HU176226B - Process for producing 4-deacetyl- or 4-deacetoxy-vinblastin-3-carboxamide derivatives - Google Patents

Process for producing 4-deacetyl- or 4-deacetoxy-vinblastin-3-carboxamide derivatives Download PDF

Info

Publication number
HU176226B
HU176226B HU76EI664A HUEI000664A HU176226B HU 176226 B HU176226 B HU 176226B HU 76EI664 A HU76EI664 A HU 76EI664A HU EI000664 A HUEI000664 A HU EI000664A HU 176226 B HU176226 B HU 176226B
Authority
HU
Hungary
Prior art keywords
compounds
alk
vinblastine
deacetoxyvinblastine
reacted
Prior art date
Application number
HU76EI664A
Other languages
English (en)
Hungarian (hu)
Inventor
George J Cullinan
Koert Gerzon
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HU176226B publication Critical patent/HU176226B/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04Dimeric indole alkaloids, e.g. vincaleucoblastine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HU76EI664A 1975-01-09 1976-01-08 Process for producing 4-deacetyl- or 4-deacetoxy-vinblastin-3-carboxamide derivatives HU176226B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53968175A 1975-01-09 1975-01-09

Publications (1)

Publication Number Publication Date
HU176226B true HU176226B (en) 1981-01-28

Family

ID=24152219

Family Applications (1)

Application Number Title Priority Date Filing Date
HU76EI664A HU176226B (en) 1975-01-09 1976-01-08 Process for producing 4-deacetyl- or 4-deacetoxy-vinblastin-3-carboxamide derivatives

Country Status (13)

Country Link
JP (1) JPS5195100A (fr)
BE (1) BE837390A (fr)
CA (1) CA1067073A (fr)
CH (1) CH624962A5 (fr)
CS (1) CS199615B2 (fr)
DE (1) DE2558027A1 (fr)
FR (1) FR2297043A1 (fr)
GB (1) GB1538921A (fr)
HU (1) HU176226B (fr)
IE (1) IE42385B1 (fr)
IL (1) IL48685A (fr)
NL (1) NL7515253A (fr)
PH (1) PH17563A (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR69783B (fr) * 1976-09-08 1982-07-07 Lilly Co Eli
USRE30561E (en) 1976-12-06 1981-03-31 Eli Lilly And Company Vinca alkaloid intermediates
GR68940B (fr) * 1977-01-19 1982-03-29 Lilly Co Eli
US4191688A (en) 1977-08-08 1980-03-04 Eli Lilly And Company Amides of leurosine, leuroformine, desacetylleurosine and desacetylleuroformine
US4195022A (en) 1978-03-27 1980-03-25 Eli Lilly And Company 4-Desacetoxy-4α-hydroxyvinblastine and related compounds
US4166810A (en) * 1978-04-20 1979-09-04 Eli Lilly And Company Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide
US4199504A (en) * 1978-05-15 1980-04-22 Eli Lilly And Company Bridged cathranthus alkaloid dimers
AR225153A1 (es) * 1978-10-10 1982-02-26 Lilly Co Eli Un procedimiento para la preparacion de sulfato de vindesina
US4357334A (en) 1980-03-20 1982-11-02 Eli Lilly And Company Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
LU83822A1 (fr) * 1981-12-08 1983-09-01 Omnichem Sa Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR204004A1 (es) * 1973-04-02 1975-11-12 Lilly Co Eli Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina

Also Published As

Publication number Publication date
IE42385B1 (en) 1980-07-30
IL48685A (en) 1980-03-31
CS199615B2 (en) 1980-07-31
CH624962A5 (en) 1981-08-31
GB1538921A (en) 1979-01-24
FR2297043B1 (fr) 1978-08-11
NL7515253A (nl) 1976-07-13
CA1067073A (fr) 1979-11-27
BE837390A (fr) 1976-07-08
FR2297043A1 (fr) 1976-08-06
JPS5195100A (fr) 1976-08-20
IE42385L (en) 1976-07-09
PH17563A (en) 1984-10-01
IL48685A0 (en) 1976-02-29
DE2558027A1 (de) 1976-07-15

Similar Documents

Publication Publication Date Title
EP0005051B1 (fr) 4-Désacétyl VLB C-3 carboxhydrazides, leur préparation et compositions qui les contiennent
HU185261B (en) Process for preparing n-/vinblastinoyl-23/-derivatives of some aminoacids and peptides
DK141511B (da) Analogifremgangsmåde til fremstilling af derivater af vindblastin, leurosidin eller leurocristin.
HU176226B (en) Process for producing 4-deacetyl- or 4-deacetoxy-vinblastin-3-carboxamide derivatives
US6403636B1 (en) Xanthone compounds, their preparation and use as medicament
Azab et al. Synthesis of chiral macrocyclic candidates: IV. Synthesis and antimicrobial activity of some tricyclooctacosa (triaconta) hexaene bis-Schiff base derivatives
HU187803B (en) Process for producing n-bracket-vinblastinoyl-23-bracket closed-derivatives of amino acids and pharmaceutical compositions containing them
US3954773A (en) 4-Desacetoxyvinblastine
CS195344B2 (en) Method of producing spirooxazolidindiones
JPS624398B2 (fr)
HU182952B (en) Process for producing 1-formyl-indol-dihydroindol derivatives
EP0207336B1 (fr) Dérivés nitro de bis-indolo du type vinblastine, procédé pour leur préparation et compositions pharmaceutiques les contenant
HU182482B (en) Process for producing 3-comma above-alpha-hydroxy-3-comma above-beta-hydroxy- and 3-comma aaove-oxo-leurosine derivatives
US4110330A (en) 5'-Acetonylvincristine and related compounds
EP0205168B1 (fr) Dérivés furfuryle de bis-indoles du type vinblastine, procédé pour leur préparation et compositions pharmaceutiques les contenant
GB2086884A (en) Cytostatic Compounds
KR820001241B1 (ko) 4-데스아세틸 vlb c-3카복스하이드라지드의 항종양유도체 제조방법
HU181874B (en) Process for preparing amides of deacetyl-leurosine and deacetyl-leuroformine
KR820001240B1 (ko) 4-데스 아세틸 vlb c-3카복스하이드라지드의 항종양 유도체 제조방법
KR790000810B1 (ko) 빈브라스틴 유도체의 제조방법
GB2086378A (en) Process for the Preparation of Cytostatic Compounds
US4757077A (en) Bis-indole derivatives and pharmaceutical compositions containing them
KR830002079B1 (ko) 4'-데옥시 vlb "a"와 "b" 및 관련 1-포르밀 화합물의 3'-산화된 유도체의 제조방법
WO1988000826A1 (fr) Compositions antitumorales et procedes d'utilisation
PL90467B1 (fr)

Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee