HU176692B - Tablets for cleaning dental protheses in aquous solutions and process for producing the tablets - Google Patents

Abstract

The tablet contains, as the calcium-binding organic acid, an amido-sulphonic acid, ethylenediaminetetraacetic acid, dialkylthiourea and a non-ionic fluorochemical surfactant, in addition to the customary gas-forming and calcium-binding substances, acid carriers, oxidising agents, surfactants, excipients and parting agents, polymeric dyestuff carriers and dyestuffs and also aromatic substances. The tablet has a disintegration time of 1-2 min coupled with a total cleaning time of 3-5 min and yields a pH of 6.3-6.5 in 1% strength aqueous solution. It is prepared by mixing the gas former, calcium binder, polyethylene glycol and a part of the amidosulphonic acid, granulation of the mixture, mixing of the granules with the residual components and tabletting of the mixture obtained.

Description

FIELD OF THE INVENTION The present invention relates to a cleansing tablet suitable for cleaning dental prostheses in aqueous solution and having a pH of less than 7.0 in a 1% solution of dentures containing 15-25% by weight of sodium drug carbonate, sodium hexametaphosphate, polysulphate, high molecular weight, , amidosulfonic acid, peroxo-mono-sulfuric acid salts, at least 0.5% by weight surfactants in the alkyl and / or alkylarylsulfonate base, ethylenediamine derivatives, polycarboxylic acid sodium salt containing 10 dye additives and 0.5-1.5% by weight peppermint and / or other flavoring agents and other carriers and disintegrants. The present invention also relates to a process for preparing a tablet. 15

No. 2,357,720. A cleaning tablet is already disclosed in the German Federal Publication, in which at least one of the two layers forming the tablet has the aforementioned composition.

A 1% solution has a pH of 6.5-7. In the known cleaning tablet, ethylene diamine tetraacetate is proposed as a complexing agent for the formation of chelate-like complexes of metal ions. Citric acid is used as a lime-binding organic acid in the known cleaning tablet. 25

No. 2,357,720. Sodium bicarbonate is used as a pH stabilizing and gasifying agent in a cleansing tablet in the Federal Republic of Germany. Sodium hexametaphosphate acts as a water softener, while lemon 30

Each of these layers exerts an antimicrobial effect of 20 acids and, moreover, a dissolving effect on the tooth sites present on the denture to be cleaned. The ethylenediaminetetraacetate additive has a water-softening and demineralizing effect, 5 due to chelation, and in addition has a descaling effect. The high molecular weight polyethylene glycol used acts as an antimicrobial agent and acts as a disintegrant. The surfactants together exert an emulsifying effect and, due to their surface activity at the known cleaning tablet, degrade the coating of the denture. Sodium pyrophosphate degrades the coating of the denture through its reducing and water softening and surfactant action. The karates used, i.e. salts of the Caro acid, serve as oxidizing agents. As a polymeric dye carrier having a surfactant cleaning effect, the known cleaning tablet preferably employs a standard polycarboxylic acid sodium salt as disclosed in U.S. Patent No. 2,357,720. It is described in lines 15 and 16 of page 17 of the disclosure document of the Federal Republic of Germany, which also improves the cleaning effect. As the alkylbenzenesulfonate for use as a surfactant, U.S. Pat. For example, a disclosure document in the Federal Republic of Germany proposes sodium dodecylbenzene sulfonate, and fatty acid disodium sulfosuccinate may be added. The preferred molecular weight of the polyethylene glycol used in the known cleaning tablets may be between 4,000 and 25,000, but preferably about 20,000.

No. 2,357,720. The disclosure document in the Federal Republic of Germany is fully effective. However, for some application purposes, it appeared desirable that U.S. Pat. Instead of the cleaning time of about 10-15 minutes available with the 5 Federal Patent Publications, the cleaning time is much shorter. The dual-layer construction of the known cleaning tablet for some applications has also proven to be relatively disadvantageous in terms of cost.

