HRP20240185T1 - Mobilni ultraširokopojasni radar za praćenje razine torakalne tekućine i kardio-respiratorne funkcije - Google Patents

Mobilni ultraširokopojasni radar za praćenje razine torakalne tekućine i kardio-respiratorne funkcije Download PDF

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HRP20240185T1
HRP20240185T1 HRP20240185TT HRP20240185T HRP20240185T1 HR P20240185 T1 HRP20240185 T1 HR P20240185T1 HR P20240185T T HRP20240185T T HR P20240185TT HR P20240185 T HRP20240185 T HR P20240185T HR P20240185 T1 HRP20240185 T1 HR P20240185T1
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uwb
tissue
reflected
data
lung tissue
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Emre Ertin
William T. Abraham
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Ohio State Innovation Foundation
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/0816—Measuring devices for examining respiratory frequency
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/024—Detecting, measuring or recording pulse rate or heart rate
    • A61B5/02405—Determining heart rate variability
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/0507—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  using microwaves or terahertz waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A61B5/0537—Measuring body composition by impedance, e.g. tissue hydration or fat content
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/07—Endoradiosondes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
    • A61B5/0803—Recording apparatus specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1495—Calibrating or testing of in-vivo probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683—Means for maintaining contact with the body
    • A61B5/6832—Means for maintaining contact with the body using adhesives
    • A61B5/6833—Adhesive patches
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S13/00—Systems using the reflection or reradiation of radio waves, e.g. radar systems; Analogous systems using reflection or reradiation of waves whose nature or wavelength is irrelevant or unspecified
    • G01S13/003—Bistatic radar systems; Multistatic radar systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S13/00—Systems using the reflection or reradiation of radio waves, e.g. radar systems; Analogous systems using reflection or reradiation of waves whose nature or wavelength is irrelevant or unspecified
    • G01S13/02—Systems using reflection of radio waves, e.g. primary radar systems; Analogous systems
    • G01S13/0209—Systems with very large relative bandwidth, i.e. larger than 10 %, e.g. baseband, pulse, carrier-free, ultrawideband
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S13/00—Systems using the reflection or reradiation of radio waves, e.g. radar systems; Analogous systems using reflection or reradiation of waves whose nature or wavelength is irrelevant or unspecified
    • G01S13/02—Systems using reflection of radio waves, e.g. primary radar systems; Analogous systems
    • G01S13/50—Systems of measurement based on relative movement of target
    • G01S13/52—Discriminating between fixed and moving objects or between objects moving at different speeds
    • G01S13/522—Discriminating between fixed and moving objects or between objects moving at different speeds using transmissions of interrupted pulse modulated waves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S13/00—Systems using the reflection or reradiation of radio waves, e.g. radar systems; Analogous systems using reflection or reradiation of waves whose nature or wavelength is irrelevant or unspecified
    • G01S13/88—Radar or analogous systems specially adapted for specific applications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0223—Operational features of calibration, e.g. protocols for calibrating sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/02—Operational features
    • A61B2560/0242—Operational features adapted to measure environmental factors, e.g. temperature, pollution
    • A61B2560/0247—Operational features adapted to measure environmental factors, e.g. temperature, pollution for compensation or correction of the measured physiological value
    • A61B2560/0252—Operational features adapted to measure environmental factors, e.g. temperature, pollution for compensation or correction of the measured physiological value using ambient temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S13/00—Systems using the reflection or reradiation of radio waves, e.g. radar systems; Analogous systems using reflection or reradiation of waves whose nature or wavelength is irrelevant or unspecified
    • G01S13/88—Radar or analogous systems specially adapted for specific applications
    • G01S13/887—Radar or analogous systems specially adapted for specific applications for detection of concealed objects, e.g. contraband or weapons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S7/00—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
    • G01S7/02—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S13/00
    • G01S7/41—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S13/00 using analysis of echo signal for target characterisation; Target signature; Target cross-section
    • G01S7/415—Identification of targets based on measurements of movement associated with the target

