HU207792B - Cosmetical composition for treating mouth-and gingivitis - Google Patents

Abstract

Toothpaste comprises 0.5-60 plant extract in water or alcohol soln. using eg. Plantago lanceolata and Solidago canadensis. Other commonly used additives, such as solid or liquid carriers or other plant extracts can be used.

Description

BACKGROUND OF THE INVENTION The present invention relates to a cosmetic composition for reducing inflammation of the mouth and gums, comprising extract of fennel and golden-grass and medicinal water.

In the XX. The accelerated civilization of the twentieth century brought a significant change from the former natural way of life. Our diet has changed, age has significantly shifted, so we have a greater chance of having various oral and gum diseases. Lack of chewing prevents the teeth from self-cleaning at an early age, and tooth damage occurs at a very young age.

Many types of dentifrices are recommended to eliminate these adverse effects. Some contain mineral abrasives and other synthetic ingredients, while others contain some natural plant extracts.

It is known that tooth decay, oral and pharyngeal inflammation and tooth decay are useful in dentifrice compositions for the treatment of toothache caused by toothache and kelp. (Béla Varró Aladár: Medicinal Effects of Herbs 1991, Reprint 170; p. 202; Dr. Gizella Petri: Modern Therapeutic Use of Medicinal Herbs, Medicina 1989, p. 111; Dr. Nature: Medicine in the Grass, Kódex Kft., 1990, 27, 64)

No. T 48452. Hungarian Patent Publication No. 28,69,1989, discloses a dentifrice composition containing medicinal water and / or abrasive material thereof having a particle size not exceeding 50 micrometres.

DE 1959275, incorporated herein by reference. German Patent No. 4,600,500 discloses an oral care composition in which chamomile extract is used as an anti-inflammatory agent.

The above formulations are of limited use for the indicated dental care purposes, but their applicability is relatively limited. Due to differences in individual susceptibility, tolerability of formulations, and the variety of complaints, it is desirable to use a combination formulation which is relatively widely applicable and synergistic.

Thus, in the course of developing the present invention, we have set out to develop a widely used cosmetic composition containing naturally occurring components that reduce inflammation of the mouth and gums.

In our experiments, it was surprisingly found that using an aqueous and / or ethanolic extract of leaves and / or flowers of Plantago lanceolata (Solid grass) and Solidago canadiensis (golden grass), it is possible to reduce inflammation of the mouth and gums.

Oral inflammation of the mouth and gums may be more advantageously influenced by using medicated water rather than distilled water as the liquid carrier.

Thus, the oral and gum inflammatory cosmetic composition of the present invention comprises from 0.2% to 2.4% by weight of a dry weight content of water and / or ethanol extracts of grasses and kelp containing from 2% to 45% by weight of the composition. 1, and 15-70% by weight, based on the total weight of the composition, of a pH of 7.0 to 8.2, with one or more carriers and / or excipients known in the cosmetics industry.

The plant extracts are prepared in a manner known per se, for example by extracting, if desired, pre-dried plant parts with 2 to 30 times the dry weight of the plant in water or aqueous ethanol solution, preferably at a temperature of 15 to 95 ° C. plant parts) are separated from the liquid phase.

The extraction can be carried out, for example, by extraction, or it is also possible to grind the plant parts and soak them in the solvent used for the extraction. The duration of the soaking can vary widely, preferably from 5 to 48 hours. Extraction is more suitable for industrial applications because in this case the extract can be prepared in a shorter time (30-60 minutes).

At the end of the extraction, if desired, the resulting product may be sterilized, for example, by heating it three times to 80 ° C and holding it briefly at this temperature.

The composition is filled with alkaline medicinal water instead of distilled water. Examples of suitable medicinal waters include Csokonai mineral water from wells 1-2-3 in Debrecen. Csokonai's healing water has a slightly alkaline effect, thus creating unfavorable conditions for the growth of bacteria in the microflora of the mouth, so that there is no or less formation of degradation products that are present in the teeth and teeth. responsible for gingivitis. Another advantage is that its mineral components contain large amounts of fluorides, calcium and magnesium ions, but are completely devoid of nitrite and nitrate ions that are harmful to the body.

