HRP20171119T1 - Analozi agonista receptora opioida mu endomorfina - Google Patents

Analozi agonista receptora opioida mu endomorfina Download PDF

Info

Publication number
HRP20171119T1
HRP20171119T1 HRP20171119TT HRP20171119T HRP20171119T1 HR P20171119 T1 HRP20171119 T1 HR P20171119T1 HR P20171119T T HRP20171119T T HR P20171119TT HR P20171119 T HRP20171119 T HR P20171119T HR P20171119 T1 HRP20171119 T1 HR P20171119T1
Authority
HR
Croatia
Prior art keywords
nhr
peptide according
group
glu
opioid receptor
Prior art date
Application number
HRP20171119TT
Other languages
English (en)
Croatian (hr)
Inventor
James E. Zadina
Laszlo Hackler
Original Assignee
The Administrators Of The Tulane Educational Fund
United States Department Of Veterans Affairs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45441820&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20171119(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by The Administrators Of The Tulane Educational Fund, United States Department Of Veterans Affairs filed Critical The Administrators Of The Tulane Educational Fund
Publication of HRP20171119T1 publication Critical patent/HRP20171119T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/126—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9486—Analgesics, e.g. opiates, aspirine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70571—Assays involving receptors, cell surface antigens or cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
HRP20171119TT 2010-07-09 2011-07-08 Analozi agonista receptora opioida mu endomorfina HRP20171119T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36303910P 2010-07-09 2010-07-09
EP11804387.6A EP2590992B1 (en) 2010-07-09 2011-07-08 Mu opioid receptor agonist analogs of the endomorphins
PCT/US2011/043306 WO2012006497A2 (en) 2010-07-09 2011-07-08 Mu opioid receptor agonist analogs of the endomorphins

Publications (1)

Publication Number Publication Date
HRP20171119T1 true HRP20171119T1 (hr) 2017-10-06

Family

ID=45441820

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20171119TT HRP20171119T1 (hr) 2010-07-09 2011-07-08 Analozi agonista receptora opioida mu endomorfina

Country Status (13)

Country Link
US (3) US8716436B2 (https=)
EP (2) EP3246333B1 (https=)
JP (2) JP6039553B2 (https=)
CA (1) CA2810170C (https=)
CY (1) CY1120618T1 (https=)
ES (1) ES2632787T3 (https=)
HR (1) HRP20171119T1 (https=)
HU (1) HUE033875T2 (https=)
PL (1) PL2590992T3 (https=)
PT (1) PT2590992T (https=)
RS (1) RS56129B1 (https=)
SI (1) SI2590992T1 (https=)
WO (1) WO2012006497A2 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110065648A1 (en) * 2009-09-15 2011-03-17 Maione Theodore E Advantageous mu-opiate receptor peptide compounds
US20130178427A1 (en) * 2010-07-09 2013-07-11 The Administrators Of The Tulane Educational Fund Mu opioid receptor agonist analogs of the endomorphins
US20160176930A1 (en) 2010-07-09 2016-06-23 The Administrators Of The Tulane Educational Fund Mu opioid receptor agonist analogs of the endomorphins
WO2014137496A1 (en) * 2013-03-08 2014-09-12 The Administrators Of The Tulane Educational Fund Mu opioid receptor agonist analogs of the endomorphins
US10975121B2 (en) 2017-06-24 2021-04-13 Cytogel Pharma, Llc Analgesic mu-opioid receptor binding peptide pharmaceutical formulations and uses thereof
EP3681900A4 (en) 2017-09-11 2021-09-08 Protagonist Therapeutics, Inc. OPIOID AGONIST PEPTIDES AND THEIR USES
JP2021503481A (ja) * 2017-11-17 2021-02-12 サイトジェル ファーマ リミテッド ライアビリティ カンパニー μオピオイド受容体のポリマーアゴニスト
AU2018375087B2 (en) * 2017-11-30 2023-10-05 Cytogel Pharma, Llc Novel analgesic pharmaceutical formulations and uses thereof
US11578100B2 (en) 2018-03-28 2023-02-14 Florida Atlantic University Research Corporation Cyclic peptides, cyclic peptide conjugates and methods of use thereof
RU2687740C1 (ru) * 2018-11-26 2019-05-16 Федеральное государственное бюджетное образовательное учреждение высшего образования "Курский государственный медицинский университет" Министерства здравоохранения Российской Федерации Применение пептида Gly-His-Lys-Pro-Gly-Pro для достижения анальгетического эффекта при боли, вызванной температурным раздражением
WO2020227134A1 (en) * 2019-05-03 2020-11-12 The Administrators Of The Tulane Educational Fund Method for treating opioid use disorder
WO2023235232A2 (en) * 2022-05-31 2023-12-07 The Administrators Of The Tulane Educational Fund Glycosylated cyclic endomorphin analogs
CN116120402B (zh) * 2022-11-04 2024-03-15 深圳市维琪科技股份有限公司 一种环肽及其组合物和用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9203496D0 (sv) * 1992-11-20 1992-11-20 Kabi Pharmacia Ab New oligopeptides
US5885958A (en) 1997-03-25 1999-03-23 Administrators Of The Tulane Educational Fund Mu-opiate receptor peptides
US6759520B1 (en) * 1999-10-28 2004-07-06 The New England Medical Center Hospitals, Inc. Chimeric analgesic peptides
EP1578786A2 (en) 2002-12-23 2005-09-28 Janssen Pharmaceutica N.V. Heteroaryl peptidomimetics as thrombin receptor antagonists
US7399762B2 (en) * 2005-04-25 2008-07-15 Research Triangle Institute Opioid receptor agonist compounds and their use in treatment of pain
US8809278B2 (en) * 2008-07-11 2014-08-19 University Of Kansas Cyclic tetrapeptides

