HRP980248A2 - Erythromycin derivatives - Google Patents
Erythromycin derivativesInfo
- Publication number
- HRP980248A2 HRP980248A2 HR60/046,150A HRP980248A HRP980248A2 HR P980248 A2 HRP980248 A2 HR P980248A2 HR P980248 A HRP980248 A HR P980248A HR P980248 A2 HRP980248 A2 HR P980248A2
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- desosaminyl
- deoxy
- carbamate
- methyl
- Prior art date
Links
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 104
- YVTFLQUPRIIRFE-QUMKBVJLSA-N erythronolide A Chemical compound CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O YVTFLQUPRIIRFE-QUMKBVJLSA-N 0.000 claims description 35
- 150000003839 salts Chemical class 0.000 claims description 35
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 32
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 30
- -1 4-phenyl-imidazol-1-yl Chemical group 0.000 claims description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 19
- 125000000623 heterocyclic group Chemical group 0.000 claims description 19
- 125000000217 alkyl group Chemical group 0.000 claims description 17
- 238000000034 method Methods 0.000 claims description 17
- 239000002253 acid Substances 0.000 claims description 16
- 208000035143 Bacterial infection Diseases 0.000 claims description 14
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 14
- 208000010362 Protozoan Infections Diseases 0.000 claims description 14
- 208000022362 bacterial infectious disease Diseases 0.000 claims description 14
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims description 12
- 241000251468 Actinopterygii Species 0.000 claims description 11
- 241000124008 Mammalia Species 0.000 claims description 11
- 238000011282 treatment Methods 0.000 claims description 11
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims description 10
- 229910052799 carbon Inorganic materials 0.000 claims description 10
- 125000005843 halogen group Chemical group 0.000 claims description 10
- 125000001589 carboacyl group Chemical group 0.000 claims description 9
- 125000005842 heteroatom Chemical group 0.000 claims description 9
- 229910052739 hydrogen Inorganic materials 0.000 claims description 9
- 229910052757 nitrogen Inorganic materials 0.000 claims description 9
- 229910052760 oxygen Inorganic materials 0.000 claims description 9
- 229910052717 sulfur Inorganic materials 0.000 claims description 9
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 8
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 8
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- 125000001424 substituent group Chemical group 0.000 claims description 8
- 125000003118 aryl group Chemical group 0.000 claims description 7
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- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims description 4
- 229930193775 erythronolide Natural products 0.000 claims description 4
- ZFBRGCCVTUPRFQ-UHFFFAOYSA-N erythronolide-B Natural products CCC1OC(=O)C(C)C(O)C(C)C(O)C(C)(O)CC(C)C(=O)C(C)C(O)C1C ZFBRGCCVTUPRFQ-UHFFFAOYSA-N 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 3
- ZDYVRSLAEXCVBX-UHFFFAOYSA-N pyridinium p-toluenesulfonate Chemical compound C1=CC=[NH+]C=C1.CC1=CC=C(S([O-])(=O)=O)C=C1 ZDYVRSLAEXCVBX-UHFFFAOYSA-N 0.000 claims description 3
- 230000009969 flowable effect Effects 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 2
- 125000004549 quinolin-4-yl group Chemical group N1=CC=C(C2=CC=CC=C12)* 0.000 claims description 2
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
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- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 10
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- 238000005481 NMR spectroscopy Methods 0.000 description 3
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4615097P | 1997-05-09 | 1997-05-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP980248A2 true HRP980248A2 (en) | 1999-02-28 |
Family
ID=21941889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR60/046,150A HRP980248A2 (en) | 1997-05-09 | 1998-05-08 | Erythromycin derivatives |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6162794A (fr) |
| AP (1) | AP9801235A0 (fr) |
| AR (1) | AR012847A1 (fr) |
| AU (1) | AU6932098A (fr) |
| CO (1) | CO4810380A1 (fr) |
| HR (1) | HRP980248A2 (fr) |
| MA (1) | MA26493A1 (fr) |
| PA (1) | PA8450901A1 (fr) |
| TN (1) | TNSN98061A1 (fr) |
| WO (1) | WO1998051696A1 (fr) |
| ZA (1) | ZA983902B (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6710033B1 (en) | 1996-08-14 | 2004-03-23 | Vanderbilt University | Methods and treatment of multiple sclerosis |
| US6890526B2 (en) | 1997-05-06 | 2005-05-10 | Vanderbilt University | Methods and reagents for the treatment of multiple sclerosis |
| HN1998000159A (es) * | 1997-10-29 | 1999-02-09 | Monsanto Co | Derivados de 9- amino - 3 ceto eritromicina |
| AP9801420A0 (en) * | 1998-01-02 | 1998-12-31 | Pfizer Prod Inc | Novel macrolides. |
| CN1351608A (zh) * | 1999-05-24 | 2002-05-29 | 辉瑞产品公司 | 13－甲基红霉素衍生物 |
| US20020115621A1 (en) * | 2000-08-07 | 2002-08-22 | Wei-Gu Su | Macrolide antibiotics |
| PT1836211E (pt) | 2004-12-21 | 2010-04-08 | Pfizer Prod Inc | Macrólidos |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992009614A1 (fr) * | 1990-11-28 | 1992-06-11 | Taisho Pharmaceutical Co., Ltd. | Derive de 6-o-methylerythromycine a |
| ATE145212T1 (de) * | 1992-04-22 | 1996-11-15 | Taisho Pharmaceutical Co Ltd | 5-0-desosaminylerythronolide a derivate |
| FR2718450B1 (fr) * | 1994-04-08 | 1997-01-10 | Roussel Uclaf | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. |
| DK0922050T3 (da) * | 1996-05-07 | 2003-11-24 | Abbott Lab | 3-Descladinose-2,3-anhydroerythromycin-derivater |
-
1998
- 1998-05-01 AU AU69320/98A patent/AU6932098A/en not_active Abandoned
- 1998-05-01 WO PCT/IB1998/000661 patent/WO1998051696A1/fr active Application Filing
- 1998-05-01 US US09/355,092 patent/US6162794A/en not_active Expired - Fee Related
- 1998-05-06 TN TNTNSN98061A patent/TNSN98061A1/fr unknown
- 1998-05-06 MA MA25063A patent/MA26493A1/fr unknown
- 1998-05-07 AR ARP980102141A patent/AR012847A1/es unknown
- 1998-05-07 AP APAP/P/1998/001235A patent/AP9801235A0/en unknown
- 1998-05-08 CO CO98025810A patent/CO4810380A1/es unknown
- 1998-05-08 ZA ZA9803902A patent/ZA983902B/xx unknown
- 1998-05-08 HR HR60/046,150A patent/HRP980248A2/hr not_active Application Discontinuation
- 1998-05-08 PA PA19988450901A patent/PA8450901A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MA26493A1 (fr) | 2004-12-20 |
| AR012847A1 (es) | 2000-11-22 |
| ZA983902B (en) | 1999-11-08 |
| TNSN98061A1 (fr) | 2005-03-15 |
| US6162794A (en) | 2000-12-19 |
| WO1998051696A1 (fr) | 1998-11-19 |
| PA8450901A1 (es) | 2000-05-24 |
| AU6932098A (en) | 1998-12-08 |
| CO4810380A1 (es) | 1999-06-30 |
| AP9801235A0 (en) | 1999-11-07 |
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