HRP20230625T1 - Pohrana mikroorganizama - Google Patents
Pohrana mikroorganizama Download PDFInfo
- Publication number
- HRP20230625T1 HRP20230625T1 HRP20230625TT HRP20230625T HRP20230625T1 HR P20230625 T1 HRP20230625 T1 HR P20230625T1 HR P20230625T T HRP20230625T T HR P20230625TT HR P20230625 T HRP20230625 T HR P20230625T HR P20230625 T1 HRP20230625 T1 HR P20230625T1
- Authority
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- Croatia
- Prior art keywords
- acid
- compartment
- compartment system
- water
- microcapsules
- Prior art date
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- 244000005700 microbiome Species 0.000 title claims 9
- 238000004321 preservation Methods 0.000 title claims 2
- 239000003094 microcapsule Substances 0.000 claims 6
- 238000002360 preparation method Methods 0.000 claims 5
- 150000007524 organic acids Chemical class 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 235000005985 organic acids Nutrition 0.000 claims 3
- ZEYHEAKUIGZSGI-UHFFFAOYSA-N 4-methoxybenzoic acid Chemical compound COC1=CC=C(C(O)=O)C=C1 ZEYHEAKUIGZSGI-UHFFFAOYSA-N 0.000 claims 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
- 108010010803 Gelatin Proteins 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 2
- 239000008273 gelatin Substances 0.000 claims 2
- 229920000159 gelatin Polymers 0.000 claims 2
- 235000019322 gelatine Nutrition 0.000 claims 2
- 235000011852 gelatine desserts Nutrition 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims 2
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 2
- 239000004626 polylactic acid Substances 0.000 claims 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
- 244000215068 Acacia senegal Species 0.000 claims 1
- 229920001817 Agar Polymers 0.000 claims 1
- 239000005711 Benzoic acid Substances 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims 1
- 239000004287 Dehydroacetic acid Substances 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- 229920002148 Gellan gum Polymers 0.000 claims 1
- 229920000084 Gum arabic Polymers 0.000 claims 1
- 241000186684 Lactobacillus pentosus Species 0.000 claims 1
- 240000006024 Lactobacillus plantarum Species 0.000 claims 1
- 235000013965 Lactobacillus plantarum Nutrition 0.000 claims 1
- 241000218588 Lactobacillus rhamnosus Species 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims 1
- 235000010489 acacia gum Nutrition 0.000 claims 1
- 239000000205 acacia gum Substances 0.000 claims 1
- 235000011054 acetic acid Nutrition 0.000 claims 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 claims 1
- 239000008272 agar Substances 0.000 claims 1
- 229940072056 alginate Drugs 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 235000010233 benzoic acid Nutrition 0.000 claims 1
- 239000006172 buffering agent Substances 0.000 claims 1
- 230000003139 buffering effect Effects 0.000 claims 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims 1
- -1 caprylic triglycerides Chemical class 0.000 claims 1
- 235000010418 carrageenan Nutrition 0.000 claims 1
- 239000000679 carrageenan Substances 0.000 claims 1
- 229920001525 carrageenan Polymers 0.000 claims 1
- 229940113118 carrageenan Drugs 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 235000010980 cellulose Nutrition 0.000 claims 1
- 235000015165 citric acid Nutrition 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 235000019258 dehydroacetic acid Nutrition 0.000 claims 1
- PGRHXDWITVMQBC-UHFFFAOYSA-N dehydroacetic acid Natural products CC(=O)C1C(=O)OC(C)=CC1=O PGRHXDWITVMQBC-UHFFFAOYSA-N 0.000 claims 1
- JEQRBTDTEKWZBW-UHFFFAOYSA-N dehydroacetic acid Chemical compound CC(=O)C1=C(O)OC(C)=CC1=O JEQRBTDTEKWZBW-UHFFFAOYSA-N 0.000 claims 1
- 229940061632 dehydroacetic acid Drugs 0.000 claims 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims 1
- 239000003925 fat Substances 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 235000019253 formic acid Nutrition 0.000 claims 1
- 239000001530 fumaric acid Substances 0.000 claims 1
- 235000011087 fumaric acid Nutrition 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 235000010492 gellan gum Nutrition 0.000 claims 1
- 239000000216 gellan gum Substances 0.000 claims 1
- 239000000174 gluconic acid Substances 0.000 claims 1
- 235000012208 gluconic acid Nutrition 0.000 claims 1
