HRP20191059T1 - Skup aktivnih sastojaka za topikalnu primjenu u restrukturiranju izmijenjene kožne barijere poslije kožnih bolesti - Google Patents
Skup aktivnih sastojaka za topikalnu primjenu u restrukturiranju izmijenjene kožne barijere poslije kožnih bolesti Download PDFInfo
- Publication number
- HRP20191059T1 HRP20191059T1 HRP20191059TT HRP20191059T HRP20191059T1 HR P20191059 T1 HRP20191059 T1 HR P20191059T1 HR P20191059T T HRP20191059T T HR P20191059TT HR P20191059 T HRP20191059 T HR P20191059T HR P20191059 T1 HRP20191059 T1 HR P20191059T1
- Authority
- HR
- Croatia
- Prior art keywords
- cutaneous
- use according
- restructuring
- altered
- association
- Prior art date
Links
- 230000000699 topical effect Effects 0.000 title claims 6
- 239000004480 active ingredient Substances 0.000 title claims 2
- 230000004888 barrier function Effects 0.000 title 1
- 208000017520 skin disease Diseases 0.000 title 1
- 239000000203 mixture Substances 0.000 claims 5
- 239000000839 emulsion Substances 0.000 claims 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims 1
- BHYOQNUELFTYRT-UHFFFAOYSA-N Cholesterol sulfate Natural products C1C=C2CC(OS(O)(=O)=O)CCC2(C)C2C1C1CCC(C(C)CCCC(C)C)C1(C)CC2 BHYOQNUELFTYRT-UHFFFAOYSA-N 0.000 claims 1
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 229940106189 ceramide Drugs 0.000 claims 1
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- BHYOQNUELFTYRT-DPAQBDIFSA-N cholesterol sulfate Chemical compound C1C=C2C[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 BHYOQNUELFTYRT-DPAQBDIFSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims 1
- 239000007764 o/w emulsion Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 150000004671 saturated fatty acids Chemical class 0.000 claims 1
- 230000008591 skin barrier function Effects 0.000 claims 1
- 239000007762 w/o emulsion Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Birds (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Emergency Medicine (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (7)
1. Skup koji sadrži:
a) najmanje jedan ceramid,
b) najmanje jednu zasićenu masnu kiselinu C12-C22,
c) kolesterol
d) kolesterol sulfat
za topikalnu primjenu u restrukturiranju izmijenjene kožne barijere posle psorijaze.
2. Skup za primjenu prema patentnom zahtjevu 1, gdje navedeni skup je u obliku topikalne kompozicije, koja sadrži navedeni skup kao aktivni sastojak u kombinaciji sa pogodnim ekscipijensima i/ili razblaživačima.
3. Skup za primjenu prema patentnom zahtjevu 2, gdje navedena topikalna kompozicija sadrži svaku komponentu a), b), c) i d) u koncentracijama sadržanim između 0,1 i 5% po masi na ukupnu masu navedene kompozicije.
4. Skup za primjenu prema patentnom zahtjevu 2 ili 3, gdje navedena topikalna kompozicija je u obliku emulzija ulje u vodi.
5. Skup za primjenu prema patentnom zahtjevu 4, gdje navedena emulzija ulje u vodi je u obliku suštinski hidrofilnih emulzija.
6. Skup za primjenu prema patentnom zahtjevu 2 ili 3, gdje navedena topikalna kompozicija je u obliku emulzija voda u ulju.
7. Skup za primjenu prema patentnom zahtjevu 6, gdje navedena emulzija voda u ulju je u obliku suštinski lipofilnih emulzija.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI20140623 | 2014-04-04 | ||
| PCT/IB2015/052389 WO2015151040A1 (en) | 2014-04-04 | 2015-04-01 | Association of active ingredients for topical use in restructuring altered cutaneous barrier following to cutaneous diseases |
| EP15718629.7A EP3125865B1 (en) | 2014-04-04 | 2015-04-01 | Association of active ingredients for topical use in restructuring altered cutaneous barrier following to cutaneous diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20191059T1 true HRP20191059T1 (hr) | 2019-09-06 |
Family
ID=50897758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20191059TT HRP20191059T1 (hr) | 2014-04-04 | 2019-06-13 | Skup aktivnih sastojaka za topikalnu primjenu u restrukturiranju izmijenjene kožne barijere poslije kožnih bolesti |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP3125865B1 (hr) |
| DK (1) | DK3125865T3 (hr) |
| ES (1) | ES2731250T3 (hr) |
| HR (1) | HRP20191059T1 (hr) |
| HU (1) | HUE044885T2 (hr) |
| PL (1) | PL3125865T3 (hr) |
| PT (1) | PT3125865T (hr) |
| SI (1) | SI3125865T1 (hr) |
| WO (1) | WO2015151040A1 (hr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4008406A1 (en) * | 2020-12-07 | 2022-06-08 | Clariant International Ltd | Cosmetic composition based on acroyl taurate type polymers |
| IT202100003539A1 (it) * | 2021-02-16 | 2022-08-16 | Unifarco S P A | Composizioni ad uso topico ottimizzate in lipidi epidermici e fosfatidilglicerolo |
| IT202100029171A1 (it) * | 2021-11-18 | 2023-05-18 | Unifarco S P A | Composizione liquida stabile di ceramidi e ammidi dell’acido palmitico |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE192928T1 (de) * | 1992-06-19 | 2000-06-15 | Univ California | Lipide zur epidermalen befeuchtung und zur wiederherstellung der barrierefunktion |
| US20020098207A1 (en) * | 1999-02-08 | 2002-07-25 | Daniel H. Maes | Cholesterol sulfate compositions for enhancement of stratum corneum function |
-
2015
- 2015-04-01 PL PL15718629T patent/PL3125865T3/pl unknown
- 2015-04-01 DK DK15718629.7T patent/DK3125865T3/da active
- 2015-04-01 HU HUE15718629 patent/HUE044885T2/hu unknown
- 2015-04-01 WO PCT/IB2015/052389 patent/WO2015151040A1/en active Application Filing
- 2015-04-01 ES ES15718629T patent/ES2731250T3/es active Active
- 2015-04-01 SI SI201530781T patent/SI3125865T1/sl unknown
- 2015-04-01 PT PT15718629T patent/PT3125865T/pt unknown
- 2015-04-01 EP EP15718629.7A patent/EP3125865B1/en active Active
-
2019
- 2019-06-13 HR HRP20191059TT patent/HRP20191059T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT3125865T (pt) | 2019-07-04 |
| WO2015151040A1 (en) | 2015-10-08 |
| DK3125865T3 (da) | 2019-07-08 |
| HUE044885T2 (hu) | 2019-11-28 |
| SI3125865T1 (sl) | 2019-08-30 |
| EP3125865B1 (en) | 2019-05-22 |
| PL3125865T3 (pl) | 2019-10-31 |
| EP3125865A1 (en) | 2017-02-08 |
| ES2731250T3 (es) | 2019-11-14 |
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