It is known to use particularly sour detergents such as those disclosed in U.S. Patent No. 480,840. Swiss Patent Specification, at which pH values of 1.5 to 5 are better soluble in calcium compounds on prostheses and their metal parts, as well as metal parts of the jaw regulators, but this solution has the disadvantage that the chelating complexes used are not since the threshold for exerting such a complexing effect is k'o. It is at pH 6.

The object of the present invention was to provide a cleaning tablet of the kind mentioned in the introduction which provides a very fast, reliable cleaning in a single-layer structure.

The cleaning tablet according to the invention is characterized in that the tablet has a disintegration time of 1-2 minutes, a cleaning time of 3-5 minutes, and 10-12% by weight of sodium hexametaphosphate, 5.5-7.5% by weight of acidic disodium pyrophosphate, 20-24%. % by weight of peroxo-mono-sulfuric acid salt, 15-30% by weight of amidosulfonic acid, 2-6% by weight of ethylenediaminetetraacetic acid, 1-4% by weight of polyethylene glycol of 4,000-20,000 molecular weight, 0.5-2% by weight of sodium 35 polyacrylate sodium salt 0.8-1.1% by weight of sodium benzoate, 1.5 to 2.5 weight% and 0.2 to 0.5 weight% dialkiltiokarbamidot non-ionic fluorine compound, preferably C ₈ F _ls O _{(CH2 CH2} O ) contains a compound of the formula _n -CH ₃ - wherein C ₈ Fi _{5 is} a residue of tetrafluoroethylene tetramer and n is 8. In addition, the 1% solution has a pH of 6.3-6.5 and a surface tension of 25-26 dynes / cm.

Particularly successful is the cleansing tablet according to the invention according to the following formula:

10-12% by weight

18-20% by weight

1.5-2.0% by weight

24-30% by weight

20-24% by weight

5.5 to 7.5% by weight

2-3% by weight

0.5 2.0% by weight

0.5-1.5 weight%

0.5-1.5% by weight

0.3-1.0% by weight of sodium hexametaphosphate, sodium bicarbonate, polyethylene glycol having a molecular weight of 20,000, amidosulfonic acid, karate, acidic disodium pyrophosphate, ethylenediaminetetraacetic acid, polycarboxylic acid sodium salt, U.S. Pat. 15 and 16), peppermint powder, sodium dodecylbenzene sulphonate, lauryl polyglycol ether sulphosuccinate,

0.2-0.4% by weight

0.8-1.1% by weight

1.5-2.0% by weight

1.5-2.0% by weight

0.5-1.5% by weight

0.8 to 1.2% by weight of a nonionic fluorine compound, sodium benzoate, dialkylthiourea, polyvinylpolypyrrolidone, disodium sulfosuccinate and alkylarylsulfonate.

The process for the preparation of a cleaning tablet according to the invention is characterized in that firstly, 15-25% by weight of sodium bicarbonate,

10 to 12% by weight of sodium hexametaphosphate, 1 to 4% by weight of polyethylene glycol, and 30 to 50% by weight of the total amount of 15 to 30% by weight of amidosulfonic acid are mixed together and processed into granules, the granulate thus obtained is mixed with acidic disodium pyrophosphate - 6% by weight of ethylenediaminetetraacetic acid, the polycarboxylic acid sodium salt containing 0,5 to 2% by weight of dye additive, the more than 0,5% by weight of surfactant, 20 to 24% by weight of the peroxo-mono-sulfuric acid salt, 0,8 to 1,1 by weight with sodium benzoate, 1.5-2.5% by weight dialkylthiourea, 0.2-0.5% by weight non-ionic fluorine compound, 0.5-1.5% by weight peppermint and / or other flavoring agents, carrier and degradation with excipients and the remainder of the amidosulfonic acid and from the mixture to form a cleaning tablet.

Particularly preferred embodiments of the process of the present invention are contained in the corresponding claims.

It is understood that the Composition of the present invention may also be used as a powder detergent, but in this case of course, the compression and glidants necessary for tabletting are not used. In addition, unlike the cleaning tablets used to date for dentures, which are highly alkaline, neutral or weakly acidic (by way of example, reference is made to DE-OS 23 57 720), the cleaning tablets according to the invention provide accurate pH ranges during dissolution, 6.3-6. 5 pH range with a maximum deviation of ± 0.3.

