HRP20120039T1 - Method for linking sequences of interest - Google Patents

Method for linking sequences of interest Download PDF

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HRP20120039T1
HRP20120039T1 HR20120039T HRP20120039T HRP20120039T1 HR P20120039 T1 HRP20120039 T1 HR P20120039T1 HR 20120039 T HR20120039 T HR 20120039T HR P20120039 T HRP20120039 T HR P20120039T HR P20120039 T1 HRP20120039 T1 HR P20120039T1
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B. Oleksiewicz Martin
S. Nielsen Lars
S. Aandersen Peter
H. Hansen Margit
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Symphogen A/S
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    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
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    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
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Abstract

Biblioteka srodnih parova koja sadrži povezane nukleinskokiselinske sljedove koji kodiraju varijabilno područje, naznačena time što je svaki srodni par izvorni par nepovezanih nukleinskokiselinskih sljedova umnoženih iz pojedinačnog limfocita, te što se biblioteka nalazi u više posuda, gdje svaka posuda sadrži pojedinačni srodni par. Patent sadrži još 21 patentni zahtjev.A library of related pairs containing linked nucleic acid sequences encoding a variable region, wherein each related pair is a native pair of unrelated nucleic acid sequences multiplied from a single lymphocyte, and the library is located in multiple vessels, where each vessel contains an individual related pair. The patent contains 21 more claims.

Description

LISTA SEKVENCI LIST OF SEQUENCES

SPISAK SLJEDOVA LIST OF SEQUENCES

[0476] [0476]

<110> Symphogen A/S <110> Symphogen A/S

<120> POSTUPAK POVEZIVANJA SLJEDOVA OD INTERESA <120> PROCEDURE OF CONNECTING SEQUENCES OF INTEREST

<130> 15881PCT00 <130> 15881PCT00

<160> 377 <160> 377

<170> PatentIn version 3.3 <170> PatentIn version 3.3

<210> 1 <210> 1

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 1 <400> 1

agcctatact attgattagg cgcgcccagr tgcagctggt gcart 45 agcctatact attgattagg cgcgcccagr tgcagctggt gcart 45

<210> 2 <210> 2

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 2 <400> 2

agcctatact attgattagg cgcgccsagg tccagctggt rcagt 45 agcctatact attgattagg cgcgccsagg tccagctggt rcagt 45

<210> 3 <210> 3

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 3 <400> 3

agcctatact attgattagg cgcgcccagr tcaccttgaa ggagt 45 agcctatact attgattagg cgcgcccagr tcaccttgaa ggagt 45

<210> 4 <210> 4

<211> 44 <211> 44

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 4 <400> 4

agcctatact attgattagg cgcgccsagg tgcagctggt ggag 44 agcctatact attgattagg cgcgccsagg tgcagctggt ggag 44

<210> 5 <210> 5

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 5 <400> 5

agcctatact attgattagg cgcgcccagg tgcagctaca gcagt 45 agcctatact attgattagg cgcgcccagg tgcagctaca gcagt 45

<210> 6 <210> 6

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 6 <400> 6

agcctatact attgattagg cgcgcccags tgcagctgca ggagt 45 agcctatact attgattagg cgcgcccags tgcagctgca ggagt 45

<210> 7 <210> 7

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 7 <400> 7

agcctatact attgattagg cgcgccgarg tgcagctggt gcagt 45 agcctatact attgattagg cgcgccgarg tgcagctggt gcagt 45

<210> 8 <210> 8

<211> 46 <211> 46

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 8 <400> 8

agcctatact attgattagg cgcgcccagg tacagctgca gcagtc 46 agcctatact attgattagg cgcgcccagg tacagctgca gcagtc 46

<210> 9 <210> 9

<211> 20 <211> 20

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 9 <400> 9

gacsgatggg cccttggtgg 20 gacsgatggg cccttggtgg 20

<210> 10 <210> 10

<211> 47 <211> 47

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 10 <400> 10

cgcctaatca atagtatagg ctagccgaca tccagwtgac ccagtct 47 cgcctaatca atagtatagg ctagccgaca tccagwtgac ccagtct 47

<210> 11 <210> 11

<211> 47 <211> 47

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 11 <400> 11

cgcctaatca atagtatagg ctagccgatg ttgtgatgac tcagtct 47 cgcctaatca atagtatagg ctagccgatg ttgtgatgac tcagtct 47

<210> 12 <210> 12

<211> 47 <211> 47

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 12 <400> 12

cgcctaatca atagtatagg ctagccgaaa ttgtgwtgac rcagtct 47 cgcctaatca atagtatagg ctagccgaaa ttgtgwtgac rcagtct 47

<210> 13 <210> 13

<211> 47 <211> 47

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 13 <400> 13

cgcctaatca atagtatagg ctagccgata ttgtgatgac ccacact 47 cgcctaatca atagtatagg ctagccgata ttgtgatgac ccacact 47

<210> 14 <210> 14

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 14 <400> 14

cgcctaatca atagtatagg ctagccgaaa cgacactcac gcagt 45 cgcctaatca atagtatagg ctagccgaaa cgacactcac gcagt 45

<210> 15 <210> 15

<211> 47 <211> 47

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 15 <400> 15

cgcctaatca atagtatagg ctagccgaaa ttgtgctgac tcagtct 47 cgcctaatca atagtatagg ctagccgaaa ttgtgctgac tcagtct 47

<210> 16 <210> 16

<211> 38 <211> 38

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 16 <400> 16

atatatatgc ggccgcttat taacactctc ccctgttg 38 atatatatgc ggccgcttat taacactctc ccctgttg 38

<210> 17 <210> 17

<211> 26 <211> 26

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 17 <400> 17

atattctcga gacggtgacc agggtg 26 atattctcga gacggtgacc agggtg 26

<210> 18 <210> 18

<211> 25 <211> 25

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 18 <400> 18

atattctcga gacggtgacc attgt 25 atattctcga gacggtgacc attgt 25

<210> 19 <210> 19

<211> 27 <211> 27

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 19 <400> 19

atattctcga gacggtgacc agggttc 27 atattctcga gacggtgacc agggttc 27

<210> 20 <210> 20

<211> 25 <211> 25

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 20 <400> 20

atattctcga gacggtgacc gtggt 25 atattctcga gacggtgacc gtggt 25

<210> 21 <210> 21

<211> 51 <211> 51

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 21 <400> 21

accgcctcca ccggcggccg cttattaaca ctctcccctg ttgaagctct t 51 accgcctcca ccggcggccg cttattaaca ctctcccctg ttgaagctct t 51

<210> 22 <210> 22

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> primer slijed <223> example sequence

<400> 22 <400> 22

gctagcatta ttattaccat ggcccagrtg cagctggtgc art 43 gctagcatta ttattaccat ggcccagrtg cagctggtgc art 43

<210> 23 <210> 23

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 23 <400> 23

gctagcatta ttattaccat ggccsaggtc cagctggtrc agt 43 gctagcatta ttattaccat ggccsaggtc cagctggtrc agt 43

<210> 24 <210> 24

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 24 <400> 24

gctagcatta ttattaccat ggcccagrtc accttgaagg agt 43 gctagcatta ttattaccat ggcccagrtc accttgaagg agt 43

<210> 25 <210> 25

<211> 42 <211> 42

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 25 <400> 25

gctagcatta ttattaccat ggccsaggtg cagctggtgg ag 42 gctagcatta ttattaccat ggccsaggtg cagctggtgg ag 42

<210> 26 <210> 26

<211> 36 <211> 36

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 26 <400> 26

tattggcgcg ccatggccsa ggtgcagctg gtggag 36 tattggcgcg ccatggccsa ggtgcagctg gtggag 36

<210> 27 <210> 27

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 27 <400> 27

gctagcatta ttattaccat ggcccaggtg cagctacagc agt 43 gctagcatta ttattaccat ggcccaggtg cagctacagc agt 43

<210> 28 <210> 28

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 28 <400> 28

gctagcatta ttattaccat ggcccagstg cagctgcagg agt 43 gctagcatta ttattaccat ggcccagstg cagctgcagg agt 43

<210> 29 <210> 29

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 29 <400> 29

gctagcatta ttattaccat ggccgargtg cagctggtgc agt 43 gctagcatta ttattaccat ggccgargtg cagctggtgc agt 43

<210> 30 <210> 30

<211> 44 <211> 44

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 30 <400> 30

gctagcatta ttattaccat ggcccaggta cagctgcagc agtc 44 gctagcatta ttattaccat ggcccaggta cagctgcagc agtc 44

<210> 31 <210> 31

<211> 26 <211> 26

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 31 <400> 31

atattctcga gacggtgacc agggtg 26 atattctcga gacggtgacc agggtg 26

<210> 32 <210> 32

<211> 27 <211> 27

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 32 <400> 32

atattctcga gacggtgacc attgtcc 27 atattctcga gacggtgacc attgtcc 27

<210> 33 <210> 33

<211> 27 <211> 27

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 33 <400> 33

atattctcga gacggtgacc agggttc 27 atattctcga gacggtgacc agggttc 27

<210> 34 <210> 34

<211> 27 <211> 27

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 34 <400> 34

atattctcga gacggtgacc gtggtcc 27 atattctcga gacggtgacc gtggtcc 27

<210> 35 <210> 35

<211> 44 <211> 44

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 35 <400> 35

ccatggtaat aataatgcta gccgacatcc agwtgaccca gtct 44 ccatggtaat aataatgcta gccgacatcc agwtgaccca gtct 44

<210> 36 <210> 36

<211> 44 <211> 44

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 36 <400> 36

ccatggtaat aataatgcta gccgatgttg tgatgactca gtct 44 ccatggtaat aataatgcta gccgatgttg tgatgactca gtct 44

<210> 37 <210> 37

<211> 44 <211> 44

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 37 <400> 37

ccatggtaat aataatgcta gccgaaattg tgwtgacrca gtct 44 ccatggtaat aataatgcta gccgaaattg tgwtgacrca gtct 44

<210> 38 <210> 38

<211> 44 <211> 44

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 38 <400> 38

ccatggtaat aataatgcta gccgatattg tgatgaccca cact 44 ccatggtaat aataatgcta gccgatattg tgatgaccca cact 44

<210> 39 <210> 39

<211> 42 <211> 42

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 39 <400> 39

ccatggtaat aataatgcta gccgaaacga cactcacgca gt 42 ccatggtaat aataatgcta gccgaaacga cactcacgca gt 42

<210> 40 <210> 40

<211> 44 <211> 44

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Početnički slijed <223> Beginner sequence

<400> 40 <400> 40

ccatggtaat aataatgcta gccgaaattg tgctgactca gtct 44 ccatggtaat aataatgcta gccgaaattg tgctgactca gtct 44

<210> 41 <210> 41

<211> 37 <211> 37

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 41 <400> 41

tattggcgcg ccatggccca grtgcagctg gtgcart 37 tattggcgcg ccatggccca grtgcagctg gtgcart 37

<210> 42 <210> 42

<211> 37 <211> 37

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 42 <400> 42

tattggcgcg ccatggccsa ggtccagctg gtrcagt 37 tattggcgcg ccatggccsa ggtccagctg gtrcagt 37

<210> 43 <210> 43

<211> 37 <211> 37

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 43 <400> 43

tattggcgcg ccatggccca grtcaccttg aaggagt 37 tattggcgcg ccatggccca grtcaccttg aaggagt 37

<210> 44 <210> 44

<211> 36 <211> 36

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 44 <400> 44

tattggcgcg ccatggccsa ggtgcagctg gtggag 36 tattggcgcg ccatggccsa ggtgcagctg gtggag 36

<210> 45 <210> 45

<211> 36 <211> 36

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 45 <400> 45

tattggcgcg ccatggccca ggtgcagcta cagcag 36 tattggcgcg ccatggccca ggtgcagcta cagcag 36

<210> 46 <210> 46

<211> 37 <211> 37

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 46 <400> 46

tattggcgcg ccatggccca gstgcagctg caggagt 37 tattggcgcg ccatggccca gstgcagctg caggagt 37

<210> 47 <210> 47

<211> 37 <211> 37

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 47 <400> 47

tattggcgcg ccatggccga rgtgcagctg gtgcagt 37 tattggcgcg ccatggccga rgtgcagctg gtgcagt 37

<210> 48 <210> 48

<211> 38 <211> 38

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 48 <400> 48

tattggcgcg ccatggccca ggtacagctg cagcagtc 38 tattggcgcg ccatggccca ggtacagctg cagcagtc 38

<210> 49 <210> 49

<211> 23 <211> 23

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 49 <400> 49

aagtagtcct tgaccaggca gcc 23 aagtagtcct tgaccaggca gcc 23

<210> 50 <210> 50

<211> 20 <211> 20

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 50 <400> 50

tgagttccac gacaccgtca 20 tgagttccac gacaccgtca 20

<210> 51 <210> 51

<211> 20 <211> 20

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 51 <400> 51

agaggtgctc ttggaggagg 20 agaggtgctc ttggaggagg 20

<210> 52 <210> 52

<211> 21 <211> 21

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 52 <400> 52

agttttgtca caagatttgg g 21 agttttgtca caagatttgg g 21

<210> 53 <210> 53

<211> 23 <211> 23

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 53 <400> 53

gttgcagatg taggtctggg tgc 23 gttgcagatg taggtctggg tgc 23

<210> 54 <210> 54

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 54 <400> 54

gccatggcgc gccaatagct agccgacatc cagwtgaccc agtct 45 gccatggcgc gccaatagct agccgacatc cagwtgaccc agtct 45

<210> 55 <210> 55

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 55 <400> 55

gccatggcgc gccaatagct agccgatgtt gtgatgactc agtct 45 gccatggcgc gccaatagct agccgatgtt gtgatgactc agtct 45

<210> 56 <210> 56

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 56 <400> 56

gccatggcgc gccaatagct agccgaaatt gtgwtgacrc agtct 45 gccatggcgc gccaatagct agccgaaatt gtgwtgacrc agtct 45

<210> 57 <210> 57

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 57 <400> 57

gccatggcgc gccaatagct agccgatatt gtgatgaccc acact 45 gccatggcgc gccaatagct agccgatatt gtgatgaccc acact 45

<210> 58 <210> 58

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 58 <400> 58

gccatggcgc gccaatagct agccgaaacg acactcacgc agt 43 gccatggcgc gccaatagct agccgaaacg acactcacgc agt 43

<210> 59 <210> 59

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 59 <400> 59

gccatggcgc gccaatagct agccgaaatt gtgctgactc agtct 45 gccatggcgc gccaatagct agccgaaatt gtgctgactc agtct 45

<210> 60 <210> 60

<211> 40 <211> 40

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 60 <400> 60

atatatatgc ggccgcttat taacactctc ccctgttgaa 40 atatatatgc ggccgcttat taacactctc ccctgttgaa 40

<210> 61 <210> 61

<211> 30 <211> 30

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 61 <400> 61

ggaggcgctc gagacggtga ccagggtgcc 30 ggaggcgctc gagacggtga ccagggtgcc 30

<210> 62 <210> 62

<211> 30 <211> 30

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 62 <400> 62

ggaggcgctc gagacggtga ccattgtccc 30 ggaggcgctc gagacggtga ccattgtccc 30

<210> 63 <210> 63

<211> 30 <211> 30

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 63 <400> 63

ggaggcgctc gagacggtga ccagggttcc 30 ggaggcgctc gagacggtga ccagggttcc 30

<210> 64 <210> 64

<211> 30 <211> 30

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 64 <400> 64

ggaggcgctc gagacggtga ccgtggtccc 30 ggaggcgctc gagacggtga ccgtggtccc 30

<210> 65 <210> 65

<211> 47 <211> 47

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 65 <400> 65

cgcctaatca atagtatagg ctagcccagt ctgtgctgac tcagcca 47 cgcctaatca atagtatagg ctagcccagt ctgtgctgac tcagcca 47

<210> 66 <210> 66

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 66 <400> 66

cgcctaatca atagtatagg ctagcccagt ctgtgytgac gcagc 45 cgcctaatca atagtatagg ctagcccagt ctgtgytgac gcagc 45

<210> 67 <210> 67

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 67 <400> 67

cgcctaatca atagtatagg ctagcccagt ctgtcgtgac gcagc 45 cgcctaatca atagtatagg ctagcccagt ctgtcgtgac gcagc 45

<210> 68 <210> 68

<211> 47 <211> 47

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 68 <400> 68

cgcctaatca atagtatagg ctagcccart ctgccctgac tcagcct 47 cgcctaatca atagtatagg ctagcccart ctgccctgac tcagcct 47

<210> 69 <210> 69

<211> 47 <211> 47

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 69 <400> 69

cgcctaatca atagtatagg ctagcctcct atgwgctgac tcagcca 47 cgcctaatca atagtatagg ctagcctcct atgwgctgac tcagcca 47

<210> 70 <210> 70

<211> 47 <211> 47

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 70 <400> 70

cgcctaatca atagtatagg ctagcctctt ctgagctgac tcaggac 47 cgcctaatca atagtatagg ctagcctctt ctgagctgac tcaggac 47

<210> 71 <210> 71

<211> 47 <211> 47

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 71 <400> 71

cgcctaatca atagtatagg ctagcccacg ttatactgac tcaaccg 47 cgcctaatca atagtatagg ctagcccacg ttatactgac tcaaccg 47

<210> 72 <210> 72

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 72 <400> 72

cgcctaatca atagtatagg ctagcccagg ctgtgctgac tcagc 45 cgcctaatca atagtatagg ctagcccagg ctgtgctgac tcagc 45

<210> 73 <210> 73

<211> 49 <211> 49

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 73 <400> 73

cgcctaatca atagtatagg ctagccaatt ttatgctgac tcagcccca 49 cgcctaatca atagtatagg ctagccaatt ttatgctgac tcagcccca 49

<210> 74 <210> 74

<211> 46 <211> 46

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 74 <400> 74

cgcctaatca atagtatagg ctagcccagr ctgtggtgac ycagga 46 cgcctaatca atagtatagg ctagcccagr ctgtggtgac ycagga 46

<210> 75 <210> 75

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 75 <400> 75

cgcctaatca atagtatagg ctagcccwgc ctgtgctgac tcagc 45 cgcctaatca atagtatagg ctagcccwgc ctgtgctgac tcagc 45

<210> 76 <210> 76

<211> 31 <211> 31

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 76 <400> 76

gccgcttatt atgaacattc tgtaggggcc a 31 gccgcttatt atgaacattc tgtaggggcc a 31

<210> 77 <210> 77

<211> 31 <211> 31

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 77 <400> 77

gccgcttatt aagagcattc tgcaggggcc a 31 gccgcttatt aagagcattc tgcaggggcc a 31

<210> 78 <210> 78

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 78 <400> 78

atatatatgc ggccgcttat tatgaacatt ctgtaggggc cactg 45 atatatatgc ggccgcttat tatgaacatt ctgtaggggc cactg 45

<210> 79 <210> 79

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 79 <400> 79

atatatatgc ggccgcttat taagagcatt ctgcaggggc cactg 45 atatatatgc ggccgcttat taagagcatt ctgcaggggc cactg 45

<210> 80 <210> 80

<211> 36 <211> 36

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 80 <400> 80

atatatatgc ggccgcttaa tgggctgcct cgggaa 36 atatatatgc ggccgcttaa tgggctgcct cgggaa 36

<210> 81 <210> 81

<211> 47 <211> 47

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 81 <400> 81

gccatggcgc gccaatagct agccttagag cagctcgtac tgacgaa 47 gccatggcgc gccaatagct agccttagag cagctcgtac tgacgaa 47

<210> 82 <210> 82

<211> 41 <211> 41

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 82 <400> 82

tattggcgcg ccatggccat gagtgagctt gaccagttac g 41 tattggcgcg ccatggccat gagtgagctt gaccagttac g 41

<210> 83 <210> 83

<211> 47 <211> 47

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 83 <400> 83

ggtacctaat aataatcgat cgcttagttc cagatcttga ggaagct 47 ggtacctaat aataatcgat cgcttagttc cagatcttga ggaagct 47

<210> 84 <210> 84

<211> 48 <211> 48

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 84 <400> 84

cgatcgatta ttattaggta ccccatgcca gtaatcaata ttgaggac 48 cgatcgatta ttattaggta ccccatgcca gtaatcaata ttgaggac 48

<210> 85 <210> 85

<211> 38 <211> 38

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 85 <400> 85

ggaggcgctc gagttatgaa atcacacagc ctcctttg 38 ggaggcgctc gagttatgaa atcacacagc ctcctttg 38

<210> 86 <210> 86

<211> 34 <211> 34

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<221> Miješana karakteristika <221> Mixed characteristic

<222> (18)..(34) <222> (18)..(34)

<223> Genski specifično područje <223> Gene-specific region

<400> 86 <400> 86

tattcccagc ggccgccgcc acaggtgccc actc 34 tattcccagc ggccgccgcc acaggtgccc actc 34

<210> 87 <210> 87

<211> 34 <211> 34

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<221> Miješana karakteristika <221> Mixed characteristic

<222> (18)..(34) <222> (18)..(34)

<223> Genski specifično područje <223> Gene-specific region

<400> 87 <400> 87

tattcccagc ggccgcccct tcmtgggtct tgtc 34 tattcccagc ggccgcccct tcmtgggtct tgtc 34

<210> 88 <210> 88

<211> 35 <211> 35

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<221> Miješana karakteristika <221> Mixed characteristic

<222> (18)..(35) <222> (18)..(35)

<223> Genski specifično područje <223> Gene-specific region

<400> 88 <400> 88

tattcccagc ggccgcctta raaggtgtcc agtgt 35 tattcccagc ggccgcctta raaggtgtcc agtgt 35

<210> 89 <210> 89

<211> 32 <211> 32

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<221> Miješana karakteristika <221> Mixed characteristic

<222> (18)..(32) <222> (18)..(32)

<223> Genski specifično područje <223> Gene-specific region

<400> 89 <400> 89

tattcccagc ggccgccccc agatgggtcc tg 32 tattcccagc ggccgccccc agatgggtcc tg 32

<210> 90 <210> 90

<211> 34 <211> 34

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<221> Miješana karakteristika <221> Mixed characteristic

<222> (18)..(34) <222> (18)..(34)

<223> Genski specifično područje <223> Gene-specific region

<400> 90 <400> 90

tattcccagc ggccgccctc caaggagtct gttc 34 tattcccagc ggccgccctc caaggagtct gttc 34

<210> 91 <210> 91

<211> 35 <211> 35

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<221> Miješana karakteristika <221> Mixed characteristic

<222> (18)..(35) <222> (18)..(35)

<223> Genski specifično područje <223> Gene-specific region

<400> 91 <400> 91

tattcccagc ggccgcccca tggggtgtcc tgtca 35 tattcccagc ggccgcccca tggggtgtcc tgtca 35

<210> 92 <210> 92

<211> 33 <211> 33

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<221> Miješana karakteristika <221> Mixed characteristic

<222> (18)..(33) <222> (18)..(33)

<223> Genski specifično područje <223> Gene-specific region

<400> 92 <400> 92

tattcccagc ggccgccgca acaggtgccc act 33 tattcccagc ggccgccgca acaggtgccc act 33

<210> 93 <210> 93

<211> 41 <211> 41

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<221> Miješana karakteristika <221> Mixed characteristic

<222> (25)..(41) <222> (25)..(41)

<223> Genski specifično područje <223> Gene-specific region

<400> 93 <400> 93

ggcggccgct gggaatagct agcgytccca ggtgccagat g 41 ggcggccgct gggaatagct agcgytccca ggtgccagat g 41

<210> 94 <210> 94

<211> 40 <211> 40

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<221> Miješana karakteristika <221> Mixed characteristic

<222> (25)..(40) <222> (25)..(40)

<223> Genski specifično područje <223> Gene-specific region

<400> 94 <400> 94

ggcggccgct gggaatagct agcggtccct ggatccagtg 40 ggcggccgct gggaatagct agcggtccct ggatccagtg 40

<210> 95 <210> 95

<211> 42 <211> 42

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<221> Miješana karakteristika <221> Mixed characteristic

<222> (25)..(42) <222> (25)..(42)

<223> Genski specifično područje <223> Gene-specific region

<400> 95 <400> 95

ggcggccgct gggaatagct agcgctccca gataccaccg ga 42 ggcggccgct gggaatagct agcgctccca gataccaccg ga 42

<210> 96 <210> 96

<211> 39 <211> 39

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<221> Miješana karakteristika <221> Mixed characteristic

<222> (25)..(39) <222> (25)..(39)

<223> Genski specifično područje <223> Gene-specific region

<400> 96 <400> 96

ggcggccgct gggaatagct agcgatctct ggtgcctac 39 ggcggccgct gggaatagct agcgatctct ggtgcctac 39

<210> 97 <210> 97

<211> 42 <211> 42

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<221> Miješana karakteristika <221> Mixed characteristic

<222> (25)..(42) <222> (25)..(42)

<400> 97 <400> 97

ggcggccgct gggaatagct agcgatctct gataccaggg ca 42 ggcggccgct gggaatagct agcgatctct gataccaggg ca 42

<210> 98 <210> 98

<211> 42 <211> 42

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<221> Miješana karakteristika <221> Mixed characteristic

<222> (25)..(42) <222> (25)..(42)

<223> Genski specifično područje <223> Gene-specific region

<400> 98 <400> 98

ggcggccgct gggaatagct agcggttcca gcctccaggg gt 42 ggcggccgct gggaatagct agcggttcca gcctccaggg gt 42

<210> 99 <210> 99

<211> 37 <211> 37

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 99 <400> 99

atatatatgg cgcgccttaa cactctcccc tgttgaa 37 atatatatgg cgcgccttaa cactctcccc tgttgaa 37

<210> 100 <210> 100

<211> 48 <211> 48

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Vektorski slijed <223> Vector sequence

<400> 100 <400> 100

atgaaatatc ttctaccaac agcggcagct ggattattgg cggccgcc 48 atgaaatatc ttctaccaac agcggcagct ggattattgg cggccgcc 48

<210> 101 <210> 101

<211> 48 <211> 48

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Vektorski slijed <223> Vector sequence

<400> 101 <400> 101

atgaaatatt tgctaccaac agcggcagct ggattattgt tactagcg 48 atgaaatatt tgctaccaac agcggcagct ggattattgt tactagcg 48

<210> 102 <210> 102

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 102 <400> 102

tgttgttcta gatgaaggcg cgcccagrtg cagctggtgc art 43 tgttgttcta gatgaaggcg cgcccagrtg cagctggtgc art 43

<210> 103 <210> 103

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 103 <400> 103

tgttgttcta gatgaaggcg cgccsaggtc cagctggtrc agt 43 tgttgttcta gatgaaggcg cgccsaggtc cagctggtrc agt 43

<210> 104 <210> 104

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 104 <400> 104

tgttgttcta gatgaaggcg cgcccagrtc accttgaagg agt 43 tgttgttcta gatgaaggcg cgcccagrtc accttgaagg agt 43

<210> 105 <210> 105

<211> 42 <211> 42

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 105 <400> 105

tgttgttcta gatgaaggcg cgccsaggtg cagctggtgg ag 42 tgttgttcta gatgaaggcg cgccsaggtg cagctggtgg ag 42

<210> 106 <210> 106

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 106 <400> 106

tgttgttcta gatgaaggcg cgcccaggtg cagctacagc agt 43 tgttgttcta gatgaaggcg cgcccaggtg cagctacagc agt 43

<210> 107 <210> 107

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 107 <400> 107

tgttgttcta gatgaaggcg cgcccagstg cagctgcagg agt 43 tgttgttcta gatgaaggcg cgcccagstg cagctgcagg agt 43

<210> 108 <210> 108

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 108 <400> 108

tgttgttcta gatgaaggcg cgccgargtg cagctggtgc agt 43 tgttgttcta gatgaaggcg cgccgargtg cagctggtgc agt 43

<210> 109 <210> 109

<211> 44 <211> 44

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 109 <400> 109

tgttgttcta gatgaaggcg cgcccaggta cagctgcagc agtc 44 tgttgttcta gatgaaggcg cgcccaggta cagctgcagc agtc 44

<210> 110 <210> 110

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 110 <400> 110

aacaacacta gtgataggct agccgacatc cagwtgaccc agtct 45 aacaacacta gtgataggct agccgacatc cagwtgaccc agtct 45

<210> 111 <210> 111

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 111 <400> 111

aacaacacta gtgataggct agccgatgtt gtgatgactc agtct 45 aacaacacta gtgataggct agccgatgtt gtgatgactc agtct 45

<210> 112 <210> 112

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 112 <400> 112

aacaacacta gtgataggct agccgaaatt gtgwtgacrc agtct 45 aacaacacta gtgataggct agccgaaatt gtgwtgacrc agtct 45

<210> 113 <210> 113

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 113 <400> 113

aacaacacta gtgataggct agccgatatt gtgatgaccc acact 45 aacaacacta gtgataggct agccgatatt gtgatgaccc acact 45

<210> 114 <210> 114

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 114 <400> 114

aacaacacta gtgataggct agccgaaacg acactcacgc agt 43 aacaacacta gtgataggct agccgaaacg acactcacgc agt 43

<210> 115 <210> 115

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 115 <400> 115

aacaacacta gtgataggct agccgaaatt gtgctgactc agtct 45 aacaacacta gtgataggct agccgaaatt gtgctgactc agtct 45

<210> 116 <210> 116

<211> 36 <211> 36

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 116 <400> 116

tattcccatg gcgcgcccag rtgcagctgg tgcart 36 tattcccatg gcgcgcccag rtgcagctgg tgcart 36

<210> 117 <210> 117

<211> 36 <211> 36

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 117 <400> 117

tattcccatg gcgcgccsag gtccagctgg trcagt 36 tattcccatg gcgcgccsag gtccagctgg trcagt 36

<210> 118 <210> 118

<211> 36 <211> 36

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 118 <400> 118

tattcccatg gcgcgcccag rtcaccttga aggagt 36 tattcccatg gcgcgcccag rtcaccttga aggagt 36

<210> 119 <210> 119

<211> 35 <211> 35

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 119 <400> 119

tattcccatg gcgcgccsag gtgcagctgg tggag 35 tattcccatg gcgcgccsag gtgcagctgg tggag 35

<210> 120 <210> 120

<211> 36 <211> 36

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 120 <400> 120

tattcccatg gcgcgcccag gtgcagctac agcagt 36 tattcccatg gcgcgcccag gtgcagctac agcagt 36

<210> 121 <210> 121

<211> 36 <211> 36

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 121 <400> 121

tattcccatg gcgcgcccag stgcagctgc aggagt 36 tattcccatg gcgcgcccag stgcagctgc aggagt 36

<210> 122 <210> 122

<211> 36 <211> 36

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 122 <400> 122

tattcccatg gcgcgccgar gtgcagctgg tgcagt 36 tattcccatg gcgcgccgar gtgcagctgg tgcagt 36

<210> 123 <210> 123

<211> 37 <211> 37

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 123 <400> 123

tattcccatg gcgcgcccag gtacagctgc agcagtc 37 tattcccatg gcgcgcccag gtacagctgc agcagtc 37

<210> 124 <210> 124

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 124 <400> 124

ggcgcgccat gggaatagct agccgacatc cagwtgaccc agtct 45 ggcgcgccat gggaatagct agccgacatc cagwtgaccc agtct 45

<210> 125 <210> 125

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 125 <400> 125

ggcgcgccat gggaatagct agccgatgtt gtgatgactc agtct 45 ggcgcgccat gggaatagct agccgatgtt gtgatgactc agtct 45

<210> 126 <210> 126

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 126 <400> 126

ggcgcgccat gggaatagct agccgaaatt gtgwtgacrc agtct 45 ggcgcgccat gggaatagct agccgaaatt gtgwtgacrc agtct 45

<210> 127 <210> 127

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 127 <400> 127

ggcgcgccat gggaatagct agccgatatt gtgatgaccc acact 45 ggcgcgccat gggaatagct agccgatatt gtgatgaccc acact 45

<210> 128 <210> 128

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 128 <400> 128

ggcgcgccat gggaatagct agccgaaacg acactcacgc agt 43 ggcgcgccat gggaatagct agccgaaacg acactcacgc agt 43

<210> 129 <210> 129

<211> 45 <211> 45

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 129 <400> 129

ggcgcgccat gggaatagct agccgaaatt gtgctgactc agtct 45 ggcgcgccat gggaatagct agccgaaatt gtgctgactc agtct 45

<210> 130 <210> 130

<211> 37 <211> 37

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 130 <400> 130

atatatatgc ggccgcttaa cactctcccc tgttgaa 37 atatatatgc ggccgcttaa cactctcccc tgttgaa 37

<210> 131 <210> 131

<211> 20 <211> 20

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Vektorski slijed <223> Vector sequence

<400> 131 <400> 131

aggaaacagg agatatacat 20 aggaaacagg agatatacat 20

<210> 132 <210> 132

<211> 20 <211> 20

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Vektorski slijed <223> Vector sequence

<400> 132 <400> 132

tcgccaagga gacagtcata 20 tcgccaagga gacagtcata 20

<210> 133 <210> 133

<211> 369 <211> 369

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 133 <400> 133

gggcgcgccc aggtgcagct ggtgcaatct ggacctgaag tgaagaagcc tggggcctca 60 gggcgcgcc aggtgcagct ggtgcaatct ggacctgaag tgaagaagcc tggggcctca 60

gtgagggtct cctgcaaggc ctctggttac tcctttaaga actatggtat ccactgggtg 120 gtgagggtct cctgcaaggc ctctggttac tcctttaaga actatggtat ccactgggtg 120

cgacaggccc ctggacaggg gcttgagtgg atggggtgga tcagcgctga caatggtgac 180 cgacaggccc ctggacaggg gcttgagtgg atggggtgga tcagcgctga caatggtgac 180

acaaccactg cactgaacct ccggggcaga gtctccatga ccacagacac atccacaaac 240 acaaccactg cactgaacct ccggggcaga gtctccatga ccacagacac atccacaaac 240

acagtctaca tggaggtgaa gagcctaaga tctgacgaca cggccatata tttctgtgcg 300 acagtctaca tggaggtgaa gagcctaaga tctgacgaca cggccatata tttctgtgcg 300

cgagattttt atagtgggag ttaccggtcc tttgactgct ggggccaggg caccctggtc 360 cgagattttt atagtgggag ttaccggtcc tttgactgct ggggccaggg caccctggtc 360

accgtctcg 369 accgtctcg 369

<210> 134 <210> 134

<211> 378 <211> 378

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 134 <400> 134

gggcgcgccc aggtgcagct acagcagtct gggggaggcc tggtcaagcc tggggggtcc 60 gggcgcgcc aggtgcagct acagcagtct gggggaggcc tggtcaagcc tgggggtcc 60

ctgagactct cctgtgcagc ctctggattc accttcagta gctatagcat gaactgggtc 120 ctgagactct cctgtgcagc ctctggattc accttcagta gctatagcat gaactgggtc 120

cgccaggctc cagggaaggg gctggagtgg gtctcatcca ttagtagtag tagtagttac 180 cgccaggctc cagggaaggg gctggagtgg gtctcatcca ttagtagtag tagtagttac 180

atatactacg cagactcagt gaagggccga ttcaccatct ccagagacaa cgccaagaac 240 atatactacg cagactcagt gaagggccga ttcaccatct ccagagacaa cgccaagaac 240

tcactgtatc tgcaaatgaa cagcctgaga gccgaggaca cggctgtgta ttactgtgcg 300 tcactgtatc tgcaaatgaa cagcctgaga gccgaggaca cggctgtgta ttactgtgcg 300

agacgccctg gttgggctgc tactcgggcg gcgggtgctt ttgatatctg gggccaaggg 360 agacgccctg gttgggctgc tactcgggcg gcgggtgctt ttgatatctg gggccaaggg 360

acaatggtca ccgtctcg 378 acaatggtca ccgtctcg 378

<210> 135 <210> 135

<211> 357 <211> 357

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 135 <400> 135

gggcgcgccc aggtgcagct ggtgcaatct ggacctgaac tgaagaagcc tggggcctca 60 gggcgcgcc aggtgcagct ggtgcaatct ggacctgaac tgaagaagcc tggggcctca 60

gtgaggatct cctgcaaggc ctctgagaaa tgtgatatcc actgggtgcg acaggcccct 120 gtgaggatct cctgcaaggc ctctgagaaa tgtgatatcc actgggtgcg acaggcccct 120

ggacaggggc ttgagtggat gggatggatc agcgctgacg atggtgggac aaccactgcg 180 ggacaggggc ttgagtggat gggatggatc agcgctgacg atggtgggac aaccactgcg 180

ctgaacctcc ggggcagagt ctccatgacc acagacagag ccacaaacac agtatacatg 240 ctgaacctcc ggggcagagt ctccatgacc agacagag ccacaaacac agtatacatg 240

gaactgaaga gcctaagatc tgacgacacg gccatttatt tctgtgcgcg agatttttat 300 gaactgaaga gcctaagatc tgacgacacg gccatttatt tctgtgcgcg agatttttat 300

agtgggactt accggtcctt tgactactgg ggccagggaa ccctggtcac cgtctcg 357 agtgggactt accggtcctt tgactactgg ggccagggaa ccctggtcac cgtctcg 357

