HRP20200452T1 - Liječenje insuficijencije nadbubrežne žlijezde - Google Patents
Liječenje insuficijencije nadbubrežne žlijezde Download PDFInfo
- Publication number
- HRP20200452T1 HRP20200452T1 HRP20200452TT HRP20200452T HRP20200452T1 HR P20200452 T1 HRP20200452 T1 HR P20200452T1 HR P20200452T T HRP20200452T T HR P20200452TT HR P20200452 T HRP20200452 T HR P20200452T HR P20200452 T1 HRP20200452 T1 HR P20200452T1
- Authority
- HR
- Croatia
- Prior art keywords
- preparation
- accordance
- insufficiency
- adrenal gland
- hydroxypropylmethylcellulose
- Prior art date
Links
- 206010001367 Adrenal insufficiency Diseases 0.000 title claims 3
- 208000017515 adrenocortical insufficiency Diseases 0.000 title claims 3
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 8
- 210000004100 adrenal gland Anatomy 0.000 claims 7
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 6
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 6
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 6
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 6
- 206010010356 Congenital anomaly Diseases 0.000 claims 4
- 229960000890 hydrocortisone Drugs 0.000 claims 4
- 206010020718 hyperplasia Diseases 0.000 claims 4
- 230000000873 masking effect Effects 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 238000007789 sealing Methods 0.000 claims 3
- 239000001856 Ethyl cellulose Substances 0.000 claims 2
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 2
- 235000019325 ethyl cellulose Nutrition 0.000 claims 2
- 229920001249 ethyl cellulose Polymers 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 206010020571 Hyperaldosteronism Diseases 0.000 claims 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 1
- 239000008108 microcrystalline cellulose Substances 0.000 claims 1
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000004535 ovarian dysfunction Diseases 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940037128 systemic glucocorticoids Drugs 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- Physiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Claims (9)
1. Farmaceutski pripravak prilagođen za oralnu primjenu, naznačen time što sadrži:
(a) nosač, koji sadrži čestice mikrokristalne celuloze, gdje navedeni nosač sadrži na ili u sebi otprilike 0,65% tež./tež. hidrokortizonskog pripravka i vezivo koje sadrži hidroksipropilmetilcelulozu, gdje hidroksipropilmetilceluloza dolazi u količini između 0,1-5,0% tež./tež. pripravka;
(b) brtveni sloj, koji sadrži hidroksipropilmetilcelulozu;
(c) i sloj polimera za prikrivanje okusa u kontaktu s navedenim brtvenim slojem,
gdje brtveni sloj se nalazi između hidroksipropilmetilceluloze i hidrokortizona i sloja za prikrivanje okusa, i
gdje navedeni pripravak je namijenjen upotrebi u liječenju insuficijencije nadbubrežne žlijezde kod pedijatrijskih i starijih subjekata.
2. Pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 1, naznačen time što se promjer čestica kreće u rasponu od 100 µm-1200 µm.
3. Pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 1 ili 2, naznačen time što hidrokortizon dolazi u količini između 0,25 mg i 30 mg hidrokortizona po jedinici doziranja.
4. Pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1-3, naznačen time što sloj polimera za prikrivanje okusa dolazi u količini od 0,5%-2,5% tež./tež. pripravka.
5. Pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1-4, naznačen time što je navedeni sloj polimera za prikrivanje okusa kombinacija hidroksipropilmetilceluloze i etilceluloze.
6. Pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 5, naznačen time što hidroksipropilmetilceluloza dolazi u količini od otprilike 0,3% tež./tež., a etilceluloza dolazi u količini od otprilike 1,2% tež./tež. pripravka.
