HRP20110608T1 - Uporaba spojeva c-(2-fenil-cikloheksil)-metilamina za liječenje anksioznih poremećaja - Google Patents
Uporaba spojeva c-(2-fenil-cikloheksil)-metilamina za liječenje anksioznih poremećaja Download PDFInfo
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- HRP20110608T1 HRP20110608T1 HR20110608T HRP20110608T HRP20110608T1 HR P20110608 T1 HRP20110608 T1 HR P20110608T1 HR 20110608 T HR20110608 T HR 20110608T HR P20110608 T HRP20110608 T HR P20110608T HR P20110608 T1 HRP20110608 T1 HR P20110608T1
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- cyclohexyl
- dimethylaminomethyl
- phenol
- phenyl
- cyclohexylmethyl
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- 208000019901 Anxiety disease Diseases 0.000 title claims abstract 4
- JIRYWFYYBBRJAN-UHFFFAOYSA-N 3-[2-[(dimethylamino)methyl]cyclohexyl]phenol Chemical compound CN(C)CC1CCCCC1C1=CC=CC(O)=C1 JIRYWFYYBBRJAN-UHFFFAOYSA-N 0.000 claims abstract 7
- VTXTVLAQPBIPPF-UHFFFAOYSA-N 1-[2-(3-methoxyphenyl)cyclohexyl]-n,n-dimethylmethanamine Chemical compound COC1=CC=CC(C2C(CCCC2)CN(C)C)=C1 VTXTVLAQPBIPPF-UHFFFAOYSA-N 0.000 claims abstract 4
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000003814 drug Substances 0.000 claims abstract 3
- 150000003839 salts Chemical class 0.000 claims abstract 3
- WMFQEDGHYPJQSG-UHFFFAOYSA-N 1-[2-(3-methoxyphenyl)cyclohexyl]-n-methylmethanamine Chemical compound CNCC1CCCCC1C1=CC=CC(OC)=C1 WMFQEDGHYPJQSG-UHFFFAOYSA-N 0.000 claims abstract 2
- WMRBLCTVXONZBT-UHFFFAOYSA-N 3-[2-(aminomethyl)cyclohexyl]phenol Chemical compound NCC1CCCCC1C1=CC=CC(O)=C1 WMRBLCTVXONZBT-UHFFFAOYSA-N 0.000 claims abstract 2
- KUGOVDMEUQXLRD-UHFFFAOYSA-N 3-[2-(methylaminomethyl)cyclohexyl]phenol Chemical compound CNCC1CCCCC1C1=CC=CC(O)=C1 KUGOVDMEUQXLRD-UHFFFAOYSA-N 0.000 claims abstract 2
- CKMPEIWYGQTXJB-UHFFFAOYSA-N 4-[2-[(dimethylamino)methyl]cyclohexyl]benzene-1,2-diol Chemical compound CN(C)CC1CCCCC1C1=CC=C(O)C(O)=C1 CKMPEIWYGQTXJB-UHFFFAOYSA-N 0.000 claims abstract 2
- FMGWPVLPVFJEAH-UHFFFAOYSA-N 6-[3-[2-[(dimethylamino)methyl]cyclohexyl]phenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CN(C)CC1CCCCC1C1=CC=CC(OC2C(C(O)C(O)C(O2)C(O)=O)O)=C1 FMGWPVLPVFJEAH-UHFFFAOYSA-N 0.000 claims abstract 2
- NPZGGTZKFXTTSR-UHFFFAOYSA-N [3-[2-[(dimethylamino)methyl]cyclohexyl]phenyl] hydrogen sulfate Chemical compound CN(C)CC1CCCCC1C1=CC=CC(OS(O)(=O)=O)=C1 NPZGGTZKFXTTSR-UHFFFAOYSA-N 0.000 claims abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 150000004677 hydrates Chemical class 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims abstract 2
- 239000012453 solvate Substances 0.000 claims abstract 2
- VTXTVLAQPBIPPF-HOCLYGCPSA-N 1-[(1r,2r)-2-(3-methoxyphenyl)cyclohexyl]-n,n-dimethylmethanamine Chemical compound COC1=CC=CC([C@H]2[C@@H](CCCC2)CN(C)C)=C1 VTXTVLAQPBIPPF-HOCLYGCPSA-N 0.000 claims 2
- 150000001204 N-oxides Chemical class 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- JIRYWFYYBBRJAN-ZFWWWQNUSA-N faxeladol Chemical compound CN(C)C[C@@H]1CCCC[C@H]1C1=CC=CC(O)=C1 JIRYWFYYBBRJAN-ZFWWWQNUSA-N 0.000 claims 2