<210> 136 <210> 136

<211> 396 <211> 396

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 136 <400> 136

gggcgcgcca aggtgcagct ggtggagtct gggggaggcg tggtccagcc tgggacgtcc 60 gggcgcgcca aggtgcagct ggtggagtct gggggaggcg tggtccagcc tgggacgtcc 60

ctcagactct cctgtgtagt ctctggattc accttcagaa cctatggtat gaactgggtc 120 ctcagactct cctgtgtagt ctctggattc accttcagaa cctatggtat gaactgggtc 120

cgccaggctc caggcaaggg gctggagtgg ctggcatttc tatcatctga tgggagcgat 180 cgccaggctc caggcaaggg gctggagtgg ctggcatttc tatcatctga tgggagcgat 180

gaattctacg cggactccgt gaagggccga ttcaccgtct ccagggacaa ttccaagagc 240 gaattctacg cggactccgt gaagggccga ttcaccgtct ccagggacaa ttccaagagc 240

actctctttc tgaaaatgaa cagtctgaga cctgatgaca cggctgtcta ttactgtgcg 300 actctctttc tgaaaatgaa cagtctgaga cctgatgaca cggctgtcta ttactgtgcg 300

agggatcgtg gggcccaaat tacacttttt ggagcccctc ttataaggcc ttcgtccttt 360 agggatcgtg gggcccaaat tacacttttt ggagcccctc ttataaggcc ttcgtccttt 360

gactcctggg gccagggcac cctggtcacc gtctcg 396 gactcctggg gccagggcac cctggtcacc gtctcg 396

<210> 137 <210> 137

<211> 362 <211> 362

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 137 <400> 137

gggcgcgccc aggtgcagct gcaggagtct ggacctgagg tgaagaagcc tggggcctca 60 gggcgcgcc aggtgcagct gcaggagtct ggacctgagg tgaagaagcc tggggcctca 60

gtgaaggtgt cctgcaaggc ttctggctac acgtttaaca gttatggaat cgcctgggtg 120 gtgaaggtgt cctgcaaggc ttctggctac acgtttaaca gttatggaat cgcctgggtg 120

cgacaggtcc ctggacaagg gcttgagtgg atgggatgga tcagccctta cagtggtcac 180 cgacaggtcc ctggacaagg gcttgagtgg atgggatgga tcagccctta cagtggtcac 180

acaaactatg cagagaaggt ccagggcaga gtcaccatga ccacagacac cgccacgagc 240 acaaactatg cagagaaggt ccagggcaga gtcaccatga ccacagacac cgccacgagc 240

acagcctgca tggagctgac gagcctgaga tctgacgaca cggccgttta tttctgtgcg 300 acagcctgca tggagctgac gagcctgaga tctgacgaca cggccgttta tttctgtgcg 300

agagactaca gtagtccgta ccactttgac tactggggcc agggcacctg gtcaccgtct 360 agagactaca gtagtccgta ccactttgac tactggggcc agggcacctg gtcaccgtct 360

cg 362 cg 362

<210> 138 <210> 138

<211> 366 <211> 366

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 138 <400> 138

gggcgcgccc agatcacctt gaaggagtct ggtcctacgc tggtgaaacc cacacagacc 60 gggcgcgccc agatcacctt gaaggagtct ggtcctacgc tggtgaaacc cacacagacc 60

ctcacgctga cctgcacctt gtctgggttc tcactctaca ctactggagt gggtgtgggc 120 ctcacgctga cctgcacctt gtctgggttc tcactctaca ctactggagt gggtgtgggc 120

tggatccgtc agcccccagg aaaggccctg gagtggctgg cacgcattta ttgggatgat 180 tggatccgtc agcccccagg aaaggccctg gagtggctgg cacgcattta ttgggatgat 180

gatgagcgct acaacccgtc tctgaagagc aggctcacca tcaccaagga cgcctccaaa 240 gatgagcgct acaacccgtc tctgaagagc aggctcacca tcaccaagga cgcctccaaa 240

aaccaggtgg tccttaaaat gaccaacatg gaccctgtgg acacagccac atattactgt 300 aaccaggtgg tccttaaaat gaccaacatg gaccctgtgg acacagccac atattactgt 300

gcccggacca tgggcgtcgt tcttccattt gactactggg gccagggaac cctggtcacc 360 gcccggacca tgggcgtcgt tcttccatt gactactggg gccagggaac cctggtcacc 360

gtctcg 366 gtctcg 366

<210> 139 <210> 139

<211> 351 <211> 351

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 139 <400> 139

gggcgcgcca aggtgcagct ggtggagtct gggggaggcc tggtcaagcc gggggggtcc 60 gggcgcgcca aggtgcagct ggtggagtct gggggaggcc tggtcaagcc gggggggtcc 60

ctgagactct cctgtgtagt ttctgggttc cccctcaata gatacaccat gaactgggtc 120 ctgagactct cctgtgtagt ttctgggttc cccctcaata gatacaccat gaactgggtc 120

cgccaggctc cagggaaggg gctggagtgg ctctcgtcca ttagtagtac tagttcttac 180 cgccaggctc cagggaaggg gctggagtgg ctctcgtcca ttagtagtac tagttcttac 180

atatactacg cagactcagt gaagggccga ttcaccatct ccagagacaa cgccaagaat 240 atatactacg cagactcagt gaagggccga ttcaccatct ccagagacaa cgccaagaat 240

tctctgtttc tgcagatgaa cagcctgaga gccgacgaca cggctctcta tttctgtgcg 300 tctctgtttc tgcagatgaa cagcctgaga gccgacgaca cggctctcta tttctgtgcg 300

agtggcaata ctcatgacta ctggggccag ggaaccctgg tcaccgtctc g 351 agtggcaata ctcatgacta ctggggccag ggaaccctgg tcaccgtctc g 351

<210> 140 <210> 140

<211> 378 <211> 378

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 140 <400> 140

gggcgcgccc aggtgcagct ggtgcagtct ggggctgagg tgaagaagct tgggacgtca 60 gggcgcgcc aggtgcagct ggtgcagtct ggggctgagg tgaagaagct tgggacgtca 60

gtgagggtct cctgcaagac tcctggaggc tatgttttca gctgggtgcg acaggcccct 120 gtgagggtct cctgcaagac tcctggaggc tatgttttca gctgggtgcg acaggcccct 120

ggacaagggc ctgagtggat gggagggatc atcaccaact ttgggacaac aaactacgca 180 ggacaagggc ctgagtggat gggagggatc atcaccaact ttgggacaac aaactacgca 180

cggaagttcc agggcagaat cacggttacc gcggacaaat ccacgaacac agtgtacatg 240 cggaagttcc agggcagaat cacggttacc gcggacaaat ccacgaacac agtgtacatg 240

gatttgagca acctggcatc tgaggacacg gccgtgtatt actgtgcgag agccccccga 300 gatttgagca acctggcatc tgaggacacg gccgtgtatt actgtgcgag agccccccga 300

ggcacgtcga ctatagcagc tcgttttaat cgatatttct ttgactcctg gggccagggc 360 ggcacgtcga ctatagcagc tcgttttaat cgatatttct ttgactcctg gggccagggc 360

accctggtca ccgtctcg 378 accctggtca ccgtctcg 378

<210> 141 <210> 141

<211> 396 <211> 396

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 141 <400> 141

gggcgcgccc aggtgcagct tcaggagtct gggggaggcg tggtccagcc tgggacgtcc 60 gggcgcgcc aggtgcagct tcaggagtct gggggaggcg tggtccagcc tgggacgtcc 60

ctcagactct cctgtgtagt ctctggattc accttcagaa cctatggtat gaactgggtc 120 ctcagactct cctgtgtagt ctctggattc accttcagaa cctatggtat gaactgggtc 120

cgccaggctc caggcaaggt gctggagtgg ctggcatttg tatcatctga tgggagcgat 180 cgccaggctc caggcaaggt gctggagtgg ctggcatttg tatcatctga tgggagcgat 180

gaattctacg cggactccgt gaagggccga ttcaccgtct ccagggacaa ttccaagagc 240 gaattctacg cggactccgt gaagggccga ttcaccgtct ccagggacaa ttccaagagc 240

actctctttc tgaaaatgaa cagtctgaga gctgatgaca cggctgtcta ttactgtgcg 300 actctctttc tgaaaatgaa cagtctgaga gctgatgaca cggctgtcta ttactgtgcg 300

agagatcgtg gggcccaaat tacacttttt ggagcccctc ttataaggcc ttcgtccttt 360 agagatcgtg gggcccaaat tacacttttt ggagcccctc ttataaggcc ttcgtccttt 360

gactcctggg gccagggaac cctggtcacc gtctcg 396 gactcctggg gccagggaac cctggtcacc gtctcg 396

<210> 142 <210> 142

<211> 378 <211> 378

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 142 <400> 142

gggcgcgccg aggtgcagct ggtggagtct ggggctgagg tgaagaagcc tgggacctca 60 gggcgcgccg aggtgcagct ggtggagtct ggggctgagg tgaagaagcc tgggacctca 60

gtgagggtct cctgcaagac ttctggaggc tatgttttca gctgggtgcg acaggcccct 120 gtgagggtct cctgcaagac ttctggaggc tatgttttca gctgggtgcg acaggcccct 120

ggacaagggc ctgagtggat gggagggatc atcaccagct ttgggacaac aagctacgca 180 ggacaagggc ctgagtggat gggagggatc atcaccagct ttgggacaac aagctacgca 180

cagaagttcc agggcagagt cacgattacc gcggacaaag ccacgaacac agtgtacatg 240 cagaagttcc agggcagagt cacgattacc gcggacaaag ccacgaacac agtgtacatg 240

gatttgagcg acctgacatc tgaggacacg gccatatatt actgtgcgaa agccccccga 300 gatttgagcg acctgacatc tgaggacacg gccatatatt actgtgcgaa agccccccga 300

ggcacgtcga ctatagcagc tcgttttaat cgctatttct ttgactcctg gggccagggc 360 ggcacgtcga ctatagcagc tcgttttaat cgctatttct ttgactcctg gggccagggc 360

accctggtca ccgtctcg 378 accctggtca ccgtctcg 378

<210> 143 <210> 143

<211> 366 <211> 366

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 143 <400> 143

gggcgcgccc aggtgcagct gcaggagtct ggtcctacgc tggtgaaacc cacacagacc 60 gggcgcgcc aggtgcagct gcaggagtct ggtcctacgc tggtgaaacc cacacagacc 60

ctcacgctga cctgctcgtt ctctggtttc tcactcggca ctactggagt caatgtgggc 120 ctcacgctga cctgctcgtt ctctggtttc tcactcggca ctactggagt caatgtgggc 120

tggatccgtc agcccccggg aaaggccctg gagtggcttg cactcatttc ttgggatggt 180 tggatccgtc agcccccggg aaaggccctg gagtggcttg cactcatttc ttgggatggt 180

ggtaagcact acagcccatc tctgaactcc aggatcaccc tcactaagga cgcctccaga 240 ggtaagcact acagcccatc tctgaactcc aggatcaccc tcactaagga cgcctccaga 240

gagcaggtgg tggtccctac aatgaccaac atggaccctg cggacacagg cagatattat 300 gagcaggtgg tggtccctac aatgaccaac atggaccctg cggacacagg cagatattat 300

tgtgcacgta tagtggggac tcacggcttt gactactggg gccagggaac cctggtcacc 360 tgtgcacgta tagtggggac tcacggcttt gactactggg gccagggaac cctggtcacc 360

gtctcg 366 gtctcg 366

<210> 144 <210> 144

<211> 393 <211> 393

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 144 <400> 144

gggcgcgcca aggtgcagct ggtggagtct ggagctgagg tgaagaagcc tggggccaca 60 gggcgcgcca aggtgcagct ggtggagtct ggagctgagg tgaagaagcc tggggccaca 60

gtcagggtct cctgtaaggc ttctggttac aggtttaacg actattgtat cagctgggtg 120 gtcagggtct cctgtaaggc ttctggttac aggtttaacg actattgtat cagctggggtg 120

cgacaggccc ctggacaagg gcttgagtgg atggggtgga tcaacggtaa caatgctgac 180 cgacaggccc ctggacaagg gcttgagtgg atggggtgga tcaacggtaa caatgctgac 180

acattctatg caccgaagct ccagggcaga gtcaccatga gcacagacac atccacgagc 240 acattctatg caccgaagct ccagggcaga gtcaccatga gcacagacac atccacgagc 240

acagcctaca tggagctgag gaacttgaga tcggacgaca cggccgttta tttctgtgcg 300 acagcctaca tggagctgag gaacttgaga tcggacgaca cggccgttta tttctgtgcg 300

cgagatcgag gacgtattac tctttttggc gaagttattt taagggcggg atggttcgac 360 cgagatcgag gacgtattac tctttttggc gaagttatt taagggcggg atggttcgac 360

tcctggggcc agggcaccct ggtcaccgtc tcg 393 tcctggggcc agggcaccct ggtcaccgtc tcg 393

<210> 145 <210> 145

<211> 372 <211> 372

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 145 <400> 145

gggcgcgccc aggtgcagct ggtgcagtct gggggaggcc tggtcaagcc gggggggtcc 60 gggcgcgcc aggtgcagct ggtgcagtct gggggaggcc tggtcaagcc gggggggtcc 60

ctgagactct cctgtgcagc ctctggattc tcctttagta ataataacat gaattgggtc 120 ctgagactct cctgtgcagc ctctggattc tcctttagta samaaacat gaattgggtc 120

cgccagactc caggaaaggg actggagtgg gtcgcatcta ttagttttgg aagtcattac 180 cgccagactc caggaaaggg actggagtgg gtcgcatcta ttagttttgg aagtcattac 180

atatcctacg cagactcagt gaagggccga ttcaccatct ccagagacaa cgccaggaat 240 atatcctacg cagactcagt gaagggccga ttcaccatct ccagagacaa cgccaggaat 240

gcagtttatc tgcagatgaa cagcctgaga gtcgaggaca cggctgtcta ttactgcacg 300 gcagtttatc tgcagatgaa cagcctgaga gtcgaggaca cggctgtcta ttactgcacg 300

agatgcaggg gcggaactcg tacctattat tacatggacg tctggggcaa aggcaccctg 360 agatgcaggg gcggaactcg tacctattat tacatggacg tctggggcaa aggcaccctg 360

gtcaccgtct cg 372 gtcaccgtct cg 372

<210> 146 <210> 146

<211> 372 <211> 372

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 146 <400> 146

gggcgcgcca aggtgcagct ggtggagtct gggggaggcc tggtcaagcc aggggggtcc 60 gggcgcgcca aggtgcagct ggtggagtct gggggaggcc tggtcaagcc aggggggtcc 60

ctgagactct cctgtgcagc ctctggatcc tcctttagta ataataacat gaattgggtc 120 ctgagactct cctgtgcagc ctctggatcc tcctttagta gaattggtc 120

cgccagactc caggaaaggg actggagtgg gtcgcatcca ttagttttgg aagtcattac 180 cgccagactc caggaaaggg actggagtgg gtcgcatcca ttagttttgg aagtcattac 180

atatcctacg cagactcagt gaagggccga ttcaccatct ccagagacaa cgccaggaat 240 atatcctacg cagactcagt gaagggccga ttcaccatct ccagagacaa cgccaggaat 240

gcagtttatc tgcagatgaa cagcctgaga gtcgaggaca cggctgtcta ttactgcacg 300 gcagtttatc tgcagatgaa cagcctgaga gtcgaggaca cggctgtcta ttactgcacg 300

agatgcaggg gcggaactcg tacctattat tacatggacg tctggggcaa aggcaccctg 360 agatgcaggg gcggaactcg tacctattat tacatggacg tctggggcaa aggcaccctg 360

gtcaccgtct cg 372 gtcaccgtct cg 372

<210> 147 <210> 147

<211> 390 <211> 390

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 147 <400> 147

gggcgcgccc agatgcagct ggtgcaatct ggggctgagg tgaagaagcc tgggtcctcg 60 gggcgcgccc agatgcagct ggtgcaatct ggggctgagg tgaagaagcc tgggtcctcg 60

gtgaaggtct cctgccagtc ttctggaggc ccccccaaaa gttatactct cagctgggtg 120 gtgaaggtct cctgccagtc ttctggaggc ccccccaaaaa gttatactct cagctgggtg 120

cggcaggccc ctggacaagg ccctgagtgg atgggcggaa tcattctaat ctttggccca 180 cggcaggccc ctggacaagg ccctgagtgg atgggcggaa tcattctaat ctttggccca 180

ccaaactacg cccagaagtt ccaggacaga ctcacgatca ccgcggacaa gtccaccaac 240 ccaaactacg cccagaagtt ccaggacaga ctcacgatca ccgcggacaa gtccaccaac 240

acagtctaca tggagttaag tagcctgaga tctgatgaca cggccatgta ctactgtgtg 300 acagtctaca tggagttaag tagcctgaga tctgatgaca cggccatgta ctactgtgtg 300

acagcccccg acgacactgg cactatatta gctcgtcaca accgttacta ctttgactcc 360 acagcccccg acgacactgg cactatatta gctcgtcaca accgttacta ctttgactcc 360

tggggccagg gcaccctggt caccgtctcg 390 tggggccagg gcaccctggt caccgtctcg 390

<210> 148 <210> 148

<211> 390 <211> 390

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 148 <400> 148

gggcgcgcca aggtgcagct ggtgcagtct ggagcagagg tgaagaagcc cggggagtct 60 gggcgcgcca aggtgcagct ggtgcagtct ggagcagagg tgaagaagcc cggggagtct 60

ctgaaaatct cctgtcaggc ttctggatac ggctttaccg tctactggat cggctgggtg 120 ctgaaaatct cctgtcaggc ttctggatac ggctttaccg tctactggat cggctgggtg 120

cgccagccgc ccgggaaagg cctggagtgg ctgggtatca tctatcctgg tgactctgat 180 cgccagccgc ccgggaaagg cctggagtgg ctgggtatca tctatcctgg tgactctgat 180

accagataca atccgtcctt ccaaggccag gtcaccatct cagccgacaa gtccgtcagc 240 accagataca atccgtcctt ccaaggccag gtcaccatct cagccgacaa gtccgtcagc 240

accacctacc tgcagtggag cagcctgaag gcctcggaca ccgccattta ctactgtgcg 300 accacctacc tgcagtggag cagcctgaag gcctcggaca ccgccattta ctactgtgcg 300

agacatctgg actcatacga tgttttcact ggttataatt tggggggcta catggacgtc 360 agacatctgg actcatacga tgttttcact ggttataatt tggggggcta catggacgtc 360

tggggcaagg gaaccctggt caccgtctcg 390 tggggcaagg gaaccctggt caccgtctcg 390

<210> 149 <210> 149

<211> 351 <211> 351

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 149 <400> 149

gggcgcgcca aagtgtagct ggtgcagtct gggggaggcc tggtcaagcc tggggggtcc 60 gggcgcgcca aagtgtagct ggtgcagtct gggggaggcc tggtcaagcc tggggggtcc 60

ctgagactct cctgtgtagt ctctggattc cccctcaata gatacatcat gaactgggtc 120 ctgagactct cctgtgtagt ctctggattc cccctcaata gatacatcat gaactgggtc 120

cgccagactc cagggaaggg gctggagtgg ctctcgtcca ttagtagtac cagttcttac 180 cgccagactc cagggaaggg gctggagtgg ctctcgtcca ttagtagtac cagttcttac 180

atatactacg cagactcagc gaagggccga ttcaccatct ccagagacaa cgccaagaat 240 atatactacg cagactcagc gaagggccga ttcaccatct ccagagacaa cgccaagaat 240

tctctgtttc tgcagatgaa cagcctgaga gccgaggaca caggtctcta ttactgtgcg 300 tctctgtttc tgcagatgaa cagcctgaga gccgaggaca caggtctcta ttactgtgcg 300

agtggcaata ctcatgacta ttggggccag ggcaccctgg tcaccgtctc g 351 agtggcaata ctcatgacta ttggggccag ggcaccctgg tcaccgtctc g 351

<210> 150 <210> 150

<211> 378 <211> 378

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 150 <400> 150

gggcgcgccc agatgcagct ggtgcagtct ggggctgagg tgaagaagcc tgggacctca 60 gggcgcgccc agatgcagct ggtgcagtct ggggctgagg tgaagaagcc tgggacctca 60

gtgagggtct cctgcaagac ttctggaggc tatgttttca gctgggtgcg acaggcccct 120 gtgagggtct cctgcaagac ttctggaggc tatgttttca gctgggtgcg acaggcccct 120

ggacaagggc ctgagtggat gggagggatc atcaccaact ttgggacaac aaactacgca 180 ggacaagggc ctgagtggat gggagggatc atcaccaact ttgggacaac aaactacgca 180

cagaagttcc agggcagagt cacgattacc gcggacaaat ccacgaacac agtgtatatg 240 cagaagttcc agggcagagt cacgattacc gcggacaaat ccacgaacac agtgtatatg 240

gatttgagca acctgacatc tgaggacacg gccgtgtatt actgtgcgag agccccccga 300 gatttgagca acctgacatc tgaggacacg gccgtgtatt actgtgcgag agccccccga 300

ggcacgtcga ctatagcagc tcgttttaat cggtatttct ttgactcctg gggccagggc 360 ggcacgtcga ctatagcagc tcgttttaat cggtatttct ttgactcctg gggccagggc 360

accctggtca ccgtctcg 378 accctggtca ccgtctcg 378

<210> 151 <210> 151

<211> 372 <211> 372

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 151 <400> 151

gggcgcgcca aggtgcagct ggtggagtct ggggctgagg tgaagaagcc tgggtcctcg 60 gggcgcgcca aggtgcagct ggtggagtct ggggctgagg tgaagaagcc tgggtcctcg 60

gtgaaggtct cctgcaaggc ctctggaggc agcttcagca cctatgctat cacctgggtg 120 gtgaaggtct cctgcaaggc ctctggaggc agcttcagca cctatgctat cacctgggtg 120

cgccaggccc ctggacaggg gcttgaatgg atgggaggga tcatccctat ctttgcttca 180 cgccaggccc ctggacaggg gcttgaatgg atgggaggga tcatccctat ctttgcttca 180

agagactacg cacagaagtt tcagggcaga gtcacagtca ccgcggacga atccacgagg 240 agagactacg cacagaagtt tcagggcaga gtcacagtca ccgcggacga atccacgagg 240

acagtgtaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca 300 acagtgtaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca 300

agagtgctgg gaggtacaag gctctactac gctctgaacg tctggggcca agggacaatg 360 agagtgctgg gaggtacaag gctctactac gctctgaacg tctggggcca agggacaatg 360

gtcaccgtct cg 372 gtcaccgtct cg 372

<210> 152 <210> 152

<211> 372 <211> 372

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 152 <400> 152

gggcgcgcca aggtgcagct ggtggagtct ggggctgagg tgaagaagcc tgggtcctcg 60 gggcgcgcca aggtgcagct ggtggagtct ggggctgagg tgaagaagcc tgggtcctcg 60

gtgaaggtct cctgcaagac atctggaggc agtttcagca catactctat cacctgggtg 120 gtgaaggtct cctgcaagac atctggaggc agtttcagca catactctat cacctgggtg 120

cgccaggccc ctggacaggg gcttgagtgg atgggaggga tcaaccctat cttcgctaca 180 cgccaggccc ctggacaggg gcttgagtgg atgggaggga tcaaccctat cttcgctaca 180

agagactacg cacagaagtt ccagggcaga gtcacgatca ccgcggacga atccacgagg 240 agagactacg cacagaagtt ccagggcaga gtcacgatca ccgcggacga atccacgagg 240

acagtctaca tggagttgag gaacttgaga tctgaggaca cggccgtgta ttattgtgca 300 acagtctaca tggagttgag gaacttgaga tctgaggaca cggccgtgta ttatgtgca 300

agagtgttcg gaggaacaag actctactac gccctgaacg tctggggcca aggcaccctg 360 agagtgttcg gaggaacaag actctactac gccctgaacg tctggggcca aggcaccctg 360

gtcaccgtct cg 372 gtcaccgtct cg 372

<210> 153 <210> 153

<211> 378 <211> 378

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 153 <400> 153

gggcgcgccg aagtgcagct ggtgcagtct ggggctgagg tgaagaagcc tgggacgtca 60 gggcgcgccg aagtgcagct ggtgcagtct ggggctgagg tgaagaagcc tgggacgtca 60

gtgagggtct cctgcaagac tcctggaggc tatgttttca gctgggtgcg acaggcccct 120 gtgagggtct cctgcaagac tcctggaggc tatgttttca gctgggtgcg acaggcccct 120

ggacaagggc ctgagtggat gggagggatc atcaccaact ttgggacaac aaactacgca 180 ggacaagggc ctgagtggat gggagggatc atcaccaact ttgggacaac aaactacgca 180

cggaagttcc agggcagaat cacggttacc gcggacaaat ccacgaacac agtgtacatg 240 cggaagttcc agggcagaat cacggttacc gcggacaaat ccacgaacac agtgtacatg 240

gatttgagca acctggcatc tgaggacacg gccgtgtatt actgtgcgag agccccccga 300 gatttgagca acctggcatc tgaggacacg gccgtgtatt actgtgcgag agccccccga 300

ggcacgtcga ctatagcagc tcgttttaat cgatatttct ttgactcctg gggccagggc 360 ggcacgtcga ctatagcagc tcgttttaat cgatatttct ttgactcctg gggccagggc 360

accctggtca ccgtctcg 378 accctggtca ccgtctcg 378

<210> 154 <210> 154

<211> 372 <211> 372

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 154 <400> 154

gggcgcgcca aggtgcagct ggtggagtct gggggaggcc tggtcaagcc gggggggtcc 60 gggcgcgcca aggtgcagct ggtggagtct gggggaggcc tggtcaagcc gggggggtcc 60

ctgagactct cctgtgcagc ctctggattc tcctttagta ataataacat gaattgggtc 120 ctgagactct cctgtgcagc ctctggattc tcctttagta samaaacat gaattgggtc 120

cgccagaccc caggaaaggg actggagtgg gtcgcatcca ttagttttgg aagtcattac 180 cgccagaccc caggaaaggg actggagtgg gtcgcatcca ttagttttgg aagtcattac 180

atatcctacg cagactcagt gaagggccga ttcaccatct ccagagacaa cgccaggaat 240 atatcctacg cagactcagt gaagggccga ttcaccatct ccagagacaa cgccaggaat 240

gcagtttatc tgcagatgaa cagcctgaga gtcgaggaca cggctgtcta ttactgcacg 300 gcagtttatc tgcagatgaa cagcctgaga gtcgaggaca cggctgtcta ttactgcacg 300

agatgcaggg gcggaactcg tacctattat tacatggacg tctggggcaa agggacaatg 360 agatgcaggg gcggaactcg tacctattat tacatggacg tctggggcaa agggacaatg 360

gtcaccgtct cg 372 gtcaccgtct cg 372

<210> 155 <210> 155

<211> 390 <211> 390

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 155 <400> 155

gggcgcgcca aggtgcagct ggtgcagtct ggagcagagg tgaagaagcc cggggagtct 60 gggcgcgcca aggtgcagct ggtgcagtct ggagcagagg tgaagaagcc cggggagtct 60

ctgaaaatct cctgtcaggc ttctggatac ggctttaccg tctactggat cggctgggtg 120 ctgaaaatct cctgtcaggc ttctggatac ggctttaccg tctactggat cggctgggtg 120

cgccagccgc cegggaaagg cctggagtgg ctgggtatca tctatcctgg tgactctgat 180 cgccagccgc cegggaaagg cctggagtgg ctgggtatca tctatcctgg tgactctgat 180

accagataca atccgtcctt ccaaggccag gtcaccatct cagccgacaa gtccgtcagc 240 accagataca atccgtcctt ccaaggccag gtcaccatct cagccgacaa gtccgtcagc 240

accacctacc tgcagtggag cagcctgaag gcctcggaca ccgccattta ctactgtgcg 300 accacctacc tgcagtggag cagcctgaag gcctcggaca ccgccattta ctactgtgcg 300

agacatctgg actcatacga tgttttcact ggttataatt tggggggcta catggacgtc 360 agacatctgg actcatacga tgttttcact ggttataatt tggggggcta catggacgtc 360

tggggcaagg gaaccctggt caccgtctcg 390 tggggcaagg gaaccctggt caccgtctcg 390

<210> 156 <210> 156

<211> 378 <211> 378

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 156 <400> 156

gggcgcgccc aggtgcagct ggtggagtct ggggctgaag tgaagaagcc tgggtcctca 60 gggcgcgcc aggtgcagct ggtggagtct ggggctgaag tgaagaagcc tgggtcctca 60

gtgaaggtct cctgcaagtc ttctggaggc tatgttttca gctgggtgcg acaggcccct 120 gtgaaggtct cctgcaagtc ttctggaggc tatgttttca gctgggtgcg acaggcccct 120

gggcaaggac tagagtggat gggagggatc atctccaact ttcgcacggc agagtacgca 180 gggcaaggac tagagtggat gggagggatc atctccaact ttcgcacggc agagtacgca 180

cggaagttcc agggtagagt caccatgacc gcggacacat ccacgaacac aatctacatg 240 cggaagttcc agggtagat caccatgacc gcggacacat ccacgaacac aatctacatg 240

gagctgacca gcctgacatc tgaagacacg gccgtatatt tctgtgtgag cgccccccga 300 gagctgacca gcctgacatc tgaagacacg gccgtatatt tctgtgtgag cgccccccga 300

gacacgtcga ctatagcagc tcgttttaat cgatacttct ttgacacctg gggccagggc 360 gacacgtcga ctatagcagc tcgttttaat cgatacttct ttgacacctg gggccagggc 360

accctggtca ccgtctcg 378 accctggtca ccgtctcg 378

<210> 157 <210> 157

<211> 378 <211> 378

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 157 <400> 157

gggcgcgccc aggtgcagct acagcagtcg gggggaggcg tggtccagcc tgggaggtcc 60 gggcgcgcc aggtgcagct acagcagtcg gggggaggcg tggtccagcc tgggaggtcc 60

ctgagactct cctgtgctgc ctctggattc gccttcagag actatgccat gcactgggtc 120 ctgagactct cctgtgctgc ctctggattc gccttcagag actatgccat gcactgggtc 120

cgccaggccc caggcaaggg gctggagtgg atgggagtta tctcatttaa tggagatcag 180 cgccaggccc caggcaaggg gctggagtgg atgggagtta tctcatttaa tggagatcag 180

atattttacg cagactccat gaagggccgc ttcaccatct ccagagagaa ctccaagaac 240 atattttacg cagactccat gaagggccgc ttcaccatct ccagagagaa ctccaagaac 240

acgctgcatc tgcgcatgaa cagcctgaga cctgaggaca cggctgtcta ttactgtgcg 300 acgctgcatc tgcgcatgaa cagcctgaga cctgaggaca cggctgtcta ttactgtgcg 300

agagcccgac ttcttttttg tagcggtggt aggtgcgaca tggactcttg gggccaggga 360 agagcccgac ttcttttttg tagcggtggt aggtgcgaca tggactcttg gggccaggga 360

accctggtca ccgtctcg 378 accctggtca ccgtctcg 378

<210> 158 <210> 158

<211> 378 <211> 378

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 158 <400> 158

gggcgcgcca aagtgcagct ggtgcagtct ggggctgagg tgaagaagcc tgggacctca 60 gggcgcgcca aagtgcagct ggtgcagtct ggggctgagg tgaagaagcc tgggacctca 60

gtgagggtct cctgcaagac ttctggaggc tatgttttca gttgggtgcg acaggcccct 120 gtgagggtct cctgcaagac ttctggaggc tatgttttca gttgggtgcg acaggcccct 120

ggacacgggc ctgaatggat gggagggatc atcaccaact ttgggacagc aacctacgca 180 ggacacgggc ctgaatggat gggagggatc atcaccaact ttgggacagc aacctacgca 180

cagaagttcc agggcagagt ctcgattacc gcggacacat ccacgaacac attttacatg 240 cagaagttcc agggcagagt ctcgattacc gcggacacat ccacgaacac attttacatg 240

gatttgaaca atctgaaatc tgacgacacg gccgtttatt actgtgcgag cgccccccga 300 gatttgaaca atctgaaatc tgacgacacg gccgtttat actgtgcgag cgccccccga 300

gacacgtcga ctatagcggc tcggtttaat cggtacttct ttgacttctg gggcccgggc 360 gacacgtcga ctatagcggc tcggtttaat cggtacttct ttgacttctg gggcccgggc 360

accctggtca ccgtctcg 378 accctggtca ccgtctcg 378

<210> 159 <210> 159

<211> 348 <211> 348

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 159 <400> 159

gggcgcgcct aggtgcagct ggtgcagtct gggggaggct tggtaaaacc tggggggtcc 60 gggcgcgcct aggtgcagct ggtgcagtct gggggaggct tggtaaaacc tgggggtcc 60

cttagactct cctgtgcagc ctctggattc actttcagta acgcctggat gagctgggtc 120 cttagactct cctgtgcagc ctctggattc actttcagta acgcctggat gagctgggtc 120

cgccaggctc cagggaaggg gctggagtgg gttggccatg ttaaaagcat gactgatggt 180 cgccaggctc cagggaaggg gctggagtgg gttggccatg ttaaaagcat gactgatggt 180

gggacaacag actacgctgc acccgtgaaa ggcagattca ccatctcaag agatgattca 240 gggacaacag actacgctgc acccgtgaaa ggcagattca ccatctcaag agatgattca 240

gaaaacacgc tgtatctgca aatgaacagc ctgaagaccg acgacacagc cgtgtattac 300 gaaaacacgc tgtatctgca aatgaacagc ctgaagaccg acgacacagc cgtgtattac 300

tgtaccactc atgactactg gggccagggc accctggtca ccgtctcg 348 tgtaccactc atgactactg gggccagggc accctggtca ccgtctcg 348