Also Published As

Publication number Publication date
AU2011274522A1 (en) 2013-02-07
AU2011274522B2 (en) 2016-03-31
EP3246333B1 (en) 2020-10-07
AU2011274522A8 (en) 2016-04-14
EP2590992A2 (en) 2013-05-15
HK1246811A1 (en) 2018-09-14
CY1120618T1 (el) 2019-12-11
US8716436B2 (en) 2014-05-06
JP2013533890A (ja) 2013-08-29
EP2590992A4 (en) 2013-12-18
SI2590992T1 (sl) 2017-11-30
US20150315238A1 (en) 2015-11-05
EP3246333A1 (en) 2017-11-22
ES2632787T3 (es) 2017-09-15
US20120322740A1 (en) 2012-12-20
EP2590992B1 (en) 2017-04-26
HUE033875T2 (en) 2018-01-29
JP6039553B2 (ja) 2016-12-07
JP6279626B2 (ja) 2018-02-14
RS56129B1 (sr) 2017-10-31
US20180222940A1 (en) 2018-08-09
WO2012006497A3 (en) 2012-05-24
JP2016084357A (ja) 2016-05-19
WO2012006497A2 (en) 2012-01-12
CA2810170A1 (en) 2012-01-12
PL2590992T3 (pl) 2017-09-29
CA2810170C (en) 2022-01-25
PT2590992T (pt) 2017-07-26

Similar Documents

Publication Publication Date Title
HRP20171119T1 (hr) Analozi agonista receptora opioida mu endomorfina
US8455617B2 (en) Melanocortin receptor-specific peptides
JP2013533890A5 (https=)
AU2009257631B2 (en) Melanocortin receptor-specific peptides for treatment of sexual dysfunction
HRP20160481T1 (hr) Peptidi za cjepiva protiv alergije na brezu
RS52786B (sr) Peptidi koji imaju farmakološku aktivnost za lečenje poremećaja povezanih sa izmenjenom migracijom ćelija, kao što je kancer
EP2440572A2 (en) Lactam-bridged melanocortin receptor-specific peptides
CN104271596A (zh) 肽激素的降钙素cgrp家族的肽拮抗剂和它们的用途
AU2025201154A1 (en) Melanocortin receptor-specific peptide formulations and methods for gastrointestinal tract-specific delivery
Ballet et al. Novel selective human melanocortin-3 receptor ligands: use of the 4-amino-1, 2, 4, 5-tetrahydro-2-benzazepin-3-one (Aba) scaffold
Axén et al. Small potent ligands to the insulin‐regulated aminopeptidase (IRAP)/AT4 receptor
US11124541B2 (en) Chimeric melanocortin ligands and methods of use thereof
CN108976287B (zh) 一类阿片和神经肽ff受体多靶点分子bn-9的二硫键环化类似物及其制备方法与应用
Rist et al. CGRP 27–37 analogues with high affinity to the CGRP1 receptor show antagonistic properties in a rat blood flow assay
Fang et al. Pressor and tachycardic responses to intrathecal administration of neuropeptide FF in anesthetized rats
US10301352B2 (en) Peptidomimetics with antiangiogenic activity
US10738083B2 (en) Influenza virus neutralizing peptidomimetic compounds
Fang et al. Pharmacological effects of the dansylated neuropeptide FF analogues on body temperature and morphine analgesia
Wang et al. Synthesis and antinociceptive effects of endomorphin-1 analogs with C-terminal linked by oligoarginine
WO2022188628A1 (zh) 一类阿片/神经肽ff受体多靶点环肽分子及其制备和应用
Fichna et al. [Dmt1, d-1-Nal3] morphiceptin, a novel opioid peptide analog with high analgesic activity
US7220720B2 (en) Melanin-concentrating hormone analogs
CN118834271A (zh) 一类3位点含芳香结构氨基酸的环六肽类似物及其制备和应用
US20040147432A1 (en) Melanin-concentrating hormone analogs
Inamine et al. Tritium-labelled isovaleryl-RYYRIK-NH2 as potential antagonist probe for ORL1 nociceptin receptor