- WMFQEDGHYPJQSG-ZFWWWQNUSA-N 1-[(1r,2r)-2-(3-methoxyphenyl)cyclohexyl]-n-methylmethanamine Chemical compound CNC[C@@H]1CCCC[C@H]1C1=CC=CC(OC)=C1 WMFQEDGHYPJQSG-ZFWWWQNUSA-N 0.000 claims 1
- WMRBLCTVXONZBT-AAEUAGOBSA-N 3-[(1r,2r)-2-(aminomethyl)cyclohexyl]phenol Chemical compound NC[C@@H]1CCCC[C@H]1C1=CC=CC(O)=C1 WMRBLCTVXONZBT-AAEUAGOBSA-N 0.000 claims 1
- KUGOVDMEUQXLRD-JSGCOSHPSA-N 3-[(1r,2r)-2-(methylaminomethyl)cyclohexyl]phenol Chemical compound CNC[C@@H]1CCCC[C@H]1C1=CC=CC(O)=C1 KUGOVDMEUQXLRD-JSGCOSHPSA-N 0.000 claims 1
- CKMPEIWYGQTXJB-STQMWFEESA-N 4-[(1r,2r)-2-[(dimethylamino)methyl]cyclohexyl]benzene-1,2-diol Chemical compound CN(C)C[C@@H]1CCCC[C@H]1C1=CC=C(O)C(O)=C1 CKMPEIWYGQTXJB-STQMWFEESA-N 0.000 claims 1
- FMGWPVLPVFJEAH-QXASIPDLSA-N 6-[3-[(1r,2r)-2-[(dimethylamino)methyl]cyclohexyl]phenoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CN(C)C[C@@H]1CCCC[C@H]1C1=CC=CC(OC2C(C(O)C(O)C(O2)C(O)=O)O)=C1 FMGWPVLPVFJEAH-QXASIPDLSA-N 0.000 claims 1
- UMDGVFXQBMCYNZ-JSGCOSHPSA-N [(1r,2r)-2-(3-methoxyphenyl)cyclohexyl]methanamine Chemical compound COC1=CC=CC([C@H]2[C@@H](CCCC2)CN)=C1 UMDGVFXQBMCYNZ-JSGCOSHPSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000000935 antidepressant agent Substances 0.000 abstract 3
- 229940005513 antidepressants Drugs 0.000 abstract 3
- 239000002671 adjuvant Substances 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- LOMMOGHGUYMOEF-UHFFFAOYSA-N 1-[2-(3-methoxyphenyl)cyclohexyl]-n,n-dimethylmethanamine oxide Chemical compound COC1=CC=CC(C2C(CCCC2)C[N+](C)(C)[O-])=C1 LOMMOGHGUYMOEF-UHFFFAOYSA-N 0.000 abstract 1
- -1 3-(2-dimethylaminomethyl-cyclohexyl)-phenol N-oxide Chemical class 0.000 abstract 1
- 241000700159 Rattus Species 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 230000000949 anxiolytic effect Effects 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 239000002767 noradrenalin uptake inhibitor Substances 0.000 abstract 1
- 229940126569 noradrenaline reuptake inhibitor Drugs 0.000 abstract 1
- 230000000966 norepinephrine reuptake Effects 0.000 abstract 1
- 239000003402 opiate agonist Substances 0.000 abstract 1
- 230000000697 serotonin reuptake Effects 0.000 abstract 1
- 229940126570 serotonin reuptake inhibitor Drugs 0.000 abstract 1
- 239000003772 serotonin uptake inhibitor Substances 0.000 abstract 1
- 229940125725 tranquilizer Drugs 0.000 abstract 1
- 239000003204 tranquilizing agent Substances 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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Abstract
Uporaba spojeva C-(2-fenil-cikloheksil)-metilamina naznačena time da su odabrani od: • 3-(2-dimetilaminometil-cikloheksil)-fenola, • (1R,2R)-3-(2-dimetilaminometil-cikloheksil)-fenola, • [2-(3-metoksifenil)-cikloheksilmetil]-dimetilamina, • (1R,2R)-[2-(3-metoksifenil)-cikloheksilmetil]-dimetilamina, • mono-[3-(2-dimetilaminometil-cikloheksil)-fenil] estera sumporne kiseline, • mono-(1R,2R)-[3-(2-dimetilaminometil-cikloheksil)-fenil] estera sumporne kiseline, • 3-(2-metilaminometil-cikloheksil)-fenola, • (1R,2R)-3-(2-metilaminometil-cikloheksil)-fenola, • 3-(2-dimetilaminometil-cikloheksil)-fenol, N-oksida, • (1R,2R)-3-(2-dimetilaminometil-cikloheksil)-fenol, N-oksida, • 6-[3-(2-dimetilaminometil-cikloheksil)-fenoksi]-3,4,5-trihidroksi-tetrahidropiran-2-karboksilne