When using the cleaning tablets of the invention, it is not necessary to clean the dentures daily in order to remove deposits of food residues and saliva residues throughout the day, the application of the invention provides a very fast cleaning effect with a disintegration time of 1-2 minutes. , 3-5 minutes total cleaning time. It is important for the present invention that amidosulfonic acid is used in combination with a dialkylthiourea which acts as an anti-corrosive agent, thus acting as an inhibitor of amidosulfonic acid, to prevent any damage to the prosthesis material or metal parts by commercially available LITHSOLVENT-HC. KG from Düsseldorf. This anti-corrosive agent or inhibitor acts synergistically with the sodium benzoate of the present invention, which has a known disinfectant effect, and additionally exhibits a synergistic effect with active oxygen (derived from caries), since the inhibitor acts as an antioxidant. There is also a synergistic effect between the anticorrosive agent and the amidosulfonic acid. This prevents peroxide degradation during storage of the cleaning tablet.

Particularly suitable as sodium hexaphosphate is the commercially available formulation, marketed under the designation Budit 8 H, which is available as a powder and which, upon proper treatment with water, dissolves immediately and completely.

By using powdered ethylenediaminetetroacetic acid according to the invention, the pH of the chelating agent is substantially less than 2.5 when using ethylene diamine tetroacetate in a saturated aqueous solution. The powdered ethylenediaminetetroacetic acid (H ₄ EDTA) proposed in accordance with the present invention is marketed under the tradename Versene Acid by the US Daw Chemical Company.

The combination of the surfactants of the present invention with non-ionic fluorine compounds results in an extremely low surface tension of the cleaning bath (25-26 dynes / cm). This low surface tension greatly increases the wetting capacity or emulsifying ability of the cleaning bath, which results in a short cleaning time. Suitable surfactants are, for example, the raw materials known from Rewo Chemische Fabrik GmbH, Steinapol NKS 100 and Rewo-DERM S 1333 from Stenau. These surfactants provide durable, creamy and hard foams at a surface tension of 0.1% aqueous solution of aqueous solution containing NKS 100. 25 dynes / cm and the surface tension of a 0.1% aqueous solution of the product S 1333 is approx. 30-35 dynes / cm. By adding the proposed nonionic fluorine compound of the invention, available from ICI Company as Monflor51 or Monflor 52, at a concentration of 0.2-0.5% in the tablet, the surface tension of the entire cleaning bath is 25-26 zł / cm. decrease. Thus, the wetting and penetration properties of the surfactants are particularly enhanced.

For the first time, the cleaning tablet of the present invention has enabled the development of an ultra-fast detergent having a surface tension of 25-26 dynes / cm in a cleaning bath, while other detergents have an average surface tension of 35-90 dynes / cm.

Materials similar to those described in U.S. Patent No. 2,357,720 may be used as press and auxiliary materials. It is proposed in a disclosure document in the Federal Republic of Germany. These materials include, for example, the fatty acid esters available under the tradenames Wasag 7 and Wasag 15. These products are marketed under the name Sucrapan in Switzerland, Austria and Eastern Europe. However, materials commercially available as Luviskd V 64, Aerosil, Tamol, Awycol or Waxy Mais as well as natural starches, saccharified starches and derivatives thereof such as starch sugar, anhydrous dextrose, pdiethylene glycol and microcrystalline celluloses may also be used as press and lubricants.

The following is a detailed description of a cleaning tablet according to the invention and a process for its preparation.

