HU206269B - Process for producing solution or ointment suitable for relieving rheumatic pains - Google Patents

Abstract

Soln. and ointment contg. drugs of vegetable origin for relief of rheumatic pains contain aloe extract. The prepns. are made with at least 50 wt. % ethanolic tincture based on green plant. - Soln. also contains an organic reducing agent (ascorbic acid, or hydroquinone), sodium-lauryl-sulphate, eucalyptus and pepper mint oils. The ointment contains ung. hydrophyllicum, nonionicum, lactic acid, urea, betainum-chloratum, glycerol, lemon and lavender oi

Description

The subject of the patent is a solution and ointment made from an extract of an aloe plant belonging to the family Liliaceae, which is suitable for the relief of secondary myalgia and neuralgia. It can be effectively used to reduce alternating "rheumatic pains" 5 caused by degeneration of the intervertebral discs, which radiate to the back, back, waist, or limbs.

The patented plant extract is obtained from the leaves of the aloe plant. It contains aloin, aloeododine and other anthracene derivatives as well as resins as anthranil glycoside. The binding of the aloin C-glycoside in the anthron form is difficult to cleave.

The Ethyl Alcohol Extract, which can be diluted with water, has a characteristic bitter taste. The vegetable juice, insoluble in ethyl alcohol, has a maximum juice content of 5% and a maximum ash content of 2%. The ethyl alcohol-water extract can be stored for a long time in the presence of mild organic reducing agents and retains its efficacy.

The aloe extract solution or ointment is applied to the painful area and then gently rubbed into the skin until dry or absorbed. Treatments should be done on dry skin after washing in the evening and in the morning. If necessary, three times daily treatment can be given. Both formulations can be used separately and together. 25

The solution according to the invention comprises 5 to 95% by weight of ethyl alcohol tincture of aloe leaves, 0.1 to 1% by weight of ascorbic acid, hydroquinone or other organic reducing agent, 0.5 to 1% of eucalyptus oil or / and It contains 0.5-1% by weight of peppermint oil, 0.2-0.5g of sodium laurilsulfate and 30 distilled water and is characterized by a tincture of at least 50% by weight of green plant material.

The ointment according to the invention comprises 30-50% by weight of nonionic hydrophilic ointment, 5-50% by weight of aloetin tincture, up to 35-10% by weight of lactic acid, betaine chloride and urea in the same amount, additionally 1-2% by weight of lemon or lavender oil and 10- Contains 15% by volume of distilled water, characterized in that the tincture is at least 50% by weight of green plant material. 40

The healing effects of Aloe plant varieties have long been known, especially in acute obstipation (see Béla Issekutz: Pharmacology and Healing, Vol. I, 3040).

According to Madaus, Tbc. pulmonun can be successfully used in its initial stages (1938 Lehrbuch 45 Dairy biologist Heilmittel Bd. 1 Verb. G. Thieme). W. Döpp confirmed that drug extracts from leaves of different Aloe varieties have a beneficial effect on tuberculosis (Arzneimittel-Forschung 627, 1953). According to Collins, fresh aloe leaves cure 50 X-ray dermatitis (Journal Amer. Med. No. 23, 1935). Crewe describes the efficacy of healing of eczema, ulcer crusis and burns with aloe (Joum. Amer. Pharm. Asa. No. 4, 1939). According to Telenkov, muscular injection of an extract of aloe vera in patients with brucellosis has shown very good results (Med. Et. Hyg. No. 195,

S. 204, 1951). Nowadays, the medicinal importance of aloe extracts has diminished, mainly used in cosmetics. 60 o

We have no knowledge of any domestic or foreign literature that would suggest or recommend the patented aloe extract for the treatment of muscular and superficial nerve disorders.

Some herbal drugs are 1,8-dihydroxy derivatives of anthracene and are in the form of anthraquinone, anthrone and anthranol. In addition, O- and C-glycosides are also present, as indicated by the plurality of chromatographic zones of alcoholic extracts.

Further details of the preparation of the invention are illustrated in the following example:

/. example

Tincture is made from the leaves of the green aloe plant and 96% ethyl alcohol. The tincture is listed in VI. pharmacopoeia. Tincture is 50% by weight of green matter. Sodium lauryl sulfate as an emulsifier is added to the alcoholic solution, followed by dilution with eucalyptus oil and, after proper homogenization, with distilled water previously dissolved in ascorbic acid.

Tincture of aloe: 45.0 g of aloe

40.0 g ethyl alcohol (96-100% alcohol)

50.0 distilled water

Drug-containing solution: 50.0 g aloe tincture

2.0 g Sodium lauryl sulfate 1.0 g Eucalyptus oil 1.0 g Ascorbic acid

46.0 g distilled water 100.0 2

Example 2

Water-bath melted non-ionic emulsifying ointment at 60-70 ° C is mixed with a mixture of preservative solution and distilled water at 65-70 ° C in a thin stream under stirring. The emulsion is cooled to the gel state and carefully mixed with the components according to the following formula.

Nonionic Hydrophilic Ointment: Nonionic Emulsifying Ointment Conservative Occupation

Distilled water

Drug Ointment Lactic Acid

Betaine chloride Urea Non-ionic hydrophilic ointment

200.0 g 10.0 g

290.0 g

3.0 g

3.0 g (98.5% -101.0% beta) 3.0 g (99-101.03% urea)

Glycerin Distilled water Aloe tincture Lemon oil

50.0 g

5.0 g (85-88% glycerol)

10.0 g

25.0 g (50% green active ingredient) 1.0 g

100.0 g

The use of the aloe plant extract of the present invention has the advantage that it is not rubbed, reddened, itchy, rashed or rubbed against the most externally applied agents for external rheumatic muscular pain.

EN 206 269 Β cause. Its effect is already present after a short time after treatment. Thirty patients were tested and no adverse side effects occurred. The active ingredient is of natural origin and can be used to eliminate orally harmful painkillers.

Claims (1)

Patent Claim Point A process for the preparation of a solution or ointment for the treatment of rheumatic pains comprising: (a) 5-95% aloe tincture and 0.1-11% ascorbic acid or 0.1-1% hydroquinone, 0.51% eucalyptus oil or 0.5-1% peppermint oil for preparation of the solution and 0, 2-0.5% sodium lauryl sulfate 0.5-941% Mixed with water to form a curative solution, or b) for the preparation of an ointment, 5-501% aloe tincture, up to 101% lactic acid and / or up to 101% betaine chloride and / or up to 101% urea, 2-51% glyceryl and 1-21% lemon oil and / or 1- 21% lavender oil is mixed with 30-50% nonionic hydrophilic ointment to form a curative ointment.