UA35547C2 - 1,4,10,13-TETRAOXA-7,16-DIAZACYCLOOCTADECANE DERIVATIVES, DISODIUM SALT OF N,N1-BIS(DICARBOMETHYL)-1,4,10,13-TETRAOXA -7,16-DIAZACYCLOOCTADECANE -CALCIUM COMPLEX AND COMPOSITIONS ON THEIR BASIS for elimination of metal ions in living organism - Google Patents

1,4,10,13-TETRAOXA-7,16-DIAZACYCLOOCTADECANE DERIVATIVES, DISODIUM SALT OF N,N1-BIS(DICARBOMETHYL)-1,4,10,13-TETRAOXA -7,16-DIAZACYCLOOCTADECANE -CALCIUM COMPLEX AND COMPOSITIONS ON THEIR BASIS for elimination of metal ions in living organism

Info

Publication number
UA35547C2
UA35547C2 UA5001786A UA5001786A UA35547C2 UA 35547 C2 UA35547 C2 UA 35547C2 UA 5001786 A UA5001786 A UA 5001786A UA 5001786 A UA5001786 A UA 5001786A UA 35547 C2 UA35547 C2 UA 35547C2
Authority
UA
Ukraine
Prior art keywords
diazacyclooctadecane
tetraoxa
metal
group
hydrogen
Prior art date
Application number
UA5001786A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Йожеф ЕМРІ
Йожеф ЭМРИ
Бейла ДЕРІ
Бейла ДЕРИ
Золтан Ковач
Ерньо БРЮХЕР
Эрне БРЮХЕР
Ласло СТАНІК
Ласло СТАНИК
Ласло ВАРГА
Йодьон КІРАЙ
Йоден КИРАЙ
Бейла КАНЯР
Original Assignee
Орсагош "Фредерік Жоліо-Кюрі" Шугарбіологіаі Еш Шугарегесшетюдьї Кутато Інтезет
Орсагош "Фредерик Жолио-Кюри" Шугарбиологиаи Эш Шугарегесшетюдьи Кутато Интезет
Кошшут Лайош Тудоманьедетем
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Орсагош "Фредерік Жоліо-Кюрі" Шугарбіологіаі Еш Шугарегесшетюдьї Кутато Інтезет, Орсагош "Фредерик Жолио-Кюри" Шугарбиологиаи Эш Шугарегесшетюдьи Кутато Интезет, Кошшут Лайош Тудоманьедетем filed Critical Орсагош "Фредерік Жоліо-Кюрі" Шугарбіологіаі Еш Шугарегесшетюдьї Кутато Інтезет
Publication of UA35547C2 publication Critical patent/UA35547C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/08—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and more than one oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The invention relates to partially novel metal complexes, salts and double salts of 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane compounds of formula (I) (I) wherein Q1 and Q2 mean hydrogen or a group of formula (III), (III) in the groups of formula (III) the R substituents independently represent hydrogen, a C1-5 straight or branched chain alkyl group, a C2-5 straight or branched chain alkenyl group, phenyl or phenyl-C1-5alkyl group, the two latter ones optionally being substituted on their aromatic part by one or more halogen(s), C1-5alkyl, C1-5alkoxy, cyano or nitro group(s), with the proviso that at least one of Q1 and Q2 is other than hydrogen; Me stands for an alkaline metal or alkaline earth metal or transition metal ion; q is 0 or 1; M and N, independently from each other, stand for hydrogen or an alkaline metal, alkaline earth metal or optionally substituted ammonium ion; m, n and p are integers each being equal to the charge of M, N or Me, respectively; s and r are, independently from each other, 0, 1, 2, 3 or 4, with the proviso that (i) r, s and q cannot simultaneously be 0; and (ii) the number of hydrogens in the meaning of M or N may be 0, 1 or 2, as well as pharmaceutical compositions containing these compounds. The compounds and compositions according to the invention can be used for decorporation of metal ions, mainly radioactive isotopes such as radioactive strontium or cerium being harmful to the living organism. The active agents according to the invention exert their effects either in intravenous or local, transdermal or rectal route of administration.
UA5001786A 1990-01-16 1990-11-07 1,4,10,13-TETRAOXA-7,16-DIAZACYCLOOCTADECANE DERIVATIVES, DISODIUM SALT OF N,N1-BIS(DICARBOMETHYL)-1,4,10,13-TETRAOXA -7,16-DIAZACYCLOOCTADECANE -CALCIUM COMPLEX AND COMPOSITIONS ON THEIR BASIS for elimination of metal ions in living organism UA35547C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU90145A HU210667B (en) 1990-01-16 1990-01-16 Process for producing n,n'-bis(dicarboxy-methyl)-1,4,10,13-tetraoxa-7,16-diaza-cyclooktadecane derivatives, salts and complexes thereof and pharmaceutical compositions containing them
PCT/HU1990/000070 WO1991010655A1 (en) 1990-01-16 1990-11-07 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane derivatives, pharmaceutical compositions containing them and their use for the removal of toxic metal ions and radioactive isotopes from the living organism