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Remote Sensing (AREA)
  • Radar, Positioning & Navigation (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • General Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Electromagnetism (AREA)
  • Optics & Photonics (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Claims (11)

1. Postupak za određivanje tjelesnih karakteristika, koji sadrži: prikupljanje skupova reflektiranih povratno raspršenih podataka (1003) za niz ultra-širokopojasnih (UWB) impulsa odaslanih preko UWB senzora koji se sastoji od niza parova antena za odašiljanje (TX) i primanje (RX) postavljenih na tijelo korisnika, i odgovarajuće kalibracijsko mjerenje iz kalibracijskog kanala u UWB senzoru; određivanje koeficijenata refleksije (1021) za svako sučelje tkiva na temelju skupova reflektiranih povratno raspršenih podataka, koeficijenti refleksije utvrđeni iz profila refleksije na temelju reflektiranih povratno raspršenih podataka za taj niz UWB impulsa i odgovarajuće kalibracijsko mjerenje, profil refleksije povezan s modelom slojeva tkiva u tijelu između UWB senzora i plućnog tkiva; i određivanje razine tekućine u plućnom tkivu (1027) na temelju koeficijenata refleksije, pri čemu skupovi reflektiranih povratno raspršenih podataka (1003) sadrže reflektirane povratno raspršene podatke dobivene za svaki od TX i RX parova antena u UWB senzoru koji se kombiniraju za generiranje širokopojasnog signala oblikovanog snopa (1006) za svaki skup reflektiranih povratno raspršenih podataka, i naznačen time što profili refleksije se određuju na temelju rijetke dekonvolucije (1021) širokopojasnog signala oblikovanog snopa tog skupa reflektiranih povratno raspršenih podataka (1003) korištenjem kompenziranog UWB oblika pulsa koji se temelji na odgovarajućem kalibracijskom mjerenju, pri čemu se kompenzirani UWB oblik pulsa kompenzira za promjene temperature.
2. Postupak prema zahtjevu 1, naznačen time što se rijetka dekonvolucija (1021) širokopojasnog signala oblikovanog snopa implementira za svaki od K frekvencijskih pojaseva.
3. Postupak prema bilo kojem od zahtjeva 1-2, koji sadrži: identificiranje dubine sučelja plućnog tkiva na gornjoj, srednjoj i donjoj točki u respiracijskom ciklusu plućnog tkiva (1024) na temelju koeficijenata refleksije; i gdje određivanje sadržaja razine tekućine (1027) u plućnom tkivu uključuje određivanje sadržaja razine tekućine na gornjoj, srednjoj i donjoj točki u ciklusu disanja.
4. Postupak prema bilo kojem od zahtjeva 1-2, koji sadrži određivanje karakteristika slojeva tkiva smještenih između UWB senzora i plućnog tkiva.
5. Postupak prema zahtjevu 4, naznačen time što karakteristike slojeva tkiva sadrže lokaciju najmanje jednog sučelja sloja tkiva ili dielektrično svojstvo najmanje jednog sloja tkiva.
6. Mobilni sustav za nadzor tijela (100), koji sadrži: ultra-širokopojasni (UWB) senzor koji se sastoji od niza antena (109) koji se sastoji od parova odašiljačkih (TX) i prijemnih (RX) antena (109), i kalibracijski kanal, UWB senzor konfiguriran da se postavi na tijelo korisnika (103); radio-frekvencijski (RF) prednji kraj koji sadrži UWB generator impulsa (106) spojen na TX antene (109t) niza antena (109) i UWB prijemnik (121) spojen na RX antene (109r) niza antena (109), gdje se UWB impulsi koje generira UWB generator impulsa (106) sekvencijalno prenose u tijelo korisnika (103) kroz TX antene (109t) i reflektirani povratno raspršeni signali primaju se kroz RX antenu (109r) tog para TX i RX antene (109t, 109r); bežični odašiljač (127) konfiguriran za komunikaciju podataka povezanih s reflektiranim povratnim raspršenjem i odgovarajućim kalibracijskim mjerenjem iz kalibracijskog kanala; i računalni