HU185849B - Conserved composition based on quail's egg first of all for cosmetical purposes - Google Patents

Abstract

Quail's egg based stabilized composition comprising 5-75 % by weight of quail's egg, 20-80 % by weight of one or more carrier(s), 0-50 % by weight of one or more additive(s) and not more than 3 % - preferably 0.001-1.0 % by weight - of a conserving agent; whereby in the case of foamed compositions optionally filled into aerosol flasks the composition also comprises a propellant and the weight ratio of the foamed composition and propellant amounts to 1 : 1 - 20 : 1. The compositions of the present invention are particularly suitable for cosmetic purposes and can be stored for a very long period of time without decomposition and discoloration due to their excellent stability.

Description

The present invention relates to quail egg-based preserved cosmetic foam formulations which can be used primarily for cosmetic purposes.

Over the last 10 to 15 years, personal care products in which the cosmetic effect is mainly provided by substances of natural origin have become increasingly sought after. Cosmetic preparations, in particular creams, which contain collagen, placental extracts, etc. are known in the art. They contain. The use of cosmetics in the form of aerosol foams is also preferred (Romvári, Modern Body and Beauty Care, Natura-Medicina, Budapest, [1978J, p. 356).

Facial refreshing wraps made of drill eggs are preferred for cosmetic treatments, since quail eggs contain valuable skin care materials (Cosmetic Materials Volume III, pp. 104-105, Technical Publisher, Budapest [1973]). Thus, the yolk, fat, lecithin and vitamin A content of quail eggs is higher than that of hen eggs (Chemical Abstracts, 79, 77108; [1973]). The high content of vitamin A is particularly important in the treatment of dry skin, while lecithin influences the permeability of the cell wall and facilitates the absorption of valuable biologically active substances in quail eggs.

Quail egg yolk contains more important amino acids, among them essential, than chicken eggs. Such amino acids include tyrosine, threonine, serine, lysine, glycine and histidine (Chemical Abstracts, 97, 37669d (1982)). Higher levels of tyrosine are important because this amino acid plays an important role in metabolism and promotes pigmentation, a healthier complexion.

In making quail egg-based facial refreshment packs, the beautician usually opens the quail egg just before use, and assembles a mass that can be applied and adhered to the face to be treated using the carrier used in cosmetic practice. The so-called face refreshment pack has a beneficial physiological effect, but it cannot be stored and deteriorates easily as it is an excellent medium for microbes; its composition varies from time to time, is not reproducible and its microbiological purity is not assured. Most of the interested users are unable to make these wraps.

Commercially available is spray-dried quail egg powder, in which the quail egg juice is heat-sterilized by contact with air at 80-120 ° C and packaged with rice flour. Although heat sterilization ensures the stability of egg powder contained in the enclosure - the germ free material cannot be contaminated in the enclosure - the bioavailability of the resulting egg powder as a raw material is low as some skin nutrients are damaged during heat treatment.

The other features (consistency, color, odor, etc.) of a homemade face refreshment pack made from natural egg juice do not meet the requirements of modern cosmetics. More sophisticated cosmetic formulations, such as sunscreen, hair wraps, body lotions, etc., or reusable cosmetic formulations, such as aerosol foams, cannot be produced at home.

In conclusion, due to the inability of preservation, cosmetic products based on quail eggs have not been commercialized and the use of raw quail eggs in cosmetics has not become widespread.

No. 174,863. According to the Hungarian patent, the temporary preservation of chicken egg juice is carried out by adding potassium sorbate and adjusting the pH to 4.8-5.4. Egg juice so treated may be stored at 4-8 ° C for 10 days, but may not be stored at or above this temperature.

We have tried to preserve the natural quail egg juice in a similar manner, but with similar results; after a few days it had already become a very unpleasant odor and, as a result, had become unusable.

It is an object of the present invention to provide a wide range of cosmetic foam formulations which, in addition to the valuable biological effects of the nutrients present in quail eggs, have sufficient stability and shelf life and enable persons of different skin types to utilize the formulations best suited to them.

