HRP20201231T1 - Kortikosteroidi, namijenjeni liječenju upalnih bolesti gastrointestinalnog sustava - Google Patents
Kortikosteroidi, namijenjeni liječenju upalnih bolesti gastrointestinalnog sustava Download PDFInfo
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- HRP20201231T1 HRP20201231T1 HRP20201231TT HRP20201231T HRP20201231T1 HR P20201231 T1 HRP20201231 T1 HR P20201231T1 HR P20201231T T HRP20201231T T HR P20201231TT HR P20201231 T HRP20201231 T HR P20201231T HR P20201231 T1 HRP20201231 T1 HR P20201231T1
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- esophagus
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- preparation intended
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- 229960002475 halometasone Drugs 0.000 claims 1
- GGXMRPUKBWXVHE-MIHLVHIWSA-N halometasone Chemical compound C1([C@@H](F)C2)=CC(=O)C(Cl)=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]2(C)C[C@@H]1O GGXMRPUKBWXVHE-MIHLVHIWSA-N 0.000 claims 1
- KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 claims 1
- 229910000271 hectorite Inorganic materials 0.000 claims 1
- 229920001519 homopolymer Polymers 0.000 claims 1
- 235000012907 honey Nutrition 0.000 claims 1
- 229960002453 hydrocortisone aceponate Drugs 0.000 claims 1
- MFBMYAOAMQLLPK-FZNHGJLXSA-N hydrocortisone aceponate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(C)=O)(OC(=O)CC)[C@@]1(C)C[C@@H]2O MFBMYAOAMQLLPK-FZNHGJLXSA-N 0.000 claims 1
- 229960001524 hydrocortisone butyrate Drugs 0.000 claims 1
- 229960002846 hydrocortisone probutate Drugs 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 229960001798 loteprednol Drugs 0.000 claims 1
- YPZVAYHNBBHPTO-MXRBDKCISA-N loteprednol Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)OCCl)[C@@H]4[C@@H]3CCC2=C1 YPZVAYHNBBHPTO-MXRBDKCISA-N 0.000 claims 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 229960001810 meprednisone Drugs 0.000 claims 1
- PIDANAQULIKBQS-RNUIGHNZSA-N meprednisone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)CC2=O PIDANAQULIKBQS-RNUIGHNZSA-N 0.000 claims 1
- 150000002730 mercury Chemical class 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 229960004584 methylprednisolone Drugs 0.000 claims 1
- 229960002037 methylprednisolone aceponate Drugs 0.000 claims 1
- DALKLAYLIPSCQL-YPYQNWSCSA-N methylprednisolone aceponate Chemical compound C1([C@@H](C)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@@](C(=O)COC(C)=O)(OC(=O)CC)[C@@]2(C)C[C@@H]1O DALKLAYLIPSCQL-YPYQNWSCSA-N 0.000 claims 1
- 230000000116 mitigating effect Effects 0.000 claims 1
- 229960002744 mometasone furoate Drugs 0.000 claims 1
- WOFMFGQZHJDGCX-ZULDAHANSA-N mometasone furoate Chemical compound O([C@]1([C@@]2(C)C[C@H](O)[C@]3(Cl)[C@@]4(C)C=CC(=O)C=C4CC[C@H]3[C@@H]2C[C@H]1C)C(=O)CCl)C(=O)C1=CC=CO1 WOFMFGQZHJDGCX-ZULDAHANSA-N 0.000 claims 1
- 108010014241 oxypolygelatine Proteins 0.000 claims 1
- 229960002858 paramethasone Drugs 0.000 claims 1
- 235000010987 pectin Nutrition 0.000 claims 1
- 239000001814 pectin Substances 0.000 claims 1
- 229920001277 pectin Polymers 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 230000002980 postoperative effect Effects 0.000 claims 1
- 229920001592 potato starch Polymers 0.000 claims 1
- 229940116317 potato starch Drugs 0.000 claims 1
- 229960002794 prednicarbate Drugs 0.000 claims 1
- FNPXMHRZILFCKX-KAJVQRHHSA-N prednicarbate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)CC)(OC(=O)OCC)[C@@]1(C)C[C@@H]2O FNPXMHRZILFCKX-KAJVQRHHSA-N 0.000 claims 1
- 229960005205 prednisolone Drugs 0.000 claims 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims 1
- 229960004618 prednisone Drugs 0.000 claims 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 claims 1
- 230000002441 reversible effect Effects 0.000 claims 1
- 229940100486 rice starch Drugs 0.000 claims 1
- 229960001487 rimexolone Drugs 0.000 claims 1
- QTTRZHGPGKRAFB-OOKHYKNYSA-N rimexolone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CC)(C)[C@@]1(C)C[C@@H]2O QTTRZHGPGKRAFB-OOKHYKNYSA-N 0.000 claims 1
- 235000012239 silicon dioxide Nutrition 0.000 claims 1
- 239000000377 silicon dioxide Substances 0.000 claims 1
- 235000010413 sodium alginate Nutrition 0.000 claims 1