uređaj konfiguriran za primanje podataka i određivanje tjelesnih karakteristika korisnika (103) na temelju reflektiranog povratnog raspršenja i odgovarajućeg kalibracijskog mjerenja, pri čemu kalibracijski kanal sadrži temperaturnu kalibracijsku petlju koja ima opterećenje poznate impedancije smješteno u blizini niza antena (109) pri čemu je računalni uređaj konfiguriran za: određivanje profila refleksije na temelju podataka povezanih s reflektiranim povratnim raspršenjem i odgovarajućim kalibracijskim mjerenjem za niz odaslanih UWB impulsa, profil refleksije povezan s modelom slojeva tkiva u tijelu (103) između UWB senzora i ciljnog tkiva; određivanje koeficijenta refleksije na temelju profila refleksije; i određivanje karakteristika ciljnog tkiva iz generiranih podataka ciljnog tkiva, pri čemu karakteristike ciljnog tkiva uključuju dubinu sučelja s ciljnim tkivom ili dielektrična svojstva ciljnog tkiva, pri čemu je ciljno tkivo plućno tkivo i pri čemu je računalni uređaj konfiguriran za prepoznavanje mjere sadržaja plućne tekućine na temelju karakteristika plućnog tkiva, i naznačen time što profil refleksije određen je kroz rijetku dekonvoluciju signala prosječnog širokopojasnog povratnog raspršenja na temelju podataka povezanih s reflektiranim povratnim raspršenjem za niz UWB impulsa, koristeći kompenzirani UWB oblik pulsa koji se temelji na odgovarajućem kalibracijskom mjerenju pri čemu se kompenzirani UWB oblik pulsa kompenzira temperaturne promjene.
7. Mobilni sustav za nadzor tijela (100) prema zahtjevu 6, naznačen time što je računalni uređaj konfiguriran za istodobnu identifikaciju jednog ili više otkucaja srca, varijabilnosti otkucaja srca, brzine disanja ili plimnog volumena.
8. Mobilni sustav za nadzor tijela (100) prema zahtjevu 6, naznačen time što je računalni uređaj konfiguriran za identifikaciju gornje i donje dubine sučelja plućnog tkiva tijekom ciklusa disanja plućnog tkiva.
9. Mobilni sustav za nadzor tijela (100) prema zahtjevu 8, naznačen time što je računalni uređaj konfiguriran za identifikaciju dielektričnih svojstava na gornjoj i donjoj dubini i na prosječnoj dubini u ciklusu disanja plućnog tkiva.
10. Mobilni sustav za nadzor tijela (100) prema bilo kojem od zahtjeva 7-9, naznačen time što je računalni uređaj konfiguriran za određivanje profila refleksije za svaki od niza skupova reflektiranih povratno raspršenih podataka, svaki skup reflektiranih povratno raspršenih podataka sadrži podatke povezane s refleksijom povratnog raspršenja za niz odaslanih UWB impulsa povezanih s tim skupom.
11. Mobilni sustav za nadzor tijela (100) prema zahtjevu 6, naznačen time što se varijacije u odaslanim UWB impulsima kompenziraju na temelju odgovarajućeg kalibracijskog mjerenja.
HRP20240185TT 2018-07-17 2019-07-17 Mobilni ultraširokopojasni radar za praćenje razine torakalne tekućine i kardio-respiratorne funkcije HRP20240185T1 (hr)

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EP19837024.9A EP3823522B1 (en) 2018-07-17 2019-07-17 Mobile ultrawideband radar for monitoring thoracic fluid levels and cardio-respiratory function
PCT/US2019/042267 WO2020018707A1 (en) 2018-07-17 2019-07-17 Mobile ultrawideband radar for monitoring thoracic fluid levels and cardio-respiratory function

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WO2023178267A2 (en) * 2022-03-18 2023-09-21 Ohio State Innovation Foundation Mobile ultrawideband radar for monitoring thoracic fluid levels and cardio-respiratory function

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EP3823522C0 (en) 2023-11-15
EP4332627A2 (en) 2024-03-06
SG11202100325XA (en) 2021-02-25
BR112021000784A2 (pt) 2021-04-13

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