Csokonai Healing Water, which is preferably used as an alkaline mineral water, has the following formula:

tially: Na-ion 1651 mg / dm ³ Who are you 21 mg / dm ³ NH ₄ ion 13 mg / dm ³ Ca-ion 13 mg / dm ³ Mg ion 7 mg / dm ³ Fe-ion 0.2 mg / dm ³ Cl-ion 1624 mg / dm ³ Br-ion 5 mg / dm ³ .T-ion 2 mg / dm ³ F-ion 1 mg / dm ³ HCO ₃ ion 1732 mg / dm ³ HBÖ ₂ ion 90 mg / dm ³ H ₂ SiO ₃ 38 mg / dm ³ Free CO ₂ 56 mg / dm ³

The pH of the water is 7.8

The composition according to the invention is a carrier and / or excipient used in the cosmetics industry, such as disinfectants, circulatory agents, epithelializers, abrasives, enamelers, thickeners, moisturizers, foams.

It may contain substances, solubilizers, sweeteners and flavorings.

Suitable disinfectants are, for example, sodium dehydroacetate, trichlorocarbon, triclosan, sodium salicylate, polyvinylpyrrolidone-iodine complex.

Vitamin E nicotinate, benzyl nicotinate, for example, may be used as a blood circulation stimulant.

Examples of missing materials include bisabolol, allantoin, panthenol.

Examples of abrasives for the mechanical cleaning of teeth and the removal of tartar include calcium carbonate, calcium phosphate, silica, calcium lactate, magnesium aluminum silicate, 8-hydroxyquinoline silicofluoride, sodium pyrophosphate, and the like. It can be used.

Suitable enamel forming agents are, for example, sodium monofluorophosphate, sodium fluoride, amine fluoride, dicalcium phosphate, magnesium sulfate.

Suitable thickeners include, for example, carboxymethylcellulose sodium salt (CMC sodium), polyacrylic acid sodium salt, methylcellulose, tragacantha gum and the like. It can be used.

For example, sorbitol, glycerol, propylene glycol, urea may be used.

Exemplary foaming agents are sodium lauryl sulfate.

Suitable solubilizing agents are, for example, hydrogenated linseed oil, sorboxetene derivatives. .

Sweetening and flavoring agents include, for example, Jerusalem artichoke (inulin), sucrose, camphor, menthol, mint oil and the like. It can be used.

Preservatives include, for example, p-hydroxybenzoic acid esters such as methyl esters, potassium sorbate and the like. can be used.

The preparation of the active ingredient of the composition according to the invention and the composition according to the invention are illustrated by the following examples, without limiting the invention to the examples.

Example 1

1 kg of a 1: 1 mixture of Plantago lanceolata leaf and Solidago canadiensis leaf is washed and then, in a special extractor, 7 liters of 95 ° C deionized water is circulated through the mixture for 30 minutes. The extract was cooled to 30 ° C, filtered and then pressed into a steam-sterilized stainless steel container and heated three times at 80 ° C for 1.5 hours for 1.5 hours. The extract had a solids content of 2.41%.

Example 2

A 1: 5 mixture of Plantago lanceolata leaf and flower and Solidago canadiensis flower was ground in a weight ratio of 1: 5 and soaked in 1 L of deionized water for 12 hours and filtered. The extract thus obtained was heat treated as in Example 1. The extract thus obtained has a solids content of 0.21%.

Example 3

A 5: 1 mixture of Plantago lanceolata leaf and flower and Solidago canadiensis leaf and flower was milled in a 5: 1 weight ratio and 1 kg of the mixture was extracted with 10 liters of 70% ethyl alcohol at 50 ° C for 25 minutes in a special extractor. The extract was then cooled to 25 ° C and filtered.

The extract has a dry matter content of 1.21%.