In order to achieve the above object, we have attempted to make a sustained quail egg-based cosmetic foam formulation by adding to the quail egg juice conventional carriers and additives in cosmetic practice and attempting to stabilize the formulation by adding one or more antiseptics. with the addition of boric acid, melyl ester of p-hydroxybenzoic acid and / or salicylic acid, the composition deteriorated after 1-3 weeks, so these conventional stabilizers were not sufficient to preserve the cosmetic composition based on quail eggs.

Sulphonamides are known to inhibit bacterial growth and this effect is enhanced with sulphonamides potentiated by 2,4-diamino-5- (3 ', 4', 5'-trimethoxybenzyl) - pyrirnidine (trimethoprim!) (Chemical Abstracts, 91, 204 990m [1979]; Arzneimittel-Forschung, 2! [5], 577-583 1971). Therefore, we have attempted to preserve the quail egg-based cosmetic foam formulation by adding 4% by weight of various sulfonamides, trimethoprim and trimethoprim-potentiated sulfonamide. However, these highly effective antibacterial agents also provided stability for only 4-12 weeks. then the preparations went bad.

Of course, such short-term stability is not sufficient for a commercially available cosmetic product. Stability is required for at least 1 year, but preferably longer.

Surprisingly, it has been found that a shelf-life quail egg-based composition is obtained by adding to the quail egg carriers, additives, and preservatives that are both antiseptic material (s) and sulfonamide / sulfonamide potentiated with trimethylprime (1: 5) (5: 1). available.

The present invention is a preserved egg based on quail eggs

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cosmetic foam composition 5-75% by weight ⁰ / quail eggs, 20-80% by weight cosmetic vehicle (s), 0-40% by weight cosmetic additive (s), preservative 0.1-1% by weight antiseptic substance (s), namely acid, sorbic acid, benzoic acid, salicylic acid, p-hydroxybenzoic acid, p-hydroxybenzoic acid (C 1 -C 4 alkyl or benzoate ester) and / or C 2 -C 4 beta-phenylalkanol in its alkyl chain and a total of 1 -3 wt%, 2,4-di-10

sulfonamides / amides potentiated by amino-5- (3 ', 4', 5'-trimethoxybenzyl) -pyrimidine (1.5.5) to (5: 1), and N '- (5-methyl-3-) isoxazolyl N-sulfanylamide (sulfamethoxazole), N '- (6-chloro or 6-methoxy-3-pyridazinyl) sulfanyl- ^15- amide (sulfachloropyridazine or sulfamethoxypyridazine), N ¹ - (2- pyrimidinyl) sulfanylamide (sulfadiazine), N '- (4,6-dimethyl- or 5-methoxypyrimidinyl) sulfanylamide (sulfadimidine or ₂ θ sulfomethoxydiazine), I-sulfanylthiourea (sulfathiourea), and and / or N'-arr.idinosulfanylamide (sulfaguanidine) and 5-20% by weight propellant.

Stability of foam compositions according to the invention was investigated in ₂₅ as follows:

parts of natural fürjtojáslét, 1.26 part by weight of stearic acid, 0.308 parts by weight of myristic acid, 1.232 parts by weight of triethanolamine, 1.12 parts of glycerol, 19.68 parts of water and 0.1 _3Q sómentssitett parts of fragrance were mixed as described in Example 1. To the resulting emulsion was added a mixture of the preservative (s) listed in Table I, 2 parts water and 0.6 parts polyethylene glycol (molecular weight 300). The resulting emulsions of ₃₅ suspension being filled into aerosol bottles and the bottles were sealed and then charged with 14.8 parts of propellant. The flasks were stored at 25 ° C and sampled weekly. The samples were subjected to organoleptic examination (consistency and odor of the printed foam _4Q ). Loose, flowing foam or slight odor reminiscent of ruffled eggs indicated a lack of stability.

Table 1 shows the composition of the preservative used and the number of weeks that the formulation was stable.

Samples were stored until deterioration of the formulation or, in the absence thereof, for two years.

