU900145D0 (en
Inventor
László Varga
József Emri
Béla Győri
Zoltán Kovács
B. László Sztanyik
Ernő Brücher
Béla Kanyár
Ödön Király
Original Assignee
NUCLETECH Kutató-Fejlesztő, Egészségügyi és Kereskedelmi Korlátolt Felelősségű Társaság
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NUCLETECH Kutató-Fejlesztő, Egészségügyi és Kereskedelmi Korlátolt Felelősségű Társaság filed Critical NUCLETECH Kutató-Fejlesztő, Egészségügyi és Kereskedelmi Korlátolt Felelősségű Társaság
Priority to HU90145A priority Critical patent/HU210667B/en
Priority to HU9502769A priority patent/HUT73493A/en
Publication of HU900145D0 publication Critical patent/HU900145D0/en
Priority to JP2515439A priority patent/JPH04505626A/en
Priority to AU67116/90A priority patent/AU645507B2/en
Priority to KR1019910701044A priority patent/KR970009042B1/en
Priority to EP90916523A priority patent/EP0463123A1/en
Priority to CA002048627A priority patent/CA2048627A1/en
Priority to SU905001786A priority patent/RU2060256C1/en
Priority to PCT/HU1990/000070 priority patent/WO1991010655A1/en
Priority to UA5001786A priority patent/UA35547C2/en
Priority to IN943/MAS/90A priority patent/IN171733B/en
Priority to US08/102,955 priority patent/US5440031A/en
Priority to HU95P/P00244P priority patent/HU211923A9/en
Publication of HU210667B publication Critical patent/HU210667B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/08—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and more than one oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A találmány tárgya eljárás új N,N'-bisz(dikarbőxi-metil)-1,4,10,13-tetraőxa-7,16-diaza-ciklőőktadekán és származékai (I) általánősképletű vízőldható sói és kőmplexei előállítására. A képletben R jelentése hidrőgénatőm, 1–5 szénatőmős egyenes vagy elágazó láncúalkilcsőpőrt vagy benzilcsőpőrt, M és N jelentése azőnős vagy különböző és lehet hidrőgén-atőm, alkálifém-vagy alkáliföldfém-atőm vagy ammóniűmiőn és Me jelentése átmeneti fém, előnyösen vas- vagy cinkatőm vagyalkáliföldfém-atőm, előnyösen magnéziűm- vagy kalciűmatőm m és n 1 vagy 2 p 1, 2 vagy 3 q 0 vagy 1, s és r 0, 1 vagy 2, azzal a megkötéssel, hőgy a hidrőgénatőmők száma 0, 1 vagy 2 és azzal a megkötéssel, hőgy ha q 1 akkőr s és r nem lehet egyszerre 0vagy 2, és azzal a megkötéssel, hőgy ha q 0, akkőr M és N nem lehetalkáliföldfém-atőm vagy ammóniűmiőn, tővábbá, ha q jelentése 0 ésmindkét R jelentése hidrőgénatőm, akkőr M és N nem lehet azőnősátriűm- vagy lítiűmatőm. A találmány tárgya tővábbá ezeket avegyületeket tartalmazó radiőaktív fémizőtópők kiürülését főkőzógyógyászati készítmények előállítása is. ŕThe present invention relates to a process for the preparation of novel N, N'-bis (dicarboxymethyl) -1,4,10,13-tetraoxa-7,16-diaza-cyclooctadecane and its derivatives (I) of the general formula. In the formula, R is hydrogen, C1-C5 straight or branched alkyl or benzyl, M and N are single or different and may be hydrogen, alkali or alkaline earth or ammonium, preferably iron or metal, and Me is , preferably magnesium or calcium, m and n 1 or 2 p 1, 2 or 3 q 0 or 1, s and r 0, 1 or 2, with the proviso that the number of hydrogen atoms is 0, 1 or 2 and with the proviso that q 1 then s and r cannot be 0 or 2 at the same time, and with the proviso that q 0, then M and N cannot be alkaline earth metal or ammonium, especially if q is 0 and both R are hydrogen, then M and N cannot be my mother tent or lithium mat. It is a further object of the present invention to provide major stoning pharmaceutical compositions for the depletion of radioactive metallization ponds containing these compounds. ŕ

HU90145A 1990-01-16 1990-01-16 Process for producing n,n'-bis(dicarboxy-methyl)-1,4,10,13-tetraoxa-7,16-diaza-cyclooktadecane derivatives, salts and complexes thereof and pharmaceutical compositions containing them HU210667B (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
HU90145A HU210667B (en) 1990-01-16 1990-01-16 Process for producing n,n'-bis(dicarboxy-methyl)-1,4,10,13-tetraoxa-7,16-diaza-cyclooktadecane derivatives, salts and complexes thereof and pharmaceutical compositions containing them
HU9502769A HUT73493A (en) 1990-01-16 1990-01-16 Salts and complexes of n,n`-bis(dicarboxy-methyl)-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadekane derivatives, ad pharmaceutical compositions containing them
UA5001786A UA35547C2 (en) 1990-01-16 1990-11-07 1,4,10,13-TETRAOXA-7,16-DIAZACYCLOOCTADECANE DERIVATIVES, DISODIUM SALT OF N,N1-BIS(DICARBOMETHYL)-1,4,10,13-TETRAOXA -7,16-DIAZACYCLOOCTADECANE -CALCIUM COMPLEX AND COMPOSITIONS ON THEIR BASIS for elimination of metal ions in living organism
CA002048627A CA2048627A1 (en) 1990-01-16 1990-11-07 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane derivatives, pharmaceutical compositions containing them and their use for the removal of toxic metal ions and radioactive isotopes from the living organism
AU67116/90A AU645507B2 (en) 1990-01-16 1990-11-07 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane derivatives, pharmaceutical compositions containing them and their use for the removal of toxic metal ions and radioactive isotopes from the living organism
KR1019910701044A KR970009042B1 (en) 1990-01-16 1990-11-07 1.4.10.13 - tetraoxa -7.16-diazacycloactadecane derivatives and pharmaceutical compositions containing them
EP90916523A EP0463123A1 (en) 1990-01-16 1990-11-07 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane derivatives, pharmaceutical compositions containing them and their use for the removal of toxic metal ions and radioactive isotopes from the living organism
JP2515439A JPH04505626A (en) 1990-01-16 1990-11-07 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane derivatives, pharmaceutical compositions containing them and their use for the removal of toxic metal ions and radioisotopes from living organisms
SU905001786A RU2060256C1 (en) 1990-01-16 1990-11-07 Derivatives of 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane showing capability to eliminate radioactive isotopes from the living organism, and pharmaceutical composition for elimination of radioactive isotopes from organism
PCT/HU1990/000070 WO1991010655A1 (en) 1990-01-16 1990-11-07 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane derivatives, pharmaceutical compositions containing them and their use for the removal of toxic metal ions and radioactive isotopes from the living organism
IN943/MAS/90A IN171733B (en) 1990-01-16 1990-11-22
US08/102,955 US5440031A (en) 1990-01-16 1993-08-06 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane derivatives, pharmaceutical compositions containing them and their use for the removal of toxic metal ions and radioactive isotopes from living organism
HU95P/P00244P HU211923A9 (en) 1990-01-16 1995-06-19 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane derivatives, pharmaceutical compositions containing them and their use for the removal of toxic metal ions and radioactive isotopes from the living organism

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU90145A HU210667B (en) 1990-01-16 1990-01-16 Process for producing n,n'-bis(dicarboxy-methyl)-1,4,10,13-tetraoxa-7,16-diaza-cyclooktadecane derivatives, salts and complexes thereof and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
HU900145D0 HU900145D0 (en) 1990-03-28
HU210667B true HU210667B (en) 1998-03-30

Family

ID=10948158

Family Applications (2)

Application Number Title Priority Date Filing Date
HU9502769A HUT73493A (en) 1990-01-16 1990-01-16 Salts and complexes of n,n`-bis(dicarboxy-methyl)-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadekane derivatives, ad pharmaceutical compositions containing them
HU90145A HU210667B (en) 1990-01-16 1990-01-16 Process for producing n,n'-bis(dicarboxy-methyl)-1,4,10,13-tetraoxa-7,16-diaza-cyclooktadecane derivatives, salts and complexes thereof and pharmaceutical compositions containing them

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HU9502769A HUT73493A (en) 1990-01-16 1990-01-16 Salts and complexes of n,n`-bis(dicarboxy-methyl)-1,4,10,13-tetraoxa-7,16-diaza-cyclooctadekane derivatives, ad pharmaceutical compositions containing them

Country Status (10)

Country Link
EP (1) EP0463123A1 (en)
JP (1) JPH04505626A (en)
KR (1) KR970009042B1 (en)
AU (1) AU645507B2 (en)
CA (1) CA2048627A1 (en)
HU (2) HUT73493A (en)
IN (1) IN171733B (en)
RU (1) RU2060256C1 (en)
UA (1) UA35547C2 (en)
WO (1) WO1991010655A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0554358A4 (en) * 1990-09-27 1995-09-06 Brunswick Corp Chelating agents
HUP1100731A2 (en) * 2011-12-30 2013-06-28 Stratoxer S Kft Complex forming compounds
EA019079B1 (en) * 2012-06-19 2013-12-30 Елена Владимировна ОРЛОВА BIOSAFETY NANOCOMPOSITE POLYMER SORBENT FOR SELECTIVE BINDING OF Sr AND Cs ISOTOPES FROM LIQUID MEDIUMS AND RAW MIX FOR PRODUCING SAME

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4190462A (en) * 1978-07-04 1980-02-26 Shell Oil Company Dissolving barium sulfate scale with aqueous solutions of salts of carboxymethyl monocyclic macrocyclic polyamines
US4597903A (en) * 1984-08-21 1986-07-01 University Of Maryland Process for the direct preparation of N,N-disubstituted derivatives for 4,13-diaza-18-crown-6
JPS61263964A (en) * 1985-05-17 1986-11-21 Terumo Corp Novel crown (thio)ether and production thereof

Also Published As

Publication number Publication date
HU9502769D0 (en) 1995-11-28
HU900145D0 (en) 1990-03-28
UA35547C2 (en) 2001-04-16
KR920701184A (en) 1992-08-11
AU645507B2 (en) 1994-01-20
RU2060256C1 (en) 1996-05-20
CA2048627A1 (en) 1991-07-17
IN171733B (en) 1992-12-26
KR970009042B1 (en) 1997-06-03
AU6711690A (en) 1991-08-05
WO1991010655A1 (en) 1991-07-25
EP0463123A1 (en) 1992-01-02
JPH04505626A (en) 1992-10-01
HUT73493A (en) 1996-08-28

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Legal Events

Date Code Title Description
HMM4 Cancellation of final prot. due to non-payment of fee
HPC4 Succession in title of patentee

Owner name: NUCLETECH KUTATO-FEJLESZTOE, EGESZSEGUEGYI ES KERE

HMM4 Cancellation of final prot. due to non-payment of fee
HMM4 Cancellation of final prot. due to non-payment of fee