Example 4

Jelly herbal toothpaste

Example 1 Herb Extract Sorbitol solution 70% v / v 3.0 g (humectant) "45.0 g Glycerin (Moisturizer) 11.8 g Sodium monofluorophosphate (enamel protection material) 0.6 g Methyl p-hydroxybenzoate divorce times) 0.1g CMC-Sodium (thickener) 0.9 g Sodium laureth sulfate (cleaning, foaming agent) 1.6 g aroma Material 0.5 g Bunch of mineral water ad 100.0 g Example 5 Whitening, scouring toothpaste Example 1 herbal extract 7.00 g Glycerin (Moisturizer) 20.00 g Methyl p-hydroxybenzoate divorce times) 0.15 g Sodium monofluorophosphate (enamel protection material) 0.66 g Dicalcium phosphate (abrasive) 37.00 g Silica (abrasive) 3.00 g CMC-Sodium (thickener) 1.20 g Sodium laureth sulfate (cleaning, foaming agent) 1.30 g aroma Material 0.50 g Bunch of mineral water ad 100.00 g Example 6 Anti-calculus toothpaste Example 1 herbal extract 5.0 g Glycerin (Moisturizer) 25.0 g Sodium fluoride (enamel protection material) 0.2 g Potassium pyrophosphate (descaler material) 4,5g Silica (abrasive) 21.5 g Titanium dioxide (abrasive) 0.5 g CMC-Sodium (thickener) 1.0 g Sodium laureth sulfate (cleaning, foaming agent) 2.0 g aroma Material 0.5 g Bunch of mineral water ad 100.0 g Example 7 gums atrophy toothpaste Example 1 herbal extract 7.00 g Glycerin (Moisturizer) 20.00 g Sodium monofluorophosphate (enamel protection material) 0.60 g Methyl p-hydroxybenzoate divorce times) 0.20 g

HU 207,792 Β

Bisabolol (anti-inflammatory agent) 0.05 g Sodium monofluorophosphate Vitamin E nicotine (enamel protection material) 0.60 g (blood circulation enhancer) ι, θο g Glycerin (Moisturizer) 30.00 g Sodium laureth sulfate aroma Material 0.50 g (cleaning, foaming agent) 1.00 g 5 Bunch of mineral water ad 100.00 g

