HU204691B - Dodorant cosmetic with perfume-free basic material and perfumable at option - Google Patents

Abstract

A scent-free deodorant cosmetic prepn. contains (all wt.%-s): 1.3-27.8 Al chloride or hydroxide, 0.27-11.8 boric acid and/or Na benzoate, 1.13-22.2 ethanol and distilled water to -100. Customary cosmetic agents may also be added.

Description

FIELD OF THE INVENTION The present invention relates to a perfume-free deodorant cosmetic composition.

Today, a wide variety of deodorant cosmetics are available to cover up unpleasant odors such as sweating of the body and feet, and sweating symptoms during adolescence and 5 changes.

The vast majority of deodorant formulations currently known have the disadvantage that only perspiration 10 is deodorized but has little or no effect on the function of sweat glands. Therefore, the effects of such formulations, particularly in conditions of severe sweating, are not sustained and often require re-use of deodorant when the particular situation makes it impossible. Another characteristic disadvantage is that the odoriferous base material (e.g. camphor) usually has a characteristic odor in itself, and this odor must be modified by the addition of additional fragrances. The vast majority of deodorants on the market are fragrant preparations and, because of their distinctive fragrance, are recommended primarily for women or primarily for men and do not allow the simultaneous use of any other male or female perfume or mascara due to any unpleasant odor mixing.

A fragrance-free deodorant product that acts directly on the sweat glands is described in "The Formulation of Cosmetic Specialties". publication (ed.;

Keithler; Drug and Cosm. Ind. N. Y., 1956). The composition disclosed therein contains 8% by weight of aluminum chloride in aqueous ethanol as a carrier; other cosmetic additives (e.g., glycerol) may be added if desired. The aluminum chloride in the composition has a pore tightening and bactericidal action, thereby acting as a sweat reducing, deodorizing and disinfecting agent. The serious advantage of the preparation is that it is completely odorless and thus does not cause unpleasant odor when used in combination with other cosmetics. However, it has the disadvantage 40 that the antiperspirant effect is not long lasting and fungicidal composition is used it is recommended, for example, to use with powdery mildew containing fungicidal active ingredient).

Another major group of deodorant formulations are compositions containing a disinfectant in addition to carriers and other cosmetic excipients (such as perfumes). These compositions are particularly useful for eliminating or suppressing unpleasant odor due to microbial infections. The cosmetic use of boric acid is described in J. Am. Coll. Toxicol. 2, 87 (1983), according to which boric acid has an antiseptic action 55, which may be useful in the treatment of various dermatitis, but at a concentration greater than 5% by weight, causes skin irritation. The Cosmetics Industry Handbook 389, page 389 of Dr. Imre Hajdú, Technical Publishing House, Budapest, 1962, describes a disinfectant powder containing 3% by weight of 60 boric acid. (Ferenc Bodor, Publisher: Technical Publishing House, Budapest, 1973), page 46 states that sodium benzoate can be used as a preservative in cosmetic formulations, and that due to its anti-infective effect it can be used as an active ingredient addition of boric acid and / or sodium benzoate to the deodorant composition containing chlorine increases synergistically the antiperspirant and antimicrobial activity of the composition. Thus, such compositions have a bidirectional deodorant effect (based on inhibition of sweat gland function and suppression of microbial infections) and in both areas significantly exceed the value expected from the sum of the individual activity of the components.

The present invention therefore relates to a cosmetic composition of an odorless, aromatic, deodorant and disinfectant composition which

1.3-27.8% by weight of aluminum chloride or its hydrate

It contains from 1.13% to 22.2% by weight of ethanol and distilled water, optionally together with one or more known cosmetic excipients or compositions. The composition according to the invention contains, in addition to the components listed, from 0.27% to 11.8% by weight of boric acid and / or sodium benzoate, provided that the amount of boric acid is not more than 5% by weight.

The composition of the invention is preferably

10-20% by weight of aluminum chloride or hydrate,

1-5% by weight of boric acid and / or sodium benzoate,

It contains 4-8% by weight of ethanol and the remainder of distilled water.

In the composition of the present invention, 96% by volume ethanol is used in accordance with the general cosmetic specifications. Water, distilled water is also used in accordance with the generally applicable rules for cosmetics. 96% by volume ethanol has a strong disinfectant effect and has a astringent effect in the composition of the invention.

The composition containing aluminum chloride, boric acid and / or sodium benzoate, ethanol and distilled water is completely odorless and therefore, when used in combination with any perfume, facial makeup or other perfumed cosmetic product, does not cause any unpleasant odor mixing. A completely odorless version of the composition of the invention can be used by anyone, regardless of age and gender. However, if desired, any of the fragrances listed above may be admixed to form a perfumed composition.

As mentioned above, the compositions of the invention may optionally contain known cosmetic excipients. Known cosmetic assistant2

One of the characteristic groups of substances B is the various fragrance flavoring substances; another typical group is the propellant for aerosol formation, which may be an environmentally friendly material (e.g. nitrogen) other than Freon type gas

The deodorant composition of the present invention may also be admixed with a known cosmetic composition (e.g., perfumery, lotion, etc.).

The composition of the present invention, in addition to its long-lasting and potent antiperspirant effect, also exhibits excellent antimicrobial activity and is particularly effective against Escherichia coh, Staphylococcus epidermidis, Candida albicans, Microsporum canis and Trichophyton mentagrophytes.

The invention is further illustrated by the following non-limiting Examples.