Table I

Preservative type Quantity - _{Stable |} G, parts time, seven boric acid 4 1 sorbic acid 4 1 benzoic acid 4 1 p-hydroxybenzoic acid 4 1 p-hydroxybenzoic acid THE 9 methyl ester salicylic 4 2 p -hydroxybenzoic acid- THE 9 ethyl ester

-3 '. spreadsheet

Preservative type quantity G, parts Time for stability, seven p-hyd rox i-benzoic acid- Λ propyl ester J p-hydroxybenzoic acid Λ 9 butyl methanesulfonate p-hydroxybenzoic acid Λ 9 benzyl ester beta-phenylethanol 4 3 carboline-phenyl propanol 4 4 beta-phenyl-butanol 4 2 boric acid 2 9 beta-phenylethanol 2 p -hydroxybenzoic acid- 1 methyl ester 1 1 3 beta-phenyl propanol J trimethoprim 4 4 sulfamethoxazole 4 5 sulfa-methoxypyridazine 2 5 sulfamethoxazole 2 sulfa-butylamino 4 4 trimethoprim 1 8 sulfadiazine 3 Sulfamethaxazole 2 sulfa-meloxidiazin 2.2 12 trimethoprim 0.8 szulfatiokarbamid 4 2 sulfaguanidine 4 6 trimethoprim 0.7 12 szulfametoxazil 3.3 trimethoprim 3 10 sulfa-butylamino 1 boric acid com 1 beta-phenylethanol com 7 trimethoprim u / 1 104 * sulfa-klórpiridazin- 2 sodium sorbic acid 1 trimethoprim 0.5 100 sulfamethoxazole 2.5 benzoic acid 0.2 salicylic 0.8 100 trimethoprim 2.5 szulíainctoxazol 0.5 p-hydroxybenzoic acid 0.1 beta-phenyl-butanol 0.9 104 * trimethoprim 1.5 sulfa-methoxypyridazine 1.5 p-hydroxybenzoic acid 0 5 methyl ester beta-phenyl propanol 0.5 trimethoprim 1 104 * sulfadiazine 2 p -hydroxybenzoic acid- 1 ethyl ester trimethoprim 0.5 104 Sulfamethaxazole 2.5 3

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f. spreadsheet

Type of preservative

Amount _{S [abilile} bulk ^id 4 =. ml

p-hydroxybenzoic acid propyl ester 0.1 boric acid 0.3 beta-phenylethanol 0.6 trimethoprim 0.6 sulfa-metoxidiazin 0.8 sulfamethoxazole 1.6 p-hydroxybenzoic acid < benzyl ester I trimethoprim 2 szulfatiokarbamid 1 salicylic 0.1 beta-phenyl-butanol 0.3 p-hydroxybenzoic acid Π Λ methyl ester U 0 trimethoprim 1.5 sulfaguanidine 1.5

104 *

100 * The formulation was stable after 2 years (104 weeks).

It is clear from Table I that the preservative combination used in the foam formulation of the present invention provides greater stability than its individual components.

The foam compositions of the present invention consist of an emulsion and a propellant present before use. The emulsion is foamed by the propellant when pressed out of the bottle. In this way, the quail egg-based cosmetic composition is applied in the form of a foam to the surface of the body to be treated, which is easily distributed and absorbed. The cosmetic foam composition of the present invention may be, for example, facial foam for women and men of different skin types, body foam, shampoo or hair wrap, shaving foam, suntan foam, and the like.

Quail eggs mean eggs of the domesticated drill (Coturnix coturnix), or more specifically the material made available after the breaking of the egg, which may be whole egg (natural egg juice), egg yolk, protein, whole egg enriched with yellow or protein, that is, freeze-dried). (Freeze-drying does not cause biological damage.)

The cosmetic carrier is a carrier customarily used in cosmetic compositions, preferably water; mono- or polyhydric alcohol such as ethyl alcohol, cetyl alcohol, octyldodecanol, oleyl alcohol, ethylene glycol, polyethylene glycol, polyglycol ether or glycerol; a fatty acid such as stearic acid or myristic acid; fatty acid alkali metal salt; a fatty acid ester such as myristic acid propyl ester or a fatty alcohol ester of oleic acid; paraffin; wax; vaseline; wool grease, etc.