Example 1

For the purpose of preparing the cleaning tablets of the present invention: first, 10.55 parts by weight of lime binder (commercially available as Bu10 dit 8 H), 10.85 parts by weight of amidosulphonic acid (sulphamic acid), 19.0 parts by weight of sodium bicarbonate and 1.81 parts by weight of 20,000 molecular weight polyethylene through a metering container and an elevator into a metal container having a stirrer 15. The metal container is then connected to a GLATT granulator. The components to be granulated are heated with air at 100-115 ° C, adjusting the air inlet to 5-6 and the outlet air to 2-3. The components to be granulated are heated under constant stirring, at a temperature of 60-65 ° C, which is cooled to ca. Keep for 10 minutes - granulation takes place. At a temperature of 60-65 ° C, the polyethylene glycol of molecular weight 20,000 melts completely over the specified 10 minute period, thereby completing the granulation. By aligning the air inlet and outlet, the granulate is cooled to about 25 ° C by supplying cooling air at 6-10 ° C. The granules are then loaded into an impermeable container, such as polyethylene bags, with regular moisture checks of up to 0.25%.

42.21 parts by weight of the granulate thus produced are disclosed in U.S. Patent No. 2,357,720. Reference is made in detail to the other components of the cleaning tablet, as described in detail in the disclosure of the Federal Republic of Germany, namely, 22.60 parts by weight of carat, 6.23 parts by weight of disodium pyrophosphate, 2.26 parts by weight of ethylenediamine, 2.26 parts by weight. (Versene acid), 1.18 parts by weight of standard polycarboxylic acid sodium salt (see German Patent Publication No. 2,357,720, page 17, lines 15 and 16, with dye additive), 1.00 parts by weight of peppermint powder, 0 , 81 parts by weight of sodium dodecylbenzene sulphonate (Steinaril NKS 100, product of Rewo Chemische Werke GmbH), 0.54 parts by weight of lauryl polyglycol cholesterol sulphosuccinate (Rewo-DERM S 1333, product of Rewo Chemische Fabrik GmbH), 0.30 parts by weight of non-fluoro, product of ICI), 0.90 parts by weight of sodium benzoate 1.81 parts by weight of polyvinylpolypyrrolidone (Plasdone XL from GAF (Germany) GmbH), 1.00 parts by weight of disodium sulfosuccinate (trade name Wasag), 1.81 parts by weight of dialkylthiourea (product of LITHSOLVENT-HC, Keller and Bohacek KG, Düsseldorf) ?), 1.00 parts by weight of alkylarylsulfonate (Wasag 15) and an additional 16.27 parts by weight of amidosulfonic acid (sulfamide).

After mixing, the mixture is transferred to a double conical dryer and dried at a pressure of 55 torr and 34 ° C to a residual moisture of 0.20%. The mixture is then compressed into a cleaning tablet.

Example 2

To prepare the cleaning tablets of the present invention, analogous to those described in Example 1, 16 parts by weight of granules with a maximum moisture content of 0.25% were used in 16 parts by weight of sodium metaphosphate, 32 parts by weight of amidosulfonic acid, 50 parts by weight of sodium bicarbonate and 2 parts by weight.

50 parts by weight of the granulate thus produced are contained in

As described in Example 1, it is mixed with the other components of the cleaning tablet, namely 24% by weight of carat, 7.5% by weight of disodium pyrophosphate, 2.26% by weight of ethylenediaminetetraacetic acid, 2% by weight of dye additive polyacrylate, 1.5% by weight of peppermint flavor. with sodium dodecyl sulfonate, 1.0 wt% lauryl polyglycol ether sulfosuccinate, 0.2 wt%

C ₈ Fi _s O (CH ₂ CH ₂ O) ₈ -CH ₃ (Monoflor 51), 1.1 wt% sodium benzoate, 1.5 wt% dialkylthiourea, 2 wt% polyvinylpyrrolidone, 1.5 wt% disodium sulfosuccinate, and l With 2% by weight of alkylaryl sulfonate. After mixing and drying in a vacuum dryer (about 50 torr and 32 ° C), the mixture is compressed into a cleaning tablet.

Example 3

The cleaning tablet is prepared in a manner analogous to that described in Examples 1 and 2, firstly preparing 30 parts by weight of sodium metaphosphate, 30 parts by weight of amidosulfonic acid, 36 parts by weight of sodium bicarbonate and 4 parts by weight of polyethylene glycol granules.