<210> 160 <210> 160

<211> 378 <211> 378

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 160 <400> 160

gggcgcgcca aagtgcagct ggtgcagtct ggggctgagg tgaagaagcc tgggacgtca 60 gggcgcgcca aagtgcagct ggtgcagtct ggggctgagg tgaagaagcc tgggacgtca 60

gtgagggtct cctgcaagac tcctggaggc tatgttttca gctgggtgcg acaggcccct 120 gtgagggtct cctgcaagac tcctggaggc tatgttttca gctgggtgcg acaggcccct 120

ggacaagggc ctgagtggat gggagggatc atcaccaact ttgggacaac aaactacgca 180 ggacaagggc ctgagtggat gggagggatc atcaccaact ttgggacaac aaactacgca 180

cggaagttcc agggcagaat cacggttacc gcggacaaat ccacgaacac agtgtacatg 240 cggaagttcc agggcagaat cacggttacc gcggacaaat ccacgaacac agtgtacatg 240

gatttgagca acctggcatc tgaggacacg gccgtgtatt actgtgcgag agccccccga 300 gatttgagca acctggcatc tgaggacacg gccgtgtatt actgtgcgag agccccccga 300

ggcacgtcga ctatagcagc tcgttttaat cgatatttct ttgactcctg gggccagggc 360 ggcacgtcga ctatagcagc tcgttttaat cgatatttct ttgactcctg gggccagggc 360

accctggtca ccgtctcg 378 accctggtca ccgtctcg 378

<210> 161 <210> 161

<211> 393 <211> 393

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 161 <400> 161

gggcgcgccc aggtgcagct ggtggagtct ggggctgaga tgaagaagcc tgggtcctcg 60 gggcgcgccc aggtgcagct ggtggagtct ggggctgaga tgaagaagcc tgggtcctcg 60

gtgaaggtct cctgccaggc ctctggaggc accttcagca actatggcat caattgggtg 120 gtgaaggtct cctgccaggc ctctggaggc accttcagca actatggcat caattgggtg 120

cgacacgccc ctggacaagg gcttgagtgg atgggaggaa tcgtccctat ctatggtcca 180 cgacacgccc ctggacaagg gcttgagtgg atgggaggaa tcgtccctat ctatggtcca 180

ccgaagtacg cacagaagtt ccagggcaga gtcacgatta ctgcggacac gtccacgagc 240 ccgaagtacg cacagaagtt ccagggcaga gtcacgatta ctgcggacac gtccacgagc 240

acagcctaca tggagctgag cagcctgagc tctgatgaca cggccgtgta ttactgtgcg 300 acagcctaca tggagctgag cagcctgagc tctgatgaca cggccgtgta ttactgtgcg 300

cgactttccc ggactgtgtt tggctcgggg acttatcgtc cgggctacta ctacatggac 360 cgactttccc ggactgtgtt tggctcgggg acttatcgtc cgggctacta ctacatggac 360

gtctggggca tagggaccac ggtcaccgtc tcg 393 gtctggggca tagggaccac ggtcaccgtc tcg 393

<210> 162 <210> 162

<211> 372 <211> 372

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 162 <400> 162

gggcgcgcct aggtgcagct acagcagtct gggggaggcc tggtcaagcc gggggggtcc 60 gggcgcgcct aggtgcagct acagcagtct gggggaggcc tggtcaagcc gggggggtcc 60

ctgagactct cctgtgcagc ctctggattc tcctttagta ataataacat gaattgggtc 120 ctgagactct cctgtgcagc ctctggattc tcctttagta samaaacat gaattgggtc 120

cgccagactc caggaaaggg actggagtgg gtcgcatcca ttagttttgg aagtcattac 180 cgccagactc caggaaaggg actggagtgg gtcgcatcca ttagttttgg aagtcattac 180

atatcctacg cagactcagt gaagggccga ttcaccatct ccagagacaa cgccaggaat 240 atatcctacg cagactcagt gaagggccga ttcaccatct ccagagacaa cgccaggaat 240

gcagtttatc tgcagatgaa cagcctgaga gtcgaggaca cggctgtcta ttactgcacg 300 gcagtttatc tgcagatgaa cagcctgaga gtcgaggaca cggctgtcta ttactgcacg 300

agatgcaggg gcggaactcg tacctattat tacatggacg tctggggcaa aggcaccctg 360 agatgcaggg gcggaactcg tacctattat tacatggacg tctggggcaa aggcaccctg 360

gtcaccgtct cg 372 gtcaccgtct cg 372

<210> 163 <210> 163

<211> 378 <211> 378

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 163 <400> 163

gggcgcgcca aggtgcagct ggtgcagtct ggggctgagg tgaagaagcc tgggacctca 60 gggcgcgcca aggtgcagct ggtgcagtct ggggctgagg tgaagaagcc tgggacctca 60

gtgagggtct cctgcaagac ttctggaggc tatgttttca gctgggtgcg acaggcccct 120 gtgagggtct cctgcaagac ttctggaggc tatgttttca gctgggtgcg acaggcccct 120

ggacaagggc ctgagtggat gggagggatc atcaccaact ttgggacaac aaactacgea 180 ggacaagggc ctgagtggat gggagggatc atcaccaact ttgggacaac aaactacgea 180

cagaagttcc agggcagagt cacgattacc gcggacaaat ccacgaacac agtgtacatg 240 cagaagttcc agggcagagt cacgattacc gcggacaaat ccacgaacac agtgtacatg 240

gatttgagca acctgacatc tgaggacacg gccgtgtatt actgtgcgag agccccccga 300 gatttgagca acctgacatc tgaggacacg gccgtgtatt actgtgcgag agccccccga 300

ggcacgtcga ctatagcagc tcgttttaat cggtatttct ttgactcctg gggccagggc 360 ggcacgtcga ctatagcagc tcgttttaat cggtatttct ttgactcctg gggccagggc 360

accctggtca ccgtctcg 378 accctggtca ccgtctcg 378

<210> 164 <210> 164

<211> 372 <211> 372

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 164 <400> 164

gggcgcgccg aagtgcagct ggtgcagtct ggggctgagg tgaagaagcc tgggtcctcg 60 gggcgcgccg aagtgcagct ggtgcagtct ggggctgagg tgaagaagcc tgggtcctcg 60

gtgaaggtct cctgcaagac tgaaggaggc accttcagca cctatgttat cagttggatg 120 gtgaaggtct cctgcaagac tgaaggaggc accttcagca cctatgttat cagttggatg 120

cgacaggccc ctggacaagg gcttgagtgg atgggaggga tcgtccccat ctttaacaca 180 cgacaggccc ctggacaagg gcttgagtgg atgggaggga tcgtccccat ctttaacaca 180

ccaaactacg ctcagaaatt ccagggcaga gtcacaatta ccgcggacag atccacgagc 240 ccaaactacg ctcagaaatt ccagggcaga gtcacaatta ccgcggacag atccacgagc 240

acagcctaca tggagctgag gagcctggga tctgaggaca cggccgtcta ttactgtgcg 300 acagcctaca tggagctgag gagcctggga tctgaggaca cggccgtcta ttactgtgcg 300

agggtagtgg gaggtacaag gtcctactac gctttgggct tctggggcca ggggaccacg 360 agggtagtgg gaggtacaag gtcctactac gctttgggct tctggggcca ggggaccacg 360

gtcaccgtct cg 372 gtcaccgtct cg 372

<210> 165 <210> 165

<211> 366 <211> 366

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 165 <400> 165

gggcgcgccc aggtcacctt gaaggagtct ggtcctacgc tggtgaaacc cacacagacc 60 gggcgcgcc aggtcacctt gaaggagtct ggtcctacgc tggtgaaacc cacacagacc 60

ctcacgctga cctgcacgtt ctctggtttc tcactcggca ctactggagt caatgtgggc 120 ctcacgctga cctgcacgtt ctctggtttc tcactcggca ctactggagt caatgtgggc 120

tggatccgtc agcccccagg aaaggccctg gagtggcttg cactcatttc ttggggtggt 180 tggatccgtc agcccccagg aaaggccctg gagtggcttg cactcatttc ttggggtggt 180

ggtaagcact acagcccatc tctgaactcc aggatcaccc tcactaagga cgcctccaga 240 ggtaagcact acagcccatc tctgaactcc aggatcaccc tcactaagga cgcctccaga 240

gagcaggtgg tggtccttac aatggccaac atggaccctg tggacacagg cagatattat 300 gagcaggtgg tggtccttac aatggccaac atggaccctg tggacacagg cagatattat 300

tgtgcacgta tagtggggac tcacggcttt gactactggg gccagggcac cctggtcacc 360 tgtgcacgta tagtggggac tcacggcttt gactactggg gccagggcac cctggtcacc 360

gtctcg 366 gtctcg 366

<210> 166 <210> 166

<211> 372 <211> 372

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 166 <400> 166

gggcgcgccg aggtccagct ggtgcagtct gggggaggtg tggtgcggcc tggggggtcc 60 gggcgcgccg aggtccagct ggtgcagtct gggggaggtg tggtgcggcc tgggggtcc 60

ctgagactct cgtgtgcagg ctctggattc acctttgatg aatacgctat gagctgggtc 120 ctgagactct cgtgtgcagg ctctggattc acctttgatg aatacgctat gagctgggtc 120

cgccaagctc cagggaaggg gctggagtgg gtcgctttta ttaattggaa tggtgatagc 180 cgccaagctc cagggaaggg gctggagtgg gtcgctttta ttaattggaa tggtgatagc 180

acatattatg cagactctgt gaagggccga ttcaccgtct ccagaaccaa cgccaagaac 240 acatattatg cagactctgt gaagggccga ttcaccgtct ccagaaccaa cgccaagaac 240

tccctgtatc tgcaaatgaa cagtctgaga gccgaggaca cggccttcta ttactgtgcg 300 tccctgtatc tgcaaatgaa cagtctgaga gccgaggaca cggccttcta ttactgtgcg 300

agagaccccc gcactaaact ggggatgtcc tattttgact attggggcca gggcaccctg 360 agagacccccc gcactaaact ggggatgtcc tattttgact attggggcca gggcaccctg 360

gtcaccgtct cg 372 gtcaccgtct cg 372

<210> 167 <210> 167

<211> 390 <211> 390

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 167 <400> 167

gggcgcgccg aagtgcagct ggtgcagtct ggagcagagg tgaagaagcc cggggagtct 60 gggcgcgccg aagtgcagct ggtgcagtct ggagcagagg tgaagaagcc cggggagatct 60

ctgaaaatct cctgtcaggc ttctggatac ggctttaccg tctactggat cggctgggtg 120 ctgaaaatct cctgtcaggc ttctggatac ggctttaccg tctactggat cggctgggtg 120

cgccagctgc ccgggaaagg cctggagtgg ctgggtatca tctatcctgg tgactctgat 180 cgccagctgc ccgggaaagg cctggagtgg ctgggtatca tctatcctgg tgactctgat 180

accagataca atccgtcctt ccaaggccag gtcaccatct cagccgacaa gtccgtcagc 240 accagataca atccgtcctt ccaaggccag gtcaccatct cagccgacaa gtccgtcagc 240

accacctacc tgcagtggag cagcctgaag gcctcggaca ccgccattta ctactgtgcg 300 accacctacc tgcagtggag cagcctgaag gcctcggaca ccgccattta ctactgtgcg 300

agacatctgg actcatacga tgttttcact ggttataatt tggggggcta catggacgtc 360 agacatctgg actcatacga tgttttcact ggttataatt tggggggcta catggacgtc 360

tggggcaagg ggacaatggt caccgtctcg 390 tggggcaagg ggacaatggt caccgtctcg 390

<210> 168 <210> 168

<211> 369 <211> 369

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 168 <400> 168

gggcgcgccg aggtgcagct ggtgcagtct ggacctgaag tgaagaagcc tggggectca 60 gggcgcgccg aggtgcagct ggtgcagtct ggacctgaag tgaagaagcc tggggectca 60

gtgagggtct cctgcaaggc ctctggttac tcccttaaga actatggtat ccactgggtg 120 gtgagggtct cctgcaaggc ctctggttac tcccttaaga actatggtat ccactgggtg 120

cgacaggccc ctggacaggg gcttgagtgg atggggtgga tcagcgctga caatggtgac 180 cgacaggccc ctggacaggg gcttgagtgg atggggtgga tcagcgctga caatggtgac 180

acaaccactg cactgaacct ccggggcaga gtctccatga ccacagacac atccacaaac 240 acaaccactg cactgaacct ccggggcaga gtctccatga ccacagacac atccacaaac 240

acagtctaca tggaggtgaa gagcctaaga tctgacgaca cggccatata tttctgtgcg 300 acagtctaca tggaggtgaa gagcctaaga tctgacgaca cggccatata tttctgtgcg 300

cgagattttt atagtgggag ttaccggtcc tttgactact ggggccaggg caccctggtc 360 cgagattttt atagtgggag ttaccggtcc tttgactact ggggccaggg caccctggtc 360

accgtctcg 369 accgtctcg 369

<210> 169 <210> 169

<211> 378 <211> 378

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 169 <400> 169

gggcgcgccg aagtgcagct ggtgcagtcg ggcccaggac tggtgaagcc ttcggagacc 60 gggcgcgccg aagtgcagct ggtgcagtcg ggcccaggac tggtgaagcc ttcggagacc 60

ctgtccctca catgcgctgt ctctggtgcc tccgtcagcg gtggtgatta ctactggagc 120 ctgtccctca catgcgctgt ctctggtgcc tccgtcagcg gtggtgatta ctactggagc 120

tggatccggc agcccccagg gaaggcactg gagtggattg ggtatatcta ttacataggg 180 tggatccggc agcccccagg gaaggcactg gagtggattg ggtatatcta ttacataggg 180

agcaccaact acaatccctc tctcaagagt cgactctccc tatcagtaga cacggccaag 240 agcaccaact acaatccctc tctcaagagt cgactctccc tatcagtaga cacggccaag 240

agccagttct ccctgaagtt gagctctgtg accgctgcgg acacggccat ttatttctgt 300 agccagttct ccctgaagtt gagctctgtg accgctgcgg acacggccat ttattctgt 300

gcgagagcac gtcggacgta tagtggctac gactccgcct ttgactactg gggccaggga 360 gcgagagcac gtcggacgta tagtggctac gactccgcct ttgactactg gggccaggga 360

accctggtca ccgtctcg 378 accctggtca ccgtctcg 378

<210> 170 <210> 170

<211> 372 <211> 372

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 170 <400> 170

gggcgcgccc aggtgcagct gcagcagtcg ggcccaggac tggtgaagcc ctcggagacc 60 gggcgcgcc aggtgcagct gcagcagtcg ggcccaggac tggtgaagcc ctcggagacc 60

ctgcccctca cctgcactgt ctctggtggc tccttcagta cctactactg gagctggatc 120 ctgcccctca cctgcactgt ctctggtggc tccttcagta cctactactg gagctggatc 120

cggcagtccc cagagaaggg actggagtgg attggatata tccaaaacag tgtgaacacc 180 cggcagtccc cagagaaggg actggagtgg attggatata tccaaaacag tgtgaacacc 180

aactacaacc cctccctcaa gagtcgtgtc atcatttcag tggacacgtc caacaaccag 240 aactacaacc cctccctcaa gagtcgtgtc atcatttcag tggacacgtc caacaaccag 240

ttctccctga agctgaggtc tgtgaccgct gcggacacgg ccgtatatta ctgtgcgaga 300 ttctccctga agctgaggtc tgtgaccgct gcggacacgg ccgtatatta ctgtgcgaga 300

gtaagcggct ggggcccaag gggaggcatc tactttgact actggggcca gggaaccctg 360 gtaagcggct ggggcccaag gggaggcatc tactttgact actggggcca gggaaccctg 360

gtcaccgtct cg 372 gtcaccgtct cg 372

<210> 171 <210> 171

<211> 378 <211> 378

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 171 <400> 171

gggcgcgcca aggtgcagct ggtgcagtct ggggctgaag tgaagaagcc tgggtcctca 60 gggcgcgcca aggtgcagct ggtgcagtct ggggctgaag tgaagaagcc tgggtcctca 60

gtgaaggtct cctgcaagtc ttctggaggc tatgttttca gctgggtgcg acaggcccct 120 gtgaaggtct cctgcaagtc ttctggaggc tatgttttca gctgggtgcg acaggcccct 120

gggcaaggac tagagtggat gggagggatc atctccaact ttcacacggc agagtacgca 180 gggcaaggac tagagtggat gggagggatc atctccaact ttcacacggc agatacgca 180

cagaagttcc agggtagagt caccatgacc gcggacacat ccacgaacac aatctacatg 240 cagaagttcc agggtagat caccatgacc gcggacacat ccacgaacac aatctacatg 240

gagctgacca gcctgacatc tgaagacacg gccgtatatt tctgcgtgag cgccccccga 300 gagctgacca gcctgacatc tgaagacacg gccgtatatt tctgcgtgag cgccccccga 300

gacacgtcga ctatagcagc tcgttttaat cgatacttct ttgacacctg gggccagggc 360 gacacgtcga ctatagcagc tcgttttaat cgatacttct ttgacacctg gggccagggc 360

accctggtca ccgtctcg 378 accctggtca ccgtctcg 378

<210> 172 <210> 172

<211> 378 <211> 378

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 172 <400> 172

gggcgcgccg aggtgcagct ggtgcagtct ggggctgagg tgaagaagcc tgggacgtca 60 gggcgcgccg aggtgcagct ggtgcagtct ggggctgagg tgaagaagcc tgggacgtca 60

gtgagggtct cccgcaagac tcctggaggc tatgttttca gctgggtgcg acaggcccca 120 gtgagggtct cccgcaagac tcctggaggc tatgttttca gctgggtgcg acaggcccca 120

ggacaagggc ctgagtggat gggagggatc atcaccaact ttgggacaac aaactacgca 180 ggacaagggc ctgagtggat gggagggatc atcaccaact ttgggacaac aaactacgca 180

cggaagttcc agggcagaat cacggttacc gcggacaaat ccacgaacac agtgtacatg 240 cggaagttcc agggcagaat cacggttacc gcggacaaat ccacgaacac agtgtacatg 240

gatttgagca acctggcatc tgaggacacg gccgtgtatt actgtgcgag agccccccga 300 gatttgagca acctggcatc tgaggacacg gccgtgtatt actgtgcgag agccccccga 300

ggcacgtcga ctatagcagc tcgttttaat cgatatttct ttgactcctg gagccagggc 360 ggcacgtcga ctatagcagc tcgttttaat cgatatttct ttgactcctg gagccagggc 360

accctggtca ccgtctcg 378 accctggtca ccgtctcg 378

<210> 173 <210> 173

<211> 372 <211> 372

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 173 <400> 173

gggcgcgccg aggtgcagct ggtggagtct ggggctgagg tgaagaagcc tgggtcctcg 60 gggcgcgccg aggtgcagct ggtggagtct ggggctgagg tgaagaagcc tgggtcctcg 60

gtgaaggtct cctgcaaggc ctctggaggc agcttcagca cctatatttt cacctgggtg 120 gtgaaggtct cctgcaaggc ctctggaggc agcttcagca cctatatttt cacctgggtg 120

cgccaggccc ctggacaggg gcttgagtgg atgggaggga tcaatcctat ctttgctaca 180 cgccaggccc ctggacaggg gcttgagtgg atgggaggga tcaatcctat ctttgctaca 180

agagactacc caaagaagtt ccagggcaga gtcacgatca ccgcggacga atccacgagg 240 agagactacc caaagaagtt ccagggcaga gtcacgatca ccgcggacga atccacgagg 240

actgtctata tggagttgag cagcctcaca tctgaggaca cggccgtcta ttactgtgca 300 actgtctata tggagttgag cagcctcaca tctgaggaca cggccgtcta ttactgtgca 300

agagtgttgg gaggtacaag gctctactac gctctgaacg tctggggcca agggaccacg 360 agagtgttgg gaggtacaag gctctactac gctctgaacg tctggggcca agggaccacg 360

gtcaccgtct cg 372 gtcaccgtct cg 372

<210> 174 <210> 174

<211> 372 <211> 372

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 174 <400> 174

gggcgcgccg aagtgcagct ggtgcagtct gggggaggtg tggtgcggcc tggggggtcc 60 gggcgcgccg aagtgcagct ggtgcagtct gggggaggtg tggtgcggcc tgggggtcc 60

ctgagactct cgtgtgcagg ctctggattc acctttgatg aatacgecat gagctgggtc 120 ctgagactct cgtgtgcagg ctctggattc acctttgatg aatacgecat gagctgggtc 120

cgccaagctc cagggaaggg gctgaagtgg gtcgctttta ttaattggaa tggtgatagc 180 cgccaagctc cagggaaggg gctgaagtgg gtcgctttta ttaattggaa tggtgatagc 180

acatattatg cagactctgt gaagggccga ttcaccgtct ccagatccaa cgccaagaac 240 acatattatg cagactctgt gaagggccga ttcaccgtct ccagatccaa cgccaagaac 240

tccctgtatc tgcaaatgaa cagtctgaga gccgaggaca cggccttcta ttgctgtgcg 300 tccctgtatc tgcaaatgaa cagtctgaga gccgaggaca cggccttcta ttgctgtgcg 300

agagaccccc gcactaaact ggggatgtcc tattttgact attggggcca gggcaccctg 360 agagacccccc gcactaaact ggggatgtcc tattttgact attggggcca gggcaccctg 360

gtcaccgtct cg 372 gtcaccgtct cg 372

<210> 175 <210> 175

<211> 372 <211> 372

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 175 <400> 175

gggcgcgccg aggtgcagct ggtgcagtct ggggctgagg tgaagaagcc tgggtcctcg 60 gggcgcgccg aggtgcagct ggtgcagtct ggggctgagg tgaagaagcc tgggtcctcg 60

gtgaaggtct cctgcaaggc ctctggaggc agcttcagca cctatgctat cacctgggtg 120 gtgaaggtct cctgcaaggc ctctggaggc agcttcagca cctatgctat cacctgggtg 120

cgccaggccc ctggacaggg gcttgaatgg atgggaggga tcatccctat ctttgcttca 180 cgccaggccc ctggacaggg gcttgaatgg atgggaggga tcatccctat ctttgcttca 180

agagactacg cacagaagtt tcagggcaga gtcacaatca ccgcggacga atccacgagg 240 agagactacg cacagaagtt tcagggcaga gtcacaatca ccgcggacga atccacgagg 240

acagtgtaca tggagccgag gagcctgaga tctgaagaca cggccgtgta ttactgtgca 300 acagtgtaca tggagccgag gagcctgaga tctgaagaca cggccgtgta ttactgtgca 300

agagtgctgg gaggtacaag gctctactac gctctgaacg tctggggcca aggcaccctg 360 agagtgctgg gaggtacaag gctctactac gctctgaacg tctggggcca aggcaccctg 360

gtcaccgtct cg 372 gtcaccgtct cg 372

<210> 176 <210> 176

<211> 378 <211> 378

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 176 <400> 176

gggcgcgccg aggtgcagct ggtgcagtcg ggcccaggac tggtgaagcc ttcggagacc 60 gggcgcgccg aggtgcagct ggtgcagtcg ggcccaggac tggtgaagcc ttcggagacc 60

ctgtccctca catgegctgt ctctggtgcc tccgtcagcg gtggtgatta ctactggagc 120 ctgtccctca catgegctgt ctctggtgcc tccgtcagcg gtggtgatta ctactggagc 120

tggatccggc agcccccagg gaaggcactg gagtggattg ggtatatcta ttacataggg 180 tggatccggc agcccccagg gaaggcactg gagtggattg ggtatatcta ttacataggg 180

agcaccaact acaatccctc tctcaagagt cgactctccc tatcagtaga cacggccaag 240 agcaccaact acaatccctc tctcaagagt cgactctccc tatcagtaga cacggccaag 240

agccagttct ccctgaagtt gagctctgtg accgctgcgg acacggccac ttatttctgt 300 agccagttct ccctgaagtt gagctctgtg accgctgcgg acaccggccac ttattctgt 300

gcgagagcac gtcggacgta tagtggctac gactccgcct ttgactactg gggccaggga 360 gcgagagcac gtcggacgta tagtggctac gactccgcct ttgactactg gggccaggga 360

accctggtca ccgtctcg 378 accctggtca ccgtctcg 378

<210> 177 <210> 177

<211> 372 <211> 372

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 177 <400> 177

gggcgcgccg aggtgcagct ggtggagtct ggggctgagg tgaagaagcc tgggtcctcg 60 gggcgcgccg aggtgcagct ggtggagtct ggggctgagg tgaagaagcc tgggtcctcg 60

gtgaaggtct cctgcaaggc ctctggaggc agcttcagca cctatgctat cacctgggtg 120 gtgaaggtct cctgcaaggc ctctggaggc agcttcagca cctatgctat cacctgggtg 120

cgccaggccc ctggacaggg gcttgaatgg atgggaggga tcatccctat ctttgcttca 180 cgccaggccc ctggacaggg gcttgaatgg atgggaggga tcatccctat ctttgcttca 180

agagactacg cacagaagtt tcagggcaga gtcacaatca ccgcggacga atccacgagg 240 agagactacg cacagaagtt tcagggcaga gtcacaatca ccgcggacga atccacgagg 240

acagtgtaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca 300 acagtgtaca tggagctgag cagcctgaga tctgacgaca cggccgtgta ttactgtgca 300

agagtgctgg gaggtacaag gctctactac gctctgaacg tctggggcca agggaccacg 360 agagtgctgg gaggtacaag gctctactac gctctgaacg tctggggcca agggaccacg 360

gtcaccgtct cg 372 gtcaccgtct cg 372

<210> 178 <210> 178

<211> 369 <211> 369

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 178 <400> 178

gggcgcgccc aggtcacctt gaaggagtct ggtcctacag tggtgaaacc cacacagacc 60 gggcgcgcc aggtcacctt gaaggagtct ggtcctacag tggtgaaacc cacacagacc 60

ctcacgctga cctgtagcct ctctgggttc gcactcggca ctaceggagt ggctgtgggc 120 ctcacgctga cctgtagcct ctctgggttc gcactcggca ctaceggagt ggctgtgggc 120

tggatccgtc agcccccagg aaaggccctg gaatggcttg gactcatcga ttggaatgat 180 tggatccgtc agcccccagg aaaggccctg gaatggcttg gactcatcga ttggaatgat 180

gataggcgct acagaccctc tctgaagacc agactcacca tcacccagga catgtccagg 240 gataggcgct acagaccctc tctgaagacc agactcacca tcacccagga catgtccagg 240

aaccaggtgg tccttagact gaccaacttg gacccactgg acacaggcac atatttttgt 300 aaccaggtgg tccttagact gaccaacttg gacccactgg acacaggcac atatttttgt 300

gcacgttcag tagtgccggc gactagggcc tttgacttct ggggccaggg caccctggtc 360 gcacgttcag tagtgccggc gactagggcc tttgacttct ggggccaggg caccctggtc 360

accgtctcg 369 accgtctcg 369

<210> 179 <210> 179

<211> 366 <211> 366

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 179 <400> 179

gggcgcgccc aggtcacctt gaaggagtct ggtcctacgc tggtgaaacc cacacagacc 60 gggcgcgcc aggtcacctt gaaggagtct ggtcctacgc tggtgaaacc cacacagacc 60

ctcacgctga cctgcacctt gtctgggttc tcactctaca ctactggagt gggtgtgggc 120 ctcacgctga cctgcacctt gtctgggttc tcactctaca ctactggagt gggtgtgggc 120

tggatccgtc agcccccagg aaaggccctg gagtgactgg cacgcattta ttgggatgat 180 tggatccgtc agcccccagg aaaggccctg gagtgactgg cacgcattta ttgggatgat 180

gatgageget acaacccgtc tctgaagagc aggctcacca tcaccaagga cgcctccaaa 240 gatgageget acaacccgtc tctgaagagc aggctcacca tcaccaagga cgcctccaaa 240

aaccaggtgg tccttaaaat gaccaacatg gaccctgtgg acacagccac atattactgt 300 aaccaggtgg tccttaaaat gaccaacatg gaccctgtgg acacagccac atattactgt 300

gcccggacca tgggcgtcgt tcttccattt gactactggg gccagggaac cctggtcacc 360 gcccggacca tgggcgtcgt tcttccatt gactactggg gccagggaac cctggtcacc 360

gtctcg 366 gtctcg 366

<210> 180 <210> 180

<211> 327 <211> 327

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 180 <400> 180

ctagccgaaa ttgtgctgac tcagtctcca tcctccctgt ctgcatctct aggagacaga 60 ctagccgaaa ttgtgctgac tcagtctcca tcctccctgt ctgcatctct aggagacaga 60

gtcaccatca cttgccgggc aagtcagcac attagcaatt atttaaattg gtatcagcag 120 gtcaccatca cttgccgggc aagtcagcac attagcaatt atttaaattg gtatcagcag 120

aaacctggga aagcccctaa actcctgatc tgtgctgcat ccagtttgca aagtggggtc 180 aaacctggga aagcccctaa actcctgatc tgtgctgcat ccagtttgca aagtggggtc 180

ccatcaaggt tcactggcag tggatctggg gcagattaca ccctcaccat cagcagtctg 240 ccatcaaggt tcactggcag tggatctggg gcagattaca ccctcaccat cagcagtctg 240

caacctgaag attttgcaac ttactactgt caacagagtt acagtacctc gtggacgttc 300 caacctgaag attttgcaac ttactactgt caacagagtt acagtacctc gtggacgttc 300

ggccaaggga ccacggtgga aatcaaa 327 ggccaaggga ccacggtgga aatcaaa 327

<210> 181 <210> 181

<211> 327 <211> 327

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 181 <400> 181

ctagccgaaa ttgtgttgac acagtctcca tcctccctgt ctgcatctgt aggagacaga 60 ctagccgaaa ttgtgttgac acagtctcca tcctccctgt ctgcatctgt aggagacaga 60

gtcaccatca cttgccgggc gagtcagggc attagcaatt atttagcctg gtatcagcag 120 gtcaccatca cttgccgggc gagtcagggc attagcaatt atttagcctg gtatcagcag 120

aaaccaggga aagttcctaa gctcctgatc tatgctgcat ccactttgca atcaggggtc 180 aaaccaggga aagttcctaa gctcctgatc tatgctgcat ccactttgca atcaggggtc 180

ccatctcggt tcagtggcag tggatctggg acagatttca ctctcaccat cagcagcctg 240 ccatctcggt tcagtggcag tggatctggg acagatttca ctctcaccat cagcagcctg 240

cagcctgaag atgttgcaac ttattactgt caaaagtata acagtgcccc gtacactttt 300 cagcctgaag atgttgcaac ttattactgt caaaagtata acagtgcccc gtacactttt 300

ggccagggga ccaagctgga gatcaaa 327 ggccaggggga ccaagctggga gatcaaa 327

<210> 182 <210> 182

<211> 327 <211> 327

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 182 <400> 182

ctagccgatg ttgtgatgac tcagtctcca tcctccctgt ctgcatctct aggagacaga 60 ctagccgatg ttgtgatgac tcagtctcca tcctccctgt ctgcatctct aggagacaga 60

gtcagcatca cttgccgggc aagtcaacat attagcaatt atataaattg gtatcagcag 120 gtcagcatca cttgccgggc aagtcaacat attagcaatt atataaattg gtatcagcag 120

aaacctggga aagcccctaa actcctgatc tatgctgctt ccactttgca aagtggggtc 180 aaacctggga aagcccctaa actcctgatc tatgctgctt ccactttgca aagtggggtc 180

ccatcaaggt tcactggcag tggatctggg gcagattaca ctctcaccat caccagtctg 240 ccatcaaggt tcactggcag tggatctggg gcagattaca ctctcaccat caccagtctg 240

caacctgaag attttgcaac ttactactgt caacagagtt acggtacctc gtggacgttc 300 caacctgaag attttgcaac ttactactgt caacagagtt acggtacctc gtggacgttc 300

ggccaaggga ccacggtgga aatcaaa 327 ggccaaggga ccacggtgga aatcaaa 327

<210> 183 <210> 183

<211> 327 <211> 327

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 183 <400> 183

ctagccgatg ttgtgatgac tcagtctcca tcctccctgt ctgcatctgt gggagacaga 60 ctagccgatg ttgtgatgac tcagtctcca tcctccctgt ctgcatctgt gggagacaga 60

gtcaccatca cttgccaggc gagtcaagac attaccaact atttaaattg gtatcagcag 120 gtcaccatca cttgccaggc gagtcaagac attaccaact atttaaattg gtatcagcag 120

aaaccaggga aagcccctaa gctcctgatc tacgatgcat ccaatttgca accaggggtc 180 aaaccaggga aagcccctaa gctcctgatc tacgatgcat ccaatttgca accaggggtc 180

ccatcaaggt tcagtggaag tggatctgtg acagatttta ctttcaccat cagcagcctg 240 ccatcaaggt tcagtggaag tggatctgtg acagattta ctttcaccat cagcagcctg 240

cggcctgaag atattgcaac atattactgt caacagtatg atggtccagt gcttactttc 300 cggcctgaag atattgcaac atattactgt caacagtatg atggtccagt gcttactttc 300

ggcggaggga ccaaggtaga gatcaaa 327 ggcggaggga ccaaggtaga gatcaaa 327

<210> 184 <210> 184

<211> 327 <211> 327

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 184 <400> 184

ctagccgatg ttgtgatgac tcagtctcca tcctccctgt ctgcatctgt aggagacaga 60 ctagccgatg ttgtgatgac tcagtctcca tcctccctgt ctgcatctgt aggagacaga 60

gtcaccatct cttgccgggc aagtcagccc attagcacct atttaaattg gtatcagcag 120 gtcaccatct cttgccgggc aagtcagccc attagcacct atttaaattg gtatcagcag 120

aaaccaggga aagcccctaa gatcctgatc tttggtgcat ctcgtttgca aagtggtgtc 180 aaaccaggga aagcccctaa gatcctgatc tttggtgcat ctcgtttgca aagtggtgtc 180

ccatcaaggt tcagcggcag tggatctggg acagatttca gtctcaccat caccagtctc 240 ccatcaaggt tcagcggcag tggatctggg acagatttca gtctcaccat caccagtctc 240

caacctgaag attttgcaac ttacatctgt caacaaagca agagtccccc gtacaatttt 300 caacctgaag attttgcaac ttacatctgt caacaaagca agagtcccccc gtacaatttt 300

ggccggggga ccaagctgga gatcaaa 327 ggccggggga ccaagctggga gatcaaa 327

<210> 185 <210> 185

<211> 330 <211> 330

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 185 <400> 185

ctagccgaaa ttgtgttgac acagtctcct tccaccctgt ctgcatctgt aggcgacaga 60 ctagccgaaa ttgtgttgac acagtctcct tccaccctgt ctgcatctgt aggcgacaga 60

gtcaccatca cttgccgggc cagtcagagt attggtagct ggttggcctg gtatcaacag 120 gtcaccatca cttgccgggc cagtcagagt attggtagct ggttggcctg gtatcaacag 120

aaaccaggga aagcccctaa actcctgatc tataaggcgt ctactttaca aagtgagacc 180 aaaccaggga aagcccctaa actcctgatc tataaggcgt ctactttaca aagtgagacc 180

ccttcaaggt tccgcggcag tggatctggg accgaattca ctctcaccat cagcagcctg 240 ccttcaaggt tccgcggcag tggatctggg accgaattca ctctcaccat cagcagcctg 240

cagcctgatg attttgcaac ttactactgc caacagttta atagtttttc tccgtggacg 300 cagcctgatg attttgcaac ttactactgc caacagttta atagtttttc tccgtggacg 300

ttcggccaag ggaccaaggt ggaattcaaa 330 ttcggccaag ggaccaaggt ggaattcaaa 330

<210> 186 <210> 186

<211> 327 <211> 327

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 186 <400> 186

ctagccgatg ttgtgatgac tcagtctcca tcgtccctgt ctgcatctgt tggtgacaga 60 ctagccgatg ttgtgatgac tcagtctcca tcgtccctgt ctgcatctgt tggtgacaga 60

gtcaccatca cttgccgggc aagtcagagc attaacatta atttaaattg gtttcagcag 120 gtcaccatca cttgccgggc aagtcagagc attaacatta atttaaattg gtttcagcag 120

aaacccggga aagcccctaa cctactgatc tattctgcat ccactttgca aactggggtc 180 aaacccggga aagcccctaa cctactgatc tattctgcat ccactttgca aactggggtc 180

ccctcaaggt tcagtggaag tggatctggg acagagttca ctctcaccat cagcagtcta 240 ccctcaaggt tcagtggaag tggatctggg acagagttca ctctcaccat cagcagtcta 240

caacctgaag attttgcaac ttactactgt caacagattt acagtcatgt taggacgttc 300 caacctgaag attttgcaac ttactactgt caacagattt acagtcatgt taggacgttc 300

ggccaaggga ccaaggtgga gatcaaa 327 ggccaaggga ccaaggtgga gatcaaa 327

<210> 187 <210> 187

<211> 345 <211> 345

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 187 <400> 187

ctagccgatg ttgtgatgac tcagtctcca gactccctgg ctgtgtctct gggcgagagg 60 ctagccgatg ttgtgatgac tcagtctcca gactccctgg ctgtgtctct gggcgagagg 60

gccaccatca actgcaagtc cagccagagt cttttgtaca gctccaacaa taagaattac 120 gccaccatca actgcaagtc cagccagagt cttttgtaca gctccaacaa taagaattac 120

ttagcttggt accagcagaa accaggacag cctcctaagt tgctcattta ctgggcatct 180 ttagcttggt accagcagaa accagcaga cctcctaagt tgctcattta ctgggcatct 180

acccgggaat ccggggtccc tgaccgattc agtggcagcg ggtctgggac agatttcact 240 acccgggaat ccggggtccc tgaccgattc agtggcagcg ggtctgggac agatttcact 240

ctcaccatca gcagcctgca ggctgaagat gtggcagttt attactgtca gcaatattat 300 ctcaccatca gcagcctgca ggctgaagat gtggcagttt attactgtca gcaatattat 300

agtactcctc cgatgttcgg ccaagggacc aaggtggaaa tcaaa 345 agtactcctc cgatgttcgg ccaagggacc aaggtggaaa tcaaa 345