kiseline, • 6-[(1R,2R)-3-(2-dimetilaminometil-cikloheksil)-fenoksi]-3,4,5-trihidroksi-tetrahidropiran-2-karboksilne kiseline, • 4-(2-dimetilaminometil-cikloheksil)-katekola, • (1R,2R)-4-(2-dimetilaminometil-cikloheksil)-katekola, • 3-(2-aminometil-cikloheksil)-fenola, • (1R,2R)-3-(2-aminometil-cikloheksil)-fenola, • C-[2-(3-metoksi-fenil)-cikloheksil]-metilamina, • (1R,2R)-C-[2-(3-metoksi-fenil)-cikloheksil]-metilamina, • [2-(3-metoksi-fenil)-cikloheksilmetil]-metilamina, • (1R,2R)-[2-(3-metoksi-fenil)-cikloheksilmetil]-metilamina, • [2-(3-metoksi-fenil)-cikloheksilmetil]-dimetilamin, N-oksid ili• (1R,2R)-[2-(3-metoksi-fenil)-cikloheksilmetil]-dimetilamin, N-oksid, proizvoljno u obliku njihovih racemata, njihovih čistih stereoizomera, naročito enantiomera ili diastereomera, ili u obliku mješavina stereoizomera, naročito enantiomera ili diastereomera, u bilo kojem željenom omjeru miješanja; u prikazanom obliku ili u obliku njihovih kiselina ili njihovih baza ili u obliku njihovih soli, naročito fiziološki prihvatljivih soli, ili u obliku njihovih solvata, naročito hidrata; za dobivanje lijeka za liječenje anksioznih poremećaja. Patent sadrži još 1 patentni zahtjev.
Claims (2)
1. Uporaba spojeva C-(2-fenil-cikloheksil)-metilamina naznačena time da su odabrani od:
• 3-(2-dimetilaminometil-cikloheksil)-fenola,
• (1R,2R)-3-(2-dimetilaminometil-cikloheksil)-fenola,
• [2-(3-metoksifenil)-cikloheksilmetil]-dimetilamina,
• (1R,2R)-[2-(3-metoksifenil)-cikloheksilmetil]-dimetilamina,
• mono-[3-(2-dimetilaminometil-cikloheksil)-fenil] estera sumporne kiseline,
• mono-(1R,2R)-[3-(2-dimetilaminometil-cikloheksil)-fenil] estera sumporne kiseline,
• 3-(2-metilaminometil-cikloheksil)-fenola,
• (1R,2R)-3-(2-metilaminometil-cikloheksil)-fenola,
• 3-(2-dimetilaminometil-cikloheksil)-fenol, N-oksida,
• (1R,2R)-3-(2-dimetilaminometil-cikloheksil)-fenol, N-oksida,
• 6-[3-(2-dimetilaminometil-cikloheksil)-fenoksi]-3,4,5-trihidroksi-tetrahidropiran-2-karboksilne kiseline,
• 6-[(1R,2R)-3-(2-dimetilaminometil-cikloheksil)-fenoksi]-3,4,5-trihidroksi-tetrahidropiran-2-karboksilne kiseline,
• 4-(2-dimetilaminometil-cikloheksil)-katekola,
• (1R,2R)-4-(2-dimetilaminometil-cikloheksil)-katekola,
• 3-(2-aminometil-cikloheksil)-fenola,
• (1R,2R)-3-(2-aminometil-cikloheksil)-fenola,
• C-[2-(3-metoksi-fenil)-cikloheksil]-metilamina,
• (1R,2R)-C-[2-(3-metoksi-fenil)-cikloheksil]-metilamina,
• [2-(3-metoksi-fenil)-cikloheksilmetil]-metilamina,
• (1R,2R)-[2-(3-metoksi-fenil)-cikloheksilmetil]-metilamina,
• [2-(3-metoksi-fenil)-cikloheksilmetil]-dimetilamin, N-oksid ili
• (1R,2R)-[2-(3-metoksi-fenil)-cikloheksilmetil]-dimetilamin, N-oksid,
proizvoljno u obliku njihovih racemata, njihovih čistih stereoizomera, naročito enantiomera ili diastereomera, ili u obliku mješavina stereoizomera, naročito enantiomera ili diastereomera, u bilo kojem željenom omjeru miješanja; u prikazanom obliku ili u obliku njihovih kiselina ili njihovih baza ili u obliku njihovih soli, naročito fiziološki prihvatljivih soli, ili u obliku njihovih solvata, naročito hidrata; za dobivanje lijeka za liječenje anksioznih poremećaja.
