HRP20181104T1 - Spremnik za i postupak prikupljanja, transportiranja i spremanja uzoraka bioloških tkiva - Google Patents

Spremnik za i postupak prikupljanja, transportiranja i spremanja uzoraka bioloških tkiva Download PDF

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Publication number
HRP20181104T1
HRP20181104T1 HRP20181104TT HRP20181104T HRP20181104T1 HR P20181104 T1 HRP20181104 T1 HR P20181104T1 HR P20181104T T HRP20181104T T HR P20181104TT HR P20181104 T HRP20181104 T HR P20181104T HR P20181104 T1 HRP20181104 T1 HR P20181104T1
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HR
Croatia
Prior art keywords
component
container
fixative
filling
accordance
Prior art date
Application number
HRP20181104TT
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English (en)
Inventor
Marco Bellini
Giovanni Bussolati
Michele Martinelli
Francesco Visinoni
Original Assignee
Milestone S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Milestone S.R.L. filed Critical Milestone S.R.L.
Publication of HRP20181104T1 publication Critical patent/HRP20181104T1/hr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0096—Casings for storing test samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/142—Preventing evaporation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/025—Displaying results or values with integrated means
    • B01L2300/028—Graduation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0848—Specific forms of parts of containers
    • B01L2300/0851—Bottom walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N2001/305—Fixative compositions

Claims (15)

1. Spremnik (1) za prikupljanje, transportiranje i spremanje uzoraka bioloških tkiva, naznačen time što se spremnik (1) napuni prvom komponentom (3), koja je fiksativ, a druga komponenta (4) je tekućina, gdje druga komponenta (4) – ima manju specifičnu gustoću u usporedbi s fiksativom (3), i – ne miješa se s fiksativom (3), gdje druga komponenta (4) čini sloj iznad fiksativa (3), tako da druga komponenta (4) posve pokriva gornju površinu prve komponente (3) u spremniku (1) tvoreći zaštitni film, koji sprječava izlaženje para fiksativa iz spremnika (1).
2. Spremnik (1) u skladu s patentnim zahtjevom 1, naznačen time što je druga komponenta (4) otopina, po mogućnosti čista otopina ili miješana otopina organskih ili anorganskih komponenata.
3. Spremnik (1) u skladu s patentnim zahtjevom 1 ili 2, naznačen time što je druga komponenta (4) manje toksična od fiksativa (3) i po mogućnosti nije toksična ili je niskotoksična za ljude prilikom udisanja.
4. Spremnik (1) u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što drugu komponentu (4) čine mineralna ulja ili smjesa mineralnih ulja, ugljikovodici ili smjesa ugljikovodika, ili izoparafin C9-C12.
5. Spremnik (1) u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je druga komponenta (4) u tekućem, želatinoznom ili pjenastom stanju.
6. Spremnik (1) u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što druga komponenta (4) sadrži bojilo radi boljeg razlikovanja druge komponente (4) od fiksativa (3).
7. Spremnik (1) u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je prva komponenta (3) otopina.
8. Spremnik (1) u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je prva komponenta (3) formalin, po mogućnosti 10%-tni neutralno puferirani formalin (NBF), cink-formalin ili glutaraldehid ili bilo koji drugi fiksativ kojeg se upotrebljava u histologiji.
9. Spremnik (1) u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što se volumen druge komponente (4) kreće od 0,1% do 50% od ukupnog volumena obje komponente (3, 4), po mogućnosti između 3% i 5%.
10. Spremnik (1) u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je volumen spremnika između 5 ml i 10 l.
11. Spremnik (1) u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što dodatno sadrži element za zatvaranje (2), namijenjen selektivnom zatvaranju gornjeg otvora (6) spremnika (1).
12. Postupak prikupljanja, transportiranja i spremanja uzoraka bioloških tkiva, naznačen time što se sastoji u koracima: – punjenja prve komponente (3), koja je fiksativ, u spremnik (1) u skladu s bilo kojim od patentnih zahtjeva 1 do 11, – punjenja druge komponente (4) koja je tekućina u spremniku (1) napunjen prvom komponentom (3), gdje druga komponenta (4) ima manju specifičnu gustoću u usporedbi s fiksativom (3) i ne miješa se s fiksativom (3), tako da druga komponenta (4) čini sloj iznad fiksativa (3), gdje druga komponenta (4) posve pokriva gornju površinu prve komponente (3) u spremniku (1) tvoreći zaštitni film, koji sprječava izlaženje para fiksativa iz spremnika (1), gdje postupak dodatno uključuje korak stavljanja uzorka biološkog tkiva u prvu komponentu (3) prije ili nakon punjenja druge komponente (4) u spremnik (1).
13. Postupak u skladu s patentnim zahtjevom 12, naznačen time što se uzorak biološkog tkiva izravno stavi u prvu komponentu (3), kojom se napuni spremnik (1), ili se stavlja u histološku kasetu prije stavljanja u prvu komponentu (3), zajedno s histološkom kasetom koja nosi uzorak biološkog tkiva.
14. Postupak u skladu s patentnim zahtjevom 12 ili 13, naznačen time što se element za zatvaranje (2), po mogućnosti uklonjivo, stavi na otvor (6) spremnika (1) kako bi se zatvorilo spremnik (1).
15. Postupak u skladu s bilo kojim od patentnih zahtjeva 12 do 14, naznačen time što se korake punjenja i/ili stavljanja provodi ručno, ili se najmanje jedan od koraka punjenja i/ili stavljanja provodi poluautomatski ili automatski.
HRP20181104TT 2014-12-08 2018-07-13 Spremnik za i postupak prikupljanja, transportiranja i spremanja uzoraka bioloških tkiva HRP20181104T1 (hr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14196823.0A EP3031524B1 (en) 2014-12-08 2014-12-08 Container and method for collecting, transporting and storing biological tissue samples

Publications (1)

Publication Number Publication Date
HRP20181104T1 true HRP20181104T1 (hr) 2018-09-07

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Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20181104TT HRP20181104T1 (hr) 2014-12-08 2018-07-13 Spremnik za i postupak prikupljanja, transportiranja i spremanja uzoraka bioloških tkiva

Country Status (4)

Country Link
US (1) US9955953B2 (hr)
EP (1) EP3031524B1 (hr)
ES (1) ES2673371T3 (hr)
HR (1) HRP20181104T1 (hr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USD883655S1 (en) 2013-05-31 2020-05-12 Maria Lotosky-Compton Medical pouch for endoscopic tools
US9839913B2 (en) * 2014-07-14 2017-12-12 Maria Lotosky-Compton Medical specimen container
IT201700112900A1 (it) * 2017-10-09 2019-04-09 Alberto Pagani Dispositivo per la fissazione di campioni biologici.
USD991707S1 (en) * 2021-06-10 2023-07-11 Upper Echelon Products Llc Bath pillow

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552087A (en) * 1993-11-15 1996-09-03 Ventana Medical Systems, Inc. High temperature evaporation inhibitor liquid
US6071748A (en) * 1997-07-16 2000-06-06 Ljl Biosystems, Inc. Light detection device
US7410753B2 (en) * 1998-09-03 2008-08-12 Ventana Medical Systems, Inc. Removal of embedding media from biological samples and cell conditioning on automated staining instruments
US6258748B1 (en) * 1999-10-27 2001-07-10 Robert J. Hamley Floral preservative and aromatherapy apparatus and method
CN102781226B (zh) * 2009-12-07 2015-05-20 朱伟星 通过超声波及温度控制的标准化组织样本保护
US20110250106A1 (en) * 2010-04-07 2011-10-13 Lafond Andre Biopsy Dish and Closure Element Therefor
ES2832554T3 (es) * 2012-06-22 2021-06-10 Leica Biosystems Nussloch Gmbh Recipiente para muestras de tejido

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Publication number Publication date
US20160157837A1 (en) 2016-06-09
US9955953B2 (en) 2018-05-01
EP3031524A1 (en) 2016-06-15
EP3031524B1 (en) 2018-05-02
ES2673371T3 (es) 2018-06-21

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