<210> 188 <210> 188

<211> 327 <211> 327

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 188 <400> 188

ctagccgaaa ttgtgttgac acagtctcca tcctccctgt ctgcatctgt gggagacaga 60 ctagccgaaa ttgtgttgac acagtctcca tcctccctgt ctgcatctgt gggagacaga 60

atcaccatca cttgccaggc gagtcaagac attaccaact atttaaattg gtatcagcag 120 atcaccatca cttgccaggc gagtcaagac attaccaact atttaaattg gtatcagcag 120

aaaccaggga aagcccctaa gctcctgatc tacgatgcat ccaatttgca accaggggtc 180 aaaccaggga aagcccctaa gctcctgatc tacgatgcat ccaatttgca accaggggtc 180

ccatcaaggt tcagtggaag tagatctggg acagatttta ctttcaccat cagcagcctg 240 ccatcaaggt tcagtggaag tagatctggg acagatttta ctttcaccat cagcagcctg 240

cggcctgaag atattgcaac atattactgt caacagtatg atggtccagt gcttactttc 300 cggcctgaag atattgcaac atattactgt caacagtatg atggtccagt gcttactttc 300

ggcggaggga ccaaggtaga gatcaaa 327 ggcggaggga ccaaggtaga gatcaaa 327

<210> 189 <210> 189

<211> 345 <211> 345

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 189 <400> 189

ctagccgaaa ttgtgttgac acagtctcca gactccctgg ctgtgtctct gggcgagagg 60 ctagccgaaa ttgtgttgac acagtctcca gactccctgg ctgtgtctct gggcgagagg 60

gccaccatca actgcaagtc cagccagagt cttttataca gctccaacaa taagaactac 120 gccaccatca actgcaagtc cagccagagt cttttataca gctccaacaa taagaactac 120

ttagcttggt accagcagaa accaggacag cctcctaagt tgctcattta ctgggcatct 180 ttagcttggt accagcagaa accagcaga cctcctaagt tgctcattta ctgggcatct 180

acccgggaat ccggggtccc tgaccgattc agtggcagcg ggtctgggac agatttcacc 240 acccgggaat ccggggtccc tgaccgattc agtggcagcg ggtctgggac agatttcacc 240

ctcaccatca gcagcctgca ggctgaagat gtggcagttt attactgtca gcaatattat 300 ctcaccatca gcagcctgca ggctgaagat gtggcagttt attactgtca gcaatattat 300

agtactcctc cgatgttcgg ccaagggacc aaggtggaaa tcaaa 345 agtactcctc cgatgttcgg ccaagggacc aaggtggaaa tcaaa 345

<210> 190 <210> 190

<211> 330 <211> 330

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 190 <400> 190

ctagccgaaa ttgtgttgac acagtctcca tccttcctgt ctgcatctgt aggagacaga 60 ctagccgaaa ttgtgttgac acagtctcca tccttcctgt ctgcatctgt aggagacaga 60

gtcaccatca cttgccgggc cagtcagggc attgggaatt ttttagcctg gtatcagcaa 120 gtcaccatca cttgccgggc cagtcagggc attgggaatt ttttagcctg gtatcagcaa 120

aaaccaggga aagcccctaa gctcctaatc tctggtgcat ccactttgca aagttgggtc 180 aaaccaggga aagcccctaa gctcctaatc tctggtgcat ccactttgca aagttgggtc 180

ccatcaaggt tcagcggccg tggatctggg accgaattca ccctcacaat cagcagcctg 240 ccatcaaggt tcagcggccg tggatctggg accgaattca ccctcacaat cagcagcctg 240

cagcctgaag attttgcaac ttattactgt caacagctta atcgttaccc tccatacact 300 cagcctgaag attttgcaac ttattactgt caacagctta atcgttaccc tccataact 300

tttggccagg ggaccaagct ggagatcaaa 330 tttggccagg ggaccaagct ggagatcaaa 330

<210> 191 <210> 191

<211> 327 <211> 327

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 191 <400> 191

ctagccgaaa ttgtgatgac gcagtctcca tcctccctgt ctgcatctgt gggagacaga 60 ctagccgaaa ttgtgatgac gcagtctcca tcctccctgt ctgcatctgt gggagacaga 60

gtcaccatca cttgccaggc gagtcaggac attagcaaat atttaaattg gtatcagcag 120 gtcaccatca cttgccaggc gagtcaggac attagcaaat atttaaattg gtatcagcag 120

aaaccaggga gagcccctaa actcctgatc tacgaagcat ccaatttgga gacaggggtc 180 aaaccaggga gagcccctaa actcctgatc tacgaagcat ccaatttgga gacaggggtc 180

ccaccaaggt tcagtggaag tggatctggg acacatttta ctttcaccat caccggcctg 240 ccaccaaggt tcagtggaag tggatctggg acacatttta ctttcaccat caccggcctg 240

cagcctgaag atattgcaac atattactgt caacagtgtg atagtctgcc tccggtcttt 300 cagcctgaag atattgcaac atattactgt caacagtgtg atagtctgcc tccggtcttt 300

ggccagggga ccaagctgga agtcaaa 327 ggccaggggga ccaagctggga agtcaaa 327

<210> 192 <210> 192

<211> 330 <211> 330

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 192 <400> 192

ctagccgaaa ttgtgctgac tcagtctcca ggcaccctgg ctttgtctcc aggtgataga 60 ctagccgaaa ttgtgctgac tcagtctcca ggcaccctgg ctttgtctcc aggtgataga 60

gccaccctct cctgcggggc cagtcagagc gtgttcggcg acttcttagc ctggtaccaa 120 gccaccctct cctgcggggc cagtcagagc gtgttcggcg acttcttagc ctggtaccaa 120

cacaagcctg gccaggctcc caggctcctc atctatggtg cttccaccag ggccactggc 180 cacaagcctg gccaggctcc caggctctc atctatggtg cttccaccag ggccactggc 180

atcccagaca ggttcagtgg cagtggagct gggacagact tcactctcac catcagcaga 240 atcccagaca ggttcagtgg cagtggagct gggacagact tcactctcac catcagcaga 240

ctggagcctg aggattttgc agtttatttc tgtcagtagt atggtgactc agtgttcacg 300 ctggagcctg aggattttgc agtttatttc tgtcagtagt atggtgactc agtgttcacg 300

ttcggccaag ggaccaagtt gggaatcaaa 330 ttcggccaag ggaccaagtt gggaatcaaa 330

<210> 193 <210> 193

<211> 330 <211> 330

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 193 <400> 193

ctagccgaaa ttgtgatgac acagtctcca ggcaccctgg ctttgtctcc aggtgataga 60 ctagccgaaa ttgtgatgac acagtctcca ggcaccctgg ctttgtctcc aggtgataga 60

gccaccctct cctgcggggc cagtcagagc gtgttcggcg acttcttagc ctggtaccaa 120 gccaccctct cctgcggggc cagtcagagc gtgttcggcg acttcttagc ctggtaccaa 120

cacaagcctg gccaggctcc caggctcctc atctatggtg cttccaccag ggccactggc 180 cacaagcctg gccaggctcc caggctctc atctatggtg cttccaccag ggccactggc 180

atcccagaca ggttcagtgg cagtggagct gggacagact tcactctcac catcagcaga 240 atcccagaca ggttcagtgg cagtggagct gggacagact tcactctcac catcagcaga 240

ctggagcctg aggattttgc agtttatttc tgtcagcagt atggtgactc agtgttcacg 300 ctggagcctg aggattttgc agtttatttc tgtcagcagt atggtgactc agtgttcacg 300

ttcggccaag ggaccaagtt ggaaatcaaa 330 ttcggccaag ggaccaagtt ggaaatcaaa 330

<210> 194 <210> 194

<211> 330 <211> 330

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 194 <400> 194

ctagccgaaa ttgtgttgac acagtctcca ggcaccctgt ctttgtctcc agggcaaaga 60 ctagccgaaa ttgtgttgac acagtctcca ggcaccctgt ctttgtctcc agggcaaaga 60

gccaccctct cctgcagggc cagtcagagt gttaacagag actacctagc ctggtaccag 120 gccaccctct cctgcagggc cagtcagagt gttaacagag actacctagc ctggtaccag 120

cagaaacctg gctaggctcc caggctcctc atctatggtg catccagcag ggccactggc 180 cagaaacctg gctaggctcc caggctcctc atctatggtg catccagcag ggccactggc 180

atcccagaca ggttcagtgg cagtgggtct ggaacagact tcactctcac catcagcaga 240 atcccagaca ggttcagtgg cagtgggtct ggaacagact tcactctcac catcagcaga 240

ctggagcgag acgattttgc agtgtatttc tgtcaccagt atggtagctc acctaacact 300 ctggagcgag acgattttgc agtgtatttc tgtcaccagt atggtagctc acctaacact 300

tttggccagg ggaccaagct ggagatcaaa 330 tttggccagg ggaccaagct ggagatcaaa 330

<210> 195 <210> 195

<211> 330 <211> 330

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 195 <400> 195

ctagccgaaa cgacactcac gcagtctcca ggcaccctgt ctttgtctcc aggggaaaga 60 ctagccgaaa cgacactcac gcagtctcca ggcaccctgt ctttgtctcc aggggaaaga 60

gccaccctct cctgcagggc cagtcagagc gttagcacca actacttagc ctggtaccga 120 gccaccctct cctgcagggc cagtcagagc gttagcacca actacttagc ctggtaccga 120

cagaaacctg gccaggctcc caggctcctc atccatggtg catccagccg ggccactggc 180 cagaaacctg gccaggctcc caggctcctc atccatggtg catccagccg ggccactggc 180

atcccagaca ggttcagtgg cagtgggtct gggacagact tcactctcac catcagcaga 240 atcccagaca ggttcagtgg cagtgggtct gggacagact tcactctcac catcagcaga 240

ctggagcctg aagattttgc agtgtatttc tgtcagcagt atggtagctc acctcagacg 300 ctggagcctg aagattttgc agtgtatttc tgtcagcagt atggtagctc acctcagacg 300

ttcggccaag ggaccaggtt ggaaatcaaa 330 ttcggccaag ggaccaggtt ggaaatcaaa 330

<210> 196 <210> 196

<211> 327 <211> 327

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 196 <400> 196

ctagccgaaa ttgtgctgac tcagtctcca tcctccctgt ctgcatctgt tggtgacaga 60 ctagccgaaa ttgtgctgac tcagtctcca tcctccctgt ctgcatctgt tggtgacaga 60

gtcaccacca cttgccggac aagtcagagc attttcatta atttaaattg gtttcagcag 120 gtcaccacca cttgccggac aagtcagagc attttcatta atttaaattg gtttcagcag 120

aaacccggga aagcccctaa actcctgatc tattctgcat ccactttgca aactggggtc 180 aaacccggga aagcccctaa actcctgatc tattctgcat ccactttgca aactggggtc 180

ccctcaaggt tcagtggcag tggatctggg acagagttca ctctcaccat cagcagtcta 240 ccctcaaggt tcagtggcag tggatctggg acagagttca ctctcaccat cagcagtcta 240

caacctgaag attttgcaac ttactactgt caacagattt acagtcaggt taggacgttc 300 caacctgaag attttgcaac ttactactgt caacagattt acagtcaggt taggacgttc 300

ggccaaggga ccaaggtgga gatcaaa 327 ggccaaggga ccaaggtgga gatcaaa 327

<210> 197 <210> 197

<211> 330 <211> 330

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 197 <400> 197

ctagccgaca tccagatgac ccagtctcca ggcaccctgt ctttgtctcc aggggaaaga 60 ctagccgaca tccagatgac ccagtctcca ggcaccctgt ctttgtctcc aggggaaaga 60

gccaccctct cctgcagggc cagtcagagt gttaacagcg acaacttagc ctggtaccag 120 gccaccctct cctgcagggc cagtcagagt gttaacagcg acaacttagc ctggtaccag 120

cagaaacctg gccaggctcc caggctcctc atgtctggtg caaccagtag ggccactgac 180 cagaaacctg gccaggctcc caggctcctc atgtctggtg caaccagtag ggccactgac 180

gtcccagaca ggttcagtgg cagtgggtct gggacagact tcactctcac catcagcaga 240 gtcccagaca ggttcagtgg cagtgggtct gggacagact tcactctcac catcagcaga 240

ctggagcctg aagattttgc agtgtattac tgtcaccagt atggtagctc agataacact 300 ctggagcctg aagattttgc agtgtattac tgtcaccagt atggtagctc agataacact 300

tttggccagg ggaccaagct ggagatcaaa 330 tttggccagg ggaccaagct ggagatcaaa 330

<210> 198 <210> 198

<211> 330 <211> 330

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 198 <400> 198

ctagccgatg ttgtgatgac tcagtttcct tcctctctgt ctgcatctgt gggagacaga 60 ctagccgatg ttgtgatgac tcagtttcct tcctctctgt ctgcatctgt gggagacaga 60

gtcaccatca cttgccgggc gagtcagggc attagcaatt ttttagcctg gtatcagcag 120 gtcaccatca cttgccgggc gagtcagggc attagcaatt ttttagcctg gtatcagcag 120

aaaccaggga aagttcctga gctccttatc tatggtgcat ccactttgca atcaggggtc 180 aaaccaggga aagttcctga gctccttatc tatggtgcat ccactttgca atcaggggtc 180

ccatctcggt tcagtggcag tggatctggg gcagagttca cactcaccat caacagcctg 240 ccatctcggt tcagtggcag tggatctggg gcagagttca cactcaccat caacagcctg 240

cagcctgaag atgttgcgac ttattactgt caaaagtatg acagtggcct gagattcact 300 cagcctgaag atgttgcgac ttattactgt caaaagtatg acagtggcct gagattcact 300

ttcggccctg ggaccaaagt ggatatcaaa 330 ttcggccctg ggaccaaagt ggatatcaaa 330

<210> 199 <210> 199

<211> 330 <211> 330

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 199 <400> 199

ctagccgatg ttgtgatgac tcagtctcct tcctctctgt ctgcatctgt aggagacaga 60 ctagccgatg ttgtgatgac tcagtctcct tcctctctgt ctgcatctgt aggagacaga 60

gtcaccatca cttgccgggc gagtcagggc attagcaatt ttttagcctg gcatcagcag 120 gtcaccatca cttgccgggc gagtcagggc attagcaatt ttttagcctg gcatcagcag 120

aaaccagggc aagttcctaa actcctgatc tatggtgcat ccactttgca atcaggggtc 180 aaaccagggc aagttcctaa actcctgatc tatggtgcat ccactttgca atcaggggtc 180

ccatctcgct tcagtggcag tggatctggc acagatttca ctctcaccat caacggcctg 240 ccatctcgct tcagtggcag tggatctggc acagatttca ctctcaccat caacggcctg 240

cagcctgaag atgttgcaac ttattactgt caaaagtatg acagtggcct gatattcact 300 cagcctgaag atgttgcaac ttattactgt caaaagtatg acagtggcct gatatcact 300

ttcggccctg ggaccagagt ggagatcaaa 330 ttcggccctg ggaccagagt ggagatcaaa 330

<210> 200 <210> 200

<211> 345 <211> 345

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 200 <400> 200

ctagccgatg ttgtgatgac tcagtctcca gactccctgg ctgtgtctct gggcgagagg 60 ctagccgatg ttgtgatgac tcagtctcca gactccctgg ctgtgtctct gggcgagagg 60

gccaccatca actgcaagtc cagccagagt cttttataca gctccaacaa taagaactac 120 gccaccatca actgcaagtc cagccagagt cttttataca gctccaacaa taagaactac 120

ttagcttggt accagcagaa accaggacag cctcctaagt tgctcattta ctgggcatct 180 ttagcttggt accagcagaa accagcaga cctcctaagt tgctcattta ctgggcatct 180

acccgggaat ccggggtccc tgaccgattc agtggcagcg ggtctgggac agatttcact 240 acccgggaat ccggggtccc tgaccgattc agtggcagcg ggtctgggac agatttcact 240

ctcaccatca gcagcctgca ggctgaagat gtggcagttt attactgtca gcaatattat 300 ctcaccatca gcagcctgca ggctgaagat gtggcagttt attactgtca gcaatattat 300

agtactcctc cgatgctcgg ccaagggacc aaggtggaaa tcaaa 345 agtactcctc cgatgctcgg ccaagggacc aaggtggaaa tcaaa 345

<210> 201 <210> 201

<211> 330 <211> 330

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 201 <400> 201

ctagccgatg ttgtgatgac ttagtctcca ggcaccctgg ctttgtctcc aggtgataga 60 ctagccgatg ttgtgatgac ttagtctcca ggcaccctgg ctttgtctcc aggtgataga 60

gccaccctct cctgcggggc cagtcagagc gtgttcggcg acttcttagc ctggtaccaa 120 gccaccctct cctgcggggc cagtcagagc gtgttcggcg acttcttagc ctggtaccaa 120

cacaagcctg gccaggctcc caggctcctc atctatgttg cttccaccag ggccactggc 180 cacaagcctg gccaggctcc caggctctc atctatgttg cttccaccag ggccactggc 180

atcccagaca ggttcagtgg cagtggagct gggacagact tcactctcac catcagcaga 240 atcccagaca ggttcagtgg cagtggagct gggacagact tcactctcac catcagcaga 240

ctggagcctg aggattttgc agtttatttc tgtcagcagt atggtgactc agtgttcacg 300 ctggagcctg aggattttgc agtttatttc tgtcagcagt atggtgactc agtgttcacg 300

ttcggccaag ggaccaagtt ggaaatcaga 330 ttcggccaag ggaccaagtt ggaaatcaga 330

<210> 202 <210> 202

<211> 330 <211> 330

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 202 <400> 202

ctagccgaaa cgacactcac gcagtctcca ggcaccctgt ctttgtctcc aggggaaaga 60 ctagccgaaa cgacactcac gcagtctcca ggcaccctgt ctttgtctcc aggggaaaga 60

gccaccctct cctgcagggc cagtcagagc gttagcacca actacttagc ctggtaccga 120 gccaccctct cctgcagggc cagtcagagc gttagcacca actacttagc ctggtaccga 120

cagaaacctg gccaggctcc caggctcctc atccatggtg catccagccg ggccactggc 180 cagaaacctg gccaggctcc caggctcctc atccatggtg catccagccg ggccactggc 180

atcccagaca ggttcagtgg cagtgggtct gggacagact tcactctcac catcagcaga 240 atcccagaca ggttcagtgg cagtgggtct gggacagact tcactctcac catcagcaga 240

ctggagcctg aagattttgc agtgtatttc tgtcagcagt atggtagctc acctcagacg 300 ctggagcctg aagattttgc agtgtatttc tgtcagcagt atggtagctc acctcagacg 300

ttcggccaag ggaccaggtt ggaaatcaaa 330 ttcggccaag ggaccaggtt ggaaatcaaa 330

<210> 203 <210> 203

<211> 330 <211> 330

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 203 <400> 203

ctagccgaaa ttgtgctgac tcagtctcca ggcaccctgt ctttgtctcc aggggaaaga 60 ctagccgaaa ttgtgctgac tcagtctcca ggcaccctgt ctttgtctcc aggggaaaga 60

gccaccctct cctgcagggc cagtcggagt gtaaacagca acaacttagc ctggtatcag 120 gccaccctct cctgcagggc cagtcggagt gtaaacagca acaacttagc ctggtatcag 120

cagaaacctg accaggctcc caggctcctc atgtatggtg catccagtag ggccactggc 180 cagaaacctg accaggctcc caggctcctc atgtatggtg catccagtag ggccactggc 180

atcccagaca ggttcactgg cagtgggtct gggacagact tcactctcac catcagcaga 240 atcccagaca ggttcactgg cagtgggtct gggacagact tcactctcac catcagcaga 240

ctggagcctg aagattttgc agtgtattac tgtcatcagt atggtgcctc agataacact 300 ctggagcctg aagattttgc agtgtattac tgtcatcagt atggtgcctc agataacact 300

tttggccagg ggaccaagct ggagatcaag 330 tttggccagg ggaccaagct ggagatcaag 330

<210> 204 <210> 204

<211> 327 <211> 327

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 204 <400> 204

ctagccgaaa ttgtgatgac acagtctcca tccttcctgt ctgcatctgt aggagacaga 60 ctagccgaaa ttgtgatgac acagtctcca tccttcctgt ctgcatctgt aggagacaga 60

gtcaccatca cttgccgggc cagtcaggac attatcactt atttagcctg gtatcaacaa 120 gtcaccatca cttgccgggc cagtcaggac attatcactt atttagcctg gtatcaacaa 120

aaaccaggga aagcccctga ggtcctgatc tttggtgcgt ccactttgca aagtggggtc 180 aaaccaggga aagcccctga ggtcctgatc tttggtgcgt ccactttgca aagtggggtc 180

ccatcaagat tcagcggcag tggatctggg accgaattca ctctcactat ctccagcctg 240 ccatcaagat tcagcggcag tggatctggg accgaattca ctctcactat ctccagcctg 240

cagcctgaag attttgcaac ttattactgt caacagatta ttcgttaccc tcgcactttc 300 cagcctgaag attttgcaac ttattactgt caacagatta ttcgttaccc tcgcactttc 300

ggccaaggga ccagggtgga aatcaaa 327 ggccaaggga ccagggtgga aatcaaa 327

<210> 205 <210> 205

<211> 330 <211> 330

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 205 <400> 205

ctagccgatg ttgtgatgac tcagtctcca ggcaccctgt ctttgtctcc aggggaaaga 60 ctagccgatg ttgtgatgac tcagtctcca ggcaccctgt ctttgtctcc aggggaaaga 60

gccaccctct cctgccgggc cagtcagagt gttaacagca acaacttagc ctggtaccag 120 gccaccctct cctgccgggc cagtcagagt gttaacagca acaacttagc ctggtaccag 120

cagaaacctg gccaggctcc caggctcctc gtctctggtg caaccaatag ggccactgac 180 cagaaacctg gccaggctcc caggctcctc gtctctggtg caaccaatag ggccactgac 180

atcccagaca ggttcagtgg cagtgggtct gggacagact tcactctcac catcagcaga 240 atcccagaca ggttcagtgg cagtgggtct gggacagact tcactctcac catcagcaga 240

ctggagcctg aagattttgc agtgtattac tgtcaccagt atggtagctc agagaacact 300 ctggagcctg aagattttgc agtgtattac tgtcaccagt atggtagctc agagaacact 300

tttggccagg ggaccaagct ggagatcaga 330 tttggccagg ggaccaagct ggagatcaga 330

<210> 206 <210> 206

<211> 327 <211> 327

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 206 <400> 206

ctagccgaaa ttgtgatgac gcagtctcca cccttcctgt ctgcatctgt aggagacaga 60 ctagccgaaa ttgtgatgac gcagtctcca cccttcctgt ctgcatctgt aggagacaga 60

gtcaccatca cttgccgggc cagtcagggc ttaagcactt atttagcctg gtatcaggta 120 gtcaccatca cttgccgggc cagtcagggc ttaagcactt atttagcctg gtatcaggta 120

aaaccaggga aagcccctaa gctcctgatc tatgctgcat ccactttgca aagtggggtc 180 aaaccaggga aagcccctaa gctcctgatc tatgctgcat ccactttgca aagtggggtc 180

ccatcaaggt tcagcggcag tggatctggg acagaattca ctctcacaat caacagcctg 240 ccatcaaggt tcagcggcag tggatctggg acagaattca ctctcacaat caacagcctg 240

cagcctgaag attttgcaac ttattactgt caacaacttg atacttaccc tctcactctc 300 cagcctgaag attttgcaac ttattactgt caacaacttg atacttaccc tctcactctc 300

ggcggaggga ccaaggtgga gatcaaa 327 ggcggaggga ccaaggtgga gatcaaa 327

<210> 207 <210> 207

<211> 345 <211> 345

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 207 <400> 207

ctagccgaaa ttgtgttgac acagtctcca gactccctgg ctgtgtctct gggcgagagg 60 ctagccgaaa ttgtgttgac acagtctcca gactccctgg ctgtgtctct gggcgagagg 60

gccaccatca actgcaagtc cagccagagt cttttataca gctccaacaa taagaactac 120 gccaccatca actgcaagtc cagccagagt cttttataca gctccaacaa taagaactac 120

ttagcttggt accagcagaa accaggacag cctcctaagt tgctcattta ctgggcatct 180 ttagcttggt accagcagaa accagcaga cctcctaagt tgctcattta ctgggcatct 180

acccgggaat ccggggtccc tgaccgattc agtggcagcg ggtctgggac agatttcact 240 acccgggaat ccggggtccc tgaccgattc agtggcagcg ggtctgggac agatttcact 240

ctcaccatca gcagcctgca ggctgaagat gtggcagttt attactgtca gcaatattat 300 ctcaccatca gcagcctgca ggctgaagat gtggcagttt attactgtca gcaatattat 300

agtactcctc cgatgttcgg ccaagggacc aaggtggaaa tcaaa 345 agtactcctc cgatgttcgg ccaagggacc aaggtggaaa tcaaa 345

<210> 208 <210> 208

<211> 345 <211> 345

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 208 <400> 208

ctagccgaca tccagatgac ccagtctcca gactccctgg ctgtgtctct gggcgagagg 60 ctagccgaca tccagatgac ccagtctcca gactccctgg ctgtgtctct gggcgagagg 60

gccaccatca actgcaagtc cagccagagt cttttataca gctccaacaa taagaactac 120 gccaccatca actgcaagtc cagccagagt cttttataca gctccaacaa taagaactac 120

ttagcttggt accagcagaa accaggacag cctcctaagt tgctcattta ctgggcatct 180 ttagcttggt accagcagaa accagcaga cctcctaagt tgctcattta ctgggcatct 180

acccgggaat ccggggtccc tgaccgattc agtggcagcg ggtctgggac agatttcact 240 acccgggaat ccggggtccc tgaccgattc agtggcagcg ggtctgggac agatttcact 240

ctcaccatca gcagcctgca ggctgaagat gtggcagttt attactgtca gcaatattat 300 ctcaccatca gcagcctgca ggctgaagat gtggcagttt attactgtca gcaatattat 300

agtactcctc cgatgttcgg ccaagggacc agggtggaaa tcaaa 345 agtactcctc cgatgttcgg ccaagggacc agggtggaaa tcaaa 345

<210> 209 <210> 209

<211> 330 <211> 330

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 209 <400> 209

ctagccgaaa ttgtgatgac acagtctcca ggcaccctgg ctttgtctcc aggtgataga 60 ctagccgaaa ttgtgatgac acagtctcca ggcaccctgg ctttgtctcc aggtgataga 60

gccaccctct cctgcggggc cagtcagagc gtgttcggcg acttcttagc ctggtaccaa 120 gccaccctct cctgcggggc cagtcagagc gtgttcggcg acttcttagc ctggtaccaa 120

cacaagcctg gccaggctcc caggcccctc atctatggtg cttccaccag ggccactggc 180 cacaagcctg gccaggctcc caggcccctc atctatggtg cttccaccag ggccactggc 180

atcccagaca ggttcagtgg cagtggagct gggacagact tcactctcac catcagcaga 240 atcccagaca ggttcagtgg cagtggagct gggacagact tcactctcac catcagcaga 240

ctggagcctg aggattttgc agtttatttc tgtcagcagt atggtgactc agtgttcacg 300 ctggagcctg aggattttgc agtttatttc tgtcagcagt atggtgactc agtgttcacg 300

ttcggccaag ggaccaagtt ggaaatcaaa 330 ttcggccaag ggaccaagtt ggaaatcaaa 330

<210> 210 <210> 210

<211> 330 <211> 330

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 210 <400> 210

ctagccgatg ttgtgatgac tcagtctcca ggcaccctgt ctttgtctcc aggggaaaga 60 ctagccgatg ttgtgatgac tcagtctcca ggcaccctgt ctttgtctcc aggggaaaga 60

gccaccctct cctgcagggc cagtcagagt gttaacagcg acaacttagc ctggtaccag 120 gccaccctct cctgcagggc cagtcagagt gttaacagcg acaacttagc ctggtaccag 120

cagaaacctg gccaggctcc caggctcctc atgtctggtg caaccagtag ggccactgac 180 cagaaacctg gccaggctcc caggctcctc atgtctggtg caaccagtag ggccactgac 180

atcccagaca ggttcagtgg cagtgggtct gggacagact tcactctcac catcagcaga 240 atcccagaca ggttcagtgg cagtgggtct gggacagact tcactctcac catcagcaga 240

ctggagcctg aagattttgc agtgtattac tgtcaccagt atggtagctc agataacact 300 ctggagcctg aagattttgc agtgtattac tgtcaccagt atggtagctc agataacact 300

tttggccagg ggaccaagct ggagatcaaa 330 tttggccagg ggaccaagct ggagatcaaa 330

<210> 211 <210> 211

<211> 330 <211> 330

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 211 <400> 211

ctagccgaca tccagttgac ccagtctcca tcctccctgt ctgcatctgt tggagacagc 60 ctagccgaca tccagttgac ccagtctcca tcctccctgt ctgcatctgt tggagacagc 60

gtcaccatca cttgccgggc gagtcagggc attagcaatt ttttagcctg gtatcagaag 120 gtcaccatca cttgccgggc gagtcagggc attagcaatt ttttagcctg gtatcagaag 120

aaaccgggaa aagttcctag gctcctgatc tatggtgcat ccactttgca atcaggggtc 180 aaaccgggaa aagttcctag gctcctgatc tatggtgcat ccactttgca atcaggggtc 180

ccatctcggt tcagtggcag tggatctggg accgatttca ctctcaccat cagcagcctg 240 ccatctcggt tcagtggcag tggatctggg accgatttca ctctcaccat cagcagcctg 240

cagcctgaag atgttgcgac ttattactgt caggagtata gcaatgccct gatattcact 300 cagcctgaag atgttgcgac ttattactgt caggagtata gcaatgccct gatattcact 300

ttcggccctg ggaccaaagt tcatatcaaa 330 ttcggccctg ggaccaaagt tcatatcaaa 330

<210> 212 <210> 212

<211> 330 <211> 330

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 212 <400> 212

ctagccgaaa ttgtgatgac acagtctcca tccttcctgt ctgcgtctgt aggagacaga 60 ctagccgaaa ttgtgatgac acagtctcca tccttcctgt ctgcgtctgt aggagacaga 60

gtcaccatca cttgccgggc cagtcagggc attgggaatt ttttagcctg gtatcagcaa 120 gtcaccatca cttgccgggc cagtcagggc attgggaatt ttttagcctg gtatcagcaa 120

aaaccaggga aagcccctaa gctcctgatc tctggtgcat ccactttgca aagttgggtc 180 aaaccaggga aagcccctaa gctcctgatc tctggtgcat ccactttgca aagttgggtc 180

ccatcaaggt tcagcggccg tggatctggg accgaattca ctctcacaat cagcagcctg 240 ccatcaaggt tcagcggccg tggatctggg accgaattca ctctcacaat cagcagcctg 240

cagcctgaag attttgcaac ttattactgt caacagctta atcgttaccc tccatacact 300 cagcctgaag attttgcaac ttattactgt caacagctta atcgttaccc tccataact 300

tttggccagg ggaccaagct ggagatcaaa 330 tttggccagg ggaccaagct ggagatcaaa 330

<210> 213 <210> 213

<211> 327 <211> 327

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 213 <400> 213

ctagccgaaa ttgtgatgac acagtctcca tcctccctgt ctgcatctgt aggagacaga 60 ctagccgaaa ttgtgatgac acagtctcca tcctccctgt ctgcatctgt aggagacaga 60

gtcaccatca cttgccgggc aagtcagacc attagcaacc atttaaattg gtatcagcag 120 gtcaccatca cttgccgggc aagtcagacc attagcaacc atttaaattg gtatcagcag 120

aaaccaggga gagcccctaa gctcctgatc tatgttgggt ccagtctgca aagtggggtc 180 aaaccaggga gagcccctaa gctcctgatc tatgttgggt ccagtctgca aagtggggtc 180

ccatcaaggt tcagtggcag tggatctggg acagatttca ctctcaccat cagtggtctg 240 ccatcaaggt tcagtggcag tggatctggg acagatttca ctctcaccat cagtggtctg 240

caacctgaag attttgcaac ttactactgt caacagagtt acagtccctc gtacactttt 300 caacctgaag attttgcaac ttactactgt caacagagtt acagtccctc gtacactttt 300

ggccagggga ccaaggtgga gatcaaa 327 ggccaggggga ccaaggtgga gatcaaa 327

<210> 214 <210> 214

<211> 330 <211> 330

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 214 <400> 214

ctagccgaca tccagttgac ccagtctcca ggcaccctgt ctttgtctcc aggggaaaga 60 ctagccgaca tccagttgac ccagtctcca ggcaccctgt ctttgtctcc aggggaaaga 60

