HRP20160994T1 - Postupak za proizvodnju ugradive koštane supstance - Google Patents
Postupak za proizvodnju ugradive koštane supstance Download PDFInfo
- Publication number
- HRP20160994T1 HRP20160994T1 HRP20160994TT HRP20160994T HRP20160994T1 HR P20160994 T1 HRP20160994 T1 HR P20160994T1 HR P20160994T T HRP20160994T T HR P20160994TT HR P20160994 T HRP20160994 T HR P20160994T HR P20160994 T1 HRP20160994 T1 HR P20160994T1
- Authority
- HR
- Croatia
- Prior art keywords
- bone
- protein solution
- albumin
- bone particles
- patient
- Prior art date
Links
- 210000000988 bone and bone Anatomy 0.000 title claims 13
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 238000000034 method Methods 0.000 claims 14
- 239000012460 protein solution Substances 0.000 claims 9
- 239000002245 particle Substances 0.000 claims 7
- 102000009027 Albumins Human genes 0.000 claims 4
- 108010088751 Albumins Proteins 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 238000002513 implantation Methods 0.000 claims 2
- 230000011164 ossification Effects 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 102000016359 Fibronectins Human genes 0.000 claims 1
- 108010067306 Fibronectins Proteins 0.000 claims 1
- 102000008100 Human Serum Albumin Human genes 0.000 claims 1
- 108091006905 Human Serum Albumin Proteins 0.000 claims 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 239000007943 implant Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
- A61L27/3645—Connective tissue
- A61L27/365—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3695—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the function or physical properties of the final product, where no specific conditions are defined to achieve this
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
- A61L27/3843—Connective tissue
- A61L27/3847—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Developmental Biology & Embryology (AREA)
- Materials For Medical Uses (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (15)
1. Postupak za proizvodnju ugradive koštane supstance pogodne da se na nju vežu matične stanice, naznačen time da se čestice kosti dovode u dodir s proteinskom otopinom koja obuhvaća albumin i spomenuta proteinska otopina se suši na spomenutim koštanim česticama liofilizacijom.
2. Postupak prema patentnom zahtjevu 1, naznačen time da spomenuta proteinska otopina obuhvaća albumin u albuminskoj otopini.
3. Postupak prema patentnom zahtjevu 1 ili 2, naznačen time da je spomenuti albumin ljudski albumin, i preporučuje se da potječe iz seruma.
4. Postupak prema bilo kojem od patentnih zahtjeva 1 do 3, naznačen time da su spomenute koštane čestice liofilizirane koštane čestice.
5. Postupak prema bilo kojem od patentnih zahtjeva 1 do 4, naznačen time da su spomenute koštane čestice mineralizirane koštane čestice koje se uglavnom čiste od organskih komponenata.
6. Postupak prema bilo kojem od patentnih zahtjeva 1 do 5, naznačen time da neki od sastojaka spomenute proteinske otopine je/jesu ljudskog podrijetla ili je/jesu imunološki humanizirani.
7. Postupak prema bilo kojem od patentnih zahtjeva 1 do 6, naznačen time da je spomenuta proteinska otopina dobivena od pacijenta kom je potrebna implantacija kosti.
8. Postupak prema patentnom zahtjevu 7, naznačen time da spomenuta proteinska otopina obuhvaća serum spomenutog pacijeta ili bilo koju njegovu frakciju.
9. Postupak prema bilo kojem od patentnih zahtjeva 1 do 8, naznačen time da spomenuta proteinska otopina nadalje obuhvaća rekombinantni protein.
10. Postupak prema bilo kojem od patentnih zahtjeva 1 do 9, naznačen time da spomenuta proteinska otopina nadalje obuhvaća fibronektin ili kolagen ili njihovu kombinaciju.
11. Postupak prema bilo kojem od patentnih zahtjeva 1 do 10, naznačen time da spomenuta proteinska otopina ne sadrži komponente koje su potencijalno imunogene za pacijenta koji treba primiti spomenutu mineraliziranu koštanu supstancu kao implantat.
12. Postupak prema bilo kojem od patentnih zahtjeva 1 do 11, naznačen time da nadalje obuhvaća korak vezanja stanica koje mogu povećati formiranje kosti na površini spomenutih koštanih čestica, spomenute stanice su preporučljivo mezenhimalne matične stanice.
13. Postupak prema bilo kojem od patentnih zahtjeva 1 do 13, naznačen time da se spomenute stanice sposobne da povećaju formiranje kosti dobivaju od pacijenta kojem je potrebna koštana implantacija.
14. Ugradiva koštana supstanca pogodna za uporabu za ugradnju grafta koju je moguće dobiti postupcima prema bilo kojem od patentnih zahtjeva 1 do 13.