2. Uporaba prema zahtjevu 1, naznačena time da su korišteni spojevi u obliku 1R,2R enantiomera.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10356362A DE10356362A1 (de) | 2003-11-28 | 2003-11-28 | Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie von Angststörungen |
PCT/EP2004/013439 WO2005051375A1 (de) | 2003-11-28 | 2004-11-26 | Verwendung von c-(2-phenyl-cyclohexyl)-methylaminverbindungen zur therapie von angststörungen |
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HRP20110608T1 true HRP20110608T1 (hr) | 2011-10-31 |
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HR20110608T HRP20110608T1 (hr) | 2003-11-28 | 2011-08-17 | Uporaba spojeva c-(2-fenil-cikloheksil)-metilamina za liječenje anksioznih poremećaja |
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US (3) | US20060258741A1 (hr) |
EP (2) | EP1970060B9 (hr) |
JP (1) | JP5013875B2 (hr) |
AT (1) | ATE509626T1 (hr) |
CA (1) | CA2546672C (hr) |
CY (2) | CY1113348T1 (hr) |
DE (1) | DE10356362A1 (hr) |
DK (2) | DK1970060T3 (hr) |
ES (2) | ES2362752T3 (hr) |
HR (1) | HRP20110608T1 (hr) |
PL (2) | PL1970060T3 (hr) |
PT (2) | PT1686984E (hr) |
SI (2) | SI1970060T1 (hr) |
WO (1) | WO2005051375A1 (hr) |
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US20050182131A1 (en) * | 2002-07-19 | 2005-08-18 | Gruenenthal Gmbh | 1-Phenyl-2-dimethylaminomethyl cyclohexane compounds and therapies for depressive symptoms, pain and incontinence |
DE102005034974A1 (de) * | 2005-07-22 | 2007-04-19 | Grünenthal GmbH | Salz von Dimethylaminomethyl-phenyl-cyclohexan und dessen kristalline Formen |
DE102005034973A1 (de) * | 2005-07-22 | 2007-02-15 | Grünenthal GmbH | Salz von Dimethylaminomethyl-phenyl-cyclohexan und dessen kristalline Formen |
DE102005061428A1 (de) * | 2005-12-22 | 2007-08-16 | Grünenthal GmbH | Substituierte Cyclohexylmethyl-Derivate |
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DE19525137C2 (de) | 1995-07-11 | 2003-02-27 | Gruenenthal Gmbh | 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe |
US6387956B1 (en) * | 1999-03-24 | 2002-05-14 | University Of Cincinnati | Methods of treating obsessive-compulsive spectrum disorders |
DE10059411A1 (de) * | 2000-11-30 | 2002-06-13 | Gruenenthal Gmbh | Verwendung von 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz |
DE10109763A1 (de) * | 2001-02-28 | 2002-09-05 | Gruenenthal Gmbh | Pharmazeutische Salze |
DE10146275A1 (de) * | 2001-09-18 | 2003-04-24 | Gruenenthal Gmbh | Kombination ausgewählter Opioide mit Muscarin-Antagonisten zur Therapie der Harninkontinenz |
WO2003048113A1 (en) * | 2001-11-30 | 2003-06-12 | Sepracor Inc. | Tramadol analogs and uses thereof |
DE10233048A1 (de) * | 2002-07-19 | 2004-01-29 | Grünenthal GmbH | Verwendung von 1-Phenyl-3dimethylamino-propanverbindungen zur Therapie von depressiven Symptomatiken |
SI3241550T1 (sl) * | 2002-11-22 | 2020-11-30 | Grunenthal Gmbh | Uporaba (1R, 2R) -3- (3-dimetilimanino-1-etil-2-metil-propil)-fenola za zdravljenje vnetnih bolečin |