gccaccctct cctgcagggc cagtcagagc gttagcacca actacttagc ctggtaccga 120 gccaccctct cctgcagggc cagtcagagc gttagcacca actacttagc ctggtaccga 120

cagaaacctg gccaggctcc caggctcctc atccatggtg catccagccg ggccactggc 180 cagaaacctg gccaggctcc caggctcctc atccatggtg catccagccg ggccactggc 180

atcccagaca ggttcagtgg cagtgggtct gggacagact tcactctcac catcagcaga 240 atcccagaca ggttcagtgg cagtgggtct gggacagact tcactctcac catcagcaga 240

ctggagcctg aagattttgc agtgtatttc tgtcagcagt atggtagctc acctcagacg 300 ctggagcctg aagattttgc agtgtatttc tgtcagcagt atggtagctc acctcagacg 300

ttcggccaag ggaccaggtt ggaaatcaaa 330 ttcggccaag ggaccaggtt ggaaatcaaa 330

<210> 215 <210> 215

<211> 327 <211> 327

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 215 <400> 215

ctagccgatg ttgtgatgac tcagtctcca tcctccctgt ctgcatctct aggagacaga 60 ctagccgatg ttgtgatgac tcagtctcca tcctccctgt ctgcatctct aggagacaga 60

gtcaccatca cttgccgggc aagtcagcat attagcaatt atttaaattg gtatcagcag 120 gtcaccatca cttgccgggc aagtcagcat attagcaatt atttaaattg gtatcagcag 120

aaacctggga aagcccctaa actcctgatc tatgctgcat ccagtttgca aagtggggtc 180 aaacctggga aagcccctaa actcctgatc tatgctgcat ccagtttgca aagtggggtc 180

ccatcaaggt tcactggcag tggatctggg gcagattaca ctctcaccat cagcagtctg 240 ccatcaaggt tcactggcag tggatctggg gcagattaca ctctcaccat cagcagtctg 240

caacctgaag attttgcaac ttactactgt caacagagtt acagcacctc gtggacgttc 300 caacctgaag attttgcaac ttactactgt caacagagtt acagcacctc gtggacgttc 300

ggccaaggga ccacggtggg aatcaaa 327 ggccaaggga ccacggtggg aatcaaa 327

<210> 216 <210> 216

<211> 327 <211> 327

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 216 <400> 216

ctagccgatg ttgtgatgac tcagtctcca tcctccctgt ctgcatctgt aggagacaga 60 ctagccgatg ttgtgatgac tcagtctcca tcctccctgt ctgcatctgt aggagacaga 60

gtcagcatca cttgccgggc aagtcggagc gttaagacct atttaaattg gtatcagcag 120 gtcagcatca cttgccgggc aagtcggagc gttaagacct atttaaattg gtatcagcag 120

aaaccaggga aagcccctaa gctcctggtc tatggttcgt ccagtttgga aagtggggtc 180 aaaccaggga aagcccctaa gctcctggtc tatggttcgt ccagtttgga aagtggggtc 180

ccatcaagat tcagtggcag tggatctggg acagatttca ctctcaccat cagcagtctg 240 ccatcaagat tcagtggcag tggatctggg acagatttca ctctcaccat cagcagtctg 240

caacctgagg attttgcaac ttactactgt caacagagtt tcggtacccc ctacactttt 300 caacctgagg attttgcaac ttactactgt caacagagtt tcggtacccc ctacactttt 300

ggccagggga ccaagctgga caccaaa 327 ggccaggggga ccaagctggga caccaaa 327

<210> 217 <210> 217

<211> 327 <211> 327

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 217 <400> 217

ctagccgaca tccagatgac ccagtctcca tcctccctgt ctgcatctgt aagtgacaga 60 ctagccgaca tccagatgac ccagtctcca tcctccctgt ctgcatctgt aagtgacaga 60

gtcaccatta cttgccgggc aagtcagagc attaacaagt tcttaaactg gtatcagcag 120 gtcaccatta cttgccgggc aagtcagagc attaacaagt tcttaaactg gtatcagcag 120

aaaccaggga aagcccctca gctcctcatc tatgctgcaa ccaatttgca gagtggggtc 180 aaaccaggga aagcccctca gctcctcatc tatgctgcaa ccaatttgca gagtggggtc 180

ccatcaaggt tcagtggcag tggatctggg acagacttca ctctcaccat cagcagtctg 240 ccatcaaggt tcagtggcag tggatctggg acagacttca ctctcaccat cagcagtctg 240

caaactgaag attttgccac ttactactgt caacagagtt acgatatgcc tcggacgttc 300 caaactgaag attttgccac ttactactgt caacagagtt acgatatgcc tcggacgttc 300

ggccaaggga ccaaggtgga gatcaaa 327 ggccaaggga ccaaggtgga gatcaaa 327

<210> 218 <210> 218

<211> 330 <211> 330

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 218 <400> 218

ctagccgaaa ttgtgctgac tcagtctcca ggcaccctgt ctttgtctcc aggggaaaga 60 ctagccgaaa ttgtgctgac tcagtctcca ggcaccctgt ctttgtctcc aggggaaaga 60

gccaccctct cctgcagggc cagtcggagt gtatacagca acaacttagc ctggtatcag 120 gccaccctct cctgcagggc cagtcggagt gtatacagca acaacttagc ctggtatcag 120

cagaaacctg accaggctcc caggctcctc atgtatggtg catccagtag ggccactggc 180 cagaaacctg accaggctcc caggctcctc atgtatggtg catccagtag ggccactggc 180

atcccagaca ggttcactgg cagtgggtct gggacagact tcactctcac catcagcaga 240 atcccagaca ggttcactgg cagtgggtct gggacagact tcactctcac catcagcaga 240

ctggagcctg aagattttgc agtgtattac tgtcatcagt atggtgcctc agataacact 300 ctggagcctg aagattttgc agtgtattac tgtcatcagt atggtgcctc agataacact 300

tttggccagg ggaccaagct ggagatcaag 330 tttggccagg ggaccaagct ggagatcaag 330

<210> 219 <210> 219

<211> 345 <211> 345

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 219 <400> 219

ctagccgaca tccagatgac ccagtctcca gactccctgg ctgtgtctct gggcgagaag 60 ctagccgaca tccagatgac ccagtctcca gactccctgg ctgtgtctct gggcgagaag 60

gccaccatca actgcaagtc cagccagagt cttttataca gctccaacaa taagaactac 120 gccaccatca actgcaagtc cagccagagt cttttataca gctccaacaa taagaactac 120

ttagcttggt accagcagaa accaggacag cctcctaagt tgctcattta ctgggcatct 180 ttagcttggt accagcagaa accagcaga cctcctaagt tgctcattta ctgggcatct 180

acccgggaat ccggggtccc tgaccgattc agtggcagcg ggtctgggac agatttcact 240 acccgggaat ccggggtccc tgaccgattc agtggcagcg ggtctgggac agatttcact 240

ctcaccatca gcagcctgca ggctgaagat gtggcagttt attactgtca gcaatattat 300 ctcaccatca gcagcctgca ggctgaagat gtggcagttt attactgtca gcaatattat 300

agtactcctc cgatgttcgg ccaagggacc aaggtggaaa tcaaa 345 agtactcctc cgatgttcgg ccaagggacc aaggtggaaa tcaaa 345

<210> 220 <210> 220

<211> 330 <211> 330

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 220 <400> 220

ctagccgaaa ttgtgatgac gcagtctcct tcctctctgt ctgcatctgt aggagacaga 60 ctagccgaaa ttgtgatgac gcagtctcct tcctctctgt ctgcatctgt aggagacaga 60

gtcaccatct cttgccgggc gagtcagggc attagcaatt ttttagcctg gtttcagcag 120 gtcaccatct cttgccgggc gagtcagggc attagcaatt ttttagcctg gtttcagcag 120

aaaccaggtc aagttcctaa gctcctgatc tatgttgcat ccactttgca atcaggggtc 180 aaaccaggtc aagttcctaa gctcctgatc tatgttgcat ccactttgca atcaggggtc 180

ccatctcggt tcagtggcag tggatctggg acagatttca gtctcaccat caacggcctg 240 ccatctcggt tcagtggcag tggatctggg acagatttca gtctcaccat caacggcctg 240

cagcctgagg atgttgcaac ttattactgt caaaggtatg acagtggcct gatattcact 300 cagcctgagg atgttgcaac ttattactgt caaaggtatg acagtggcct gatatcact 300

ttcggccctg ggaccaaagt ggagatcaaa 330 ttcggccctg ggaccaaagt ggagatcaaa 330

<210> 221 <210> 221

<211> 327 <211> 327

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 221 <400> 221

ctagccgaca tccagatgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga 60 ctagccgaca tccagatgac ccagtctcca tcctccctgt ctgcatctgt aggagacaga 60

gtcaccatca cttgccgggc aagtcagacc attagcaacc atttaaattg gtatcagcag 120 gtcaccatca cttgccgggc aagtcagacc attagcaacc atttaaattg gtatcagcag 120

aaaccaggga gagcccctaa gctcctgatc tatgttgggt ccagtctgcg aagtggggtc 180 aaaccaggga gagcccctaa gctcctgatc tatgttgggt ccagtctgcg aagtggggtc 180

ccatcaaggt tcagtggcag tggatctggg acagatttca ctctcaccat cagtggtctg 240 ccatcaaggt tcagtggcag tggatctggg acagatttca ctctcaccat cagtggtctg 240

caacctgaag attttgcaac ttactactgt caacagagtt acagtccctc gtacactttt 300 caacctgaag attttgcaac ttactactgt caacagagtt acagtccctc gtacactttt 300

ggccagggga ccaaggtgga gatcaaa 327 ggccaggggga ccaaggtgga gatcaaa 327

<210> 222 <210> 222

<211> 330 <211> 330

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 222 <400> 222

ctagccgaaa ttgtgttgac acagtctcct tcctctctgt ctgcatctgt gggagacaga 60 ctagccgaaa ttgtgttgac acagtctcct tcctctctgt ctgcatctgt gggagacaga 60

gtcaccatca cttgccgggc gagtcagggc attagcaatt ttttagcctg gtatcagcag 120 gtcaccatca cttgccgggc gagtcagggc attagcaatt ttttagcctg gtatcagcag 120

aaaccaggga aagttcctga gctccttatc tatggcgcat ccactttgca atcgggggtc 180 aaaccaggga aagttcctga gctccttatc tatggcgcat ccactttgca atcgggggtc 180

ccatctcggt tcagtggcag tggatctggg acagatttca ctctcaccat caacagcctg 240 ccatctcggt tcagtggcag tggatctggg acagatttca ctctcaccat caacagcctg 240

cagcctgaag atgttgcaac ttattactgt caaaagtatg acagtggcct gagattcact 300 cagcctgaag atgttgcaac ttattactgt caaaagtatg acagtggcct gagattcact 300

ttcggccctg gggccaaagt ggatatcaaa 330 ttcggccctg gggccaaagt ggatatcaaa 330

<210> 223 <210> 223

<211> 327 <211> 327

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 223 <400> 223

ctagccgatg ttgtgatgac tcagtctcca tcctccctgt ctgcatctgt aggagacaga 60 ctagccgatg ttgtgatgac tcagtctcca tcctccctgt ctgcatctgt aggagacaga 60

gtcagcatca cttgccgggc aagtcggagc gttaagacct atttaaattg gtatcagcag 120 gtcagcatca cttgccgggc aagtcggagc gttaagacct atttaaattg gtatcagcag 120

aaaccaggga aagcccctaa gctcctggtc tatggttcgt ccagtttgga aagtggggtc 180 aaaccaggga aagcccctaa gctcctggtc tatggttcgt ccagtttgga aagtggggtc 180

ccatcaagat tcagtggcag tggatctggg acagatttca ctctcaccat cagcagtctg 240 ccatcaagat tcagtggcag tggatctggg acagatttca ctctcaccat cagcagtctg 240

caacctgagg attttgcaac ttactgctgt caacagagtt tcggtacccc ctacactttt 300 caacctgagg attttgcaac ttactgctgt caacagagtt tcggtacccc ctacactttt 300

ggccagggga ccaagctgga catcaaa 327 ggccaggggga ccaagctggga catcaaa 327

<210> 224 <210> 224

<211> 330 <211> 330

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 224 <400> 224

ctagccgaca tccagttgac ccagtctcct tcctctctgt ctgcatctgt gggagacaga 60 ctagccgaca tccagttgac ccagtctcct tcctctctgt ctgcatctgt gggagacaga 60

gtcaccatca cttgccgggc gagtcagggc attagcaatt ttttagcctg gtatcagcag 120 gtcaccatca cttgccgggc gagtcagggc attagcaatt ttttagcctg gtatcagcag 120

aaaccaggga aagttcctga gctccttatc tatggtgcat ccaccttgca atcaggggtc 180 aaaccaggga aagttcctga gctccttatc tatggtgcat ccaccttgca atcaggggtc 180

ccatctcggt tcagtggcag tggatctggg acagagttca ctctcaccat caacagcctg 240 ccatctcggt tcagtggcag tggatctggg acagagttca ctctcaccat caacagcctg 240

cagcctgaag atgttgcgac ttattactgt caaaagtatg atagtggcct gagattcact 300 cagcctgaag atgttgcgac ttattactgt caaaagtatg atagtggcct gagattcact 300

ttcggccctg ggaccaaagt ggatatcaaa 330 ttcggccctg ggaccaaagt ggatatcaaa 330

<210> 225 <210> 225

<211> 327 <211> 327

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 225 <400> 225

ctagccgaca tccagatgac ccagtcttct tccaccctgt ctgcatctgt aggagacaga 60 ctagccgaca tccagatgac ccagtcttct tccaccctgt ctgcatctgt aggagacaga 60

gtcaccatca cttgccgggc cagtcagaat attaatatct ggttggcctg gtatcagcag 120 gtcaccatca cttgccgggc cagtcagaat attaatatct ggttggcctg gtatcagcag 120

aaagcaggga aagcccccaa actcctgatc tataaggcgt ctactttaga aaggggggtc 180 aaagcaggga aagcccccaa actcctgatc tataggcgt ctactttaga aaggggggtc 180

ccctcaaggt tcagcggcag tggatctggg acagagttca ctctcaccat caccggcctg 240 ccctcaaggt tcagcggcag tggatctggg acagagttca ctctcaccat caccggcctg 240

cgccctgacg atttcggaag ttattattgc caacactatg atggtaattc actaacgttc 300 cgccctgacg atttcggaag ttatattgc caacactatg atggtaattc actaacgttc 300

ggccaaggga ccagggtgga tatccaa 327 ggccaaggga ccagggtgga tatccaa 327

<210> 226 <210> 226

<211> 330 <211> 330

<212> DNA <212> DNA

<213> Homo sapiens <213> Homo sapiens

<400> 226 <400> 226

ctagccgaca tccagttgac ccagtctcct tccaccctgt ctgcatctgt aggcgacaga 60 ctagccgaca tccagttgac ccagtctcct tccaccctgt ctgcatctgt aggcgacaga 60

gtcaccatca cttgccgggc cagtcagagt attggtagct ggttggcctg gtatcaacag 120 gtcaccatca cttgccgggc cagtcagagt attggtagct ggttggcctg gtatcaacag 120

aaaccaggga aagcccctaa actcctgatc tataaggcgt ctactttaca aagtgagacc 180 aaaccaggga aagcccctaa actcctgatc tataaggcgt ctactttaca aagtgagacc 180

ccttcaaggt tccgcggcag tggatctggg accgaattca ctctcaccat cagcagcctg 240 ccttcaaggt tccgcggcag tggatctggg accgaattca ctctcaccat cagcagcctg 240

cagcctgatg attttgcaac ttactactgc caacagttta atagtttttc tccgtggacg 300 cagcctgatg attttgcaac ttactactgc caacagttta atagtttttc tccgtggacg 300

ttcggccaag ggaccaaggc ggaattcaaa 330 ttcggccaag ggaccaaggc ggaattcaaa 330

<210> 227 <210> 227

<211> 123 <211> 123

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 227 <400> 227

Gly Arg Ala Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Gly Arg Ala Gln Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys

1 5 10 15 1 5 10 15

Pro Gly Ala Ser Val Arg Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Gly Ala Ser Val Arg Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe

20 25 30 20 25 30

Lys Asn Tyr Gly Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Lys Asn Tyr Gly Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu

35 40 45 35 40 45

Glu Trp Met Gly Trp Ile Ser Ala Asp Asn Gly Asp Thr Thr Thr Ala Glu Trp Met Gly Trp Ile Ser Ala Asp Asn Gly Asp Thr Thr Thr Ala

50 55 60 50 55 60

Leu Asn Leu Arg Gly Arg Val Ser Met Thr Thr Asp Thr Ser Thr Asn Leu Asn Leu Arg Gly Arg Val Ser Met Thr Thr Asp Thr Ser Thr Asn

65 70 75 80 65 70 75 80

Thr Val Tyr Met Glu Val Lys Ser Leu Arg Ser Asp Asp Thr Ala Ile Thr Val Tyr Met Glu Val Lys Ser Leu Arg Ser Asp Asp Thr Ala Ile

85 90 95 85 90 95

Tyr Phe Cys Ala Arg Asp Phe Tyr Ser Gly Ser Tyr Arg Ser Phe Asp Tyr Phe Cys Ala Arg Asp Phe Tyr Ser Gly Ser Tyr Arg Ser Phe Asp

100 105 110 100 105 110

Cys Trp Gly Gln Gly Thr Leu Val Thr Val Ser Cys Trp Gly Gln Gly Thr Leu Val Thr Val Ser

115 120 115 120

<210> 228 <210> 228

<211> 126 <211> 126

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 228 <400> 228

Gly Arg Ala Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Lys Gly Arg Ala Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Lys

1 5 10 15 1 5 10 15

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe

20 25 30 20 25 30

Ser Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ser Ser Tyr Ser Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu

35 40 45 35 40 45

Glu Trp Val Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Glu Trp Val Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala

50 55 60 50 55 60

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn

65 70 75 80 65 70 75 80

Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val

85 90 95 85 90 95

Tyr Tyr Cys Ala Arg Arg Pro Gly Trp Ala Ala Thr Arg Ala Ala Gly Tyr Tyr Cys Ala Arg Arg Pro Gly Trp Ala Ala Thr Arg Ala Ala Gly

100 105 110 100 105 110

Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser

115 120 125 115 120 125

<210> 229 <210> 229

<211> 119 <211> 119

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 229 <400> 229

Gly Arg Ala Gln Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Gly Arg Ala Gln Val Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys

1 5 10 15 1 5 10 15

Pro Gly Ala Ser Val Arg Ile Ser Cys Lys Ala Ser Glu Lys Cys Asp Pro Gly Ala Ser Val Arg Ile Ser Cys Lys Ala Ser Glu Lys Cys Asp

20 25 30 20 25 30

Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly

35 40 45 35 40 45

Trp Ile Ser Ala Asp Asp Gly Gly Thr Thr Thr Ala Leu Asn Leu Arg Trp Ile Ser Ala Asp Asp Gly Gly Thr Thr Thr Ala Leu Asn Leu Arg

50 55 60 50 55 60

Gly Arg Val Ser Met Thr Thr Asp Arg Ala Thr Asn Thr Val Tyr Met Gly Arg Val Ser Met Thr Thr Asp Arg Ala Thr Asn Thr Val Tyr Met

65 70 75 80 65 70 75 80

Glu Leu Lys Ser Leu Arg Ser Asp Asp Thr Ala Ile Tyr Phe Cys Ala Glu Leu Lys Ser Leu Arg Ser Asp Asp Thr Ala Ile Tyr Phe Cys Ala

85 90 95 85 90 95

Arg Asp Phe Tyr Ser Gly Thr Tyr Arg Ser Phe Asp Tyr Trp Gly Gln Arg Asp Phe Tyr Ser Gly Thr Tyr Arg Ser Phe Asp Tyr Trp Gly Gln

100 105 110 100 105 110

Gly Thr Leu Val Thr Val Ser Gly Thr Leu Val Thr Val Ser

115 115

<210> 230 <210> 230

<211> 132 <211> 132

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 230 <400> 230

Gly Arg Ala Lys Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Gly Arg Ala Lys Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln

1 5 10 15 1 5 10 15

Pro Gly Thr Ser Leu Arg Leu Ser Cys Val Val Ser Gly Phe Thr Phe Pro Gly Thr Ser Leu Arg Leu Ser Cys Val Val Ser Gly Phe Thr Phe

20 25 30 20 25 30

Arg Thr Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Arg Thr Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu

35 40 45 35 40 45

Glu Trp Leu Ala Phe Leu Ser Ser Asp Gly Ser Asp Glu Phe Tyr Ala Glu Trp Leu Ala Phe Leu Ser Ser Asp Gly Ser Asp Glu Phe Tyr Ala

50 55 60 50 55 60

Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Ser Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Ser

65 70 75 80 65 70 75 80

Thr Leu Phe Leu Lys Met Asn Ser Leu Arg Pro Asp Asp Thr Ala Val Thr Leu Phe Leu Lys Met Asn Ser Leu Arg Pro Asp Asp Thr Ala Val

85 90 95 85 90 95

Tyr Tyr Cys Ala Arg Asp Arg Gly Ala Gln Ile Thr Leu Phe Gly Ala Tyr Tyr Cys Ala Arg Asp Arg Gly Ala Gln Ile Thr Leu Phe Gly Ala

100 105 110 100 105 110

Pro Leu Ile Arg Pro Ser Ser Phe Asp Ser Trp Gly Gln Gly Thr Leu Pro Leu Ile Arg Pro Ser Ser Phe Asp Ser Trp Gly Gln Gly Thr Leu

115 120 125 115 120 125

Val Thr Val Ser Wave Thr Wave Ser

130 130

<210> 231 <210> 231

<211> 121 <211> 121

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 231 <400> 231

Gly Arg Ala Gln Val Gln Leu Gln Glu Ser Gly Pro Glu Val Lys Lys Gly Arg Ala Gln Val Gln Leu Gln Glu Ser Gly Pro Glu Val Lys Lys

1 5 10 15 1 5 10 15

Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe

20 25 30 20 25 30

Asn Ser Tyr Gly Ile Ala Trp Val Arg Gln Val Pro Gly Gln Gly Leu Asn Ser Tyr Gly Ile Ala Trp Val Arg Gln Val Pro Gly Gln Gly Leu

35 40 45 35 40 45

Glu Trp Met Gly Trp Ile Ser Pro Tyr Ser Gly His Thr Asn Tyr Ala Glu Trp Met Gly Trp Ile Ser Pro Tyr Ser Gly His Thr Asn Tyr Ala

50 55 60 50 55 60

Glu Lys Val Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ala Thr Ser Glu Lys Val Gln Gly Arg Val Thr Met Thr Thr Asp Thr Ala Thr Ser

65 70 75 80 65 70 75 80

Thr Ala Cys Met Glu Leu Thr Ser Leu Arg Ser Asp Asp Thr Ala Val Thr Ala Cys Met Glu Leu Thr Ser Leu Arg Ser Asp Asp Thr Ala Val

85 90 95 85 90 95

Tyr Phe Cys Ala Arg Asp Tyr Ser Ser Pro Tyr His Phe Asp Tyr Trp Tyr Phe Cys Ala Arg Asp Tyr Ser Ser Pro Tyr His Phe Asp Tyr Trp

100 105 110 100 105 110

Gly Gln Gly Thr Trp Ser Pro Ser Arg Gly Gln Gly Thr Trp Ser Pro Ser Arg

115 120 115 120

<210> 232 <210> 232

<211> 122 <211> 122

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 232 <400> 232

Gly Arg Ala Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Gly Arg Ala Gln Ile Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys

1 5 10 15 1 5 10 15

Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Leu Ser Gly Phe Ser Leu Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Leu Ser Gly Phe Ser Leu

20 25 30 20 25 30

Tyr Thr Thr Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Tyr Thr Thr Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys

35 40 45 35 40 45

Ala Leu Glu Trp Leu Ala Arg Ile Tyr Trp Asp Asp Asp Glu Arg Tyr Ala Leu Glu Trp Leu Ala Arg Ile Tyr Trp Asp Asp Asp Glu Arg Tyr

50 55 60 50 55 60

Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Ala Ser Lys Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Ala Ser Lys

65 70 75 80 65 70 75 80

Asn Gln Val Val Leu Lys Met Thr Asn Met Asp Pro Val Asp Thr Ala Asn Gln Val Val Leu Lys Met Thr Asn Met Asp Pro Val Asp Thr Ala

85 90 95 85 90 95

Thr Tyr Tyr Cys Ala Arg Thr Met Gly Val Val Leu Pro Phe Asp Tyr Thr Tyr Tyr Cys Ala Arg Thr Met Gly Val Val Leu Pro Phe Asp Tyr

100 105 110 100 105 110

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser

115 120 115 120

<210> 233 <210> 233

<211> 117 <211> 117

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 233 <400> 233

Gly Arg Ala Lys Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Gly Arg Ala Lys Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys

1 5 10 15 1 5 10 15

Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Val Ser Gly Phe Pro Leu Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Val Ser Gly Phe Pro Leu

20 25 30 20 25 30

Asn Arg Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asn Arg Tyr Thr Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu

35 40 45 35 40 45

Glu Trp Leu Ser Ser Ile Ser Ser Thr Ser Ser Tyr Ile Tyr Tyr Ala Glu Trp Leu Ser Ser Ile Ser Ser Thr Ser Ser Tyr Ile Tyr Tyr Ala

50 55 60 50 55 60

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn

65 70 75 80 65 70 75 80

Ser Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Leu Ser Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Leu

85 90 95 85 90 95

Tyr Phe Cys Ala Ser Gly Asn Thr His Asp Tyr Trp Gly Gln Gly Thr Tyr Phe Cys Ala Ser Gly Asn Thr His Asp Tyr Trp Gly Gln Gly Thr

100 105 110 100 105 110

Leu Val Thr Val Ser Leu Val Thr Val Ser

115 115

<210> 234 <210> 234

<211> 126 <211> 126

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 234 <400> 234

Gly Arg Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Gly Arg Ala Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys

1 5 10 15 1 5 10 15

Leu Gly Thr Ser Val Arg Val Ser Cys Lys Thr Pro Gly Gly Tyr Val Leu Gly Thr Ser Val Arg Val Ser Cys Lys Thr Pro Gly Gly Tyr Val

20 25 30 20 25 30

Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met Gly Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met Gly

35 40 45 35 40 45

Gly Ile Ile Thr Asn Phe Gly Thr Thr Asn Tyr Ala Arg Lys Phe Gln Gly Ile Ile Thr Asn Phe Gly Thr Thr Asn Tyr Ala Arg Lys Phe Gln

50 55 60 50 55 60

Gly Arg Ile Thr Val Thr Ala Asp Lys Ser Thr Asn Thr Val Tyr Met Gly Arg Ile Thr Val Thr Ala Asp Lys Ser Thr Asn Thr Val Tyr Met

65 70 75 80 65 70 75 80

Asp Leu Ser Asn Leu Ala Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Asp Leu Ser Asn Leu Ala Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala

85 90 95 85 90 95

Arg Ala Pro Arg Gly Thr Ser Thr Ile Ala Ala Arg Phe Asn Arg Tyr Arg Ala Pro Arg Gly Thr Ser Thr Ile Ala Ala Arg Phe Asn Arg Tyr

100 105 110 100 105 110

Phe Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Phe Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser

115 120 125 115 120 125

<210> 235 <210> 235

<211> 132 <211> 132

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 235 <400> 235

Gly Arg Ala Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln Gly Arg Ala Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Val Val Gln

1 5 10 15 1 5 10 15

Pro Gly Thr Ser Leu Arg Leu Ser Cys Val Val Ser Gly Phe Thr Phe Pro Gly Thr Ser Leu Arg Leu Ser Cys Val Val Ser Gly Phe Thr Phe

20 25 30 20 25 30

Arg Thr Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Val Leu Arg Thr Tyr Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Val Leu

35 40 45 35 40 45

Glu Trp Leu Ala Phe Val Ser Ser Asp Gly Ser Asp Glu Phe Tyr Ala Glu Trp Leu Ala Phe Val Ser Ser Asp Gly Ser Asp Glu Phe Tyr Ala

50 55 60 50 55 60

Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Ser Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Ser

65 70 75 80 65 70 75 80

Thr Leu Phe Leu Lys Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Thr Leu Phe Leu Lys Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val

85 90 95 85 90 95

Tyr Tyr Cys Ala Arg Asp Arg Gly Ala Gln Ile Thr Leu Phe Gly Ala Tyr Tyr Cys Ala Arg Asp Arg Gly Ala Gln Ile Thr Leu Phe Gly Ala

100 105 110 100 105 110

Pro Leu Ile Arg Pro Ser Ser Phe Asp Ser Trp Gly Gln Gly Thr Leu Pro Leu Ile Arg Pro Ser Ser Phe Asp Ser Trp Gly Gln Gly Thr Leu

115 120 125 115 120 125

Val Thr Val Ser Wave Thr Wave Ser

130 130

<210> 236 <210> 236

<211> 126 <211> 126

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 236 <400> 236

Gly Arg Ala Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Gly Arg Ala Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys

1 5 10 15 1 5 10 15

Pro Gly Thr Ser Val Arg Val Ser Cys Lys Thr Ser Gly Gly Tyr Val Pro Gly Thr Ser Val Arg Val Ser Cys Lys Thr Ser Gly Gly Tyr Val

20 25 30 20 25 30

Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met Gly Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met Gly

35 40 45 35 40 45

Gly Ile Ile Thr Ser Phe Gly Thr Thr Ser Tyr Ala Gln Lys Phe Gln Gly Ile Ile Thr Ser Phe Gly Thr Thr Ser Tyr Ala Gln Lys Phe Gln

50 55 60 50 55 60

Gly Arg Val Thr Ile Thr Ala Asp Lys Ala Thr Asn Thr Val Tyr Met Gly Arg Val Thr Ile Thr Ala Asp Lys Ala Thr Asn Thr Val Tyr Met

65 70 75 80 65 70 75 80

Asp Leu Ser Asp Leu Thr Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Asp Leu Ser Asp Leu Thr Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala

85 90 95 85 90 95

Lys Ala Pro Arg Gly Thr Ser Thr Ile Ala Ala Arg Phe Asn Arg Tyr Lys Ala Pro Arg Gly Thr Ser Thr Ile Ala Ala Arg Phe Asn Arg Tyr

100 105 110 100 105 110

Phe Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Phe Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser

115 120 125 115 120 125

<210> 237 <210> 237

<211> 122 <211> 122

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 237 <400> 237

Gly Arg Ala Gln Val Gln Leu Gln Glu Ser Gly Pro Thr Leu Val Lys Gly Arg Ala Gln Val Gln Leu Gln Glu Ser Gly Pro Thr Leu Val Lys

1 5 10 15 1 5 10 15

Pro Thr Gln Thr Leu Thr Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Pro Thr Gln Thr Leu Thr Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu

20 25 30 20 25 30

Gly Thr Thr Gly Val Asn Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Thr Thr Gly Val Asn Val Gly Trp Ile Arg Gln Pro Pro Gly Lys

35 40 45 35 40 45

Ala Leu Glu Trp Leu Ala Leu Ile Ser Trp Asp Gly Gly Lys His Tyr Ala Leu Glu Trp Leu Ala Leu Ile Ser Trp Asp Gly Gly Lys His Tyr

50 55 60 50 55 60

Ser Pro Ser Leu Asn Ser Arg Ile Thr Leu Thr Lys Asp Ala Ser Arg Ser Pro Ser Leu Asn Ser Arg Ile Thr Leu Thr Lys Asp Ala Ser Arg

65 70 75 80 65 70 75 80

Glu Gln Val Val Val Pro Thr Met Thr Asn Met Asp Pro Ala Asp Thr Glu Gln Val Val Val Pro Thr Met Thr Asn Met Asp Pro Ala Asp Thr

85 90 95 85 90 95

Gly Arg Tyr Tyr Cys Ala Arg Ile Val Gly Thr His Gly Phe Asp Tyr Gly Arg Tyr Tyr Cys Ala Arg Ile Val Gly Thr His Gly Phe Asp Tyr

100 105 110 100 105 110

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser

115 120 115 120

<210> 238 <210> 238

<211> 131 <211> 131

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 238 <400> 238

Gly Arg Ala Lys Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Gly Arg Ala Lys Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys

1 5 10 15 1 5 10 15

Pro Gly Ala Thr Val Arg Val Ser Cys Lys Ala Ser Gly Tyr Arg Phe Pro Gly Ala Thr Val Arg Val Ser Cys Lys Ala Ser Gly Tyr Arg Phe

20 25 30 20 25 30

Asn Asp Tyr Cys Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Asn Asp Tyr Cys Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu

35 40 45 35 40 45

Glu Trp Met Gly Trp Ile Asn Gly Asn Asn Ala Asp Thr Phe Tyr Ala Glu Trp Met Gly Trp Ile Asn Gly Asn Asn Ala Asp Thr Phe Tyr Ala

50 55 60 50 55 60

Pro Lys Leu Gln Gly Arg Val Thr Met Ser Thr Asp Thr Ser Thr Ser Pro Lys Leu Gln Gly Arg Val Thr Met Ser Thr Asp Thr Ser Thr Ser

65 70 75 80 65 70 75 80

Thr Ala Tyr Met Glu Leu Arg Asn Leu Arg Ser Asp Asp Thr Ala Val Thr Ala Tyr Met Glu Leu Arg Asn Leu Arg Ser Asp Asp Thr Ala Val

85 90 95 85 90 95

Tyr Phe Cys Ala Arg Asp Arg Gly Arg Ile Thr Leu Phe Gly Glu Val Tyr Phe Cys Ala Arg Asp Arg Gly Arg Ile Thr Leu Phe Gly Glu Val

100 105 110 100 105 110

Ile Leu Arg Ala Gly Trp Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Ile Leu Arg Ala Gly Trp Phe Asp Ser Trp Gly Gln Gly Thr Leu Val

115 120 125 115 120 125

Thr Val Ser Thr Val Ser

130 130

<210> 239 <210> 239

<211> 124 <211> 124

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 239 <400> 239

Gly Arg Ala Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Gly Arg Ala Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys

1 5 10 15 1 5 10 15

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe

20 25 30 20 25 30

Ser Asn Asn Asn Met Asn Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Ser Asn Asn Asn Met Asn Trp Val Arg Gln Thr Pro Gly Lys Gly Leu

35 40 45 35 40 45

Glu Trp Val Ala Ser Ile Ser Phe Gly Ser His Tyr Ile Ser Tyr Ala Glu Trp Val Ala Ser Ile Ser Phe Gly Ser His Tyr Ile Ser Tyr Ala

50 55 60 50 55 60

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn

65 70 75 80 65 70 75 80

Ala Val Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Ala Val Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val

85 90 95 85 90 95

Tyr Tyr Cys Thr Arg Cys Arg Gly Gly Thr Arg Thr Tyr Tyr Tyr Met Tyr Tyr Cys Thr Arg Cys Arg Gly Gly Thr Arg Thr Tyr Tyr Tyr Met

100 105 110 100 105 110

Asp Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser Asp Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser

115 120 115 120

<210> 240 <210> 240

<211> 124 <211> 124

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 240 <400> 240

Gly Arg Ala Lys Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Gly Arg Ala Lys Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys

1 5 10 15 1 5 10 15

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Phe Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ser Phe

