HRPK20120436B3 - Kapsula imatinib mesilata, naäśin njezine proizvodnje i primjena - Google Patents
Kapsula imatinib mesilata, naäśin njezine proizvodnje i primjenaInfo
- Publication number
- HRPK20120436B3 HRPK20120436B3 HRP20120436AA HRP20120436A HRPK20120436B3 HR PK20120436 B3 HRPK20120436 B3 HR PK20120436B3 HR P20120436A A HRP20120436A A HR P20120436AA HR P20120436 A HRP20120436 A HR P20120436A HR PK20120436 B3 HRPK20120436 B3 HR PK20120436B3
- Authority
- HR
- Croatia
- Prior art keywords
- capsule
- production
- imatinib mesylate
- provides
- administration
- Prior art date
Links
- 239000002775 capsule Substances 0.000 title abstract 8
- 238000004519 manufacturing process Methods 0.000 title abstract 5
- 229960003685 imatinib mesylate Drugs 0.000 title abstract 3
- YLMAHDNUQAMNNX-UHFFFAOYSA-N imatinib methanesulfonate Chemical compound CS(O)(=O)=O.C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 YLMAHDNUQAMNNX-UHFFFAOYSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000003814 drug Substances 0.000 abstract 3
- 229940079593 drug Drugs 0.000 abstract 2
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- 239000005517 L01XE01 - Imatinib Substances 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000007884 disintegrant Substances 0.000 abstract 1
- 238000007908 dry granulation Methods 0.000 abstract 1
- 230000037406 food intake Effects 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 229960002411 imatinib Drugs 0.000 abstract 1
- KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 abstract 1
- 239000000314 lubricant Substances 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Predmetni izum spada u područje medicine, posebno, farmaceutske industrije, te osigurava novi oblik lijeka imatinib mesilata, naime, kapsulu. Sadržaj kapsule uključuje kao aktivni sastojak kristalni oblik imatinib mesilata, manit kao pomoćnu tvar i prihvaćene u farmaceutskoj industriji pomoćne tvari odabrane iz skupine dezintegranata, glidanata i lubrikanata. Izum također predviđa način proizvodnje kapsule i primjenu kapsule u liječenju širokog spektra bolesti ili stanja u kojima je indicirana primjena imatiniba. Granule dobivene putem suhe granulacije u postupku proizvodnje kapsula imaju povećanu gustoću, izvrsnu fluidnost bez potrebe za korištenjem vezivnih tvari, izostanak prianjanja, otpornost na upijanje atmosferske vlage. Način proizvodnje kapsule karakterizira manji broj stadija u usporedbi s proizvodnjom ostalih oblika lijeka, kao što su tablete, a dobivena kapsula ima visoku stabilnost prilikom čuvanja i pruža veću udobnost pri gutanju.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EA201100680A EA017782B1 (ru) | 2011-05-24 | 2011-05-24 | Капсула, содержащая иматиниб мезилат, и способ ее получения |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20120436A2 HRP20120436A2 (hr) | 2013-01-31 |
| HRPK20120436B3 true HRPK20120436B3 (hr) | 2015-05-22 |
Family
ID=47228909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20120436AA HRPK20120436B3 (hr) | 2011-05-24 | 2012-05-23 | Kapsula imatinib mesilata, naäśin njezine proizvodnje i primjena |
Country Status (2)
| Country | Link |
|---|---|
| EA (1) | EA017782B1 (hr) |
| HR (1) | HRPK20120436B3 (hr) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006054314A1 (en) * | 2004-11-17 | 2006-05-26 | Natco Pharma Limited | Polymorphic forms of imatinib mesylate |
| ATE445392T1 (de) * | 2005-08-15 | 2009-10-15 | Siegfried Generics Int Ag | Filmtablette oder granulat enthaltend ein pyridylpyrimidin |
| US7977348B2 (en) * | 2006-04-27 | 2011-07-12 | Sicor Inc. | Polymorphic forms of imatinib mesylate and processes for preparation of novel crystalline forms as well as amorphous and form α |
-
2011
- 2011-05-24 EA EA201100680A patent/EA017782B1/ru not_active IP Right Cessation
-
2012
- 2012-05-23 HR HRP20120436AA patent/HRPK20120436B3/hr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20120436A2 (hr) | 2013-01-31 |
| EA017782B1 (ru) | 2013-03-29 |
| EA201100680A1 (ru) | 2012-11-30 |
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