- 239000000661 sodium alginate Substances 0.000 claims 1
- 229940005550 sodium alginate Drugs 0.000 claims 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 claims 1
- 229940080350 sodium stearate Drugs 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
- 235000010356 sorbitol Nutrition 0.000 claims 1
- 235000019408 sucralose Nutrition 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000003765 sweetening agent Substances 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 230000009974 thixotropic effect Effects 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 229960005294 triamcinolone Drugs 0.000 claims 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 claims 1
- 229940100445 wheat starch Drugs 0.000 claims 1
- 229920001285 xanthan gum Polymers 0.000 claims 1
- 235000010493 xanthan gum Nutrition 0.000 claims 1
- 239000000230 xanthan gum Substances 0.000 claims 1
- 229940082509 xanthan gum Drugs 0.000 claims 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Claims (19)
1. Oralni farmaceutski pripravak namijenjen upotrebi u liječenju, sprječavanju ili ublažavanju upale jednjaka kod ljudskog djeteta ili dojenčeta topikalnom primjenom kortikosteroida u jednjak, naznačen time što oralni farmaceutski pripravak sadrži kortikosteroid, tekući vehikulum i maltodekstrin.
2. Pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 1, naznačen time što je upala jednjaka alergijski ili kaustični upalni poremećaj jednjaka.
3. Pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 1, naznačen time što se upalu jednjaka bira između: eozinofilnog ezofagitisa, upala jednjaka nakon gutanja kaustične tvari/iritansa, trajnog/povratnog sužavanja jednjaka iz bilo kojeg razloga, uključujući gutanje kaustične tvari/iritansa, ezofagitisa uzrokovanog pilulama i njihove kombinacije.
4. Pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 3, naznačen time što je upala jednjaka eozinofilni ezofagitis.
5. Pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1 do 4, naznačen time što je ljudsko dijete osoba kojoj je dijagnosticirana bolest ili stanje kojeg se bira između sistemnih bolesti, prirođenih bolesti, postoperativne upale, te njihovih kombinacija.
6. Pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1 do 5, naznačen time što se kortikosteroid bira između: aklometazona, amcinomida, beklometazona, betametazona, budezonida, ciklezonida, klobetazola, klobetazona, klokortolona, kloprednola, kortivazola, deflazakorta, deoksikortikosterona, dezonida, dezoksimetazona, deksametazona, diflorazona, diflukortolona, difluprednata, fluklorolona, fludrokortizona, fludroksikortida, flumetazona, flunizolida, fluocinolon-acetonida, fluocinonida, fluokortina, fluokortolona, fluorometolona, fluperolona, flutikazona, flutikazon-propionata, fuprednidena, formokortala, halcinonida, halometazona, hidrokortizon-aceponata, hidrokortizon-buteprata, hidrokortizon-butirata, loteprednola, medrizona, meprednizona, metilprednizolona, metilprednizolon-aceponata, mometazon-furoata, parametazona, prednikarbata, prednizona, prednizolona, prednilidena, rimeksolona, tiksokortola, triamcinolona, ulobetazola, ili njihovih farmaceutski prihvatljivih soli ili estera.
7. Pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 6, naznačen time što je kortikosteroid budezonid.
8. Pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1 do 7, naznačen time što dodatno sadrži sladilo, antioksidans, tenzid, pufersko sredstvo, ili njihovu kombinaciju.
9. Pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1 do 8, naznačen time što ima ukupni volumen od otprilike 2 ml do otprilike 20 ml.
10. Pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1 do 9, naznačen time što sadrži otprilike 250 µg do otprilike 10 mg kortikosteroida.
11. Pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1 do 10, naznačen time što je namijenjen upotrebi, gdje:
i. primjenjuje se otprilike 0,25 mg do otprilike 10 mg kortikosteroida dnevno;
ii. farmaceutski pripravak se primjenjuje jednom dnevno, dva puta dnevno ili tri puta dnevno;
iii. farmaceutski pripravak se primjenjuje najviše jednom dnevno; ili
iv. kortikosteroid se unosi cijelom duljinom jednjaka.
12. Pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1 do 11:
naznačen time što sadrži pomoćnu tvar za povećavanje viskoznosti; gdje se pomoćnu tvar za povećavanje viskoznosti može birati iz skupine koju čine umrežena poli(akrilna kiselina), karbomerni homopolimer, glicerol, karbomerni kopolimer, akacija (arapska guma), agar, aluminijev magnezijev silikat, natrijev alginat, natrijev stearat, fukus, bentonit, karbomer, karagenan, karbopol, celuloza, rogač, irska mahovina, dekstroza, furcelaran, želatina, Ghatti guma, guar guma, hektorit, laktoza, saharoza, maltodekstrin, manitol, sorbitol, med, kukuruzni škrob, pšenični škrob, rižin škrob, krumpirov škrob, želatina, sterkulijina guma, ksantanska guma, polietilen-glikol, guma tragakant, etilceluloza, etilhidroksietilceluloza, etilmetilceluloza, metilceluloza, hidroksietilceluloza, hidroksietilmetilceluloza, hidroksipropilceluloza, poli(hidroksietil-metakrilat), oksipoliželatina, pektin, poliželin, povidon, propilen-karbonat, kopolimer metil-vinil-etera s maleinskim anhidridom (PVM/MA), poli(metoksietil-metakrilat), poli(metoksietoksietil-metakrilat), hidroksipropilceluloza, hidroksipropilmetilceluloza, karboksimetilceluloza (CMC), silicijev dioksid, polivinilpirolidon (PVP = povidon), Splenda® i njihove kombinacije.
13. Pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1 do 12, naznačen time što je pripravak formuliran u obliku suspenzije, sirupa, disperzije, emulzije, otopina, tekućina ili gusta otopina.
14. Pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1 do 13, naznačen time što je kortikosteroid u obliku čestica.
15. Pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 14, naznačen time što najmanje 95 % čestica ima promjer manji od 10 µm.
16. Pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 14 ili patentnim zahtjevom 15, naznačen time što su čestice kortikosteroida suspendirane ili dispergirane u vodenom mediju.
17. Pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 1, naznačen time što sadrži između otprilike 0,1 g maltodekstrina po ml tekućeg vehikuluma i otprilike 0,6 g maltodekstrina po ml tekućeg vehikuluma.
18. Pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 17, naznačen time što je pripravak tiksotropan.
19. Pripravak namijenjen upotrebi u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je viskoznost pripravka najmanje 50 cP na 25 Celzijevih stupnjeva, a brzina smicanja otprilike 13,2 s–1.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9057508P | 2008-08-20 | 2008-08-20 | |
| US9057208P | 2008-08-20 | 2008-08-20 | |
| EP08876449.3A EP2328553B1 (en) | 2008-08-20 | 2008-11-12 | Corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract |
| PCT/US2008/083290 WO2010021636A1 (en) | 2008-08-20 | 2008-11-12 | Corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20201231T1 true HRP20201231T1 (hr) | 2020-12-11 |
Family
ID=40673463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20201231TT HRP20201231T1 (hr) | 2008-08-20 | 2020-08-06 | Kortikosteroidi, namijenjeni liječenju upalnih bolesti gastrointestinalnog sustava |
Country Status (12)
| Country | Link |
|---|---|
| EP (2) | EP3834819A1 (hr) |
| CA (1) | CA2734763C (hr) |
| CY (1) | CY1123279T1 (hr) |
| DK (1) | DK2328553T3 (hr) |
| ES (1) | ES2811051T3 (hr) |
| HR (1) | HRP20201231T1 (hr) |
| HU (1) | HUE051538T2 (hr) |
| LT (1) | LT2328553T (hr) |
| PL (1) | PL2328553T3 (hr) |
| PT (1) | PT2328553T (hr) |
| SI (1) | SI2328553T1 (hr) |
| WO (1) | WO2010021636A1 (hr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8679545B2 (en) | 2005-11-12 | 2014-03-25 | The Regents Of The University Of California | Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract |
| US8497258B2 (en) | 2005-11-12 | 2013-07-30 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