DE10254785A1 (de) * | 2002-11-22 | 2004-06-03 | Grünenthal GmbH | Kombination ausgewählter Analgetika mit COX II-Inhibitoren |
DE102005011517A1 (de) * | 2005-03-10 | 2006-09-21 | Grünenthal GmbH | Transdermales therapeutisches System zur Verabreichung von Analgetika |
US20090104266A1 (en) * | 2005-09-15 | 2009-04-23 | Tobias Jung | 3-(2-dimethylaminomethylcy clohexyl)phenol retard formulation |
-
2003
- 2003-11-28 DE DE10356362A patent/DE10356362A1/de not_active Ceased
-
2004
- 2004-11-26 PL PL08008351T patent/PL1970060T3/pl unknown
- 2004-11-26 AT AT04819227T patent/ATE509626T1/de active
- 2004-11-26 PL PL04819227T patent/PL1686984T3/pl unknown
- 2004-11-26 JP JP2006540395A patent/JP5013875B2/ja not_active Expired - Fee Related
- 2004-11-26 DK DK08008351.2T patent/DK1970060T3/da active
- 2004-11-26 PT PT04819227T patent/PT1686984E/pt unknown
- 2004-11-26 ES ES04819227T patent/ES2362752T3/es active Active
- 2004-11-26 WO PCT/EP2004/013439 patent/WO2005051375A1/de active Application Filing
- 2004-11-26 ES ES08008351T patent/ES2390931T3/es active Active
- 2004-11-26 SI SI200431926T patent/SI1970060T1/sl unknown
- 2004-11-26 CA CA2546672A patent/CA2546672C/en not_active Expired - Fee Related
- 2004-11-26 PT PT08008351T patent/PT1970060E/pt unknown
- 2004-11-26 EP EP08008351A patent/EP1970060B9/de not_active Not-in-force
- 2004-11-26 EP EP04819227A patent/EP1686984B1/de active Active
- 2004-11-26 SI SI200431677T patent/SI1686984T1/sl unknown
- 2004-11-26 DK DK04819227.2T patent/DK1686984T3/da active
-
2006
- 2006-05-25 US US11/440,005 patent/US20060258741A1/en not_active Abandoned
-
2009
- 2009-09-14 US US12/558,896 patent/US8084497B2/en not_active Expired - Fee Related
-
2010
- 2010-06-09 US US12/797,408 patent/US20100249225A1/en not_active Abandoned
-
2011
- 2011-06-21 CY CY20111100588T patent/CY1113348T1/el unknown
- 2011-08-17 HR HR20110608T patent/HRP20110608T1/hr unknown
-
2012
- 2012-09-28 CY CY20121100904T patent/CY1113162T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
JP5013875B2 (ja) | 2012-08-29 |
PT1970060E (pt) | 2012-10-02 |
US20100004341A1 (en) | 2010-01-07 |
CA2546672C (en) | 2013-01-22 |
EP1686984B1 (de) | 2011-05-18 |
EP1686984A1 (de) | 2006-08-09 |
CA2546672A1 (en) | 2005-06-09 |
SI1686984T1 (sl) | 2011-07-29 |
DK1970060T3 (da) | 2012-10-01 |
CY1113162T1 (el) | 2016-04-13 |
US20060258741A1 (en) | 2006-11-16 |
US8084497B2 (en) | 2011-12-27 |
SI1970060T1 (sl) | 2012-10-30 |
EP1970060B9 (de) | 2013-01-09 |
PL1970060T3 (pl) | 2012-11-30 |
CY1113348T1 (el) | 2016-06-22 |
EP1970060B1 (de) | 2012-08-29 |
ATE509626T1 (de) | 2011-06-15 |
ES2362752T3 (es) | 2011-07-12 |
PT1686984E (pt) | 2011-05-30 |
US20100249225A1 (en) | 2010-09-30 |
ES2390931T3 (es) | 2012-11-19 |
EP1970060A2 (de) | 2008-09-17 |
JP2007512288A (ja) | 2007-05-17 |
DE10356362A1 (de) | 2005-06-23 |
WO2005051375A1 (de) | 2005-06-09 |
EP1970060A3 (de) | 2009-04-15 |
DK1686984T3 (da) | 2011-06-20 |
PL1686984T3 (pl) | 2011-10-31 |
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