The composition of the invention may also contain more than one cosmetic carrier in a total amount of 20-80% by weight.

The cosmetic additive is an additive customary in cosmetic formulations, preferably a surfactant, a fragrance, a colorant, a bioactive substance, a sunscreen, and the like. may. The composition according to the invention may contain practically any number of cosmetic additives in a total amount of 0-40% by weight.

^5. The surfactant may be anionic, cationic or nonionic, such as sodium lauryl sulfate, polyoxyethylene fatty acid ester, szorbiíán fatty acid ester, polyoxyethylene fatty alcohol ethers, polyethylene sorbitan like.

The fragrance (s) and coloring agent (s) may be substances conventionally used in cosmetic formulations for this purpose.

In addition to quail eggs, the composition may also contain vitamins, solubilized collagen, chamomile extract, placenta extract, and other bioactive substances.

Sunscreens may contain mainly sun-tanning foams.

It is understood that the invention Ké specific carriers and additives used in compositions for selection ²⁰ is highly dependent on the way in a known manner - the destination of the compositions.

The compounds used as preservatives may also be in the form of their acid addition salts or metal salts.

The foaming propellant may be a gas or gas mixture conventionally used in aerosol formulations, for example, fluorinated and / or chlorinated hydrocarbon (s) such as difluorodichloromethane, tetrafluorodichloroethane and mixtures thereof, nitrous oxide, and the like.

The quail egg-based preserved cosmetic foam formulations of the present invention are prepared by blending 5 to 75% by weight of quail eggs, 20 to 80% by weight of carrier material (s), 0 to 40% by weight of additives / preservatives and preservatives. In doing so, the individual components are added in any order and combination. This is determined in a manner known per se by the properties of the components, in particular their solubility, and the type of formulation desired. Surfactants which are formed in situ by the addition of its ingredients, for example from the formation of salts of stearic acid and / or myristic acid and triethanolamine, may also be used as additives in the preparation.

The resulting compositions are filled into an aerosol can with a valve in a manner known per se, and the propellant gas content of the foam composition is adjusted to 5-20% by weight. Pressing the valve leaves the product in the form of a foam.

The quail egg-based cosmetic foam composition of the present invention is well-preserved for many years without degradation or discoloration. Its microbiological purity is preserved. Regular use has a beneficial effect on the treated body surface.

The invention is further illustrated by the following examples:

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Example 1

Facial spray for women Composition:

Quail eggs (natural egg juice) 55,00 parts by weight

Stearic acid - 1,260 parts by weight

Myristic acid 0.308 parts by weight

Triethanolamine 1.232 parts by weight

Glycerol 1.120 pips curd

Water (demineralised by ion exchange) 23.58 parts by volume Fragrance 0.100 parts by weight beta-phenyletharyl 0.100 parts by weight p-Hydroxybenzoic acid methyl-0.100 parts by volume

2,4-Diamino-5- (3,4,5-0,300 parts by weight)

-trimethoxybenzyl) pyrimidine N '- (5-methyl-3-isoxazolyl) - 1,500 parts by weight

sulfanyl-amide

Carbowax 300 (Polyoxyethylene-0.60 parts by weight of glycol)

Propellant gas (difluorodichloro- 14.80 parts by weight methane)

100,000 parts by weight

The myristic acid, stearic acid and the isopropyl myristate were melted by heating in a water bath to about 70 ° C ("oil phase").

Glycerol and triethanolamine are added to the water, heated to 60-70 ° C, the p-hydroxybenzoic acid methyl ester is dissolved therein, and the resulting mixture ("aqueous phase") is added in portions to the still hot melt. The resulting emulsion was stirred until cooled, and homogenized quail egg juice was added in portions followed by perfume, beta-phenylethanol and 2,4-diamino-5- (3,4,5-trimethoxybenzyl) pyrimidine and sulfonamide. A solution of 6 g of Carbowax in a mixture of 300 and 0.4 g of water. The emulsion is filled into aerosol cans, the vials are sealed after aeration and the propellant is charged. The product is stable for 2 years.

