HU0900798D0 - 4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activity - Google Patents
4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activityInfo
- Publication number
- HU0900798D0 HU0900798D0 HU0900798A HUP0900798A HU0900798D0 HU 0900798 D0 HU0900798 D0 HU 0900798D0 HU 0900798 A HU0900798 A HU 0900798A HU P0900798 A HUP0900798 A HU P0900798A HU 0900798 D0 HU0900798 D0 HU 0900798D0
- Authority
- HU
- Hungary
- Prior art keywords
- phenylamino
- protein kinase
- kinase inhibitor
- pyrimidine derivatives
- inhibitor activity
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- JLVLBDODYLEYOY-UHFFFAOYSA-N n-phenylpyrimidin-4-amine Chemical class C=1C=NC=NC=1NC1=CC=CC=C1 JLVLBDODYLEYOY-UHFFFAOYSA-N 0.000 title 1
- 239000003909 protein kinase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0900798A HU0900798D0 (en) | 2009-12-21 | 2009-12-21 | 4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activity |
| US13/517,120 US9040529B2 (en) | 2009-12-21 | 2010-12-17 | 4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activity |
| PCT/HU2010/000145 WO2011077171A1 (en) | 2009-12-21 | 2010-12-17 | 4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activity |
| DK10805286.1T DK2516405T3 (en) | 2009-12-21 | 2010-12-17 | 4-PHENYLAMINO-PYRIMIDINE DERIVATIVES WITH PROTEINKINASE INHIBITOR ACTIVITY |
| ES10805286.1T ES2558132T3 (es) | 2009-12-21 | 2010-12-17 | Derivados de 4-fenilamino pirimidina dotados de actividad inhibidora de proteína quinasas |
| EP10805286.1A EP2516405B1 (en) | 2009-12-21 | 2010-12-17 | 4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activity |
| JP2012545455A JP5857211B2 (ja) | 2009-12-21 | 2010-12-17 | プロテインキナーゼ阻害活性を有する４−フェニルアミノ−ピリミジン誘導体 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0900798A HU0900798D0 (en) | 2009-12-21 | 2009-12-21 | 4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HU0900798D0 true HU0900798D0 (en) | 2010-03-01 |
Family
ID=89989454
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0900798A HU0900798D0 (en) | 2009-12-21 | 2009-12-21 | 4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activity |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9040529B2 (hu) |
| EP (1) | EP2516405B1 (hu) |
| JP (1) | JP5857211B2 (hu) |
| DK (1) | DK2516405T3 (hu) |
| ES (1) | ES2558132T3 (hu) |
| HU (1) | HU0900798D0 (hu) |
| WO (1) | WO2011077171A1 (hu) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9498471B2 (en) | 2011-10-20 | 2016-11-22 | The Regents Of The University Of California | Use of CDK9 inhibitors to reduce cartilage degradation |
| US9617225B2 (en) | 2012-08-23 | 2017-04-11 | Virostatics Srl | 4,6-disubstituted aminopyrimidine derivatives have anti-HIV activity |
| EP2769722A1 (en) * | 2013-02-22 | 2014-08-27 | Ruprecht-Karls-Universität Heidelberg | Compounds for use in inhibiting HIV capsid assembly |
| CA3000633C (en) | 2014-10-14 | 2023-10-03 | The Regents Of The University Of California | Use of cdk9 and brd4 inhibitors to inhibit inflammation |
| JP2017531003A (ja) | 2014-10-16 | 2017-10-19 | バイエル ファーマ アクチエンゲゼルシャフト | スルホン基を含有するフッ化ベンゾフラニル−ピリミジン誘導体 |
| JP6847099B2 (ja) | 2015-09-29 | 2021-03-24 | バイエル ファーマ アクチエンゲゼルシャフト | 新規な大環状スルホンジイミン化合物 |
| WO2017060167A1 (en) | 2015-10-08 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Novel modified macrocyclic compounds |
| WO2017060322A2 (en) | 2015-10-10 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Ptefb-inhibitor-adc |