Publications (1)

Publication Number Publication Date
UA35547C2 true UA35547C2 (en) 2001-04-16

Family

ID=10948158

Family Applications (1)

Application Number Title Priority Date Filing Date
UA5001786A UA35547C2 (en) 1990-01-16 1990-11-07 1,4,10,13-TETRAOXA-7,16-DIAZACYCLOOCTADECANE DERIVATIVES, DISODIUM SALT OF N,N1-BIS(DICARBOMETHYL)-1,4,10,13-TETRAOXA -7,16-DIAZACYCLOOCTADECANE -CALCIUM COMPLEX AND COMPOSITIONS ON THEIR BASIS for elimination of metal ions in living organism

Country Status (10)

Country Link
EP (1) EP0463123A1 (en)
JP (1) JPH04505626A (en)
KR (1) KR970009042B1 (en)
AU (1) AU645507B2 (en)
CA (1) CA2048627A1 (en)
HU (2) HUT73493A (en)
IN (1) IN171733B (en)
RU (1) RU2060256C1 (en)
UA (1) UA35547C2 (en)
WO (1) WO1991010655A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992005804A1 (en) * 1990-09-27 1992-04-16 Brunswick Corporation Chelating agents
HUP1100731A2 (en) * 2011-12-30 2013-06-28 Stratoxer S Kft Complex forming compounds
EA201201241A1 (en) * 2012-06-19 2013-12-30 Елена Владимировна ОРЛОВА BIO SAFETY NANOCOMPOSITE POLYMER SORBENT FOR SELECTIVE BINDING OF Sr AND Cs ISOTOPES FROM LIQUID MEDIA AND RAW MATERIAL FOR ITS MANUFACTURE

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4190462A (en) * 1978-07-04 1980-02-26 Shell Oil Company Dissolving barium sulfate scale with aqueous solutions of salts of carboxymethyl monocyclic macrocyclic polyamines
US4597903A (en) * 1984-08-21 1986-07-01 University Of Maryland Process for the direct preparation of N,N-disubstituted derivatives for 4,13-diaza-18-crown-6
JPS61263964A (en) * 1985-05-17 1986-11-21 Terumo Corp Novel crown (thio)ether and production thereof

Also Published As

Publication number Publication date
CA2048627A1 (en) 1991-07-17
IN171733B (en) 1992-12-26
HUT73493A (en) 1996-08-28
JPH04505626A (en) 1992-10-01
KR920701184A (en) 1992-08-11
AU6711690A (en) 1991-08-05
EP0463123A1 (en) 1992-01-02
RU2060256C1 (en) 1996-05-20
AU645507B2 (en) 1994-01-20
HU9502769D0 (en) 1995-11-28
HU210667B (en) 1998-03-30
WO1991010655A1 (en) 1991-07-25
HU900145D0 (en) 1990-03-28
KR970009042B1 (en) 1997-06-03

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