- 229920001477 hydrophilic polymer Polymers 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 229940072205 lactobacillus plantarum Drugs 0.000 claims 1
- 229940057995 liquid paraffin Drugs 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 239000001630 malic acid Substances 0.000 claims 1
- 235000011090 malic acid Nutrition 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000002480 mineral oil Substances 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 235000006408 oxalic acid Nutrition 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 235000011007 phosphoric acid Nutrition 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920005862 polyol Polymers 0.000 claims 1
- 150000003077 polyols Chemical class 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 239000006041 probiotic Substances 0.000 claims 1
- 230000000529 probiotic effect Effects 0.000 claims 1
- 235000018291 probiotics Nutrition 0.000 claims 1
- 235000019260 propionic acid Nutrition 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims 1
- 229920002545 silicone oil Polymers 0.000 claims 1
- 235000002316 solid fats Nutrition 0.000 claims 1
- 239000004334 sorbic acid Substances 0.000 claims 1
- 235000010199 sorbic acid Nutrition 0.000 claims 1
- 229940075582 sorbic acid Drugs 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 1
- 239000008158 vegetable oil Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 239000000230 xanthan gum Substances 0.000 claims 1
- 229920001285 xanthan gum Polymers 0.000 claims 1
- 235000010493 xanthan gum Nutrition 0.000 claims 1
- 229940082509 xanthan gum Drugs 0.000 claims 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/04—Preserving or maintaining viable microorganisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/02—Separating microorganisms from their culture media
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
- A61K2035/115—Probiotics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Cosmetics (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Claims (11)
1. Sustav s dvama odjeljcima koji se sastoji od:
- prvog odjeljka koji se sastoji od mikrokapsula koje se sastoje od u vodi netopljive i vodonepropusne ovojnice i živih mikroorganizama sadržanih u nevodenom pripravku u jezgri navedenih mikrokapsula; i
- drugog odjeljka koji sadrži vodeni pripravak koji ima pH manji od 7,0 i koji sadrži jednu ili više organskih kiselina;
pri čemu je navedeni drugi odjeljak bez puferskih sredstava.
2. Sustav s dvama odjeljcima u skladu s patentnim zahtjevom 1, u kojem navedeni vodeni pripravak drugog odjeljka ima pH manji od 5,5, poželjno manji od 5,0, poželjnije manji od 4,5.
3. Sustav s dvama odjeljcima u skladu bilo kojim od patentnih zahtjeva 1 ili 2; u kojem je odabrana jedna ili više navedenih organskih kiselina s popisa koji sadrži benzojevu kiselinu, sorbinsku kiselinu, limunsku kiselinu, octenu kiselinu, mliječnu kiselinu, anizičnu kiselinu, oksalnu kiselinu, mravlju kiselinu, dehidrooctenu kiselinu, fumarnu kiselinu, glukonsku kiselinu, jabučnu kiselinu, jantarnu kiselinu, vinsku kiselinu, fosfornu kiselinu i propionsku kiselinu te njihove derivate.
4. Sustav s dvama odjeljcima u skladu s bilo kojim od patentnih zahtjeva 1 do 3; u kojem su navedeni živi mikroorganizmi održivi probiotički mikroorganizmi, po mogućnosti odabrani s popisa koji sadrži Lactobacillus pentosus, Lactobacillus rhamnosus i Lactobacillus plantarum.
5. Sustav s dvama odjeljcima u skladu s bilo kojim od patentnih zahtjeva 1 do 4; u kojem je navedeni mikroorganizam koji sadrži prvi odjeljak nepropustan za vodu i kisik.
6. Sustav s dvama odjeljcima u skladu s bilo kojim od patentnih zahtjeva 1 do 5; u kojem se navedena u vodi netopljiva i vodonepropusna ovojnica sastoji od alginata, ksantan gume, arapske gume, 30 gelan gume, karagena, želatine, celuloze ili njihovih derivata; ili polimera na bazi agara, proteina, poliola, želatine, PVA (polivinilnog alkohola), PLGA (poli(mliječne-ko-glikolne kiseline), PLA (polimliječne kiseline) i njihovih derivata, PCL, poliizoheksilcijanoakrilata, akrilatnih derivata ili škroba, izborno u kombinaciji s hitozanom; ili čvrstih masti.
7. Sustav s dvama odjeljcima u skladu s bilo kojim od patentnih zahtjeva 1 do 6; koji je u obliku gela, kreme, pjene, losiona ili masti koji sadrži navedene mikrokapsule.
