HRP20110225T1 - Nova kombinacija lijekova kao antidepresivi - Google Patents
Nova kombinacija lijekova kao antidepresivi Download PDFInfo
- Publication number
- HRP20110225T1 HRP20110225T1 HR20110225T HRP20110225T HRP20110225T1 HR P20110225 T1 HRP20110225 T1 HR P20110225T1 HR 20110225 T HR20110225 T HR 20110225T HR P20110225 T HRP20110225 T HR P20110225T HR P20110225 T1 HRP20110225 T1 HR P20110225T1
- Authority
- HR
- Croatia
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- donepezil
- compound
- combination
- Prior art date
Links
- 239000003814 drug Substances 0.000 title claims 2
- 230000001430 anti-depressive effect Effects 0.000 title 1
- 239000000935 antidepressant agent Substances 0.000 title 1
- 229940005513 antidepressants Drugs 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims abstract 31
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims abstract 26
- 229960003530 donepezil Drugs 0.000 claims abstract 13
- AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 claims abstract 7
- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 claims abstract 5
- GJJFMKBJSRMPLA-HIFRSBDPSA-N (1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenyl-1-cyclopropanecarboxamide Chemical compound C=1C=CC=CC=1[C@@]1(C(=O)N(CC)CC)C[C@@H]1CN GJJFMKBJSRMPLA-HIFRSBDPSA-N 0.000 claims abstract 5
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 claims abstract 5
- WSEQXVZVJXJVFP-FQEVSTJZSA-N escitalopram Chemical compound C1([C@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-FQEVSTJZSA-N 0.000 claims abstract 5
- 229960004341 escitalopram Drugs 0.000 claims abstract 5
- 229960002464 fluoxetine Drugs 0.000 claims abstract 5
- 229960004038 fluvoxamine Drugs 0.000 claims abstract 5
- CJOFXWAVKWHTFT-XSFVSMFZSA-N fluvoxamine Chemical compound COCCCC\C(=N/OCCN)C1=CC=C(C(F)(F)F)C=C1 CJOFXWAVKWHTFT-XSFVSMFZSA-N 0.000 claims abstract 5
- 229960000600 milnacipran Drugs 0.000 claims abstract 5
- 229960002296 paroxetine Drugs 0.000 claims abstract 5
- 229960002073 sertraline Drugs 0.000 claims abstract 5
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 claims abstract 5
- 150000001875 compounds Chemical class 0.000 claims 12
- 238000002360 preparation method Methods 0.000 claims 3
- 208000020401 Depressive disease Diseases 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- GLQPTZAAUROJMO-UHFFFAOYSA-N 4-(3,4-dimethoxyphenyl)benzaldehyde Chemical compound C1=C(OC)C(OC)=CC=C1C1=CC=C(C=O)C=C1 GLQPTZAAUROJMO-UHFFFAOYSA-N 0.000 claims 1
- LFMYNZPAVPMEGP-PIDGMYBPSA-N Fluvoxamine maleate Chemical compound OC(=O)\C=C/C(O)=O.COCCCC\C(=N/OCCN)C1=CC=C(C(F)(F)F)C=C1 LFMYNZPAVPMEGP-PIDGMYBPSA-N 0.000 claims 1
- XNCDYJFPRPDERF-PBCQUBLHSA-N Milnacipran hydrochloride Chemical compound [Cl-].C=1C=CC=CC=1[C@@]1(C(=O)N(CC)CC)C[C@@H]1C[NH3+] XNCDYJFPRPDERF-PBCQUBLHSA-N 0.000 claims 1
- GIYXAJPCNFJEHY-UHFFFAOYSA-N N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]-1-propanamine hydrochloride (1:1) Chemical compound Cl.C=1C=CC=CC=1C(CCNC)OC1=CC=C(C(F)(F)F)C=C1 GIYXAJPCNFJEHY-UHFFFAOYSA-N 0.000 claims 1
- 229960003135 donepezil hydrochloride Drugs 0.000 claims 1
- XWAIAVWHZJNZQQ-UHFFFAOYSA-N donepezil hydrochloride Chemical compound [H+].[Cl-].O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 XWAIAVWHZJNZQQ-UHFFFAOYSA-N 0.000 claims 1
- 229960000389 fluoxetine hydrochloride Drugs 0.000 claims 1
- 229960002107 fluvoxamine maleate Drugs 0.000 claims 1
- 229960000638 milnacipran hydrochloride Drugs 0.000 claims 1
- 229960005183 paroxetine hydrochloride Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229960003660 sertraline hydrochloride Drugs 0.000 claims 1
- 208000024714 major depressive disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005276222 | 2005-09-22 | ||