| ES2729925T3 (es) | 2007-11-13 | 2019-11-07 | Meritage Pharma Inc | Composiciones de corticosteroides |
| CA3037273C (en) | 2009-10-01 | 2022-05-03 | Fredric Jay Cohen | Orally administered corticosteroid compositions |
| WO2015034678A2 (en) | 2013-09-06 | 2015-03-12 | Aptalis Pharmatech, Inc. | Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis |
| TWI728172B (zh) | 2016-08-18 | 2021-05-21 | 美商愛戴爾製藥股份有限公司 | 治療嗜伊紅性食道炎之方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4900552A (en) | 1988-03-30 | 1990-02-13 | Watson Laboratories, Inc. | Mucoadhesive buccal dosage forms |
| PE44995A1 (es) * | 1994-01-27 | 1995-12-18 | Schering Corp | Furoato de mometasona para el tratamiento de las enfermedades pulmonares y de las vias respiratorias |
| TW438601B (en) | 1994-05-18 | 2001-06-07 | Janssen Pharmaceutica Nv | New mucoadhesive emulsion compositions and a process for the preparation thereof |
| GB9505032D0 (en) | 1995-03-13 | 1995-05-03 | Westminster Lab Ltd | Improvements in or relating to organic compositions |
| US5863910A (en) * | 1996-01-12 | 1999-01-26 | Bolonick; Joel | Treatment of chronic inflammatory disorders of the gastrointestinal tract |
| DE69833000T2 (de) | 1997-09-26 | 2006-09-07 | Noven Pharmaceuticals, Inc., Miami | Bio-klebemittelzusammensetzungen |
| US6066292A (en) * | 1997-12-19 | 2000-05-23 | Bayer Corporation | Sterilization process for pharmaceutical suspensions |
| GB9812426D0 (en) | 1998-06-10 | 1998-08-05 | Reckitt & Colmann Prod Ltd | Improvements in or relating to organic compositions |
| US20020009478A1 (en) | 1998-08-24 | 2002-01-24 | Douglas Joseph Dobrozsi | Oral liquid mucoadhesive compositions |
| US20020013331A1 (en) | 2000-06-26 | 2002-01-31 | Williams Robert O. | Methods and compositions for treating pain of the mucous membrane |
| US20060013873A1 (en) * | 2004-07-16 | 2006-01-19 | Chih-Chiang Yang | Bioadhesive dosage form of steroids |
| BRPI0606283A2 (pt) * | 2005-03-16 | 2009-06-09 | Elan Pharma Int Ltd | formulações de antagonista de receptor de leucotrieno/corticosteróide em nanopartìcula |
| US7799331B2 (en) * | 2005-08-04 | 2010-09-21 | Taro Pharmaceutical North America, Inc. | Oral suspension of prednisolone acetate |
| US8324192B2 (en) | 2005-11-12 | 2012-12-04 | The Regents Of The University Of California | Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract |
-
2008
- 2008-11-12 LT LTEP08876449.3T patent/LT2328553T/lt unknown
- 2008-11-12 WO PCT/US2008/083290 patent/WO2010021636A1/en active Application Filing
- 2008-11-12 DK DK08876449.3T patent/DK2328553T3/da active
- 2008-11-12 PL PL08876449T patent/PL2328553T3/pl unknown
- 2008-11-12 ES ES08876449T patent/ES2811051T3/es active Active
- 2008-11-12 EP EP20174451.3A patent/EP3834819A1/en not_active Withdrawn
- 2008-11-12 HU HUE08876449A patent/HUE051538T2/hu unknown
- 2008-11-12 EP EP08876449.3A patent/EP2328553B1/en not_active Revoked
- 2008-11-12 PT PT88764493T patent/PT2328553T/pt unknown
- 2008-11-12 SI SI200832133T patent/SI2328553T1/sl unknown
- 2008-11-12 CA CA2734763A patent/CA2734763C/en active Active
-
2020
- 2020-08-06 HR HRP20201231TT patent/HRP20201231T1/hr unknown
- 2020-08-12 CY CY20201100753T patent/CY1123279T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2811051T3 (es) | 2021-03-10 |
| EP3834819A1 (en) | 2021-06-16 |
| WO2010021636A1 (en) | 2010-02-25 |
| CA2734763C (en) | 2016-06-28 |
| EP2328553A1 (en) | 2011-06-08 |
| PL2328553T3 (pl) | 2020-12-14 |
| LT2328553T (lt) | 2020-09-10 |
| PT2328553T (pt) | 2020-08-25 |
| EP2328553B1 (en) | 2020-06-10 |
| CA2734763A1 (en) | 2010-02-25 |
| SI2328553T1 (sl) | 2020-10-30 |
| HUE051538T2 (hu) | 2021-03-01 |
| CY1123279T1 (el) | 2021-12-31 |
| DK2328553T3 (da) | 2020-08-24 |
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