15. Supstanca prema patentnom zahtjevu 14 za uporabu u terapiji.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0800134A HU0800134D0 (en) | 2008-02-26 | 2008-02-26 | Procedure for producing mineralized bone composition |
| PCT/IB2009/050783 WO2009107088A2 (en) | 2008-02-26 | 2009-02-26 | Method for producing an implantable bone composition |
| EP09716106.1A EP2259804B1 (en) | 2008-02-26 | 2009-02-26 | Method for producing an implantable bone composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20160994T1 true HRP20160994T1 (hr) | 2016-10-21 |
Family
ID=89988109
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20160994TT HRP20160994T1 (hr) | 2008-02-26 | 2016-08-08 | Postupak za proizvodnju ugradive koštane supstance |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8551170B2 (hr) |
| EP (1) | EP2259804B1 (hr) |
| CA (1) | CA2716745C (hr) |
| DK (1) | DK2259804T3 (hr) |
| ES (1) | ES2586615T3 (hr) |
| HR (1) | HRP20160994T1 (hr) |
| HU (2) | HU0800134D0 (hr) |
| LT (1) | LT2259804T (hr) |
| PL (1) | PL2259804T3 (hr) |
| PT (1) | PT2259804T (hr) |
| SI (1) | SI2259804T1 (hr) |
| WO (1) | WO2009107088A2 (hr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013027189A1 (en) * | 2011-08-24 | 2013-02-28 | Semmelweis University | Protein coated bioactive suture for cell transplantation and method for producing thereof |
| EP3297694A1 (en) | 2015-05-21 | 2018-03-28 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
| US10456423B2 (en) | 2016-06-13 | 2019-10-29 | SMART SURGICAL, Inc. | Compositions for biological systems and methods for preparing and using the same |
| US10426796B2 (en) | 2016-06-13 | 2019-10-01 | SMART SURGICAL, Inc. | Compositions for biological systems and methods for preparing and using the same |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4902296A (en) * | 1986-10-29 | 1990-02-20 | The University Of Virginia Alumni Patents Foundation | Use of demineralized bone matrix in the repair of segmental defects |
| US6224913B1 (en) | 1996-05-09 | 2001-05-01 | The Trustees Of The University Of Pennsylvania | Conditioning of bioactive glass surfaces in protein containing solutions |
| WO2000054821A1 (en) * | 1999-03-16 | 2000-09-21 | Regeneration Technologies, Inc. | Molded implants for orthopedic applications |
-
2008
- 2008-02-26 HU HU0800134A patent/HU0800134D0/hu unknown
-
2009
- 2009-02-26 ES ES09716106.1T patent/ES2586615T3/es active Active
- 2009-02-26 HU HUE09716106A patent/HUE030562T2/en unknown
- 2009-02-26 LT LTEP09716106.1T patent/LT2259804T/lt unknown
- 2009-02-26 WO PCT/IB2009/050783 patent/WO2009107088A2/en active Application Filing
- 2009-02-26 CA CA2716745A patent/CA2716745C/en active Active
- 2009-02-26 PT PT97161061T patent/PT2259804T/pt unknown
- 2009-02-26 DK DK09716106.1T patent/DK2259804T3/en active
- 2009-02-26 US US12/811,031 patent/US8551170B2/en active Active
- 2009-02-26 PL PL09716106.1T patent/PL2259804T3/pl unknown
- 2009-02-26 EP EP09716106.1A patent/EP2259804B1/en active Active
- 2009-02-26 SI SI200931495A patent/SI2259804T1/sl unknown
-
2013
- 2013-10-07 US US14/047,758 patent/US9381272B2/en active Active
-
2016
- 2016-08-08 HR HRP20160994TT patent/HRP20160994T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUE030562T2 (en) | 2017-05-29 |
| EP2259804B1 (en) | 2016-05-11 |
| CA2716745C (en) | 2017-07-11 |
| SI2259804T1 (sl) | 2016-09-30 |
| US8551170B2 (en) | 2013-10-08 |
| WO2009107088A2 (en) | 2009-09-03 |
| LT2259804T (lt) | 2016-09-12 |
| US20100303885A1 (en) | 2010-12-02 |
| WO2009107088A3 (en) | 2009-12-30 |
| ES2586615T3 (es) | 2016-10-17 |
| CA2716745A1 (en) | 2009-09-03 |
| PT2259804T (pt) | 2016-08-17 |
| DK2259804T3 (en) | 2016-08-22 |
| US9381272B2 (en) | 2016-07-05 |
| HU0800134D0 (en) | 2008-04-28 |
| EP2259804A2 (en) | 2010-12-15 |
| PL2259804T3 (pl) | 2016-12-30 |
| US20140044792A1 (en) | 2014-02-13 |
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