7. Pripravak namijenjen upotrebi u skladu s bilo kojim od patentnih zahtjeva 1-6, naznačen time što je insuficijencija nadbubrežne žlijezde posljedica stanja kojeg se bira iz skupine koju čine: primarno ili sekundarno ili tercijarno zatajenje nadbubrežne žlijezde, urođena hiperplazija nadbubrežne žlijezde, urođena hiperplazija nadbubrežne žlijezde s kasnim početkom, policistična insuficijencija jajnika, aldosteronizam kojeg se može liječiti glukokortikoidima (GRA).
8. Pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 7, naznačen time što je insuficijencija nadbubrežne žlijezde posljedica urođene hiperplazije nadbubrežne žlijezde s kasnim početkom.
9. Pripravak namijenjen upotrebi u skladu s patentnim zahtjevom 7, naznačen time što je insuficijencija nadbubrežne žlijezde posljedica urođene hiperplazije nadbubrežne žlijezde.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1119985.8A GB201119985D0 (en) | 2011-11-19 | 2011-11-19 | Treatment of adrenal insufficiency |
| PCT/GB2012/052864 WO2013072707A1 (en) | 2011-11-19 | 2012-11-19 | Treatment of adrenal insufficiency |
| EP12806617.2A EP2780003B1 (en) | 2011-11-19 | 2012-11-19 | Treatment of adrenal insufficiency |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20200452T1 true HRP20200452T1 (hr) | 2020-10-16 |
Family
ID=45475414
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20200452TT HRP20200452T1 (hr) | 2011-11-19 | 2020-03-18 | Liječenje insuficijencije nadbubrežne žlijezde |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US9675559B2 (hr) |
| EP (1) | EP2780003B1 (hr) |
| JP (2) | JP6228125B2 (hr) |
| KR (1) | KR101995999B1 (hr) |
| AU (1) | AU2012338583B2 (hr) |
| BR (1) | BR112014011745B1 (hr) |
| CA (1) | CA2854717C (hr) |
| CY (1) | CY1123130T1 (hr) |
| DK (1) | DK2780003T3 (hr) |
| ES (1) | ES2782503T3 (hr) |
| GB (2) | GB201119985D0 (hr) |
| HK (1) | HK1194005A1 (hr) |
| HR (1) | HRP20200452T1 (hr) |
| HU (1) | HUE048445T2 (hr) |
| IL (1) | IL232065A (hr) |
| LT (1) | LT2780003T (hr) |
| PL (1) | PL2780003T3 (hr) |
| PT (1) | PT2780003T (hr) |
| RS (1) | RS60132B1 (hr) |
| SI (1) | SI2780003T1 (hr) |
| WO (1) | WO2013072707A1 (hr) |
| ZA (1) | ZA201403462B (hr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201119985D0 (en) | 2011-11-19 | 2012-01-04 | Diurnal Ltd | Treatment of adrenal insufficiency |
| GB201308933D0 (en) | 2013-05-17 | 2013-07-03 | Diurnal Ltd | Paediatric composition |
| KR102186095B1 (ko) | 2018-05-14 | 2020-12-03 | 주식회사 엘지화학 | 화합물 및 이를 포함하는 유기 발광 소자 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2062634T3 (es) * | 1990-08-30 | 1994-12-16 | Senju Pharma Co | Composicion con liberacion controlada del farmaco. |
| AU710109B2 (en) * | 1996-01-16 | 1999-09-16 | Ap Pharma, Inc. | Topical delivery of drugs to the lower gastrointestinal tract |
| KR20000069899A (ko) * | 1997-01-06 | 2000-11-25 | 디. 제이. 우드, 스피겔 알렌 제이 | 속방성 및 미각 차폐성 약제학적 용량 형태 |
| SE0401031D0 (sv) * | 2004-04-22 | 2004-04-22 | Duocort Ab | A new glucocorticoid replacement therapy |