| US20180015153A1 (en) | 2016-07-16 | 2018-01-18 | Florida State University Research Foundation, Inc. | Compounds and methods for treatment and prevention of flavivirus infection |
| CA3057891A1 (en) | 2017-03-28 | 2018-10-04 | Bayer Aktiengesellschaft | Novel ptefb inhibiting macrocyclic compounds |
| US11254690B2 (en) | 2017-03-28 | 2022-02-22 | Bayer Pharma Aktiengesellschaft | PTEFb inhibiting macrocyclic compounds |
| US10555942B2 (en) | 2017-10-10 | 2020-02-11 | Florida State University Research Foundation, Inc. | Emetine compounds for treatment and prevention of flavivirus infection |
| IT201900004737A1 (it) | 2019-03-29 | 2020-09-29 | Virostatics Srl | Composti aventi attività enzimatica anti-CDK4/6 e anti-CDK9 per l’inibizione della proliferazione del cancro e relativi metodi di screening per la loro identificazione. |
| CN111269215B (zh) * | 2020-04-01 | 2021-10-26 | 中科利健制药(广州)有限公司 | 含氮杂环有机化合物及其制备方法和应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3478030A (en) | 1966-06-27 | 1969-11-11 | Abbott Lab | Benzamide substituted anilino aminopyrimidines |
| US3950525A (en) | 1973-06-19 | 1976-04-13 | Pfizer Inc. | Relaxation of smooth muscle in a mammal |
| ATE355841T1 (de) | 1997-12-13 | 2007-03-15 | Bristol Myers Squibb Co | Verwendung von pyrazolo ( 3,4-b) pyridin als cyclin-abhängige kinase hemmer |
| US6114365A (en) | 1999-08-12 | 2000-09-05 | Pharmacia & Upjohn S.P.A. | Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents |
| DE60134414D1 (de) | 2000-08-08 | 2008-07-24 | Ortho Mcneil Pharm Inc | 4-pyrimidinamine derivate, pharmazeutische zusammenstellungen und verwandte methoden |
| DE60223790D1 (de) | 2001-03-29 | 2008-01-10 | Vertex Pharma | Hemmer von c-jun-terminal kinase (jnk) und andere protein kinase |
| DE10129028A1 (de) | 2001-06-11 | 2003-01-02 | Schering Ag | Lösliche Cdk-inhibitorische Indirubinderivate |
| GB0226583D0 (en) * | 2002-11-14 | 2002-12-18 | Cyclacel Ltd | Compounds |
| US8084457B2 (en) | 2003-09-15 | 2011-12-27 | Lead Discovery Center Gmbh | Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases |
| JP2008542219A (ja) | 2005-05-25 | 2008-11-27 | インゲニウム ファーマシューティカルズ ジーエムビーエイチ | 疼痛処置法 |
| US20080275063A1 (en) | 2007-04-24 | 2008-11-06 | Heike Schauerte | Inhibitors of protein kinases |
| WO2008132138A1 (en) | 2007-04-25 | 2008-11-06 | Ingenium Pharmaceuticals Gmbh | Derivatives of 4,6-disubstituted aminopyrimidines |
| CA2722326A1 (en) * | 2008-04-24 | 2009-10-29 | Incyte Corporation | Macrocyclic compounds and their use as kinase inhibitors |
| US8673950B2 (en) | 2010-11-02 | 2014-03-18 | Hoffmann-Laroche Inc. | Dihydrooxazol-2-amine derivatives |
-
2009
- 2009-12-21 HU HU0900798A patent/HU0900798D0/hu unknown
-
2010
- 2010-12-17 DK DK10805286.1T patent/DK2516405T3/en active
- 2010-12-17 US US13/517,120 patent/US9040529B2/en not_active Expired - Fee Related
- 2010-12-17 ES ES10805286.1T patent/ES2558132T3/es active Active
- 2010-12-17 JP JP2012545455A patent/JP5857211B2/ja not_active Expired - Fee Related
- 2010-12-17 EP EP10805286.1A patent/EP2516405B1/en not_active Not-in-force
- 2010-12-17 WO PCT/HU2010/000145 patent/WO2011077171A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| JP5857211B2 (ja) | 2016-02-10 |
| US9040529B2 (en) | 2015-05-26 |
| ES2558132T3 (es) | 2016-02-02 |
| US20120258968A1 (en) | 2012-10-11 |
| JP2013515047A (ja) | 2013-05-02 |
| WO2011077171A1 (en) | 2011-06-30 |
| EP2516405B1 (en) | 2015-09-30 |
| EP2516405A1 (en) | 2012-10-31 |
| DK2516405T3 (en) | 2016-01-11 |
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