HU207322B - Process for producing imidazo-benzodiazepin-2/1h/-one derivatives and pharmaceutical compositions containing them - Google Patents
Process for producing imidazo-benzodiazepin-2/1h/-one derivatives and pharmaceutical compositions containing them Download PDFInfo
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- HU207322B HU207322B HU913076A HU307691A HU207322B HU 207322 B HU207322 B HU 207322B HU 913076 A HU913076 A HU 913076A HU 307691 A HU307691 A HU 307691A HU 207322 B HU207322 B HU 207322B
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- Hungary
- Prior art keywords
- formula
- compound
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- hydrogen
- acid
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- 238000000034 method Methods 0.000 title claims description 22
- 230000008569 process Effects 0.000 title claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 5
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- 125000000217 alkyl group Chemical group 0.000 claims abstract description 14
- 239000002253 acid Substances 0.000 claims abstract description 10
- 150000001875 compounds Chemical class 0.000 claims description 56
- 238000002360 preparation method Methods 0.000 claims description 16
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- 125000005843 halogen group Chemical group 0.000 claims description 2
- 231100000252 nontoxic Toxicity 0.000 claims description 2
- 230000003000 nontoxic effect Effects 0.000 claims description 2
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- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 abstract description 5
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- KLNFAMGHSZQYHR-UHFFFAOYSA-N imidazo[4,5-i][1,2]benzodiazepine Chemical compound C1=CC=NN=C2C3=NC=NC3=CC=C21 KLNFAMGHSZQYHR-UHFFFAOYSA-N 0.000 abstract 1
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- SYQIIBRVOSBWME-UHFFFAOYSA-N trichloromethyl formate Chemical compound ClC(Cl)(Cl)OC=O SYQIIBRVOSBWME-UHFFFAOYSA-N 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898920354A GB8920354D0 (en) | 1989-09-08 | 1989-09-08 | Antiviral tetrahydroimidazo(1,4)benzodiazepin-2-thiones |
| HU90896A HU204831B (en) | 1989-02-23 | 1990-02-22 | Process for producing imidazobenzodiazepine derivatives with antiviral effect and pharmaceutical compositions comprising same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU913076D0 HU913076D0 (en) | 1992-10-28 |
| HUT60742A HUT60742A (en) | 1992-10-28 |
| HU207322B true HU207322B (en) | 1993-03-29 |
Family
ID=10662764
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU913076A HU207322B (en) | 1989-09-08 | 1990-02-22 | Process for producing imidazo-benzodiazepin-2/1h/-one derivatives and pharmaceutical compositions containing them |
Country Status (4)
| Country | Link |
|---|---|
| CS (1) | CS275171B2 (cs) |
| GB (1) | GB8920354D0 (cs) |
| HU (1) | HU207322B (cs) |
| RU (1) | RU2024523C1 (cs) |
-
1989
- 1989-09-08 GB GB898920354A patent/GB8920354D0/en active Pending
-
1990
- 1990-02-22 CS CS90854A patent/CS275171B2/cs not_active IP Right Cessation
- 1990-02-22 RU SU904743129A patent/RU2024523C1/ru active
- 1990-02-22 HU HU913076A patent/HU207322B/hu not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2024523C1 (ru) | 1994-12-15 |
| GB8920354D0 (en) | 1989-10-25 |
| HU913076D0 (en) | 1992-10-28 |
| HUT60742A (en) | 1992-10-28 |
| CS9000854A3 (en) | 1992-02-19 |
| CS275171B2 (en) | 1992-02-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| HMM4 | Cancellation of final prot. due to non-payment of fee |