CA2810170C - Mu opioid receptor agonist analogs of the endomorphins - Google Patents
Mu opioid receptor agonist analogs of the endomorphins Download PDFInfo
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- CA2810170C CA2810170C CA2810170A CA2810170A CA2810170C CA 2810170 C CA2810170 C CA 2810170C CA 2810170 A CA2810170 A CA 2810170A CA 2810170 A CA2810170 A CA 2810170A CA 2810170 C CA2810170 C CA 2810170C
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Classifications
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- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9486—Analgesics, e.g. opiates, aspirine
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- A—HUMAN NECESSITIES
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- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70571—Assays involving receptors, cell surface antigens or cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
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- G—PHYSICS
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- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
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- G—PHYSICS
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- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
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- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US36303910P | 2010-07-09 | 2010-07-09 | |
| US61/363,039 | 2010-07-09 | ||
| PCT/US2011/043306 WO2012006497A2 (en) | 2010-07-09 | 2011-07-08 | Mu opioid receptor agonist analogs of the endomorphins |
Publications (2)
| Publication Number | Publication Date |
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| CA2810170A1 CA2810170A1 (en) | 2012-01-12 |
| CA2810170C true CA2810170C (en) | 2022-01-25 |
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| CA2810170A Expired - Fee Related CA2810170C (en) | 2010-07-09 | 2011-07-08 | Mu opioid receptor agonist analogs of the endomorphins |
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| EP (2) | EP3246333B1 (https=) |
| JP (2) | JP6039553B2 (https=) |
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| CY (1) | CY1120618T1 (https=) |
| ES (1) | ES2632787T3 (https=) |
| HR (1) | HRP20171119T1 (https=) |
| HU (1) | HUE033875T2 (https=) |
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| RS (1) | RS56129B1 (https=) |
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| US20110065648A1 (en) * | 2009-09-15 | 2011-03-17 | Maione Theodore E | Advantageous mu-opiate receptor peptide compounds |
| US20130178427A1 (en) * | 2010-07-09 | 2013-07-11 | The Administrators Of The Tulane Educational Fund | Mu opioid receptor agonist analogs of the endomorphins |
| US20160176930A1 (en) | 2010-07-09 | 2016-06-23 | The Administrators Of The Tulane Educational Fund | Mu opioid receptor agonist analogs of the endomorphins |
| WO2014137496A1 (en) * | 2013-03-08 | 2014-09-12 | The Administrators Of The Tulane Educational Fund | Mu opioid receptor agonist analogs of the endomorphins |
| US10975121B2 (en) | 2017-06-24 | 2021-04-13 | Cytogel Pharma, Llc | Analgesic mu-opioid receptor binding peptide pharmaceutical formulations and uses thereof |
| EP3681900A4 (en) | 2017-09-11 | 2021-09-08 | Protagonist Therapeutics, Inc. | OPIOID AGONIST PEPTIDES AND THEIR USES |
| JP2021503481A (ja) * | 2017-11-17 | 2021-02-12 | サイトジェル ファーマ リミテッド ライアビリティ カンパニー | μオピオイド受容体のポリマーアゴニスト |
| AU2018375087B2 (en) * | 2017-11-30 | 2023-10-05 | Cytogel Pharma, Llc | Novel analgesic pharmaceutical formulations and uses thereof |
| US11578100B2 (en) | 2018-03-28 | 2023-02-14 | Florida Atlantic University Research Corporation | Cyclic peptides, cyclic peptide conjugates and methods of use thereof |
| RU2687740C1 (ru) * | 2018-11-26 | 2019-05-16 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Курский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Применение пептида Gly-His-Lys-Pro-Gly-Pro для достижения анальгетического эффекта при боли, вызванной температурным раздражением |
| WO2020227134A1 (en) * | 2019-05-03 | 2020-11-12 | The Administrators Of The Tulane Educational Fund | Method for treating opioid use disorder |
| WO2023235232A2 (en) * | 2022-05-31 | 2023-12-07 | The Administrators Of The Tulane Educational Fund | Glycosylated cyclic endomorphin analogs |
| CN116120402B (zh) * | 2022-11-04 | 2024-03-15 | 深圳市维琪科技股份有限公司 | 一种环肽及其组合物和用途 |
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| SE9203496D0 (sv) * | 1992-11-20 | 1992-11-20 | Kabi Pharmacia Ab | New oligopeptides |
| US5885958A (en) | 1997-03-25 | 1999-03-23 | Administrators Of The Tulane Educational Fund | Mu-opiate receptor peptides |
| US6759520B1 (en) * | 1999-10-28 | 2004-07-06 | The New England Medical Center Hospitals, Inc. | Chimeric analgesic peptides |
| EP1578786A2 (en) | 2002-12-23 | 2005-09-28 | Janssen Pharmaceutica N.V. | Heteroaryl peptidomimetics as thrombin receptor antagonists |
| US7399762B2 (en) * | 2005-04-25 | 2008-07-15 | Research Triangle Institute | Opioid receptor agonist compounds and their use in treatment of pain |
| US8809278B2 (en) * | 2008-07-11 | 2014-08-19 | University Of Kansas | Cyclic tetrapeptides |
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- 2011-07-08 JP JP2013519718A patent/JP6039553B2/ja not_active Expired - Fee Related
- 2011-07-08 HU HUE11804387A patent/HUE033875T2/en unknown
- 2011-07-08 HR HRP20171119TT patent/HRP20171119T1/hr unknown
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- 2011-07-08 ES ES11804387.6T patent/ES2632787T3/es active Active
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2014
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2017
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Also Published As
| Publication number | Publication date |
|---|---|
| AU2011274522A1 (en) | 2013-02-07 |
| AU2011274522B2 (en) | 2016-03-31 |
| EP3246333B1 (en) | 2020-10-07 |
| AU2011274522A8 (en) | 2016-04-14 |
| EP2590992A2 (en) | 2013-05-15 |
| HK1246811A1 (en) | 2018-09-14 |
| CY1120618T1 (el) | 2019-12-11 |
| US8716436B2 (en) | 2014-05-06 |
| JP2013533890A (ja) | 2013-08-29 |
| HRP20171119T1 (hr) | 2017-10-06 |
| EP2590992A4 (en) | 2013-12-18 |
| SI2590992T1 (sl) | 2017-11-30 |
| US20150315238A1 (en) | 2015-11-05 |
| EP3246333A1 (en) | 2017-11-22 |
| ES2632787T3 (es) | 2017-09-15 |
| US20120322740A1 (en) | 2012-12-20 |
| EP2590992B1 (en) | 2017-04-26 |
| HUE033875T2 (en) | 2018-01-29 |
| JP6039553B2 (ja) | 2016-12-07 |
| JP6279626B2 (ja) | 2018-02-14 |
| RS56129B1 (sr) | 2017-10-31 |
| US20180222940A1 (en) | 2018-08-09 |
| WO2012006497A3 (en) | 2012-05-24 |
| JP2016084357A (ja) | 2016-05-19 |
| WO2012006497A2 (en) | 2012-01-12 |
| CA2810170A1 (en) | 2012-01-12 |
| PL2590992T3 (pl) | 2017-09-29 |
| PT2590992T (pt) | 2017-07-26 |
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