Example 1

The following composition is prepared:

Aluminum chloride 15% by weight

Boric acid 3% by weight

Ethanol (96% by volume) 6% by weight

Distilled water q. s. gives 100% by weight

Example 2

The following composition is prepared:

Aluminum chloride 2% by weight

Boric acid 0.4% by weight

Ethanol (96% by volume) 1.6% by weight

Distilled water q. s. gives 100.0% by weight

Example 3

The following composition is prepared:

Aluminum chloride 25% by weight

Sodium benzoate 3% by weight

Ethanol (96% by volume) 20% by weight

Distilled water q. s. gives 100% by weight

Example 4

The following composition is prepared:

Aluminum chloride 10% by weight

Boric acid 3% by weight

Sodium benzoate 7% by weight

Ethanol (96% by volume) 12% by weight

Distilled water q. s. gives 100% by weight

Example 5

Comparative Effects Test A: Test for antihypertensive activity

We included 20 subjects who complained of severe sweating. The tests were carried out on hot summer days with a relative humidity of at least 60% and an average temperature of at least 28 ° C. The subjects' right armpit was treated with a formulation of the same composition as described in Example 1 and the left armpit was treated with a formulation similar to that described in Example 1 but containing distilled water instead of boric acid. The subjects were placed with a bulb under the armpit and observed for hour by hour wetting of the bulb. The studies were performed at least three times with one person. It has been found that the subjects under the right armpit began to moisturize on average 1.5 times longer than the left underarm, demonstrating the enhanced antiperspirant effect of the composition of the invention.

The same subjects were also tested with ethanol solution (4:10 ethanol: water) containing 4% by weight boric acid. All persons complained that the solution was completely ineffective.

B: Test for antimicrobial activity

The following formulations were included in the studies:

the formulation of Example 1;

- a composition otherwise prepared as in Example 1 but not containing boric acid (hereinafter referred to as "dehydrated sample");

- a composition otherwise prepared as in Example 1 but not containing aluminum chloride (hereinafter referred to as "AlCl ₃ -free sample").

The antimicrobial activity was tested against the following microorganisms:

Escherichia (E.) coli HNCMB 33 001, Staphylococcus (S.) epidemiidis HNCMB 110 003, Candida (C.) albicans OKI 63/10,

Microsporum (M.) canis OBNI001,

Trichophyton (T.) mentagrophytes var. mentagrophytes OBNI 229/89.

Inocula were prepared from the listed microorganism strains as required by MSZ 20 546 / 11-85. Inoculum preparation was different from that described in the standard in that the culture of Candida albicans was incubated at 37 ° C for 48 hours, while the cultures of Microsporum canis and Trichophyton mentagrophytes were incubated at 25 ° C for 14 days.

The preparations to be examined were diluted 1: 100 and 1:10 with distilled water, plated on culture plates and inoculated with the following colony forming units of the microorganisms listed below:

E. coli: 4.5x10 ⁴ / ml,

S. epidermidis: 3.3x10 ⁴ / ml,

C. albicans: 5.0x10 ⁴ / ml,

M. canis: 2.2 x ^{10 4} / ml,

T. mentagrophytes: 4.4x10 ⁴ / ml.

The fungicidal activity was characterized by the number of colonies measured after 0, 24 and 48 hours of contact time. The assays were performed according to MSZ 20 546 / 11-85 with the exception that an incubation time of 14 days was used for M. canis and T. mentagrophytes.

The results are shown in the table below.

The data in the table clearly demonstrate the synergistic enhancement of the antimicrobial activity

HU 204691 Β 2

Spreadsheet

microorganisms mus Contact Time, on him Column forming unit Example 1 SKINFree pattern AICÍ ₃ -free pattern 1: 100 1:10 1: 100 1:10 1: 100 1:10 B. coli 0 0 0 9.7x10 ² 6, lx10 ² ' _: 3.2x10 ³ l, 9x10 ³ S. epidermidis 0 0 0 3.2x10 ² 0 7.2x10 ^{2 :} - 4.8x10 ² C. albicans 0 Ι, ΙΧΙΟ ⁴ 2.5x10 ³ 2.9x10 ⁴ 6.2x10 ³ 6.9x10 ⁴ 4.3x10 ⁴ M.canis 0 0 Yeah 6.9x10 ² 1.5x10 ² 2.3x10 ³ 9.7x10 ² T.mentag- rophytes 0 l, 3x10 ⁴ 3.8x10 ⁴ 4.3x10 ⁴ 3.9x10 ⁴ 7.2x10 ⁴ 6.8x10 ⁴ E. coli 24 0 0 - 3.8x10 ² 2.5x10 ² 8.5x10 ² 4.3Χ10 ² · S. epideimidis 24 0 θ . 1.7x10 ² 0 3.6x10 ² l, 9x10 ² C. albicans 48 0 ⁰ 3, lx10 ³ 3.0x10 ³ 4.2x10 ⁴ 23x10 ⁴ M. canis 48 0 She 0 0 l.lxlO ² Ι, ΟΧΙΟ ² T.meníag- rophytes 48 0 0 2.7x10 ³ 2 / lx10 ³ 5.4x10 ³ . 4, lx10 ³

1. Deodorant and disinfectant with no raw material

Claims (2)

CLAIMS 1. A deodorant and disinfectant cosmetic composition having a non-human base composition. 1.3 to 27.8% by weight of aluminum chloride or its hydrate; Containing from 1.13 to 22.2% by weight of ethanol and distilled water, optionally together with one or more known cosmetic excipients or compositions, characterized in that, in addition to the above components, from 0.27% to 11.8% by weight of boric acid and / or desire containing sodium benzoate, provided that the amount of boric acid is not more than 5% by weight Composition according to claim 1, characterized in that it contains 1-5% by weight of boric acid. Published by the National Office for Inventions, Budapest Responsible: dr. Gabriella Swoboda Head of Department