Example 2

Men's aerosol foam lotion Composition:

Quail eggs (lyophilized whole egg - 21.50 parts by weight) 1 *

myristic

stearic

Olive oil

Triethanolamine Isopropyl myristate Water (distilled)

Fragrance beta-phenylpropanol p-hydroxybenzoic acid methyl ester

Carbowax 300

2,4-Diamino-5- (3,4,5-trimethoxybenzyl) pyrimidine (6-chloropyridazin-3-yl) 0.48 parts 1.95 parts

21.50 parts by weight 1.90 parts by weight 0.67 parts by weight

33.50 parts by weight

0.10 parts by weight 0.50 parts by weight 0.50 parts by weight

3.60 parts by weight 0.30 parts by weight 1.50 parts by weight

sulfanyl-amide

Propellant gas (tetrafluoro- 12.00 parts by weight

dichloro-ethane)

100.00 parts by weight

The procedure described in Example 1 was followed. The olive oil is treated as a component of the "oil phase". The lyophilized egg is worked up with half the amount of water and the resulting mass is mixed with the emulsion. 2,4-Diamino-5- (3,4,5-trimethoxybenzyl) pyrimidine and sulfonamide are added to the emulsion in a 5: 2 mixture of Carbowax 300 and water. The product has been stable for 2 years.

Example 3

Body Lotion ₂₀ Composition:

Quail eggs (freeze-dried egg yolk)

wool grease

stearic

Emulgade 1000 (80% of saturated fatty alcohol ^{of 25} to 20% and a mixture of fatty alcohol polyglycol ether) Glycerol Propylene Glycol Triethanolamine ³⁰ Collagen (szolubiÜzált) Fragrance Water (distilled) beta-phenyl-ethanol ³⁵ Sorbic Carbowax 300

2,4-diamino-5- (3 ', 4', 5'-trimethoxybenzyl) pyrimidine (6-chloropyridine-3-yl) sulfanyl amide ⁰ Propellant

10.00 parts by weight

1.65 parts 1.10 parts 2.00 parts

2.15 parts 0.50 parts 2.00 parts 3.00 parts 0.60 parts 47.40 parts 0.60 parts 3.00 parts 6.00 parts 2.00 parts 1.00 parts 17.00 parts

100.00 parts by weight

Wool grease, stearic acid and emulsifier

4 ₅ (Emulgade 1000) at 60-70 ° C ("oil phase").

Propylene glycol, glycerol and triethanolamine are added to half the water and the mixture is heated to near boiling. The aqueous phase thus obtained is added in portions with stirring to the still warm oil phase and the emulsion is stirred until cooled. Collagen and other components are added to the cooled emulsion. Hereinafter referred to as the 1st and the

Example 2 was followed. The composition retains ₅₅ SAT than 2 years of stability.

Example 4

Aerosol Foam Shampoo or Hair Wrap ⁰

Quail eggs (freeze-dried protein-enriched egg juice 10.00 parts by weight)

Tego-Betaine L 7 15.00 parts by weight (fatty acid amidoalkyl betaine)

Pofivinylpyrrolidone 0.50 parts by weight

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Phenopon IC 42 (sulfoalkyl) 17.00 parts by weight amide) Water (distilled) 34.55 parts by weight íilatanyag 0.50 parts by weight beta-phenyl-ethanol 1.00 parts by weight Carbowax 300 2.10 parts by weight 2,4-Diamino-5- (3,4,5- 1.05 parts by weight trimethoxy-benzyl) -pyrimidin (Ó'Klór-pyridazin-3-yl) -szulfa- 1.30 parts by weight phenyl-amide propellant 17.00 parts by weight

100.00 parts by weight

Example 6

The polyvinylpyrrolidone, Tego Betaine L-7 and the _r Fenopon TC 42 was dissolved in half the amount of water at 60-70 ° C. After cooling, the lyophilized egg juice and other components are added slowly, stirring slowly, with the remainder of the water. In the following, Examples 1 and 2 are followed. A bypass from the ₂₀ preserves the stability of formulations over two years.