20 25 30 20 25 30

Ser Asn Asn Asn Met Asn Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Ser Asn Asn Asn Met Asn Trp Val Arg Gln Thr Pro Gly Lys Gly Leu

35 40 45 35 40 45

Glu Trp Val Ala Ser Ile Ser Phe Gly Ser His Tyr Ile Ser Tyr Ala Glu Trp Val Ala Ser Ile Ser Phe Gly Ser His Tyr Ile Ser Tyr Ala

50 55 60 50 55 60

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn

65 70 75 80 65 70 75 80

Ala Val Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Ala Val Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val

85 90 95 85 90 95

Tyr Tyr Cys Thr Arg Cys Arg Gly Gly Thr Arg Thr Tyr Tyr Tyr Met Tyr Tyr Cys Thr Arg Cys Arg Gly Gly Thr Arg Thr Tyr Tyr Tyr Met

100 105 110 100 105 110

Asp Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser Asp Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser

115 120 115 120

<210> 241 <210> 241

<211> 130 <211> 130

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 241 <400> 241

Gly Arg Ala Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Gly Arg Ala Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys

1 5 10 15 1 5 10 15

Pro Gly Ser Ser Val Lys Val Ser Cys Gln Ser Ser Gly Gly Pro Pro Pro Gly Ser Ser Val Lys Val Ser Cys Gln Ser Ser Gly Gly Pro Pro

20 25 30 20 25 30

Lys Ser Tyr Thr Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Lys Ser Tyr Thr Leu Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro

35 40 45 35 40 45

Glu Trp Met Gly Gly Ile Ile Leu Ile Phe Gly Pro Pro Asn Tyr Ala Glu Trp Met Gly Gly Ile Ile Leu Ile Phe Gly Pro Pro Asn Tyr Ala

50 55 60 50 55 60

Gln Lys Phe Gln Asp Arg Leu Thr Ile Thr Ala Asp Lys Ser Thr Asn Gln Lys Phe Gln Asp Arg Leu Thr Ile Thr Ala Asp Lys Ser Thr Asn

65 70 75 80 65 70 75 80

Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Met Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Met

85 90 95 85 90 95

Tyr Tyr Cys Val Thr Ala Pro Asp Asp Thr Gly Thr Ile Leu Ala Arg Tyr Tyr Cys Val Thr Ala Pro Asp Asp Thr Gly Thr Ile Leu Ala Arg

100 105 110 100 105 110

His Asn Arg Tyr Tyr Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr His Asn Arg Tyr Tyr Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr

115 120 125 115 120 125

Val Ser Val Ser

130 130

<210> 242 <210> 242

<211> 130 <211> 130

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 242 <400> 242

Gly Arg Ala Lys Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Gly Arg Ala Lys Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys

1 5 10 15 1 5 10 15

Pro Gly Glu Ser Leu Lys Ile Ser Cys Gln Ala Ser Gly Tyr Gly Phe Pro Gly Glu Ser Leu Lys Ile Ser Cys Gln Ala Ser Gly Tyr Gly Phe

20 25 30 20 25 30

Thr Val Tyr Trp Ile Gly Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Thr Val Tyr Trp Ile Gly Trp Val Arg Gln Pro Pro Gly Lys Gly Leu

35 40 45 35 40 45

Glu Trp Leu Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Asn Glu Trp Leu Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Asn

50 55 60 50 55 60

Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Val Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Val Ser

65 70 75 80 65 70 75 80

Thr Thr Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Thr Thr Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile

85 90 95 85 90 95

Tyr Tyr Cys Ala Arg His Leu Asp Ser Tyr Asp Val Phe Thr Gly Tyr Tyr Tyr Cys Ala Arg His Leu Asp Ser Tyr Asp Val Phe Thr Gly Tyr

100 105 110 100 105 110

Asn Leu Gly Gly Tyr Met Asp Val Trp Gly Lys Gly Thr Leu Val Thr Asn Leu Gly Gly Tyr Met Asp Val Trp Gly Lys Gly Thr Leu Val Thr

115 120 125 115 120 125

Val Ser Val Ser

130 130

<210> 243 <210> 243

<211> 117 <211> 117

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<220> <220>

<221> Miješana karakteristika <221> Mixed characteristic

<222> (6)..(6) <222> (6)..(6)

<223> Xaa odgovara stop kodonu <223> Xaa corresponds to the stop codon

<400> 243 <400> 243

Gly Arg Ala Lys Val Xaa Leu Val Gln Ser Gly Gly Gly Leu Val Lys Gly Arg Ala Lys Val Xaa Leu Val Gln Ser Gly Gly Gly Leu Val Lys

1 5 10 15 1 5 10 15

Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Val Ser Gly Phe Pro Leu Pro Gly Gly Ser Leu Arg Leu Ser Cys Val Val Ser Gly Phe Pro Leu

20 25 30 20 25 30

Asn Arg Tyr Ile Met Asn Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Asn Arg Tyr Ile Met Asn Trp Val Arg Gln Thr Pro Gly Lys Gly Leu

35 40 45 35 40 45

Glu Trp Leu Ser Ser Ile Ser Ser Thr Ser Ser Tyr Ile Tyr Tyr Ala Glu Trp Leu Ser Ser Ile Ser Ser Thr Ser Ser Tyr Ile Tyr Tyr Ala

50 55 60 50 55 60

Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn

65 70 75 80 65 70 75 80

Ser Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Leu Ser Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Leu

85 90 95 85 90 95

Tyr Tyr Cys Ala Ser Gly Asn Thr His Asp Tyr Trp Gly Gln Gly Thr Tyr Tyr Cys Ala Ser Gly Asn Thr His Asp Tyr Trp Gly Gln Gly Thr

100 105 110 100 105 110

Leu Val Thr Val Ser Leu Val Thr Val Ser

115 115

<210> 244 <210> 244

<211> 126 <211> 126

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 244 <400> 244

Gly Arg Ala Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Gly Arg Ala Gln Met Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys

1 5 10 15 1 5 10 15

Pro Gly Thr Ser Val Arg Val Ser Cys Lys Thr Ser Gly Gly Tyr Val Pro Gly Thr Ser Val Arg Val Ser Cys Lys Thr Ser Gly Gly Tyr Val

20 25 30 20 25 30

Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met Gly Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met Gly

35 40 45 35 40 45

Gly Ile Ile Thr Asn Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe Gln Gly Ile Ile Thr Asn Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe Gln

50 55 60 50 55 60

Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Val Tyr Met Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Val Tyr Met

65 70 75 80 65 70 75 80

Asp Leu Ser Asn Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Asp Leu Ser Asn Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala

85 90 95 85 90 95

Arg Ala Pro Arg Gly Thr Ser Thr Ile Ala Ala Arg Phe Asn Arg Tyr Arg Ala Pro Arg Gly Thr Ser Thr Ile Ala Ala Arg Phe Asn Arg Tyr

100 105 110 100 105 110

Phe Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Phe Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser

115 120 125 115 120 125

<210> 245 <210> 245

<211> 124 <211> 124

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 245 <400> 245

Gly Arg Ala Lys Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Gly Arg Ala Lys Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys

1 5 10 15 1 5 10 15

Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Phe

20 25 30 20 25 30

Ser Thr Tyr Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Ser Thr Tyr Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu

35 40 45 35 40 45

Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Ala Ser Arg Asp Tyr Ala Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Ala Ser Arg Asp Tyr Ala

50 55 60 50 55 60

Gln Lys Phe Gln Gly Arg Val Thr Val Thr Ala Asp Glu Ser Thr Arg Gln Lys Phe Gln Gly Arg Val Thr Val Thr Ala Asp Glu Ser Thr Arg

65 70 75 80 65 70 75 80

Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val

85 90 95 85 90 95

Tyr Tyr Cys Ala Arg Val Leu Gly Gly Thr Arg Leu Tyr Tyr Ala Leu Tyr Tyr Cys Ala Arg Val Leu Gly Gly Thr Arg Leu Tyr Tyr Ala Leu

100 105 110 100 105 110

Asn Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Asn Val Trp Gly Gln Gly Thr Met Val Thr Val Ser

115 120 115 120

<210> 246 <210> 246

<211> 124 <211> 124

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 246 <400> 246

Gly Arg Ala Lys Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Gly Arg Ala Lys Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys

1 5 10 15 1 5 10 15

Pro Gly Ser Ser Val Lys Val Ser Cys Lys Thr Ser Gly Gly Ser Phe Pro Gly Ser Ser Val Lys Val Ser Cys Lys Thr Ser Gly Gly Ser Phe

20 25 30 20 25 30

Ser Thr Tyr Ser Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Ser Thr Tyr Ser Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu

35 40 45 35 40 45

Glu Trp Met Gly Gly Ile Asn Pro Ile Phe Ala Thr Arg Asp Tyr Ala Glu Trp Met Gly Gly Ile Asn Pro Ile Phe Ala Thr Arg Asp Tyr Ala

50 55 60 50 55 60

Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg

65 70 75 80 65 70 75 80

Thr Val Tyr Met Glu Leu Arg Asn Leu Arg Ser Glu Asp Thr Ala Val Thr Val Tyr Met Glu Leu Arg Asn Leu Arg Ser Glu Asp Thr Ala Val

85 90 95 85 90 95

Tyr Tyr Cys Ala Arg Val Phe Gly Gly Thr Arg Leu Tyr Tyr Ala Leu Tyr Tyr Cys Ala Arg Val Phe Gly Gly Thr Arg Leu Tyr Tyr Ala Leu

100 105 110 100 105 110

Asn Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Asn Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser

115 120 115 120

<210> 247 <210> 247

<211> 126 <211> 126

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 247 <400> 247

Gly Arg Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Gly Arg Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys

1 5 10 15 1 5 10 15

Pro Gly Thr Ser Val Arg Val Ser Cys Lys Thr Pro Gly Gly Tyr Val Pro Gly Thr Ser Val Arg Val Ser Cys Lys Thr Pro Gly Gly Tyr Val

20 25 30 20 25 30

Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met Gly Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met Gly

35 40 45 35 40 45

Gly Ile Ile Thr Asn Phe Gly Thr Thr Asn Tyr Ala Arg Lys Phe Gln Gly Ile Ile Thr Asn Phe Gly Thr Thr Asn Tyr Ala Arg Lys Phe Gln

50 55 60 50 55 60

Gly Arg Ile Thr Val Thr Ala Asp Lys Ser Thr Asn Thr Val Tyr Met Gly Arg Ile Thr Val Thr Ala Asp Lys Ser Thr Asn Thr Val Tyr Met

65 70 75 80 65 70 75 80

Asp Leu Ser Asn Leu Ala Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Asp Leu Ser Asn Leu Ala Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala

85 90 95 85 90 95

Arg Ala Pro Arg Gly Thr Ser Thr Ile Ala Ala Arg Phe Asn Arg Tyr Arg Ala Pro Arg Gly Thr Ser Thr Ile Ala Ala Arg Phe Asn Arg Tyr

100 105 110 100 105 110

Phe Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Phe Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser

115 120 125 115 120 125

<210> 248 <210> 248

<211> 124 <211> 124

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 248 <400> 248

Gly Arg Ala Lys Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Gly Arg Ala Lys Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys

1 5 10 15 1 5 10 15

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe

20 25 30 20 25 30

Ser Asn Asn Asn Met Asn Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Ser Asn Asn Asn Met Asn Trp Val Arg Gln Thr Pro Gly Lys Gly Leu

35 40 45 35 40 45

Glu Trp Val Ala Ser Ile Ser Phe Gly Ser His Tyr Ile Ser Tyr Ala Glu Trp Val Ala Ser Ile Ser Phe Gly Ser His Tyr Ile Ser Tyr Ala

50 55 60 50 55 60

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn

65 70 75 80 65 70 75 80

Ala Val Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Ala Val Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val

85 90 95 85 90 95

Tyr Tyr Cys Thr Arg Cys Arg Gly Gly Thr Arg Thr Tyr Tyr Tyr Met Tyr Tyr Cys Thr Arg Cys Arg Gly Gly Thr Arg Thr Tyr Tyr Tyr Met

100 105 110 100 105 110

Asp Val Trp Gly Lys Gly Thr Met Val Thr Val Ser Asp Val Trp Gly Lys Gly Thr Met Val Thr Val Ser

115 120 115 120

<210> 249 <210> 249

<211> 130 <211> 130

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 249 <400> 249

Gly Arg Ala Lys Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Gly Arg Ala Lys Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys

1 5 10 15 1 5 10 15

Pro Gly Glu Ser Leu Lys Ile Ser Cys Gln Ala Ser Gly Tyr Gly Phe Pro Gly Glu Ser Leu Lys Ile Ser Cys Gln Ala Ser Gly Tyr Gly Phe

20 25 30 20 25 30

Thr Val Tyr Trp Ile Gly Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Thr Val Tyr Trp Ile Gly Trp Val Arg Gln Pro Pro Gly Lys Gly Leu

35 40 45 35 40 45

Glu Trp Leu Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Asn Glu Trp Leu Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Asn

50 55 60 50 55 60

Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Val Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Val Ser

65 70 75 80 65 70 75 80

Thr Thr Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Thr Thr Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile

85 90 95 85 90 95

Tyr Tyr Cys Ala Arg His Leu Asp Ser Tyr Asp Val Phe Thr Gly Tyr Tyr Tyr Cys Ala Arg His Leu Asp Ser Tyr Asp Val Phe Thr Gly Tyr

100 105 110 100 105 110

Asn Leu Gly Gly Tyr Met Asp Val Trp Gly Lys Gly Thr Leu Val Thr Asn Leu Gly Gly Tyr Met Asp Val Trp Gly Lys Gly Thr Leu Val Thr

115 120 125 115 120 125

Val Ser Val Ser

130 130

<210> 250 <210> 250

<211> 126 <211> 126

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 250 <400> 250

Gly Arg Ala Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Gly Arg Ala Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys

1 5 10 15 1 5 10 15

Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ser Ser Gly Gly Tyr Val Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ser Ser Gly Gly Tyr Val

20 25 30 20 25 30

Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly

35 40 45 35 40 45

Gly Ile Ile Ser Asn Phe Arg Thr Ala Glu Tyr Ala Arg Lys Phe Gln Gly Ile Ile Ser Asn Phe Arg Thr Ala Glu Tyr Ala Arg Lys Phe Gln

50 55 60 50 55 60

Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Asn Thr Ile Tyr Met Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Asn Thr Ile Tyr Met

65 70 75 80 65 70 75 80

Glu Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys Val Glu Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys Val

85 90 95 85 90 95

Ser Ala Pro Arg Asp Thr Ser Thr Ile Ala Ala Arg Phe Asn Arg Tyr Ser Ala Pro Arg Asp Thr Ser Thr Ile Ala Ala Arg Phe Asn Arg Tyr

100 105 110 100 105 110

Phe Phe Asp Thr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Phe Phe Asp Thr Trp Gly Gln Gly Thr Leu Val Thr Val Ser

115 120 125 115 120 125

<210> 251 <210> 251

<211> 126 <211> 126

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 251 <400> 251

Gly Arg Ala Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Val Val Gln Gly Arg Ala Gln Val Gln Leu Gln Gln Ser Gly Gly Gly Val Val Gln

1 5 10 15 1 5 10 15

Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe

20 25 30 20 25 30

Arg Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Arg Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu

35 40 45 35 40 45

Glu Trp Met Gly Val Ile Ser Phe Asn Gly Asp Gln Ile Phe Tyr Ala Glu Trp Met Gly Val Ile Ser Phe Asn Gly Asp Gln Ile Phe Tyr Ala

50 55 60 50 55 60

Asp Ser Met Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ser Lys Asn Asp Ser Met Lys Gly Arg Phe Thr Ile Ser Arg Glu Asn Ser Lys Asn

65 70 75 80 65 70 75 80

Thr Leu His Leu Arg Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Thr Leu His Leu Arg Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val

85 90 95 85 90 95

Tyr Tyr Cys Ala Arg Ala Arg Leu Leu Phe Cys Ser Gly Gly Arg Cys Tyr Tyr Cys Ala Arg Ala Arg Leu Leu Phe Cys Ser Gly Gly Arg Cys

100 105 110 100 105 110

Asp Met Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Asp Met Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser

115 120 125 115 120 125

<210> 252 <210> 252

<211> 126 <211> 126

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 252 <400> 252

Gly Arg Ala Lys Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Gly Arg Ala Lys Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys

1 5 10 15 1 5 10 15

Pro Gly Thr Ser Val Arg Val Ser Cys Lys Thr Ser Gly Gly Tyr Val Pro Gly Thr Ser Val Arg Val Ser Cys Lys Thr Ser Gly Gly Tyr Val

20 25 30 20 25 30

Phe Ser Trp Val Arg Gln Ala Pro Gly His Gly Pro Glu Trp Met Gly Phe Ser Trp Val Arg Gln Ala Pro Gly His Gly Pro Glu Trp Met Gly

35 40 45 35 40 45

Gly Ile Ile Thr Asn Phe Gly Thr Ala Thr Tyr Ala Gln Lys Phe Gln Gly Ile Ile Thr Asn Phe Gly Thr Ala Thr Tyr Ala Gln Lys Phe Gln

50 55 60 50 55 60

Gly Arg Val Ser Ile Thr Ala Asp Thr Ser Thr Asn Thr Phe Tyr Met Gly Arg Val Ser Ile Thr Ala Asp Thr Ser Thr Asn Thr Phe Tyr Met

65 70 75 80 65 70 75 80

Asp Leu Asn Asn Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Asp Leu Asn Asn Leu Lys Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala

85 90 95 85 90 95

Ser Ala Pro Arg Asp Thr Ser Thr Ile Ala Ala Arg Phe Asn Arg Tyr Ser Ala Pro Arg Asp Thr Ser Thr Ile Ala Ala Arg Phe Asn Arg Tyr

100 105 110 100 105 110

Phe Phe Asp Phe Trp Gly Pro Gly Thr Leu Val Thr Val Ser Phe Phe Asp Phe Trp Gly Pro Gly Thr Leu Val Thr Val Ser

115 120 125 115 120 125

<210> 253 <210> 253

<211> 116 <211> 116

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<220> <220>

<221> Miješana karakteristika <221> Mixed characteristic

<222> (4)..(4) <222> (4)..(4)

<223> Xaa odgovara stop kodonu <223> Xaa corresponds to the stop codon

<400> 253 <400> 253

Gly Arg Ala Xaa Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Gly Arg Ala Xaa Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys

1 5 10 15 1 5 10 15

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe

20 25 30 20 25 30

Ser Asn Ala Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Ser Asn Ala Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu

35 40 45 35 40 45

Glu Trp Val Gly His Val Lys Ser Met Thr Asp Gly Gly Thr Thr Asp Glu Trp Val Gly His Val Lys Ser Met Thr Asp Gly Gly Thr Thr Asp

50 55 60 50 55 60

Tyr Ala Ala Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Tyr Ala Ala Pro Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser

65 70 75 80 65 70 75 80

Glu Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Asp Asp Thr Glu Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Asp Asp Thr

85 90 95 85 90 95

Ala Val Tyr Tyr Cys Thr Thr His Asp Tyr Trp Gly Gln Gly Thr Leu Ala Val Tyr Tyr Cys Thr Thr His Asp Tyr Trp Gly Gln Gly Thr Leu

100 105 110 100 105 110

Val Thr Val Ser Wave Thr Wave Ser

115 115

<210> 254 <210> 254

<211> 126 <211> 126

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 254 <400> 254

Gly Arg Ala Lys Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Gly Arg Ala Lys Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys

1 5 10 15 1 5 10 15

Pro Gly Thr Ser Val Arg Val Ser Cys Lys Thr Pro Gly Gly Tyr Val Pro Gly Thr Ser Val Arg Val Ser Cys Lys Thr Pro Gly Gly Tyr Val

20 25 30 20 25 30

Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met Gly Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met Gly

35 40 45 35 40 45

Gly Ile Ile Thr Asn Phe Gly Thr Thr Asn Tyr Ala Arg Lys Phe Gln Gly Ile Ile Thr Asn Phe Gly Thr Thr Asn Tyr Ala Arg Lys Phe Gln

50 55 60 50 55 60

Gly Arg Ile Thr Val Thr Ala Asp Lys Ser Thr Asn Thr Val Tyr Met Gly Arg Ile Thr Val Thr Ala Asp Lys Ser Thr Asn Thr Val Tyr Met

65 70 75 80 65 70 75 80

Asp Leu Ser Asn Leu Ala Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Asp Leu Ser Asn Leu Ala Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala

85 90 95 85 90 95

Arg Ala Pro Arg Gly Thr Ser Thr Ile Ala Ala Arg Phe Asn Arg Tyr Arg Ala Pro Arg Gly Thr Ser Thr Ile Ala Ala Arg Phe Asn Arg Tyr

100 105 110 100 105 110

Phe Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Phe Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser

115 120 125 115 120 125

<210> 255 <210> 255

<211> 131 <211> 131

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 255 <400> 255

Gly Arg Ala Gln Val Gln Leu Val Glu Ser Gly Ala Glu Met Lys Lys Gly Arg Ala Gln Val Gln Leu Val Glu Ser Gly Ala Glu Met Lys Lys

1 5 10 15 1 5 10 15

Pro Gly Ser Ser Val Lys Val Ser Cys Gln Ala Ser Gly Gly Thr Phe Pro Gly Ser Ser Val Lys Val Ser Cys Gln Ala Ser Gly Gly Thr Phe

20 25 30 20 25 30

Ser Asn Tyr Gly Ile Asn Trp Val Arg His Ala Pro Gly Gln Gly Leu Ser Asn Tyr Gly Ile Asn Trp Val Arg His Ala Pro Gly Gln Gly Leu

35 40 45 35 40 45

Glu Trp Met Gly Gly Ile Val Pro Ile Tyr Gly Pro Pro Lys Tyr Ala Glu Trp Met Gly Gly Ile Val Pro Ile Tyr Gly Pro Pro Lys Tyr Ala

50 55 60 50 55 60

Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Thr Ser Thr Ser

65 70 75 80 65 70 75 80

Thr Ala Tyr Met Glu Leu Ser Ser Leu Ser Ser Asp Asp Thr Ala Val Thr Ala Tyr Met Glu Leu Ser Ser Leu Ser Ser Asp Asp Thr Ala Val

85 90 95 85 90 95

Tyr Tyr Cys Ala Arg Leu Ser Arg Thr Val Phe Gly Ser Gly Thr Tyr Tyr Tyr Cys Ala Arg Leu Ser Arg Thr Val Phe Gly Ser Gly Thr Tyr

100 105 110 100 105 110

Arg Pro Gly Tyr Tyr Tyr Met Asp Val Trp Gly Ile Gly Thr Thr Val Arg Pro Gly Tyr Tyr Tyr Met Asp Val Trp Gly Ile Gly Thr Thr Val

115 120 125 115 120 125

Thr Val Ser Thr Val Ser

130 130

<210> 256 <210> 256

<211> 124 <211> 124

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<220> <220>

<221> Miješana karakteristika <221> Mixed characteristic

<222> (4)..(4) <222> (4)..(4)

<223> Xaa odgovara stop kodonu <223> Xaa corresponds to the stop codon

<400> 256 <400> 256

Gly Arg Ala Xaa Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Lys Gly Arg Ala Xaa Val Gln Leu Gln Gln Ser Gly Gly Gly Leu Val Lys

1 5 10 15 1 5 10 15

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe

20 25 30 20 25 30

Ser Asn Asn Asn Met Asn Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Ser Asn Asn Asn Met Asn Trp Val Arg Gln Thr Pro Gly Lys Gly Leu

35 40 45 35 40 45

Glu Trp Val Ala Ser Ile Ser Phe Gly Ser His Tyr Ile Ser Tyr Ala Glu Trp Val Ala Ser Ile Ser Phe Gly Ser His Tyr Ile Ser Tyr Ala

50 55 60 50 55 60

Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn

65 70 75 80 65 70 75 80

Ala Val Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Ala Val Tyr Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val

85 90 95 85 90 95

Tyr Tyr Cys Thr Arg Cys Arg Gly Gly Thr Arg Thr Tyr Tyr Tyr Met Tyr Tyr Cys Thr Arg Cys Arg Gly Gly Thr Arg Thr Tyr Tyr Tyr Met

100 105 110 100 105 110

Asp Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser Asp Val Trp Gly Lys Gly Thr Leu Val Thr Val Ser

115 120 115 120

<210> 257 <210> 257

<211> 126 <211> 126

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 257 <400> 257

Gly Arg Ala Lys Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Gly Arg Ala Lys Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys

1 5 10 15 1 5 10 15

Pro Gly Thr Ser Val Arg Val Ser Cys Lys Thr Ser Gly Gly Tyr Val Pro Gly Thr Ser Val Arg Val Ser Cys Lys Thr Ser Gly Gly Tyr Val

20 25 30 20 25 30

Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met Gly Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met Gly

35 40 45 35 40 45

Gly Ile Ile Thr Asn Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe Gln Gly Ile Ile Thr Asn Phe Gly Thr Thr Asn Tyr Ala Gln Lys Phe Gln

50 55 60 50 55 60

Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Val Tyr Met Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Asn Thr Val Tyr Met

65 70 75 80 65 70 75 80

Asp Leu Ser Asn Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Asp Leu Ser Asn Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala

85 90 95 85 90 95

Arg Ala Pro Arg Gly Thr Ser Thr Ile Ala Ala Arg Phe Asn Arg Tyr Arg Ala Pro Arg Gly Thr Ser Thr Ile Ala Ala Arg Phe Asn Arg Tyr

100 105 110 100 105 110

Phe Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Phe Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser

115 120 125 115 120 125

<210> 258 <210> 258

<211> 124 <211> 124

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 258 <400> 258

Gly Arg Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Gly Arg Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys

1 5 10 15 1 5 10 15

Pro Gly Ser Ser Val Lys Val Ser Cys Lys Thr Glu Gly Gly Thr Phe Pro Gly Ser Ser Val Lys Val Ser Cys Lys Thr Glu Gly Gly Thr Phe

20 25 30 20 25 30

Ser Thr Tyr Val Ile Ser Trp Met Arg Gln Ala Pro Gly Gln Gly Leu Ser Thr Tyr Val Ile Ser Trp Met Arg Gln Ala Pro Gly Gln Gly Leu

35 40 45 35 40 45

Glu Trp Met Gly Gly Ile Val Pro Ile Phe Asn Thr Pro Asn Tyr Ala Glu Trp Met Gly Gly Ile Val Pro Ile Phe Asn Thr Pro Asn Tyr Ala

50 55 60 50 55 60

Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Arg Ser Thr Ser Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Arg Ser Thr Ser

65 70 75 80 65 70 75 80

Thr Ala Tyr Met Glu Leu Arg Ser Leu Gly Ser Glu Asp Thr Ala Val Thr Ala Tyr Met Glu Leu Arg Ser Leu Gly Ser Glu Asp Thr Ala Val

85 90 95 85 90 95

Tyr Tyr Cys Ala Arg Val Val Gly Gly Thr Arg Ser Tyr Tyr Ala Leu Tyr Tyr Cys Ala Arg Val Val Gly Gly Thr Arg Ser Tyr Tyr Ala Leu

100 105 110 100 105 110

Gly Phe Trp Gly Gln Gly Thr Thr Val Thr Val Ser Gly Phe Trp Gly Gln Gly Thr Thr Val Thr Val Ser

115 120 115 120

<210> 259 <210> 259

<211> 122 <211> 122

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 259 <400> 259

Gly Arg Ala Gln Val Thr Leu Lys Glu Ser-Gly Pro Thr Leu Val Lys Gly Arg Ala Gln Val Thr Leu Lys Glu Ser-Gly Pro Thr Leu Val Lys

1 5 10 15 1 5 10 15

Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu

20 25 30 20 25 30

Gly Thr Thr Gly Val Asn Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Thr Thr Gly Val Asn Val Gly Trp Ile Arg Gln Pro Pro Gly Lys

35 40 45 35 40 45

Ala Leu Glu Trp Leu Ala Leu Ile Ser Trp Gly Gly Gly Lys His Tyr Ala Leu Glu Trp Leu Ala Leu Ile Ser Trp Gly Gly Gly Lys His Tyr

50 55 60 50 55 60

Ser Pro Ser Leu Asn Ser Arg Ile Thr Leu Thr Lys Asp Ala Ser Arg Ser Pro Ser Leu Asn Ser Arg Ile Thr Leu Thr Lys Asp Ala Ser Arg

65 70 75 80 65 70 75 80

Glu Gln Val Val Val Leu Thr Met Ala Asn Met Asp Pro Val Asp Thr Glu Gln Val Val Val Leu Thr Met Ala Asn Met Asp Pro Val Asp Thr

85 90 95 85 90 95

Gly Arg Tyr Tyr Cys Ala Arg Ile Val Gly Thr His Gly Phe Asp Tyr Gly Arg Tyr Tyr Cys Ala Arg Ile Val Gly Thr His Gly Phe Asp Tyr

100 105 110 100 105 110

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser

115 120 115 120

<210> 260 <210> 260

<211> 124 <211> 124

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 260 <400> 260

Gly Arg Ala Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Arg Gly Arg Ala Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Arg

1 5 10 15 1 5 10 15

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe

20 25 30 20 25 30

Asp Glu Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Glu Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu

35 40 45 35 40 45

Glu Trp Val Ala Phe Ile Asn Trp Asn Gly Asp Ser Thr Tyr Tyr Ala Glu Trp Val Ala Phe Ile Asn Trp Asn Gly Asp Ser Thr Tyr Tyr Ala

50 55 60 50 55 60

Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Thr Asn Ala Lys Asn Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Thr Asn Ala Lys Asn

65 70 75 80 65 70 75 80

Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Phe Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Phe

85 90 95 85 90 95

Tyr Tyr Cys Ala Arg Asp Pro Arg Thr Lys Leu Gly Met Ser Tyr Phe Tyr Tyr Cys Ala Arg Asp Pro Arg Thr Lys Leu Gly Met Ser Tyr Phe

100 105 110 100 105 110

Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser

115 120 115 120

<210> 261 <210> 261

<211> 130 <211> 130

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 261 <400> 261

Gly Arg Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Gly Arg Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys

1 5 10 15 1 5 10 15

Pro Gly Glu Ser Leu Lys Ile Ser Cys Gln Ala Ser Gly Tyr Gly Phe Pro Gly Glu Ser Leu Lys Ile Ser Cys Gln Ala Ser Gly Tyr Gly Phe

20 25 30 20 25 30

Thr Val Tyr Trp Ile Gly Trp Val Arg Gln Leu Pro Gly Lys Gly Leu Thr Val Tyr Trp Ile Gly Trp Val Arg Gln Leu Pro Gly Lys Gly Leu

35 40 45 35 40 45

Glu Trp Leu Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Asn Glu Trp Leu Gly Ile Ile Tyr Pro Gly Asp Ser Asp Thr Arg Tyr Asn

50 55 60 50 55 60

Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Val Ser Pro Ser Phe Gln Gly Gln Val Thr Ile Ser Ala Asp Lys Ser Val Ser

65 70 75 80 65 70 75 80

Thr Thr Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile Thr Thr Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Ile

85 90 95 85 90 95

Tyr Tyr Cys Ala Arg His Leu Asp Ser Tyr Asp Val Phe Thr Gly Tyr Tyr Tyr Cys Ala Arg His Leu Asp Ser Tyr Asp Val Phe Thr Gly Tyr

100 105 110 100 105 110

Asn Leu Gly Gly Tyr Met Asp Val Trp Gly Lys Gly Thr Met Val Thr Asn Leu Gly Gly Tyr Met Asp Val Trp Gly Lys Gly Thr Met Val Thr

115 120 125 115 120 125

Val Ser Val Ser

130 130

<210> 262 <210> 262

<211> 123 <211> 123

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 262 <400> 262

Gly Arg Ala Glu Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys Gly Arg Ala Glu Val Gln Leu Val Gln Ser Gly Pro Glu Val Lys Lys

1 5 10 15 1 5 10 15

Pro Gly Ala Ser Val Arg Val Ser Cys Lys Ala Ser Gly Tyr Ser Leu Pro Gly Ala Ser Val Arg Val Ser Cys Lys Ala Ser Gly Tyr Ser Leu

20 25 30 20 25 30

Lys Asn Tyr Gly Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Lys Asn Tyr Gly Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu

35 40 45 35 40 45

Glu Trp Met Gly Trp Ile Ser Ala Asp Asn Gly Asp Thr Thr Thr Ala Glu Trp Met Gly Trp Ile Ser Ala Asp Asn Gly Asp Thr Thr Thr Ala

50 55 60 50 55 60

Leu Asn Leu Arg Gly Arg Val Ser Met Thr Thr Asp Thr Ser Thr Asn Leu Asn Leu Arg Gly Arg Val Ser Met Thr Thr Asp Thr Ser Thr Asn

65 70 75 80 65 70 75 80

Thr Val Tyr Met Glu Val Lys Ser Leu Arg Ser Asp Asp Thr Ala Ile Thr Val Tyr Met Glu Val Lys Ser Leu Arg Ser Asp Asp Thr Ala Ile

85 90 95 85 90 95

Tyr Phe Cys Ala Arg Asp Phe Tyr Ser Gly Ser Tyr Arg Ser Phe Asp Tyr Phe Cys Ala Arg Asp Phe Tyr Ser Gly Ser Tyr Arg Ser Phe Asp

100 105 110 100 105 110

Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser

115 120 115 120

<210> 263 <210> 263

<211> 126 <211> 126

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 263 <400> 263

Gly Arg Ala Glu Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Lys Gly Arg Ala Glu Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Lys

1 5 10 15 1 5 10 15

Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Ala Ser Val Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Ala Ser Val

20 25 30 20 25 30

Ser Gly Gly Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Ser Gly Gly Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys

35 40 45 35 40 45

Ala Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ile Gly Ser Thr Asn Tyr Ala Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ile Gly Ser Thr Asn Tyr

50 55 60 50 55 60

Asn Pro Ser Leu Lys Ser Arg Leu Ser Leu Ser Val Asp Thr Ala Lys Asn Pro Ser Leu Lys Ser Arg Leu Ser Leu Ser Val Asp Thr Ala Lys

65 70 75 80 65 70 75 80

Ser Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ser Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala

85 90 95 85 90 95

Ile Tyr Phe Cys Ala Arg Ala Arg Arg Thr Tyr Ser Gly Tyr Asp Ser Ile Tyr Phe Cys Ala Arg Ala Arg Arg Thr Tyr Ser Gly Tyr Asp Ser

100 105 110 100 105 110

Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser

115 120 125 115 120 125

<210> 264 <210> 264

<211> 124 <211> 124

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 264 <400> 264

Gly Arg Ala Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Gly Arg Ala Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys

1 5 10 15 1 5 10 15

Pro Ser Glu Thr Leu Pro Leu Thr Cys Thr Val Ser Gly Gly Ser Phe Pro Ser Glu Thr Leu Pro Leu Thr Cys Thr Val Ser Gly Gly Ser Phe

20 25 30 20 25 30

Ser Thr Tyr Tyr Trp Ser Trp Ile Arg Gln Ser Pro Glu Lys Gly Leu Ser Thr Tyr Tyr Trp Ser Trp Ile Arg Gln Ser Pro Glu Lys Gly Leu

35 40 45 35 40 45

Glu Trp Ile Gly Tyr Ile Gln Asn Ser Val Asn Thr Asn Tyr Asn Pro Glu Trp Ile Gly Tyr Ile Gln Asn Ser Val Asn Thr Asn Tyr Asn Pro

50 55 60 50 55 60

Ser Leu Lys Ser Arg Val Ile Ile Ser Val Asp Thr Ser Asn Asn Gln Ser Leu Lys Ser Arg Val Ile Ile Ser Val Asp Thr Ser Asn Asn Gln

65 70 75 80 65 70 75 80

Phe Ser Leu Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Ser Leu Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr

85 90 95 85 90 95

Tyr Cys Ala Arg Val Ser Gly Trp Gly Pro Arg Gly Gly Ile Tyr Phe Tyr Cys Ala Arg Val Ser Gly Trp Gly Pro Arg Gly Gly Ile Tyr Phe

100 105 110 100 105 110

Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser

115 120 115 120

<210> 265 <210> 265

<211> 126 <211> 126

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 265 <400> 265

Gly Arg Ala Lys Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Gly Arg Ala Lys Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys

1 5 10 15 1 5 10 15

Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ser Ser Gly Gly Tyr Val Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ser Ser Gly Gly Tyr Val

20 25 30 20 25 30

Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly

35 40 45 35 40 45

Gly Ile Ile Ser Asn Phe His Thr Ala Glu Tyr Ala Gln Lys Phe Gln Gly Ile Ile Ser Asn Phe His Thr Ala Glu Tyr Ala Gln Lys Phe Gln

50 55 60 50 55 60

Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Asn Thr Ile Tyr Met Gly Arg Val Thr Met Thr Ala Asp Thr Ser Thr Asn Thr Ile Tyr Met

65 70 75 80 65 70 75 80

Glu Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys Val Glu Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys Val

85 90 95 85 90 95

Ser Ala Pro Arg Asp Thr Ser Thr Ile Ala Ala Arg Phe Asn Arg Tyr Ser Ala Pro Arg Asp Thr Ser Thr Ile Ala Ala Arg Phe Asn Arg Tyr

100 105 110 100 105 110

Phe Phe Asp Thr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Phe Phe Asp Thr Trp Gly Gln Gly Thr Leu Val Thr Val Ser

115 120 125 115 120 125

<210> 266 <210> 266

<211> 126 <211> 126

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 266 <400> 266

Gly Arg Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Gly Arg Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys

1 5 10 15 1 5 10 15

Pro Gly Thr Ser Val Arg Val Ser Arg Lys Thr Pro Gly Gly Tyr Val Pro Gly Thr Ser Val Arg Val Ser Arg Lys Thr Pro Gly Gly Tyr Val

20 25 30 20 25 30

Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met Gly Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Pro Glu Trp Met Gly

35 40 45 35 40 45

Gly Ile Ile Thr Asn Phe Gly Thr Thr Asn Tyr Ala Arg Lys Phe Gln Gly Ile Ile Thr Asn Phe Gly Thr Thr Asn Tyr Ala Arg Lys Phe Gln

50 55 60 50 55 60

Gly Arg Ile Thr Val Thr Ala Asp Lys Ser Thr Asn Thr Val Tyr Met Gly Arg Ile Thr Val Thr Ala Asp Lys Ser Thr Asn Thr Val Tyr Met

65 70 75 80 65 70 75 80

Asp Leu Ser Asn Leu Ala Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Asp Leu Ser Asn Leu Ala Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala

85 90 95 85 90 95

Arg Ala Pro Arg Gly Thr Ser Thr Ile Ala Ala Arg Phe Asn Arg Tyr Arg Ala Pro Arg Gly Thr Ser Thr Ile Ala Ala Arg Phe Asn Arg Tyr

100 105 110 100 105 110

Phe Phe Asp Ser Trp Ser Gln Gly Thr Leu Val Thr Val Ser Phe Phe Asp Ser Trp Ser Gln Gly Thr Leu Val Thr Val Ser

115 120 125 115 120 125

<210> 267 <210> 267

<211> 124 <211> 124

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 267 <400> 267

Gly Arg Ala Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Gly Arg Ala Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys

1 5 10 15 1 5 10 15

Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Phe

20 25 30 20 25 30

Ser Thr Tyr Ile Phe Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Ser Thr Tyr Ile Phe Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu

35 40 45 35 40 45

Glu Trp Met Gly Gly Ile Asn Pro Ile Phe Ala Thr Arg Asp Tyr Pro Glu Trp Met Gly Gly Ile Asn Pro Ile Phe Ala Thr Arg Asp Tyr Pro

50 55 60 50 55 60

Lys Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Lys Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg

65 70 75 80 65 70 75 80

Thr Val Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Thr Val Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val

85 90 95 85 90 95

Tyr Tyr Cys Ala Arg Val Leu Gly Gly Thr Arg Leu Tyr Tyr Ala Leu Tyr Tyr Cys Ala Arg Val Leu Gly Gly Thr Arg Leu Tyr Tyr Ala Leu

100 105 110 100 105 110

Asn Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Asn Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser

115 120 115 120

<210> 268 <210> 268

<211> 124 <211> 124

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 268 <400> 268

Gly Arg Ala Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Arg Gly Arg Ala Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Arg

1 5 10 15 1 5 10 15

Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe

20 25 30 20 25 30

Asp Glu Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Asp Glu Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu

35 40 45 35 40 45

Lys Trp Val Ala Phe Ile Asn Trp Asn Gly Asp Ser Thr Tyr Tyr Ala Lys Trp Val Ala Phe Ile Asn Trp Asn Gly Asp Ser Thr Tyr Tyr Ala

50 55 60 50 55 60

Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Ser Asn Ala Lys Asn Asp Ser Val Lys Gly Arg Phe Thr Val Ser Arg Ser Asn Ala Lys Asn

65 70 75 80 65 70 75 80

Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Phe Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Phe

85 90 95 85 90 95

Tyr Cys Cys Ala Arg Asp Pro Arg Thr Lys Leu Gly Met Ser Tyr Phe Tyr Cys Cys Ala Arg Asp Pro Arg Thr Lys Leu Gly Met Ser Tyr Phe

100 105 110 100 105 110

Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser

115 120 115 120

<210> 269 <210> 269

<211> 124 <211> 124

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 269 <400> 269

Gly Arg Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Gly Arg Ala Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys

1 5 10 15 1 5 10 15

Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Phe

20 25 30 20 25 30

Ser Thr Tyr Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Ser Thr Tyr Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu

35 40 45 35 40 45

Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Ala Ser Arg Asp Tyr Ala Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Ala Ser Arg Asp Tyr Ala

50 55 60 50 55 60

Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg

65 70 75 80 65 70 75 80

Thr Val Tyr Met Glu Pro Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Thr Val Tyr Met Glu Pro Arg Ser Leu Arg Ser Glu Asp Thr Ala Val

85 90 95 85 90 95

Tyr Tyr Cys Ala Arg Val Leu Gly Gly Thr Arg Leu Tyr Tyr Ala Leu Tyr Tyr Cys Ala Arg Val Leu Gly Gly Thr Arg Leu Tyr Tyr Ala Leu

100 105 110 100 105 110

Asn Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Asn Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser

115 120 115 120

<210> 270 <210> 270

<211> 126 <211> 126

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 270 <400> 270

Gly Arg Ala Glu Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Lys Gly Arg Ala Glu Val Gln Leu Val Gln Ser Gly Pro Gly Leu Val Lys

1 5 10 15 1 5 10 15

Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Ala Ser Val Pro Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Ala Ser Val

20 25 30 20 25 30

Ser Gly Gly Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Ser Gly Gly Asp Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys

35 40 45 35 40 45

Ala Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ile Gly Ser Thr Asn Tyr Ala Leu Glu Trp Ile Gly Tyr Ile Tyr Tyr Ile Gly Ser Thr Asn Tyr

50 55 60 50 55 60

Asn Pro Ser Leu Lys Ser Arg Leu Ser Leu Ser Val Asp Thr Ala Lys Asn Pro Ser Leu Lys Ser Arg Leu Ser Leu Ser Val Asp Thr Ala Lys

65 70 75 80 65 70 75 80

Ser Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ser Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala

85 90 95 85 90 95

Thr Tyr Phe Cys Ala Arg Ala Arg Arg Thr Tyr Ser Gly Tyr Asp Ser Thr Tyr Phe Cys Ala Arg Ala Arg Arg Thr Tyr Ser Gly Tyr Asp Ser

100 105 110 100 105 110

Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser

115 120 125 115 120 125

<210> 271 <210> 271

<211> 124 <211> 124

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 271 <400> 271

Gly Arg Ala Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Gly Arg Ala Glu Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys

1 5 10 15 1 5 10 15

Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Phe Pro Gly Ser Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Ser Phe

20 25 30 20 25 30

Ser Thr Tyr Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Ser Thr Tyr Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu

35 40 45 35 40 45

Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Ala Ser Arg Asp Tyr Ala Glu Trp Met Gly Gly Ile Ile Pro Ile Phe Ala Ser Arg Asp Tyr Ala

50 55 60 50 55 60

Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Arg

65 70 75 80 65 70 75 80

Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Thr Val Tyr Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val

85 90 95 85 90 95

Tyr Tyr Cys Ala Arg Val Leu Gly Gly Thr Arg Leu Tyr Tyr Ala Leu Tyr Tyr Cys Ala Arg Val Leu Gly Gly Thr Arg Leu Tyr Tyr Ala Leu

100 105 110 100 105 110

Asn Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Asn Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser

115 120 115 120

<210> 272 <210> 272

<211> 123 <211> 123

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 272 <400> 272

Gly Arg Ala Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Val Val Lys Gly Arg Ala Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Val Val Lys

1 5 10 15 1 5 10 15

Pro Thr Gln Thr Leu Thr Leu Thr Cys Ser Leu Ser Gly Phe Ala Leu Pro Thr Gln Thr Leu Thr Leu Thr Cys Ser Leu Ser Gly Phe Ala Leu

20 25 30 20 25 30

Gly Thr Thr Gly Val Ala Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Thr Thr Gly Val Ala Val Gly Trp Ile Arg Gln Pro Pro Gly Lys

35 40 45 35 40 45

Ala Leu Glu Trp Leu Gly Leu Ile Asp Trp Asn Asp Asp Arg Arg Tyr Ala Leu Glu Trp Leu Gly Leu Ile Asp Trp Asn Asp Asp Arg Arg Tyr

50 55 60 50 55 60

Arg Pro Ser Leu Lys Thr Arg Leu Thr Ile Thr Gln Asp Met Ser Arg Arg Pro Ser Leu Lys Thr Arg Leu Thr Ile Thr Gln Asp Met Ser Arg

65 70 75 80 65 70 75 80

Asn Gln Val Val Leu Arg Leu Thr Asn Leu Asp Pro Leu Asp Thr Gly Asn Gln Val Val Leu Arg Leu Thr Asn Leu Asp Pro Leu Asp Thr Gly

85 90 95 85 90 95

Thr Tyr Phe Cys Ala Arg Ser Val Val Pro Ala Thr Arg Ala Phe Asp Thr Tyr Phe Cys Ala Arg Ser Val Val Pro Ala Thr Arg Ala Phe Asp

100 105 110 100 105 110

Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser

115 120 115 120

<210> 273 <210> 273

<211> 122 <211> 122

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<220> <220>

<221> Miješana karakteristika <221> Mixed characteristic

<222> (52)..(52) <222> (52)..(52)

<223> Xaa odgovara stop kodonu <223> Xaa corresponds to the stop codon

<400> 273 <400> 273

Gly Arg Ala Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys Gly Arg Ala Gln Val Thr Leu Lys Glu Ser Gly Pro Thr Leu Val Lys

1 5 10 15 1 5 10 15

Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Leu Ser Gly Phe Ser Leu Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Leu Ser Gly Phe Ser Leu

20 25 30 20 25 30

Tyr Thr Thr Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Tyr Thr Thr Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys

35 40 45 35 40 45

Ala Leu Glu Xaa Leu Ala Arg Ile Tyr Trp Asp Asp Asp Glu Arg Tyr Ala Leu Glu Xaa Leu Ala Arg Ile Tyr Trp Asp Asp Asp Glu Arg Tyr

50 55 60 50 55 60

Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Ala Ser Lys Asn Pro Ser Leu Lys Ser Arg Leu Thr Ile Thr Lys Asp Ala Ser Lys

65 70 75 80 65 70 75 80

Asn Gln Val Val Leu Lys Met Thr Asn Met Asp Pro Val Asp Thr Ala Asn Gln Val Val Leu Lys Met Thr Asn Met Asp Pro Val Asp Thr Ala

85 90 95 85 90 95

Thr Tyr Tyr Cys Ala Arg Thr Met Gly Val Val Leu Pro Phe Asp Tyr Thr Tyr Tyr Cys Ala Arg Thr Met Gly Val Val Leu Pro Phe Asp Tyr

100 105 110 100 105 110

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser

115 120 115 120

<210> 274 <210> 274

<211> 109 <211> 109

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 274 <400> 274

Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Leu Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln His Ile Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln His Ile Ser

20 25 30 20 25 30

Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu

35 40 45 35 40 45

Leu Ile Cys Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Leu Ile Cys Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe

50 55 60 50 55 60

Thr Gly Ser Gly Ser Gly Ala Asp Tyr Thr Leu Thr Ile Ser Ser Leu Thr Gly Ser Gly Ser Gly Ala Asp Tyr Thr Leu Thr Ile Ser Ser Leu

65 70 75 80 65 70 75 80

Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr

85 90 95 85 90 95

Ser Trp Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys Ser Trp Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys

100 105 100 105

<210> 275 <210> 275

<211> 109 <211> 109

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 275 <400> 275

Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser

20 25 30 20 25 30

Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Lys Leu

35 40 45 35 40 45

Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe

50 55 60 50 55 60

Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu

65 70 75 80 65 70 75 80

Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asn Ser Ala

85 90 95 85 90 95

Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys

100 105 100 105

<210> 276 <210> 276

<211> 109 <211> 109

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 276 <400> 276

Leu Ala Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Ala Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Leu Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln His Ile Ser Leu Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Gln His Ile Ser

20 25 30 20 25 30

Asn Tyr Ile Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Asn Tyr Ile Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu

35 40 45 35 40 45

Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe

50 55 60 50 55 60

Thr Gly Ser Gly Ser Gly Ala Asp Tyr Thr Leu Thr Ile Thr Ser Leu Thr Gly Ser Gly Ser Gly Ala Asp Tyr Thr Leu Thr Ile Thr Ser Leu

65 70 75 80 65 70 75 80

Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Gly Thr Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Gly Thr

85 90 95 85 90 95

Ser Trp Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys Ser Trp Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys

100 105 100 105

<210> 277 <210> 277

<211> 109 <211> 109

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 277 <400> 277

Leu Ala Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Ala Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Thr Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Thr

20 25 30 20 25 30

Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu

35 40 45 35 40 45

Leu Ile Tyr Asp Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg Phe Leu Ile Tyr Asp Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg Phe

50 55 60 50 55 60

Ser Gly Ser Gly Ser Val Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Ser Gly Ser Gly Ser Val Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu

65 70 75 80 65 70 75 80

Arg Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Gly Pro Arg Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Gly Pro

85 90 95 85 90 95

Val Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Val Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys

100 105 100 105

<210> 278 <210> 278

<211> 109 <211> 109

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 278 <400> 278

Leu Ala Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Ala Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Val Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Pro Ile Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Pro Ile Ser

20 25 30 20 25 30

Thr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ile Thr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ile

35 40 45 35 40 45

Leu Ile Phe Gly Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Leu Ile Phe Gly Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe

50 55 60 50 55 60

Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Thr Ser Leu Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Thr Ser Leu

65 70 75 80 65 70 75 80

Gln Pro Glu Asp Phe Ala Thr Tyr Ile Cys Gln Gln Ser Lys Ser Pro Gln Pro Glu Asp Phe Ala Thr Tyr Ile Cys Gln Gln Ser Lys Ser Pro

85 90 95 85 90 95

Pro Tyr Asn Phe Gly Arg Gly Thr Lys Leu Glu Ile Lys Pro Tyr Asn Phe Gly Arg Gly Thr Lys Leu Glu Ile Lys

100 105 100 105

<210> 279 <210> 279

<211> 110 <211> 110

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 279 <400> 279

Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly

20 25 30 20 25 30

Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu

35 40 45 35 40 45

Leu Ile Tyr Lys Ala Ser Thr Leu Gln Ser Glu Thr Pro Ser Arg Phe Leu Ile Tyr Lys Ala Ser Thr Leu Gln Ser Glu Thr Pro Ser Arg Phe

50 55 60 50 55 60

Arg Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Arg Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu

65 70 75 80 65 70 75 80

Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Phe Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Phe

85 90 95 85 90 95

Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Phe Lys Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Phe Lys

100 105 110 100 105 110

<210> 280 <210> 280

<211> 109 <211> 109

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 280 <400> 280

Leu Ala Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Ala Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn

20 25 30 20 25 30

Ile Asn Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu Ile Asn Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Asn Leu

35 40 45 35 40 45

Leu Ile Tyr Ser Ala Ser Thr Leu Gln Thr Gly Val Pro Ser Arg Phe Leu Ile Tyr Ser Ala Ser Thr Leu Gln Thr Gly Val Pro Ser Arg Phe

50 55 60 50 55 60

Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu

65 70 75 80 65 70 75 80

Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ile Tyr Ser His Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ile Tyr Ser His

85 90 95 85 90 95

Val Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Val Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys

100 105 100 105

<210> 281 <210> 281

<211> 115 <211> 115

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 281 <400> 281

Leu Ala Asp Val Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Ala Asp Val Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser

1 5 10 15 1 5 10 15

Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu

20 25 30 20 25 30

Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro

35 40 45 35 40 45

Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser

50 55 60 50 55 60

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr

65 70 75 80 65 70 75 80

Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys

85 90 95 85 90 95

Gln Gln Tyr Tyr Ser Thr Pro Pro Met Phe Gly Gln Gly Thr Lys Val Gln Gln Tyr Tyr Ser Thr Pro Pro Met Phe Gly Gln Gly Thr Lys Val

100 105 110 100 105 110

Glu Ile Lys Glu Ile Lys

115 115

<210> 282 <210> 282

<211> 109 <211> 109

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 282 <400> 282

Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Val Gly Asp Arg Ile Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Thr Val Gly Asp Arg Ile Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Thr

20 25 30 20 25 30

Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu

35 40 45 35 40 45

Leu Ile Tyr Asp Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg Phe Leu Ile Tyr Asp Ala Ser Asn Leu Gln Pro Gly Val Pro Ser Arg Phe

50 55 60 50 55 60

Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Ser Gly Ser Arg Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu

65 70 75 80 65 70 75 80

Arg Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Gly Pro Arg Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asp Gly Pro

85 90 95 85 90 95

Val Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Val Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys

100 105 100 105

<210> 283 <210> 283

<211> 115 <211> 115

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 283 <400> 283

Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser

1 5 10 15 1 5 10 15

Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu

20 25 30 20 25 30

Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro

35 40 45 35 40 45

Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser

50 55 60 50 55 60

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr

65 70 75 80 65 70 75 80

Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys

85 90 95 85 90 95

Gln Gln Tyr Tyr Ser Thr Pro Pro Met Phe Gly Gln Gly Thr Lys Val Gln Gln Tyr Tyr Ser Thr Pro Pro Met Phe Gly Gln Gly Thr Lys Val

100 105 110 100 105 110

Glu Ile Lys Glu Ile Lys

115 115

<210> 284 <210> 284

<211> 110 <211> 110

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 284 <400> 284

Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly

20 25 30 20 25 30

Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu

35 40 45 35 40 45

Leu Ile Ser Gly Ala Ser Thr Leu Gln Ser Trp Val Pro Ser Arg Phe Leu Ile Ser Gly Ala Ser Thr Leu Gln Ser Trp Val Pro Ser Arg Phe

50 55 60 50 55 60

Ser Gly Arg Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Ser Gly Arg Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu

65 70 75 80 65 70 75 80

Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Arg Tyr Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Arg Tyr

85 90 95 85 90 95

Pro Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Pro Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys

100 105 110 100 105 110

<210> 285 <210> 285

<211> 109 <211> 109

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 285 <400> 285

Leu Ala Glu Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Ala Glu Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Val Gly Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser

20 25 30 20 25 30

Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Lys Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu

35 40 45 35 40 45

Leu Ile Tyr Glu Ala Ser Asn Leu Glu Thr Gly Val Pro Pro Arg Phe Leu Ile Tyr Glu Ala Ser Asn Leu Glu Thr Gly Val Pro Pro Arg Phe

50 55 60 50 55 60

Ser Gly Ser Gly Ser Gly Thr His Phe Thr Phe Thr Ile Thr Gly Leu Ser Gly Ser Gly Ser Gly Thr His Phe Thr Phe Thr Ile Thr Gly Leu

65 70 75 80 65 70 75 80

Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Cys Asp Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Cys Asp Ser Leu

85 90 95 85 90 95

Pro Pro Val Phe Gly Gln Gly Thr Lys Leu Glu Val Lys Pro Pro Val Phe Gly Gln Gly Thr Lys Leu Glu Val Lys

100 105 100 105

<210> 286 <210> 286

<211> 110 <211> 110

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<220> <220>

<221> Miješana karakteristika <221> Mixed characteristic

<222> (93)..(93) <222> (93)..(93)

<223> Xaa odgovara stop kodonu <223> Xaa corresponds to the stop codon

<400> 286 <400> 286

Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ala Leu Ser Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ala Leu Ser

1 5 10 15 1 5 10 15

Pro Gly Asp Arg Ala Thr Leu Ser Cys Gly Ala Ser Gln Ser Val Phe Pro Gly Asp Arg Ala Thr Leu Ser Cys Gly Ala Ser Gln Ser Val Phe

20 25 30 20 25 30

Gly Asp Phe Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Gly Asp Phe Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg

35 40 45 35 40 45

Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg

50 55 60 50 55 60

Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg

65 70 75 80 65 70 75 80

Leu Glu Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Xaa Tyr Gly Asp Leu Glu Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Xaa Tyr Gly Asp

85 90 95 85 90 95

Ser Val Phe Thr Phe Gly Gln Gly Thr Lys Leu Gly Ile Lys Ser Val Phe Thr Phe Gly Gln Gly Thr Lys Leu Gly Ile Lys

100 105 110 100 105 110

<210> 287 <210> 287

<211> 110 <211> 110

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 287 <400> 287

Leu Ala Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ala Leu Ser Leu Ala Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ala Leu Ser

1 5 10 15 1 5 10 15

Pro Gly Asp Arg Ala Thr Leu Ser Cys Gly Ala Ser Gln Ser Val Phe Pro Gly Asp Arg Ala Thr Leu Ser Cys Gly Ala Ser Gln Ser Val Phe

20 25 30 20 25 30

Gly Asp Phe Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Gly Asp Phe Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg

35 40 45 35 40 45

Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg

50 55 60 50 55 60

Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg

65 70 75 80 65 70 75 80

Leu Glu Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Asp Leu Glu Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Asp

85 90 95 85 90 95

Ser Val Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ser Val Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys

100 105 110 100 105 110

<210> 288 <210> 288

<211> 110 <211> 110

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<220> <220>

<221> Miješana karakteristika <221> Mixed characteristic

<222> (45)..(45) <222> (45)..(45)

<223> Xaa odgovara stop kodonu <223> Xaa corresponds to the stop codon

<400> 288 <400> 288

Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser

1 5 10 15 1 5 10 15

Pro Gly Gln Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Pro Gly Gln Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn

20 25 30 20 25 30

Arg Asp Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Xaa Ala Pro Arg Arg Asp Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Xaa Ala Pro Arg

35 40 45 35 40 45

Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg

50 55 60 50 55 60

Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg

65 70 75 80 65 70 75 80

Leu Glu Arg Asp Asp Phe Ala Val Tyr Phe Cys His Gln Tyr Gly Ser Leu Glu Arg Asp Asp Phe Ala Val Tyr Phe Cys His Gln Tyr Gly Ser

85 90 95 85 90 95

Ser Pro Asn Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ser Pro Asn Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys

100 105 110 100 105 110

<210> 289 <210> 289

<211> 110 <211> 110

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 289 <400> 289

Leu Ala Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Leu Ala Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser

1 5 10 15 1 5 10 15

Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser

20 25 30 20 25 30

Thr Asn Tyr Leu Ala Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Arg Thr Asn Tyr Leu Ala Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Arg

35 40 45 35 40 45

Leu Leu Ile His Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Leu Leu Ile His Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg

50 55 60 50 55 60

Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg

65 70 75 80 65 70 75 80

Leu Glu Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Ser

85 90 95 85 90 95

Ser Pro Gln Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Pro Gln Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys

100 105 110 100 105 110

<210> 290 <210> 290

<211> 109 <211> 109

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 290 <400> 290

Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Val Gly Asp Arg Val Thr Thr Thr Cys Arg Thr Ser Gln Ser Ile Phe Val Gly Asp Arg Val Thr Thr Thr Cys Arg Thr Ser Gln Ser Ile Phe

20 25 30 20 25 30

Ile Asn Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Ile Asn Leu Asn Trp Phe Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu

35 40 45 35 40 45

Leu Ile Tyr Ser Ala Ser Thr Leu Gln Thr Gly Val Pro Ser Arg Phe Leu Ile Tyr Ser Ala Ser Thr Leu Gln Thr Gly Val Pro Ser Arg Phe

50 55 60 50 55 60

Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu

65 70 75 80 65 70 75 80

Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ile Tyr Ser Gln Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ile Tyr Ser Gln

85 90 95 85 90 95

Val Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Val Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys

100 105 100 105

<210> 291 <210> 291

<211> 110 <211> 110

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 291 <400> 291

Leu Ala Asp Ile Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Leu Ala Asp Ile Gln Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser

1 5 10 15 1 5 10 15

Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn

20 25 30 20 25 30

Ser Asp Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ser Asp Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg

35 40 45 35 40 45

Leu Leu Met Ser Gly Ala Thr Ser Arg Ala Thr Asp Val Pro Asp Arg Leu Leu Met Ser Gly Ala Thr Ser Arg Ala Thr Asp Val Pro Asp Arg

50 55 60 50 55 60

Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg

65 70 75 80 65 70 75 80

Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Gly Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Gly Ser

85 90 95 85 90 95

Ser Asp Asn Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ser Asp Asn Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys

100 105 110 100 105 110

<210> 292 <210> 292

<211> 110 <211> 110

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 292 <400> 292

Leu Ala Asp Val Val Met Thr Gln Phe Pro Ser Ser Leu Ser Ala Ser Leu Ala Asp Val Val Met Thr Gln Phe Pro Ser Ser Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser

20 25 30 20 25 30

Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Glu Leu Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Glu Leu

35 40 45 35 40 45

Leu Ile Tyr Gly Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Leu Ile Tyr Gly Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe

50 55 60 50 55 60

Ser Gly Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Asn Ser Leu Ser Gly Ser Gly Ser Gly Ala Glu Phe Thr Leu Thr Ile Asn Ser Leu

65 70 75 80 65 70 75 80

Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asp Ser Gly Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asp Ser Gly

85 90 95 85 90 95

Leu Arg Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Leu Arg Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys

100 105 110 100 105 110

<210> 293 <210> 293

<211> 110 <211> 110

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 293 <400> 293

Leu Ala Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Ala Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser

20 25 30 20 25 30

Asn Phe Leu Ala Trp His Gln Gln Lys Pro Gly Gln Val Pro Lys Leu Asn Phe Leu Ala Trp His Gln Gln Lys Pro Gly Gln Val Pro Lys Leu

35 40 45 35 40 45

Leu Ile Tyr Gly Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Leu Ile Tyr Gly Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe

50 55 60 50 55 60

Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Gly Leu

65 70 75 80 65 70 75 80

Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asp Ser Gly Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asp Ser Gly

85 90 95 85 90 95

Leu Ile Phe Thr Phe Gly Pro Gly Thr Arg Val Glu Ile Lys Leu Ile Phe Thr Phe Gly Pro Gly Thr Arg Val Glu Ile Lys

100 105 110 100 105 110

<210> 294 <210> 294

<211> 115 <211> 115

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 294 <400> 294

Leu Ala Asp Val Val Met Thr Gln Ser Pro Asp Ser Leu.Ala Val Ser Leu Ala Asp Val Val Met Thr Gln Ser Pro Asp Ser Leu.Ala Val Ser

1 5 10 15 1 5 10 15

Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu

20 25 30 20 25 30

Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro

35 40 45 35 40 45

Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser

50 55 60 50 55 60

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr

65 70 75 80 65 70 75 80

Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys

85 90 95 85 90 95

Gln Gln Tyr Tyr Ser Thr Pro Pro Met Leu Gly Gln Gly Thr Lys Val Gln Gln Tyr Tyr Ser Thr Pro Pro Met Leu Gly Gln Gly Thr Lys Val

100 105 110 100 105 110

Glu Ile Lys Glu Ile Lys

115 115

<210> 295 <210> 295

<211> 110 <211> 110

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<220> <220>

<221> Miješana karakteristika <221> Mixed characteristic

<222> (8)..(8) <222> (8)..(8)

<223> Xaa odgovara stop kodonu <223> Xaa corresponds to the stop codon

<400> 295 <400> 295

Leu Ala Asp Val Val Met Thr Xaa Ser Pro Gly Thr Leu Ala Leu Ser Leu Ala Asp Val Val Met Thr Xaa Ser Pro Gly Thr Leu Ala Leu Ser

1 5 10 15 1 5 10 15

Pro Gly Asp Arg Ala Thr Leu Ser Cys Gly Ala Ser Gln Ser Val Phe Pro Gly Asp Arg Ala Thr Leu Ser Cys Gly Ala Ser Gln Ser Val Phe

20 25 30 20 25 30

Gly Asp Phe Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Gly Asp Phe Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg

35 40 45 35 40 45

Leu Leu Ile Tyr Val Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Leu Leu Ile Tyr Val Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg

50 55 60 50 55 60

Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg

65 70 75 80 65 70 75 80

Leu Glu Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Asp Leu Glu Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Asp

85 90 95 85 90 95

Ser Val Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Arg Ser Val Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Arg

100 105 110 100 105 110

<210> 296 <210> 296

<211> 110 <211> 110

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 296 <400> 296

Leu Ala Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Leu Ala Glu Thr Thr Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser

1 5 10 15 1 5 10 15

Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser

20 25 30 20 25 30

Thr Asn Tyr Leu Ala Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Arg Thr Asn Tyr Leu Ala Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Arg

35 40 45 35 40 45

Leu Leu Ile His Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Leu Leu Ile His Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg

50 55 60 50 55 60

Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg

65 70 75 80 65 70 75 80

Leu Glu Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Ser

85 90 95 85 90 95

Ser Pro Gln Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Pro Gln Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys

100 105 110 100 105 110

<210> 297 <210> 297

<211> 110 <211> 110

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 297 <400> 297

Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser

1 5 10 15 1 5 10 15

Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Arg Ser Val Asn Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Arg Ser Val Asn

20 25 30 20 25 30

Ser Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro Asp Gln Ala Pro Arg Ser Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro Asp Gln Ala Pro Arg

35 40 45 35 40 45

Leu Leu Met Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Leu Leu Met Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg

50 55 60 50 55 60

Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg

65 70 75 80 65 70 75 80

Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Gly Ala Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Gly Ala

85 90 95 85 90 95

Ser Asp Asn Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ser Asp Asn Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys

100 105 110 100 105 110

<210> 298 <210> 298

<211> 109 <211> 109

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 298 <400> 298

Leu Ala Glu Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Leu Ala Glu Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ile Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ile

20 25 30 20 25 30

Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Val Thr Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Val

35 40 45 35 40 45

Leu Ile Phe Gly Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Leu Ile Phe Gly Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe

50 55 60 50 55 60

Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu

65 70 75 80 65 70 75 80

Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ile Ile Arg Tyr Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ile Ile Arg Tyr

85 90 95 85 90 95

Pro Arg Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Pro Arg Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys

100 105 100 105

<210> 299 <210> 299

<211> 110 <211> 110

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 299 <400> 299

Leu Ala Asp Val Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Leu Ala Asp Val Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser

1 5 10 15 1 5 10 15

Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn

20 25 30 20 25 30

Ser Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ser Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg

35 40 45 35 40 45

Leu Leu Val Ser Gly Ala Thr Asn Arg Ala Thr Asp Ile Pro Asp Arg Leu Leu Val Ser Gly Ala Thr Asn Arg Ala Thr Asp Ile Pro Asp Arg

50 55 60 50 55 60

Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg

65 70 75 80 65 70 75 80

Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Gly Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Gly Ser

85 90 95 85 90 95

Ser Glu Asn Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Arg Ser Glu Asn Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Arg

100 105 110 100 105 110

<210> 300 <210> 300

<211> 109 <211> 109

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 300 <400> 300

Leu Ala Glu Ile Val Met Thr Gln Ser Pro Pro Phe Leu Ser Ala Ser Leu Ala Glu Ile Val Met Thr Gln Ser Pro Pro Phe Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Leu Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Leu Ser

20 25 30 20 25 30

Thr Tyr Leu Ala Trp Tyr Gln Val Lys Pro Gly Lys Ala Pro Lys Leu Thr Tyr Leu Ala Trp Tyr Gln Val Lys Pro Gly Lys Ala Pro Lys Leu

35 40 45 35 40 45

Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Leu Ile Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe

50 55 60 50 55 60

Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Asn Ser Leu Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Asn Ser Leu

65 70 75 80 65 70 75 80

Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asp Thr Tyr Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asp Thr Tyr

85 90 95 85 90 95

Pro Leu Thr Leu Gly Gly Gly Thr Lys Val Glu Ile Lys Pro Leu Thr Leu Gly Gly Gly Thr Lys Val Glu Ile Lys

100 105 100 105

<210> 301 <210> 301

<211> 115 <211> 115

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 301 <400> 301

Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser

1 5 10 15 1 5 10 15

Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu

20 25 30 20 25 30

Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro

35 40 45 35 40 45

Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser

50 55 60 50 55 60

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr

65 70 75 80 65 70 75 80

Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys

85 90 95 85 90 95

Gln Gln Tyr Tyr Ser Thr Pro Pro Met Phe Gly Gln Gly Thr Lys Val Gln Gln Tyr Tyr Ser Thr Pro Pro Met Phe Gly Gln Gly Thr Lys Val

100 105 110 100 105 110

Glu Ile Lys Glu Ile Lys

115 115

<210> 302 <210> 302

<211> 115 <211> 115

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 302 <400> 302

Leu Ala Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Ala Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser

1 5 10 15 1 5 10 15

Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu

20 25 30 20 25 30

Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro

35 40 45 35 40 45

Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser

50 55 60 50 55 60

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr

65 70 75 80 65 70 75 80

Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys

85 90 95 85 90 95

Gln Gln Tyr Tyr Ser Thr Pro Pro Met Phe Gly Gln Gly Thr Arg Val Gln Gln Tyr Tyr Ser Thr Pro Pro Met Phe Gly Gln Gly Thr Arg Val

100 105 110 100 105 110

Glu Ile Lys Glu Ile Lys

115 115

<210> 303 <210> 303

<211> 110 <211> 110

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 303 <400> 303

Leu Ala Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ala Leu Ser Leu Ala Glu Ile Val Met Thr Gln Ser Pro Gly Thr Leu Ala Leu Ser

1 5 10 15 1 5 10 15

Pro Gly Asp Arg Ala Thr Leu Ser Cys Gly Ala Ser Gln Ser Val Phe Pro Gly Asp Arg Ala Thr Leu Ser Cys Gly Ala Ser Gln Ser Val Phe

20 25 30 20 25 30

Gly Asp Phe Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg Gly Asp Phe Leu Ala Trp Tyr Gln His Lys Pro Gly Gln Ala Pro Arg

35 40 45 35 40 45

Pro Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg Pro Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Asp Arg

50 55 60 50 55 60

Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg

65 70 75 80 65 70 75 80

Leu Glu Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Asp Leu Glu Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Asp

85 90 95 85 90 95

Ser Val Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ser Val Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys

100 105 110 100 105 110

<210> 304 <210> 304

<211> 110 <211> 110

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 304 <400> 304

Leu Ala Asp Val Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Leu Ala Asp Val Val Met Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser

1 5 10 15 1 5 10 15

Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asn

20 25 30 20 25 30

Ser Asp Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ser Asp Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg

35 40 45 35 40 45

Leu Leu Met Ser Gly Ala Thr Ser Arg Ala Thr Asp Ile Pro Asp Arg Leu Leu Met Ser Gly Ala Thr Ser Arg Ala Thr Asp Ile Pro Asp Arg

50 55 60 50 55 60

Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg

65 70 75 80 65 70 75 80

Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Gly Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Gly Ser