8. Sustav s dvama odjeljcima u skladu s bilo kojim od patentnih zahtjeva 1 do 7; u kojem je navedeni nevodeni pripravak odabran s popisa koji sadrži biljna ulja, mineralna ulja, silikonska ulja ili hidrofilne polimere; posebno kaprinske/kaprilne trigliceride, tekući parafin, polietilen glikol, silikone ili tvrde masti.
9. Sustav s dvama odjeljcima u skladu s bilo kojim od patentnih zahtjeva 1 do 8; u kojem navedena organska kiselina služi kao konzervans i u kojem je pripravak suštinski bez daljnjih konzervansa.
10. Metoda za očuvanje živih mikroorganizama koja uključuje:
- osiguranje sustava s dvama odjeljcima u skladu s patentnim zahtjevom 1
- navedene održive mikroorganizme u navedenom prvom odjeljku koji se sastoji od mikrokapsula koje se sastoje od u vodi netopljive i vodonepropusne ovojnice i živih mikroorganizama sadržanih u nevodenom pripravku u jezgri navedenih mikrokapsula;
- jednu ili više organskih kiselina u navedenom vodenom pripravku u drugom odjeljku navedenog sustava s dvama odjeljcima u količini dovoljnoj da se dobije pH manji od 7,0 pri čemu je navedeni drugi odjeljak bez puferskih sredstava.
11. Uporaba sustava s dvama odjeljcima u skladu s patentnim zahtjevom 1, za očuvanje vodenog pripravka bez oštećenja navedenih živih mikroorganizama u navedenim mikrokapsulama.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE2016/5538A BE1023757B1 (nl) | 2016-06-30 | 2016-06-30 | Bewaring van micro-organismen |
| EP17733473.7A EP3478822B1 (en) | 2016-06-30 | 2017-06-29 | Preservation of microorganisms |
| PCT/EP2017/066176 WO2018002248A1 (en) | 2016-06-30 | 2017-06-29 | Preservation of microorganisms |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20230625T1 true HRP20230625T1 (hr) | 2023-09-29 |
Family
ID=57130104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20230625TT HRP20230625T1 (hr) | 2016-06-30 | 2017-06-29 | Pohrana mikroorganizama |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20190321302A1 (hr) |
| EP (1) | EP3478822B1 (hr) |
| JP (1) | JP6964610B2 (hr) |
| KR (1) | KR102494356B1 (hr) |
| CN (1) | CN109952368A (hr) |
| AU (1) | AU2017289331B2 (hr) |
| BE (1) | BE1023757B1 (hr) |
| BR (1) | BR112018076428A2 (hr) |
| CA (1) | CA3027468A1 (hr) |
| EA (1) | EA037975B1 (hr) |
| ES (1) | ES2950497T3 (hr) |
| HR (1) | HRP20230625T1 (hr) |
| HU (1) | HUE063210T2 (hr) |
| IL (1) | IL263684B2 (hr) |
| MX (1) | MX2018015439A (hr) |
| PL (1) | PL3478822T3 (hr) |
| RS (1) | RS64957B1 (hr) |
| WO (1) | WO2018002248A1 (hr) |
| ZA (1) | ZA201900532B (hr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111067922A (zh) * | 2018-10-19 | 2020-04-28 | 临床营养国际(马来西亚)私人有限公司 | 一种延缓骨骼和肌肉衰老迹象的化合物 |
| EA202191765A1 (ru) | 2018-12-21 | 2021-09-09 | Лактобайо А/С | Композиция для наружного применения, включающая жизнеспособные микроорганизмы |
| CA3142389A1 (en) | 2019-06-13 | 2020-12-17 | Lactobio A/S | A gel composition comprising viable microorganisms |
| CN112618513B (zh) * | 2020-12-28 | 2022-03-25 | 上海城建职业学院 | 一种益生菌微胶囊及其制备方法和应用 |
| KR102581060B1 (ko) * | 2023-04-26 | 2023-09-21 | 주식회사 크리넷 | 친환경 아이스팩 조성물, 이를 포함하는 아이스팩 및 이의 제조방법 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5544725B2 (hr) * | 1973-05-10 | 1980-11-13 | ||
| IS2334B (is) | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| CZ374797A3 (cs) * | 1995-05-31 | 1998-04-15 | Schering Ag | Farmaceutické preparáty ve formě hydrogelu |
| US6043358A (en) | 1995-11-01 | 2000-03-28 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
| GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
| US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
| US6887493B2 (en) * | 2000-10-25 | 2005-05-03 | Adi Shefer | Multi component controlled release system for oral care, food products, nutraceutical, and beverages |
| CN101541947B (zh) * | 2006-08-04 | 2013-03-13 | 株式会社百奥尼 | 分离自母乳的具有益生菌活性和抑制体重增加活性的乳酸菌 |
| US20100055083A1 (en) * | 2006-10-18 | 2010-03-04 | Ray Edward Kowalski | Encapsulation of heat and moisture sensitive substances |
| JP6214395B2 (ja) * | 2010-08-10 | 2017-10-18 | アール．ピー． シェーラー テクノロジーズ エルエルシー | マイクロカプセル化されたプロバイオティクス細菌を含む安定なソフトゲルカプセルを製造する方法 |
| US9788563B2 (en) * | 2011-04-15 | 2017-10-17 | Pepsico, Inc. | Encapsulation system for protection of probiotics during processing |
| DE102015105386A1 (de) * | 2015-04-09 | 2016-10-13 | Minasolve Germany Gmbh | Stabile Lösungen von Carbonsäuren und Carbonsäuresalzen in wässrigen Alkandiolen und deren Verwendung |
| US9999640B2 (en) * | 2016-02-02 | 2018-06-19 | University Of Dammam | Microencapsulated probiotic bacteria |
| US11491089B2 (en) * | 2016-05-03 | 2022-11-08 | International Flavors & Fragrances Inc. | Reloadable microcapsules |
-
2016
- 2016-06-30 BE BE2016/5538A patent/BE1023757B1/nl active
-
2017
- 2017-06-29 HR HRP20230625TT patent/HRP20230625T1/hr unknown
- 2017-06-29 EA EA201990163A patent/EA037975B1/ru unknown
- 2017-06-29 ES ES17733473T patent/ES2950497T3/es active Active
- 2017-06-29 PL PL17733473.7T patent/PL3478822T3/pl unknown
- 2017-06-29 WO PCT/EP2017/066176 patent/WO2018002248A1/en active Application Filing
- 2017-06-29 IL IL263684A patent/IL263684B2/en unknown
- 2017-06-29 KR KR1020197002768A patent/KR102494356B1/ko active IP Right Grant
- 2017-06-29 HU HUE17733473A patent/HUE063210T2/hu unknown
- 2017-06-29 US US16/311,449 patent/US20190321302A1/en active Pending
- 2017-06-29 EP EP17733473.7A patent/EP3478822B1/en active Active
- 2017-06-29 RS RS20230618A patent/RS64957B1/sr unknown
- 2017-06-29 CN CN201780050635.4A patent/CN109952368A/zh active Pending
- 2017-06-29 AU AU2017289331A patent/AU2017289331B2/en active Active
- 2017-06-29 BR BR112018076428-0A patent/BR112018076428A2/pt unknown
- 2017-06-29 MX MX2018015439A patent/MX2018015439A/es unknown
- 2017-06-29 CA CA3027468A patent/CA3027468A1/en active Pending
- 2017-06-29 JP JP2018567292A patent/JP6964610B2/ja active Active
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2019
- 2019-01-25 ZA ZA2019/00532A patent/ZA201900532B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA037975B1 (ru) | 2021-06-18 |
| CA3027468A1 (en) | 2018-01-04 |
| EP3478822C0 (en) | 2023-06-07 |
| BE1023757B1 (nl) | 2017-07-12 |
| BR112018076428A2 (pt) | 2019-04-09 |
| JP6964610B2 (ja) | 2021-11-10 |
| AU2017289331B2 (en) | 2023-03-30 |
| IL263684A (en) | 2019-02-03 |
| EP3478822B1 (en) | 2023-06-07 |
| KR20190044614A (ko) | 2019-04-30 |
| PL3478822T3 (pl) | 2023-12-11 |
| MX2018015439A (es) | 2019-08-16 |
| CN109952368A (zh) | 2019-06-28 |
| AU2017289331A1 (en) | 2019-02-07 |
| ES2950497T3 (es) | 2023-10-10 |
| US20190321302A1 (en) | 2019-10-24 |
| IL263684B2 (en) | 2023-09-01 |
| JP2019526229A (ja) | 2019-09-19 |
| IL263684B1 (en) | 2023-05-01 |
| KR102494356B1 (ko) | 2023-01-31 |
| HUE063210T2 (hu) | 2024-01-28 |
| RS64957B1 (sr) | 2024-01-31 |
| WO2018002248A1 (en) | 2018-01-04 |
| EP3478822A1 (en) | 2019-05-08 |
| ZA201900532B (en) | 2022-12-21 |
| EA201990163A1 (ru) | 2019-06-28 |
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