Aerosol Foam Shampoo Composition:

Quail eggs (lyophilized eggs)

Tego-Betaine L 7 (Fatty Acid Amidoalkyl Betaine)

polyvinylpyrrolidone

Phenopon TC 42 (sulfoalkylamide)

Water (distilled) fiber

Collagen (solubilized)

Boric acid

Carbowax 300 (polyethylene glycol!)

N '- (5-methyl-3-isoxazolyl) sulfanylamide (sulfamethoxazole)

2,4-diamino-5- (3 ', 4', 5'-trimethoxybenzyl) pyrimidine (trimethoprim)

propellant

5.0 parts by weight

18.0 parts by weight

0.5 parts by weight

19.0 parts by weight

28.9 parts by weight

0.5 parts by weight 2.0 parts by weight 1.0 parts by weight

2.1 parts by weight

2.2 parts by weight

0.8 parts by weight

Example 5

Aerosol foam for sunbathing Composition:

Quail eggs (natural egg juice)

Triethanolamine

Sorbitol solution (70%)

Carbopol 934 (polyacrylic acid)

wool grease

Isopropyl myristate

cetyl alcohol

stearic

Water (distilled)

2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid (sunscreen) beta-Phenyl ethanol!

Carbowax 300

2,4-Diamino-5- (3,4,5-trimethoxybenzyl) pyrimidine (6-chloropyridazin-3-yl) sulfanyl amide sodium salt

propellant

15.00 parts by weight

3.43 parts 3.43 parts _3Q 0.10 parts 1.36 parts 1.60 parts 0.15 parts 4.15 parts ₃₅ 42.38 parts 4.00 parts

0.50 parts by weight 0.50 parts by weight 7.20 parts by weight 0.20 parts by weight 1.00 parts by weight

15.00 parts by weight 100.00 parts by weight

Carbopol 934 and 2-hydroxy-4-methoxy-benzophenone-5-sulfonic acid were dissolved or dispersed in a mixture of water, sorbitol solution and triethanolamine and heated to 60-70 ° C (" aqueous phase ").

The wool fat, isopropyl myristate, cetyl alcohol and stearic acid were melted in a water bath and the aqueous phase 60 ° C was added to the melt. After cooling, the other components are added to the emulsion as described in Examples 1 and 2, respectively, and further described below. 60

The product has been found to be stable for more than 2 years.

Without illustration

-620.0 parts by weight 100.0 parts by weight

The procedure described in Example 4 was followed.

Example 7

The procedure described in Example 1 was followed except that 75 parts by weight of quail eggs (natural egg juice), 9.85 parts by weight of water and 9.8 parts by weight of nitrous oxide propellant were used.

Example 8

Example 3 was repeated except that 61.4 parts by weight of distilled water and 5 parts by weight of propellant were used.

Claims (1)

Patent claim Bored egg-based preserved cosmetic foam composition, comprising from 5 to 75% by weight of quail eggs, from 20 to 80% by weight of cosmetic carrier, from 0 to 40% by weight of cosmetic additive, from 0.1 to 1% by weight of antiseptic agent / materials, boric acid, sorbic acid, salicylic acid, p-hydroxybenzoic acid, p-hydroxybenzoic acid (C1-C4 alkyl or benzyl) ester and / or C2-C4 alkylphenol in the alkyl chain, and a total of 1-3% by weight 2,4-diamino-5- (3 ', 4', 5'-trimethoxybenzyl) -pyrimidine (1: 5) - (5: 1) potassium sulphonamide / amides potentiated by weight, i.e. N '- (5-methyl) -3isoxazolylsulfanyl amide, N '- (6-chloro or 6-methoxy-3-pyridazinyl) sulphanamide amide, N' - (2-pyrimidinyl) sulfanyl amide, N * - (4.6) -dimethyl- or 5-methoxypyrimidinyl) sulfanyl amide, 1-sulfanityl thiourea and / or N'-amidino-sulphanilamide and 5-20% by weight propellant.