Dicalcium phosphate dihydrate (abrasive) 23.60 g

Dicalcium Phosphate Anhydrate (Scouring Example 11. material) 7.90 g Jelly children's toothpaste CMC-Sodium (thickener) 1.20 g Example 1 herbal extract 4.00 g aroma Material 0.50 g 10 CMC-Sodium (thickener) 0.50 g Bunch of mineral water ad 100.00 g Methyl p-hydroxybenzoate (preservative) 0.15 g δ. example Sodium monofluorophosphate Toothpaste with sea salt · (enamel protection material) 0.60 g Example 1 herbal extract 3.00 g 15 Glycerin (Moisturizer) 50.00 g Potassium sorbate (preservative) 0.20 g Silica (abrasive) 15.00 g Glycerin (Moisturizer) 7.00 g Sodium laureth sulfate Sorbitol solution 70% by volume (cleaning, foaming agent) 0.50 g (humectant) 5.00 g aroma Material 0.50 g Calcium carbonate (abrasive) 38.00 g 20 Bunch of mineral water ad 100.00 g CMC-Sodium (thickener) 1.00 g Sea salt (tartar remover) 0.30 g Example 12 aroma Material 0.60 g Tooth whitening toothpaste Bunch of mineral water ad 100.00 g Example 1 herbal extract 5.00 g 25 CMC-Sodium (thickener) 1.20 g Example 9 Sodium monofluorophosphate Sports Toothpaste (enamel protection material) 0.60 g Example 1 herbal extract 2.00 g Potassium sorbate (preservative) 0.20 g Sorbitol solution 70% v / v Glycerin (Moisturizer) 10.00 g (humectant) 20.00 g 30 Calcium carbonate (abrasive) 39.00 g Methyl p-hydroxybenzoate Sodium laureth sulfate divorce times) 0.15 g (cleaning, foaming agent) 0.40 g Sodium monofluorophosphate aroma Material 0.60 g (enamel protection material) 0.60 g Bunch of mineral water ad 100.00 g Silica (abrasive) 5.00 g 35 Titanium dioxide (abrasive) 0.50 g Example 13 CMC-Sodium (thickener) 1.20 g Vitamin mouthwash Sodium laureth sulfate Example 1 herbal extract 40.00 g (cleaning, foaming agent) 1.50 g Glycerin (Moisturizer) 5.00 g Mint oil (flavoring) 1.00 g 40 Vitamin C 1.00 g Water-soluble chlorophyll Ethyl alcohol 96% by volume (disinfectant, epithelial agent) 0,10g (disinfectant, toner) 30.00 g aroma Material 0.50 g Bisabolol (anti-inflammatory agent) 1.00 g Bunch of mineral water ad 100.00 g 45 Polyoxyethylene (40) hydrogenated-castor castor oil Example 10 (solubilizer) 4.00 g Sensitive toothpaste Methyl p-hydroxybenzoate Example 1 herbal extract 10.00 g divorce times) 0.20 g Strontium chloride (anti-inflammatory aroma Material 0.50 g material) 0.50 g 50 Bunch of mineral water ad 100.00 g CMC-Sodium (thickener) allantoin 0.50 g Example 14 epithelial, anti - inflammatory Deodorant mouthwash material) 0.20 g Example 2 herbal extract 18.00 g Bisabolol (anti-inflammatory agent) 0.10 g 55 Example 3 herbal extract 12.00 g d-Panthenol (epithelial substance) 3.00 g Bisabolol (anti-inflammatory agent) 1.00 g Sodium laureth sulfate Glycerin (Moisturizer) 5.00 g (cleaning, foaming agent) 0.50 g PoHoxi-ethylene (40) hydrogenated-castor Methyl p-hydroxybenzoate (canned Nausea oil (solubilizer) 6.00 g solubility or for preservative) 0.15 g 60 4 Ethyl alcohol 96%

HU 207,792 Β

(disinfectant, toner) 40.00 g aroma Material 0.50 g Bunch of mineral water ad 100.00 g Example 15 Anti-inflammatory mouthwash Example 2 herbal extract 35.00 g Example 3 herbal extract 25.00 g Glycerin (Moisturizer) 5.00 g Menthol (a biologically active aroma- material) 0.05 g Bisabolol (anti-inflammatory agent) 1.00 g d-Panthenol (home training material) 1.00 g Methyl p-hydroxybenzoate realistic) 0.20 g aroma Material 0.50 g Csokonai Mineral Water · ad 100.00 g 1. Experimental Example

Example 5 was tested on 30 subjects (male and female), aged 15-52 years. The test subjects were individuals who had a history of regular oral inflammation of the mouth and gums (every 3-4 weeks) with symptoms such as mucosal swelling, pain, and bleeding gums.

The formulation of Example 5 was used for 3 months on a regular basis

- In 27 cases no complaints were reported

- In 2 cases, mild swelling of the gums occurred

- No effect was observed in 1 case

2. Experimental Example

As described in Experimental Example 1, the treatment was carried out with the composition of Example 5, which did not contain extracts of plant grass (Plantago lanceolata) and golden grass (Solidago canadiensis).

After 3 months of use

- in 8 cases, mucous membrane with barely perceptible swelling, slight gingival bleeding

- In 3 cases the mucous membrane is moderately swollen and the gums are hemorrhagic

No effects were observed in -19 cases

3. Experimental Example

As described in Experimental Example 1, the treatment was carried out with the composition of Example 5, which did not contain the Csokonai mineral water and the extract of the goldenrod (Solidago canadiensis).

After 3 months of use

- In 4 cases the mucosa is moderately swollen and the gums are hemorrhagic

- No effects were observed in 26 cases

4. Experimental Example

As described in Experimental Example 1, the treatment was carried out with the composition of Example 5, which did not contain the Csokonai mineral water and extract of Plantago lanceolata.

After 3 months of use

- In 2 cases the mucous membrane is moderately swollen and the gums are hemorrhagic

- In 28 cases no effect was observed

5. Experimental Example

As described in Experimental Example 1, the treatment was carried out with the composition of Example 5, which did not contain the Csokonai mineral water, the extract of the goldenrod (Solidago canadiensis) or the extract of the plant grass (Plantago lanceolata).

After 3 months of use

- In 2 cases the gingival bleeding was reduced

- In 28 cases no effect was observed

6. Experimental Example

As described in Experimental Example 1, the treatment was carried out with the composition of Example 5, which contained extract of plantain and goldenrod, but instead of curative water. water was added during production.

after months of use

- In 6 cases no complaints were reported

- In 3 cases mild swelling of the gums is observed

- In 21 cases there is no positive change.

PATENT CLAIMS

Claims (16)

Cosmetic composition for reducing oral and gum inflammation comprising from 2 to 451% by weight of an aqueous extract and / or ethanol extract of plantain and golden-grass as a herbal extract containing from 2 to 451% by weight of the composition as a plant extract. containing from 1: 5 to 5: 1 by weight, and from 15 to 701% by weight of the composition, of a pH of 7.0 to 8.2, with one or more carriers and / or excipients known in the cosmetic industry . Composition according to Claim 1, characterized in that it contains an aqueous extract of plantain and golden-grass. Composition according to claim 1, characterized in that it contains an aqueous ethanol extract of fennel and kelp. 4. A composition according to any one of claims 1 to 4, characterized in that 16001700 mg / dm ^{3 of} sodium ion, 18-23 mg / dm ^{3 of} potassium ion, 11-16 mg / dm ^{3 of} ammonium ion, 11-16 mg / dm ^{3 of} calcium Magnesium ion 8 mg / dm ³ , Iron ion 0.160.24 mg / dm ³ , Chloride ion 1600-1700 mg / dm ³ , Bromide ion 4-6 mg / dm ³ , 0.16-0.24 mg / dm ^{3 of} iodide ion, 0.8-1.2 mg / dm ^{3 of} fluoride ion, 1620-1800 mg / dm ^{3 of} hydrogencarbonate, 80-100 mg / dm ^{3 of} hydroboroborate, 13 mg / dm ^{3 of} silicic acid contains 4570 mg / dm ^{3 of} free carbon dioxide. 5. Composition according to any one of claims 1 to 3, characterized in that it is generally used as a carrier and / or excipient in the cosmetic industry. It contains disinfectants such as disinfectants, circulating stimulants, epithelializers, abrasives, enamels, thickeners, moisturizers, foamers, solubilizers, sweeteners and flavorings. 6. Composition according to any one of claims 1 to 3, characterized in that the disinfectant is strontium chloride or ethanol. 7. A composition according to any one of claims 1 to 3, characterized in that it contains vitamin E nicotinate as a circulatory agent. 8. Composition according to any one of claims 1 to 3, characterized in that it contains bisabolol, allantoin, panthenol or water-soluble chlorophyll as the epithelializing agent. 9. Composition according to any one of claims 1 to 3, characterized in that it contains calcium carbonate, calcium phosphate, silicon dioxide, titanium dioxide, potassium pyrophosphate or sea salt as abrasives for mechanical cleaning of teeth, the removal of tartar. 10. Composition according to any one of claims 1 to 3, characterized in that it contains sodium monofluorophosphate or sodium fluoride as the enamel-forming agent. 11. Composition according to any one of claims 1 to 3, characterized in that the thickening agent comprises a sodium salt of carboxymethylcellulose. 12. Composition according to any one of claims 1 to 3, characterized in that it contains sorbitol or glycerol as the wetting agent. 13. Composition according to any one of claims 1 to 3, characterized in that it comprises sodium lauryl sulfate as a foaming agent. 14. Composition according to any one of claims 1 to 3, characterized in that it comprises hydrogenated castor oil as a solubilizer. 15. Composition according to any one of claims 1 to 3, characterized in that the flavoring agent is menthol or mint oil. 16. Composition according to any one of claims 1 to 3, characterized in that the preservative is p-hydroxybenzoic acid methyl ester or potassium sorbate.