| AU2005235369B2 (en) * | 2004-04-22 | 2010-11-11 | Acucort Ab | Pharmaceutical compositions for acute glucocorticoid therapy |
| WO2005105045A1 (ja) | 2004-04-30 | 2005-11-10 | Astellas Pharma Inc. | 経口投与用時限放出型粒子状医薬組成物及び該組成物を含有する口腔内速崩壊錠 |
| WO2006026504A2 (en) | 2004-08-27 | 2006-03-09 | Spherics, Inc. | Mucoadhesive oral formulations of high permeability, high solubility drugs |
| EP2120868A4 (en) | 2007-04-11 | 2010-08-25 | Perrigo Israel Phamaceuticals | LOW-DOSED MOMETASON FORMULATIONS |
| WO2008149894A1 (ja) * | 2007-06-06 | 2008-12-11 | Asahi Kasei Chemicals Corporation | セルロース系微小核粒子及びその製造方法 |
| GB0817120D0 (en) | 2008-09-19 | 2008-10-29 | Diurnal Ltd | Treatment of adrenal insufficiency |
| WO2010115615A1 (en) | 2009-04-07 | 2010-10-14 | Duocort Pharma Ab | Improved glucocorticoid therapy |
| US8951569B2 (en) * | 2009-09-17 | 2015-02-10 | Basf Se | Pellets coated with coatings containing active substances |
| MX337429B (es) | 2010-05-20 | 2016-03-04 | Duocort Pharma Ab | Posologia y administracion de composiciones basadas en glucocortticoides. |
| GB201119985D0 (en) | 2011-11-19 | 2012-01-04 | Diurnal Ltd | Treatment of adrenal insufficiency |
| GB201308933D0 (en) | 2013-05-17 | 2013-07-03 | Diurnal Ltd | Paediatric composition |
-
2011
- 2011-11-19 GB GBGB1119985.8A patent/GB201119985D0/en not_active Ceased
-
2012
- 2012-11-19 JP JP2014541759A patent/JP6228125B2/ja active Active
- 2012-11-19 HU HUE12806617A patent/HUE048445T2/hu unknown
- 2012-11-19 EP EP12806617.2A patent/EP2780003B1/en active Active
- 2012-11-19 GB GB1407380.3A patent/GB2509663B/en active Active
- 2012-11-19 BR BR112014011745-4A patent/BR112014011745B1/pt active IP Right Grant
- 2012-11-19 AU AU2012338583A patent/AU2012338583B2/en active Active
- 2012-11-19 RS RS20200316A patent/RS60132B1/sr unknown
- 2012-11-19 PT PT128066172T patent/PT2780003T/pt unknown
- 2012-11-19 LT LTEP12806617.2T patent/LT2780003T/lt unknown
- 2012-11-19 CA CA2854717A patent/CA2854717C/en active Active
- 2012-11-19 KR KR1020147015908A patent/KR101995999B1/ko active IP Right Grant
- 2012-11-19 WO PCT/GB2012/052864 patent/WO2013072707A1/en active Application Filing
- 2012-11-19 US US14/354,651 patent/US9675559B2/en active Active
- 2012-11-19 SI SI201231759T patent/SI2780003T1/sl unknown
- 2012-11-19 ES ES12806617T patent/ES2782503T3/es active Active
- 2012-11-19 DK DK12806617.2T patent/DK2780003T3/da active
- 2012-11-19 PL PL12806617T patent/PL2780003T3/pl unknown
-
2014
- 2014-04-10 IL IL232065A patent/IL232065A/en active IP Right Grant
- 2014-05-14 ZA ZA2014/03462A patent/ZA201403462B/en unknown
- 2014-07-23 HK HK14107519.1A patent/HK1194005A1/xx unknown
-
2017
- 2017-03-30 US US15/473,724 patent/US9717740B1/en active Active
- 2017-06-22 JP JP2017122497A patent/JP2017200942A/ja active Pending
-
2020
- 2020-03-18 HR HRP20200452TT patent/HRP20200452T1/hr unknown
- 2020-03-31 CY CY20201100304T patent/CY1123130T1/el unknown
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