50% by weight of this granulate with 20% by weight of carat, 5.5% by weight of disodium pyrophosphate, 2% by weight of ethylenediaminetetraacetic acid, 0.5% by weight of polyacrylate, 1.0% by weight of peppermint aroma, 0.5% by weight of sodium dodecylbenzene sulphonate, 0.4% by weight of lauryl polysulphate, 0.5% by weight

C ₈ Fi _s O (CH ₂ CH ₂ O) ₈ -CH ₃ (Monoflor 51), 0.8 wt% sodium benzoate, 2.5 wt% dialkylthiourea, 1 wt% polyvinylpyrrolidone, 0.5 wt% disodium sulfosuccinate, 0 With 8% by weight of alkylaryl sulfonate and again with 15.0% by weight of amidosulfonic acid, in a manner similar to that described in Examples 1 and 2, to form a cleaning tablet.

Claims (7)

Patent claims: 1. A cleansing tablet for cleaning dental prostheses in aqueous solution having a pH of less than 7.0 in a 1% solution of a cleaning tablet, containing 15-25% by weight of sodium bicarbonate, sodium hexametaphosphate, acidic disodium phosphate, polyethylene glycol mono, salts, at least 0.5% by weight surfactant in the form of alkyl and / or alkylarylsulfonates, ethylenediamine derivatives, sodium salt of polycarboxylic acid, containing dye and 0.5-1.5% by weight of peppermint and / or other flavoring agents, and other carriers. and a disintegrant, characterized in that 10 to 12% by weight of sodium hexametaphosphate, 5.5 to 7.5% by weight of acidic disodium phosphate, 20 to 24% by weight of peroxo-mono-sulfuric acid, 15 to 30% by weight of amidosulfonic acid, 2-6% by weight of ethylenediaminetetraacetic acid, 1-4% by weight of polyethylene glycol of 4,000-20,000 molecular weight, 0.5-2% by weight of sodium polyacrylate, as the sodium salt of polycarboxylic acid 5 0.8-1.1% by weight of sodium benzoate, 1.5-2.5% by weight of dialkylthiourea and 0.2-0.5% by weight of nonionic fluorine compound, preferably C ₈ F ₅ O (CH ₂ CH ₂ O) _n -CH ₃ , wherein C ₈ F _{5 is} the O moiety of tetrafluoroethylene tetramer and n is 8. Process for the preparation of a cleaning tablet according to claim 1, characterized in that firstly 15-25% by weight of sodium hydrogencarbonate, 10-12-12% by weight of sodium hexametaphosphate, 1 - 4% by weight of polycarbonate. 5-ethylene glycol and 30-50% by weight of the total amount of 15-30% by weight of amidosulfonic acid at 25-65 ° C and 25-80 torr under pressure are processed and granulated, the granulate thus obtained is mixed with acidic sodium pyrophosphate, 2- 6% by weight of ethylenediaminetetraacetic acid, 0.5% to 2% by weight of dye additive polycarboxylic acid sodium salt, at least 0.5% by weight of surfactant, 20% to 24% by weight of peroxo-mono-sulfuric acid salt, 0.8 to 1.1% by weight sodium benzoate, 1.5-2.5% by weight of dialkylthiourea, 0.2-0.5% by weight of nonionic fluorine compound, 0.5-1.5% by weight of peppermint and / or other flavoring agents, known carriers and degradation with excipients and the remainder of the amidosulfonic acid and from the blend. 3. The process according to claim 2, wherein the components are heated to 60-65 ° C and stirred for 10 minutes at this temperature, granulated and 5 finished granules were cooled to 25 ° C. 4. A process according to claim 3, wherein the heating of the components is carried out by introducing air at 100-115 ° C. 9 5. The process of claim 4, wherein the cooling of the granulate is effected by introducing cooling air at a temperature of 6 to 10 ° C. 6. A process according to any one of claims 1 to 3, characterized in that the mixing is carried out at a pressure of 50 to 60 torr and a temperature of 32 to 45 ° C. 7. The process of claim 6, wherein the resulting mixture is further processed at a residual moisture content of less than 0.5%.