85 90 95 85 90 95

Ser Asp Asn Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ser Asp Asn Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys

100 105 110 100 105 110

<210> 305 <210> 305

<211> 110 <211> 110

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 305 <400> 305

Leu Ala Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Ala Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Val Gly Asp Ser Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Val Gly Asp Ser Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser

20 25 30 20 25 30

Asn Phe Leu Ala Trp Tyr Gln Lys Lys Pro Gly Lys Val Pro Arg Leu Asn Phe Leu Ala Trp Tyr Gln Lys Lys Pro Gly Lys Val Pro Arg Leu

35 40 45 35 40 45

Leu Ile Tyr Gly Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Leu Ile Tyr Gly Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe

50 55 60 50 55 60

Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu

65 70 75 80 65 70 75 80

Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Glu Tyr Ser Asn Ala Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Glu Tyr Ser Asn Ala

85 90 95 85 90 95

Leu Ile Phe Thr Phe Gly Pro Gly Thr Lys Val His Ile Lys Leu Ile Phe Thr Phe Gly Pro Gly Thr Lys Val His Ile Lys

100 105 110 100 105 110

<210> 306 <210> 306

<211> 110 <211> 110

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 306 <400> 306

Leu Ala Glu Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Leu Ala Glu Ile Val Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Gly

20 25 30 20 25 30

Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu

35 40 45 35 40 45

Leu Ile Ser Gly Ala Ser Thr Leu Gln Ser Trp Val Pro Ser Arg Phe Leu Ile Ser Gly Ala Ser Thr Leu Gln Ser Trp Val Pro Ser Arg Phe

50 55 60 50 55 60

Ser Gly Arg Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Ser Gly Arg Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu

65 70 75 80 65 70 75 80

Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Arg Tyr Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Arg Tyr

85 90 95 85 90 95

Pro Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Pro Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys

100 105 110 100 105 110

<210> 307 <210> 307

<211> 109 <211> 109

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 307 <400> 307

Leu Ala Glu Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Ala Glu Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ser

20 25 30 20 25 30

Asn His Leu Asn Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Asn His Leu Asn Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu

35 40 45 35 40 45

Leu Ile Tyr Val Gly Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Leu Ile Tyr Val Gly Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe

50 55 60 50 55 60

Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu

65 70 75 80 65 70 75 80

Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Pro Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Pro

85 90 95 85 90 95

Ser Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys

100 105 100 105

<210> 308 <210> 308

<211> 110 <211> 110

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 308 <400> 308

Leu Ala Asp Ile Gln Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Leu Ala Asp Ile Gln Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser

1 5 10 15 1 5 10 15

Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser

20 25 30 20 25 30

Thr Asn Tyr Leu Ala Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Arg Thr Asn Tyr Leu Ala Trp Tyr Arg Gln Lys Pro Gly Gln Ala Pro Arg

35 40 45 35 40 45

Leu Leu Ile His Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Leu Leu Ile His Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg

50 55 60 50 55 60

Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg

65 70 75 80 65 70 75 80

Leu Glu Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Ser

85 90 95 85 90 95

Ser Pro Gln Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Ser Pro Gln Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys

100 105 110 100 105 110

<210> 309 <210> 309

<211> 109 <211> 109

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 309 <400> 309

Leu Ala Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Ala Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Leu Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln His Ile Ser Leu Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln His Ile Ser

20 25 30 20 25 30

Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu

35 40 45 35 40 45

Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Leu Ile Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe

50 55 60 50 55 60

Thr Gly Ser Gly Ser Gly Ala Asp Tyr Thr Leu Thr Ile Ser Ser Leu Thr Gly Ser Gly Ser Gly Ala Asp Tyr Thr Leu Thr Ile Ser Ser Leu

65 70 75 80 65 70 75 80

Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Thr

85 90 95 85 90 95

Ser Trp Thr Phe Gly Gln Gly Thr Thr Val Gly Ile Lys Ser Trp Thr Phe Gly Gln Gly Thr Thr Val Gly Ile Lys

100 105 100 105

<210> 310 <210> 310

<211> 109 <211> 109

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 310 <400> 310

Leu Ala Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Ala Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Val Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Arg Ser Val Lys Val Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Arg Ser Val Lys

20 25 30 20 25 30

Thr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Thr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu

35 40 45 35 40 45

Leu Val Tyr Gly Ser Ser.Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Leu Val Tyr Gly Ser Ser.Ser Leu Glu Ser Gly Val Pro Ser Arg Phe

50 55 60 50 55 60

Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu

65 70 75 80 65 70 75 80

Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Phe Gly Thr Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Phe Gly Thr

85 90 95 85 90 95

Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Asp Thr Lys Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Asp Thr Lys

100 105 100 105

<210> 311 <210> 311

<211> 109 <211> 109

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 311 <400> 311

Leu Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Val Ser Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn Val Ser Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Asn

20 25 30 20 25 30

Lys Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Gln Leu Lys Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Gln Leu

35 40 45 35 40 45

Leu Ile Tyr Ala Ala Thr Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Leu Ile Tyr Ala Ala Thr Asn Leu Gln Ser Gly Val Pro Ser Arg Phe

50 55 60 50 55 60

Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu

65 70 75 80 65 70 75 80

Gln Thr Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asp Met Gln Thr Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Asp Met

85 90 95 85 90 95

Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Pro Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys

100 105 100 105

<210> 312 <210> 312

<211> 110 <211> 110

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 312 <400> 312

Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser

1 5 10 15 1 5 10 15

Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Arg Ser Val Tyr Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Arg Ser Val Tyr

20 25 30 20 25 30

Ser Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro Asp Gln Ala Pro Arg Ser Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro Asp Gln Ala Pro Arg

35 40 45 35 40 45

Leu Leu Met Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Leu Leu Met Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg

50 55 60 50 55 60

Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg

65 70 75 80 65 70 75 80

Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Gly Ala Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr Gly Ala

85 90 95 85 90 95

Ser Asp Asn Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Ser Asp Asn Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys

100 105 110 100 105 110

<210> 313 <210> 313

<211> 115 <211> 115

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 313 <400> 313

Leu Ala Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Ala Asp Ile Gln Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser

1 5 10 15 1 5 10 15

Leu Gly Glu Lys Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Leu Gly Glu Lys Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu

20 25 30 20 25 30

Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Tyr Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro

35 40 45 35 40 45

Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Gln Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser

50 55 60 50 55 60

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr

65 70 75 80 65 70 75 80

Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys

85 90 95 85 90 95

Gln Gln Tyr Tyr Ser Thr Pro Pro Met Phe Gly Gln Gly Thr Lys Val Gln Gln Tyr Tyr Ser Thr Pro Pro Met Phe Gly Gln Gly Thr Lys Val

100 105 110 100 105 110

Glu Ile Lys Glu Ile Lys

115 115

<210> 314 <210> 314

<211> 110 <211> 110

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 314 <400> 314

Leu Ala Glu Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Ala Glu Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Val Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Ser Val Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Gly Ile Ser

20 25 30 20 25 30

Asn Phe Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Val Pro Lys Leu Asn Phe Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln Val Pro Lys Leu

35 40 45 35 40 45

Leu Ile Tyr Val Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Leu Ile Tyr Val Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe

50 55 60 50 55 60

Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Asn Gly Leu Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Asn Gly Leu

65 70 75 80 65 70 75 80

Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asp Ser Gly Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asp Ser Gly

85 90 95 85 90 95

Leu Ile Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys Leu Ile Phe Thr Phe Gly Pro Gly Thr Lys Val Glu Ile Lys

100 105 110 100 105 110

<210> 315 <210> 315

<211> 109 <211> 109

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 315 <400> 315

Leu Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Ala Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Ser

20 25 30 20 25 30

Asn His Leu Asn Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu Asn His Leu Asn Trp Tyr Gln Gln Lys Pro Gly Arg Ala Pro Lys Leu

35 40 45 35 40 45

Leu Ile Tyr Val Gly Ser Ser Leu Arg Ser Gly Val Pro Ser Arg Phe Leu Ile Tyr Val Gly Ser Ser Leu Arg Ser Gly Val Pro Ser Arg Phe

50 55 60 50 55 60

Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu

65 70 75 80 65 70 75 80

Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Pro Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Pro

85 90 95 85 90 95

Ser Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Ser Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys

100 105 100 105

<210> 316 <210> 316

<211> 110 <211> 110

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 316 <400> 316

Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Ala Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser

20 25 30 20 25 30

Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Glu Leu Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Glu Leu

35 40 45 35 40 45

Leu Ile Tyr Gly Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Leu Ile Tyr Gly Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe

50 55 60 50 55 60

Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Leu

65 70 75 80 65 70 75 80

Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asp Ser Gly Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asp Ser Gly

85 90 95 85 90 95

Leu Arg Phe Thr Phe Gly Pro Gly Ala Lys Val Asp Ile Lys Leu Arg Phe Thr Phe Gly Pro Gly Ala Lys Val Asp Ile Lys

100 105 110 100 105 110

<210> 317 <210> 317

<211> 109 <211> 109

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 317 <400> 317

Leu Ala Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Ala Asp Val Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Val Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Arg Ser Val Lys Val Gly Asp Arg Val Ser Ile Thr Cys Arg Ala Ser Arg Ser Val Lys

20 25 30 20 25 30

Thr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Thr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu

35 40 45 35 40 45

Leu Val Tyr Gly Ser Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Leu Val Tyr Gly Ser Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe

50 55 60 50 55 60

Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu

65 70 75 80 65 70 75 80

Gln Pro Glu Asp Phe Ala Thr Tyr Cys Cys Gln Gln Ser Phe Gly Thr Gln Pro Glu Asp Phe Ala Thr Tyr Cys Cys Gln Gln Ser Phe Gly Thr

85 90 95 85 90 95

Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Asp Ile Lys Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Asp Ile Lys

100 105 100 105

<210> 318 <210> 318

<211> 110 <211> 110

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 318 <400> 318

Leu Ala Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Ala Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser

20 25 30 20 25 30

Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Glu Leu Asn Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Val Pro Glu Leu

35 40 45 35 40 45

Leu Ile Tyr Gly Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Leu Ile Tyr Gly Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe

50 55 60 50 55 60

Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Asn Ser Leu Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Asn Ser Leu

65 70 75 80 65 70 75 80

Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asp Ser Gly Gln Pro Glu Asp Val Ala Thr Tyr Tyr Cys Gln Lys Tyr Asp Ser Gly

85 90 95 85 90 95

Leu Arg Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Leu Arg Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys

100 105 110 100 105 110

<210> 319 <210> 319

<211> 109 <211> 109

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 319 <400> 319

Leu Ala Asp Ile Gln Met Thr Gln Ser Ser Ser Thr Leu Ser Ala Ser Leu Ala Asp Ile Gln Met Thr Gln Ser Ser Ser Thr Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Asn Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Asn

20 25 30 20 25 30

Ile Trp Leu Ala Trp Tyr Gln Gln Lys Ala Gly Lys Ala Pro Lys Leu Ile Trp Leu Ala Trp Tyr Gln Gln Lys Ala Gly Lys Ala Pro Lys Leu

35 40 45 35 40 45

Leu Ile Tyr Lys Ala Ser Thr Leu Glu Arg Gly Val Pro Ser Arg Phe Leu Ile Tyr Lys Ala Ser Thr Leu Glu Arg Gly Val Pro Ser Arg Phe

50 55 60 50 55 60

Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Thr Gly Leu Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Thr Gly Leu

65 70 75 80 65 70 75 80

Arg Pro Asp Asp Phe Gly Ser Tyr Tyr Cys Gln His Tyr Asp Gly Asn Arg Pro Asp Asp Phe Gly Ser Tyr Tyr Cys Gln His Tyr Asp Gly Asn

85 90 95 85 90 95

Ser Leu Thr Phe Gly Gln Gly Thr Arg Val Asp Ile Gln Ser Leu Thr Phe Gly Gln Gly Thr Arg Val Asp Ile Gln

100 105 100 105

<210> 320 <210> 320

<211> 110 <211> 110

<212> PRT <212> PRT

<213> Homo sapiens <213> Homo sapiens

<400> 320 <400> 320

Leu Ala Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Leu Ala Asp Ile Gln Leu Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser

1 5 10 15 1 5 10 15

Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly

20 25 30 20 25 30

Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Ser Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu

35 40 45 35 40 45

Leu Ile Tyr Lys Ala Ser Thr Leu Gln Ser Glu Thr Pro Ser Arg Phe Leu Ile Tyr Lys Ala Ser Thr Leu Gln Ser Glu Thr Pro Ser Arg Phe

50 55 60 50 55 60

Arg Gly Ser Gly Ser Gly Thr Glu Phe Thr.Leu Thr Ile Ser Ser Leu Arg Gly Ser Gly Ser Gly Thr Glu Phe Thr.Leu Thr Ile Ser Ser Leu

65 70 75 80 65 70 75 80

Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Phe Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Phe

85 90 95 85 90 95

Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Ala Glu Phe Lys Ser Pro Trp Thr Phe Gly Gln Gly Thr Lys Ala Glu Phe Lys

100 105 110 100 105 110

<210> 321 <210> 321

<211> 402 <211> 402

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<220> <220>

<223> Vektorski slijed <223> Vector sequence

<400> 321 <400> 321

gctagcgctg gttgggcagc gagtaataac aatccagcgg ctgccgtagg caataggtat 60 gctagcgctg gttgggcagc gagtaataac aatccagcgg ctgccgtagg caataggtat 60

ttcattatga ctgtctcctt ggcgactagc tagtttagaa ttaattcgtg aaattgttat 120 ttcattatga ctgtctcctt ggcgactagc tagtttagaa ttaattcgtg aaattgttat 120

ccgctcacaa ttccacacaa catacgagcc ggaagcataa agtgtaaagc ctggggtgcc 180 ccgctcacaa ttccacacaa catacgagcc ggaagcataa agtgtaaagc ctggggtgcc 180

taatgagtga gctaactcac attaattgcg ttgcgctcac tgcccgcttt ccagatctta 240 taatgagtga gctaactcac attaattgcg ttgcgctcac tgcccgcttt ccagatctta 240

ctccccatcc ccctgttgac aattaatcat cggctcgtat gatgtgtgga attgtgagcg 300 ctccccatcc ccctgttgac aattaatcat cggctcgtat gatgtgtgga attgtgagcg 300

gataacaatt tcacacagga aacaggagat atacatatga aatacctgct gccgaccgct 360 gataacaatt tcacacagga aacaggagat atacatga aatacctgct gccgaccgct 360

gctgctggtc tgctgctcct cgctgcccag ccggggcgcg cc 402 gctgctggtc tgctgctcct cgctgcccag ccggggcgcg cc 402

<210> 322 <210> 322

<211> 37 <211> 37

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 322 <400> 322

tattggcgcg ccatggccgc ccagtctgtg acccagc 37 tattggcgcg ccatggccgc ccagtctgtg acccagc 37

<210> 323 <210> 323

<211> 36 <211> 36

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 323 <400> 323

tattggcgcg ccatggccgc ccagaagata actcaa 36 tattggcgcg ccatggccgc ccagaagata actcaa 36

<210> 324 <210> 324

<211> 36 <211> 36

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 324 <400> 324

tattggcgcg ccatggccga tgctaagacc acccag 36 tattggcgcg ccatggccga tgctaagacc acccag 36

<210> 325 <210> 325

<211> 36 <211> 36

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 325 <400> 325

tattggcgcg ccatggccgc ccagacagtc actcag 36 tattggcgcg ccatggccgc ccagacagtc actcag 36

<210> 326 <210> 326

<211> 37 <211> 37

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 326 <400> 326

tattggcgcg ccatggccaa acaggaggtg acacaga 37 tattggcgcg ccatggccaa acaggaggtg acacaga 37

<210> 327 <210> 327

<211> 37 <211> 37

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 327 <400> 327

tattggcgcg ccatggccgg agactcggtt acccaga 37 tattggcgcg ccatggccgg agactcggtt acccaga 37

<210> 328 <210> 328

<211> 37 <211> 37

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 328 <400> 328

tattggcgcg ccatggccgg agattcagtg acccaga 37 tattggcgcg ccatggccgg agattcagtg acccaga 37

<210> 329 <210> 329

<211> 37 <211> 37

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 329 <400> 329

tattggcgcg ccatggccag caattcagtc aagcaga 37 tattggcgcg ccatggccag caattcagtc aagcaga 37

<210> 330 <210> 330

<211> 36 <211> 36

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 330 <400> 330

tattggcgcg ccatggccgg acaaaacatt gaccag 36 tattggcgcg ccatggccgg acaaaacatt gaccag 36

<210> 331 <210> 331

<211> 37 <211> 37

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 331 <400> 331

tattggcgcg ccatggccaa aaatgaagtg gagcaga 37 tattggcgcg ccatggccaa aaatgaagtg gagcaga 37

<210> 332 <210> 332

<211> 37 <211> 37

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 332 <400> 332

tattggcgcg ccatggccga agaccaggtg acgcaga 37 tattggcgcg ccatggccga agaccaggtg acgcaga 37

<210> 333 <210> 333

<211> 37 <211> 37

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 333 <400> 333

tattggcgcg ccatggccgg aatacaagtg gagcaga 37 tattggcgcg ccatggccgg aatacaagtg gagcaga 37

<210> 334 <210> 334

<211> 37 <211> 37

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 334 <400> 334

tattggcgcg ccatggccct acatacactg gagcaga 37 tattggcgcg ccatggccct acatacactg gagcaga 37

<210> 335 <210> 335

<211> 37 <211> 37

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 335 <400> 335

tattggcgcg ccatggccga agacaaggtg gtacaaa 37 tattggcgcg ccatggccga agacaaggtg gtacaaa 37

<210> 336 <210> 336

<211> 37 <211> 37

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 336 <400> 336

tattggcgcg ccatggccga aaaccaggtg gagcaca 37 tattggcgcg ccatggccga aaaccaggtg gagcaca 37

<210> 337 <210> 337

<211> 36 <211> 36

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 337 <400> 337

tattggcgcg ccatggccca ggagaatgtg gagcag 36 tattggcgcg ccatggccca ggagaatgtg gagcag 36

<210> 338 <210> 338

<211> 36 <211> 36

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 338 <400> 338

tattggcgcg ccatggccgg agagagtgtg gggctg 36 tattggcgcg ccatggccgg agagagtgtg gggctg 36

<210> 339 <210> 339

<211> 37 <211> 37

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 339 <400> 339

tattggcgcg ccatggccgg agaggatgtg gagcaga 37 tattggcgcg ccatggccgg agaggatgtg gagcaga 37

<210> 340 <210> 340

<211> 37 <211> 37

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 340 <400> 340

tattggcgcg ccatggccag ccaaaagata gaacaga 37 tattggcgcg ccatggccag ccaaaagata gaacaga 37

<210> 341 <210> 341

<211> 36 <211> 36

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 341 <400> 341

tattggcgcg ccatggccag tcaacaggga gaagag 36 tattggcgcg ccatggccag tcaacaggga gaagag 36

<210> 342 <210> 342

<211> 36 <211> 36

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 342 <400> 342

tattggcgcg ccatggccca acaaccagtg cagagt 36 tattggcgcg ccatggccca acaaccagtg cagagt 36

<210> 343 <210> 343

<211> 37 <211> 37

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 343 <400> 343

tattggcgcg ccatggccag ccaagaactg gagcaga 37 tattggcgcg ccatggccag ccaagaactg gagcaga 37

<210> 344 <210> 344

<211> 37 <211> 37

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 344 <400> 344

tattggcgcg ccatggccgg tcaacagctg aatcaga 37 tattggcgcg ccatggccgg tcaacagctg aatcaga 37

<210> 345 <210> 345

<211> 37 <211> 37

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 345 <400> 345

tattggcgcg ccatggccac ccagctgctg gagcaga 37 tattggcgcg ccatggccac ccagctgctg gagcaga 37

<210> 346 <210> 346

<211> 36 <211> 36

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 346 <400> 346

tattggcgcg ccatggccca gcagcaggtg aaacaa 36 tattggcgcg ccatggccca gcagcaggtg aaacaa 36

<210> 347 <210> 347

<211> 36 <211> 36

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 347 <400> 347

tattggcgcg ccatggccat actgaacgtg gaacaa 36 tattggcgcg ccatggccat actgaacgtg gaacaa 36

<210> 348 <210> 348

<211> 36 <211> 36

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 348 <400> 348

tattggcgcg ccatggccga ccagcaagtt aagcaa 36 tattggcgcg ccatggccga ccagcaagtt aagcaa 36

<210> 349 <210> 349

<211> 36 <211> 36

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 349 <400> 349

tattggcgcg ccatggccgg acaacaggta atgcaa 36 tattggcgcg ccatggccgg acaacaggta atgcaa 36

<210> 350 <210> 350

<211> 36 <211> 36

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 350 <400> 350

tattggcgcg ccatggccaa ggaccaagtg tttcag 36 tattggcgcg ccatggccaa ggaccaagtg tttcag 36

<210> 351 <210> 351

<211> 21 <211> 21

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 351 <400> 351

taggcagaca gacttgtcac t 21 taggcagaca gacttgtcac t 21

<210> 352 <210> 352

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 352 <400> 352

gccatggcgc gccaatagct agccggtgaa gaagtcgccc aga 43 gccatggcgc gccaatagct agccggtgaa gaagtcgccc aga 43

<210> 353 <210> 353

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 353 <400> 353

gccatggcgc gccaatagct agccgatgcc atggtcatcc aga 43 gccatggcgc gccaatagct agccgatgcc atggtcatcc aga 43

<210> 354 <210> 354

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 354 <400> 354

gccatggcgc gccaatagct agccgaagcc caagtgaccc aga 43 gccatggcgc gccaatagct agccgaagcc caagtgaccc aga 43

<210> 355 <210> 355

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 355 <400> 355

gccatggcgc gccaatagct agcccatgcc aaagtcacac aga 43 gccatggcgc gccaatagct agcccatgcc aaagtcacac aga 43

<210> 356 <210> 356

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 356 <400> 356

gccatggcgc gccaatagct agccgacaca gccgtttccc aga 43 gccatggcgc gccaatagct agccgacaca gccgtttccc aga 43

<210> 357 <210> 357

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 357 <400> 357

gccatggcgc gccaatagct agccgaaacg ggagttacgc aga 43 gccatggcgc gccaatagct agccgaaacg ggagttacgc aga 43

<210> 358 <210> 358

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 358 <400> 358

gccatggcgc gccaatagct agccgaacct gaagtcaccc aga 43 gccatggcgc gccaatagct agccgaacct gaagtcaccc aga 43

<210> 359 <210> 359

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 359 <400> 359

gccatggcgc gccaatagct agccgaagct gacatctacc aga 43 gccatggcgc gccaatagct agccgaagct gacatctacc aga 43

<210> 360 <210> 360

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 360 <400> 360

gccatggcgc gccaatagct agccatatct ggagtctccc aca 43 gccatggcgc gccaatagct agccatatct ggagtctccc aca 43

<210> 361 <210> 361

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 361 <400> 361

gccatggcgc gccaatagct agccgatgct ggaatcaccc aga 43 gccatggcgc gccaatagct agccgatgct ggaatcaccc aga 43

<210> 362 <210> 362

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 362 <400> 362

gccatggcgc gccaatagct agccaatgct ggtgtcactc aga 43 gccatggcgc gccaatagct agccaatgct ggtgtcactc aga 43

<210> 363 <210> 363

<211> 42 <211> 42

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 363 <400> 363

gccatggcgc gccaatagct agccagtgct gtcgtctctc aa 42 gccatggcgc gccaatagct agccagtgct gtcgtctctc aa 42

<210> 364 <210> 364

<211> 42 <211> 42

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 364 <400> 364

gccatggcgc gccaatagct agccgacgct ggagtcacac aa 42 gccatggcgc gccaatagct agccgacgct ggagtcacac aa 42

<210> 365 <210> 365

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 365 <400> 365

gccatggcgc gccaatagct agccgatggt ggaatcactc agt 43 gccatggcgc gccaatagct agccgatggt ggaatcactc agt 43

<210> 366 <210> 366

<211> 42 <211> 42

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 366 <400> 366

gccatggcgc gccaatagct agccactgct gggatcaccc ag 42 gccatggcgc gccaatagct agccactgct gggatcaccc ag 42

<210> 367 <210> 367

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 367 <400> 367

gccatggcgc gccaatagct agccgaagct ggagttgccc agt 43 gccatggcgc gccaatagct agccgaagct ggagttgccc agt 43

<210> 368 <210> 368

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 368 <400> 368

gccatggcgc gccaatagct agccgaagct ggagtggttc agt 43 gccatggcgc gccaatagct agccgaagct ggagtggttc agt 43

<210> 369 <210> 369

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 369 <400> 369

gccatggcgc gccaatagct agccgaagct ggagttactc agt 43 gccatggcgc gccaatagct agccgaagct ggagttactc agt 43

<210> 370 <210> 370

<211> 42 <211> 42

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 370 <400> 370

gccatggcgc gccaatagct agccgatgct gtagttacac aa 42 gccatggcgc gccaatagct agccgatgct gtagttacac aa 42

<210> 371 <210> 371

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 371 <400> 371

gccatggcgc gccaatagct agccgatgct ggagttatcc agt 43 gccatggcgc gccaatagct agccgatgct ggagttatcc agt 43

<210> 372 <210> 372

<211> 42 <211> 42

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 372 <400> 372

gccatggcgc gccaatagct agccggtgct ggagtctccc ag 42 gccatggcgc gccaatagct agccggtgct ggagtctccc ag 42

<210> 373 <210> 373

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 373 <400> 373

gccatggcgc gccaatagct agccgatgct gatgttaccc aga 43 gccatggcgc gccaatagct agccgatgct gatgttaccc aga 43

<210> 374 <210> 374

<211> 43 <211> 43

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 374 <400> 374

gccatggcgc gccaatagct agcctctcag actattcatc aat 43 gccatggcgc gccaatagct agcctctcag actattcatc aat 43

<210> 375 <210> 375

<211> 21 <211> 21

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 375 <400> 375

caggcacacc agtgtggcct t 21 caggcacacc agtgtggcct t 21

<210> 376 <210> 376

<211> 36 <211> 36

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 376 <400> 376

caccttagag ctcttagagt ctctcagctg gtacac 36 caccttagag ctcttaggt ctctcagctg gtacac 36

<210> 377 <210> 377

<211> 33 <211> 33

<212> DNA <212> DNA

<213> Umjetno <213> Artificially

<400> 377 <400> 377

gacattatgc atgatctctg cttctgatgg ctc 33 gacattatgc atgatctctg cttctgatgg ctc 33

Claims (22)

1. Biblioteka srodnih parova koja sadrži povezane nukleinskokiselinske sljedove koji kodiraju varijabilno područje, naznačena time što je svaki srodni par izvorni par nepovezanih nukleinskokiselinskih sljedova umnoženih iz pojedinačnog limfocita, te što se biblioteka nalazi u više posuda, gdje svaka posuda sadrži pojedinačni srodni par.1. A library of related pairs containing related nucleic acid sequences that encode a variable region, characterized in that each related pair is an original pair of unrelated nucleic acid sequences amplified from an individual lymphocyte, and that the library is located in multiple vessels, where each vessel contains an individual related pair. 2. Biblioteka u skladu s patentnim zahtjevom 1, naznačena time što biblioteka sadrži najmanje 10 različitih srodnih parova.2. The library according to claim 1, characterized in that the library contains at least 10 different related pairs. 3. Biblioteka u skladu s patentnim zahtjevom 1, naznačena time što biblioteka sadrži najmanje 20 različitih srodnih parova.3. A library according to claim 1, characterized in that the library contains at least 20 different related pairs. 4. Biblioteka u skladu s patentnim zahtjevom 1, naznačena time što biblioteka sadrži najmanje 50 različitih srodnih parova.4. The library according to claim 1, characterized in that the library contains at least 50 different related pairs. 5. Biblioteka u skladu s patentnim zahtjevom 1, naznačena time što biblioteka sadrži najmanje 100 različitih srodnih parova.5. The library according to claim 1, characterized in that the library contains at least 100 different related pairs. 6. Biblioteka u skladu s patentnim zahtjevom 1, naznačena time što biblioteka sadrži najmanje 1000 različitih srodnih parova.6. The library according to claim 1, characterized in that the library contains at least 1000 different related pairs. 7. Biblioteka u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačena time što srodni parovi sadrže slijed koji kodira varijabilno područje teškog lanca imunoglobulina povezano sa slijedom koji kodira varijabilno područje lakog lanca imunoglobulina.7. A library according to any one of the preceding claims, characterized in that the related pairs contain a sequence encoding a variable region of an immunoglobulin heavy chain linked to a sequence encoding a variable region of an immunoglobulin light chain. 8. Biblioteka u skladu s patentnim zahtjevom 7, naznačena time što srodni parovi sadrže slijed koji kodira varijabilno područje teškog lanca imunoglobulina povezan sa slijedom koji kodira varijabilno područje lakog lanca, gdje su navedeni sljedovi ubačeni unutarokvirno u vektor koji sadrži sljedove koji kodiraju najmanje jednu konstantnu domenu imunoglobulina ili njegov fragment.8. The library according to patent claim 7, characterized in that the related pairs contain a sequence encoding the variable region of the immunoglobulin heavy chain linked to the sequence encoding the variable region of the light chain, where said sequences are inserted in-frame into a vector containing sequences encoding at least one constant immunoglobulin domain or its fragment. 9. Biblioteka u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačena time što je vektor sisavački ekspresijski vektor.9. A library according to any one of the preceding claims, characterized in that the vector is a mammalian expression vector. 10. Biblioteka u skladu s patentnim zahtjevom 9, naznačena time što sisavački ekspresijski vektor kodira najmanje jednu domenu konstantnog područja koje se bira između klasa IgA1, IgA2, IgD, IgE, IgG1, IgG2, IgG3, IgG4, IgM ljudskih imunoglobulina, lakog lanca kapa i lakog lanca lambda, ili između alfa, beta, delta i gama lanaca receptora ljudskih T stanica.10. The library according to claim 9, characterized in that the mammalian expression vector encodes at least one constant region domain selected from the classes of IgA1, IgA2, IgD, IgE, IgG1, IgG2, IgG3, IgG4, IgM human immunoglobulins, cap light chain and lambda light chain, or between alpha, beta, delta and gamma chains of human T cell receptors. 11. Biblioteka u skladu s patentnim zahtjevom 10, naznačena time što navedeni sisavački ekspresijski vektor koji sadrži pojedinačne srodne parove kodira protutijelo pune duljine, koje se bira između klasa IgA1, IgA2, IgD, IgE, IgG1, IgG2, IgG3, IgG4 i IgM ljudskih imunoglobulina.11. The library according to claim 10, characterized in that said mammalian expression vector containing single cognate pairs encodes a full-length antibody selected from the classes IgA1, IgA2, IgD, IgE, IgG1, IgG2, IgG3, IgG4 and IgM human immunoglobulin. 12. Biblioteka u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačena time što je navedena biblioteka subbiblioteka koja sadrži podskupinu ciljno specifičnih srodnih parova povezanih sljedova koji kodiraju varijabilno područje vežuće proteine željenom ciljnom specifičnošću.12. A library according to any of the preceding claims, characterized in that said library is a sublibrary containing a subset of target-specific cognate pairs of linked sequences encoding a variable region binding protein with a desired target specificity. 13. Subbiblioteka u skladu s patentnim zahtjevom 12, naznačena time što srodni parovi iz navedene subbiblioteke sadrže slijed koji kodira varijabilno područje teškog lanca imunoglobulina povezan sa slijedom koji kodira varijabilno područje lakog lanca imunoglobulina.13. A sublibrary according to patent claim 12, characterized in that the related pairs from said sublibrary contain a sequence encoding the variable region of the immunoglobulin heavy chain linked to the sequence encoding the variable region of the immunoglobulin light chain. 14. Subbiblioteka u skladu s patentnim zahtjevom 13, naznačena time što se srodne parove iz navedene subbiblioteke kodiraju imunoglobuline pune duljine bira između klasa IgA1, IgA2, IgD, IgE, IgG1, IgG2, IgG3, IgG4 i IgM ljudskih imunoglobulina.14. The sublibrary according to patent claim 13, characterized in that the related pairs from said sublibrary encode full-length immunoglobulins selected from the classes of IgA1, IgA2, IgD, IgE, IgG1, IgG2, IgG3, IgG4 and IgM human immunoglobulins. 15. Biblioteka u skladu s bilo kojim jedan od prethodnih patentnih zahtjeva, naznačena time što više posuda su ploče s mnogo jažica.15. A library according to any one of the preceding claims, characterized in that the plurality of vessels are multi-well plates. 16. Biblioteka u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačena time što su navedeni srodni parovi sljedova koji kodiraju varijabilna područja dobiveni postupkom koji se sastoji u sljedećim koracima: a) dobivanja stanične frakcije koja sadrži limfocite iz donora; b) dobivanja populacije izoliranih pojedinačnih stanica pojedinačnom distribucijom stanica iz navedene stanične frakcije u više posuda; i c) umnažanja i povezivanja sljedova koji kodiraju varijabilna područja koje sadrži navedena populacija izoliranih pojedinačnih stanica i) umnažanjem, postupkom višestrukog molekularnog umnažanja, nukleotidnih sljedova od interesa pomoću uzorka dobivenog iz izolirane pojedinčne stanice; i ii) povezivanjem umnoženih nukleotidnih sljedova od interesa.16. A library according to any one of the preceding patent claims, characterized in that said related pairs of sequences encoding variable regions are obtained by a process consisting of the following steps: a) obtaining the cell fraction containing lymphocytes from the donor; b) obtaining a population of isolated individual cells by individual distribution of cells from the specified cell fraction in several vessels; and c) amplification and concatenation of the sequences encoding the variable regions contained in said population of isolated individual cells i) by multiplying, by the process of multiple molecular multiplication, nucleotide sequences of interest using a sample obtained from an isolated single cell; and ii) by linking the amplified nucleotide sequences of interest. 17. Biblioteka u skladu s patentnim zahtjevom 16, naznačena time što se postupak sastoji u obogaćivanju stanične frakcije koja sadrži limfocite dobivene u koraku (a) određenom populacijom limfocita.17. The library according to claim 16, characterized in that the method consists in enriching the cell fraction containing lymphocytes obtained in step (a) with a certain population of lymphocytes. 18. Biblioteka u skladu s patentnim zahtjevom 17, naznačena time što stanična frakcija koja sadrži limfocite je obogaćen for stanice of the limfocit B linija.18. Library according to claim 17, characterized in that the cell fraction containing lymphocytes is enriched for cells of the lymphocyte B line. 19. Biblioteka u skladu s patentnim zahtjevom 17 ili 18, naznačena time što je stanična frakcija koja sadrži limfocite ili linija limfocita B obogaćena plazmacitima.19. The library according to claim 17 or 18, characterized in that the cell fraction containing lymphocytes or the B lymphocyte line is enriched in plasma cells. 20. Biblioteka u skladu s bilo kojim od patentnih zahtjeva 17-19, naznačena time što su stanice iz stanične frakcije koja sadrži limfocite, liniju limfocita B ili plazmacite obogaćene na antigensku specifičnost.20. A library according to any one of claims 17-19, characterized in that the cells from the cell fraction containing lymphocytes, B lymphocyte line or plasma cells are enriched for antigenic specificity. 21. Populacija stanica-domaćina, naznačena time što sadrži biblioteku u skladu s bilo kojim od prethodnih patentnih zahtjeva.21. A host cell population comprising a library according to any one of the preceding claims. 22. Populacija stanica-domaćina u skladu s patentnim zahtjevom 21, naznačena time što su stanice stanice sisavaca.22. The population of host cells according to claim 21, characterized in that the cells are mammalian cells.
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