| PCT/JP2006/319393 WO2007034990A1 (en) | 2005-09-22 | 2006-09-22 | Novel combination of drugs as antidepressant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110225T1 true HRP20110225T1 (hr) | 2011-04-30 |
Family
ID=37441728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110225T HRP20110225T1 (hr) | 2005-09-22 | 2011-03-29 | Nova kombinacija lijekova kao antidepresivi |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1942891B1 (sr) |
| JP (1) | JP5015159B2 (sr) |
| CY (1) | CY1112216T1 (sr) |
| DE (1) | DE602006020900D1 (sr) |
| DK (1) | DK1942891T3 (sr) |
| ES (1) | ES2362926T3 (sr) |
| HR (1) | HRP20110225T1 (sr) |
| PL (1) | PL1942891T3 (sr) |
| PT (1) | PT1942891E (sr) |
| RS (1) | RS51669B (sr) |
| SI (1) | SI1942891T1 (sr) |
| WO (1) | WO2007034990A1 (sr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008019431A1 (en) * | 2006-08-14 | 2008-02-21 | Brc Operations Pty Limited | Method and compositions for simultaneously regulating memory and mood |
| TR201001117A1 (tr) | 2010-02-15 | 2011-09-21 | Sanovel İlaç San.Ve Ti̇c.A.Ş. | Dimebolin ve memantin kombinasyonları |
| CN108147827A (zh) * | 2018-01-12 | 2018-06-12 | 安徽海螺暹罗耐火材料有限公司 | 一种碱性耐火材料用结合剂及其制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050143350A1 (en) * | 2003-11-19 | 2005-06-30 | Seed John C. | Combination drug therapy to treat obesity |
| AU2005215134B2 (en) * | 2004-02-19 | 2009-01-29 | Novartis Ag | Use of cholinesterase inhibitors for treating vascular depression |
-
2006
- 2006-09-22 ES ES06798441T patent/ES2362926T3/es active Active
- 2006-09-22 SI SI200630990T patent/SI1942891T1/sl unknown
- 2006-09-22 JP JP2008530798A patent/JP5015159B2/ja not_active Expired - Fee Related
- 2006-09-22 PT PT06798441T patent/PT1942891E/pt unknown
- 2006-09-22 EP EP06798441A patent/EP1942891B1/en active Active
- 2006-09-22 RS RS20110177A patent/RS51669B/sr unknown
- 2006-09-22 WO PCT/JP2006/319393 patent/WO2007034990A1/en active Application Filing
- 2006-09-22 DK DK06798441.9T patent/DK1942891T3/da active
- 2006-09-22 DE DE602006020900T patent/DE602006020900D1/de active Active
- 2006-09-22 PL PL06798441T patent/PL1942891T3/pl unknown
-
2011
- 2011-03-29 HR HR20110225T patent/HRP20110225T1/hr unknown
- 2011-05-23 CY CY20111100501T patent/CY1112216T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1112216T1 (el) | 2015-12-09 |
| ES2362926T3 (es) | 2011-07-15 |
| EP1942891A1 (en) | 2008-07-16 |
| EP1942891B1 (en) | 2011-03-23 |
| DE602006020900D1 (de) | 2011-05-05 |
| JP5015159B2 (ja) | 2012-08-29 |
| JP2009508849A (ja) | 2009-03-05 |
| RS51669B (sr) | 2011-10-31 |
| PL1942891T3 (pl) | 2011-08-31 |
| WO2007034990A1 (en) | 2007-03-29 |
| SI1942891T1 (sl) | 2011-06-30 |
| DK1942891T3 (da) | 2011-04-26 |
| PT1942891E (pt) | 2011-06-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021066744A5 (ja) | ブプロピオンおよびデキストロメトルファンを含む組成物 | |
| RU2011137131A (ru) | Производные 1-аминоалкилциклогексана для лечения тиннитуса, связанного с потерей слуха или незначительной потерей слуха | |
| HRP20150644T1 (hr) | Metoda za lijeäśenje atrijalne fibrilacije | |
| JP2009102342A5 (sr) | ||
| UY35624A (es) | Uso de dosis elevadas de pridopidina para tratar la enfermedad de huntington | |
| HRP20150375T1 (hr) | Derivati piridazinona | |
| RS52922B (sr) | Preparati za lečenje multiple skleroze i njihove upotrebe | |
| MA34083B1 (fr) | Compositions pharmaceutques de composé spiro-oxindole pour administration topique et leur utilisation en tant qu'agents thérapeutiques | |
| EA200700049A1 (ru) | Препаративные формы оральных лекарственных форм мемантина с модифицированным высвобождением | |
| JP2013544850A5 (sr) | ||
| MA32692B1 (fr) | Procede de liberation d'une composition pharmaceutique a un patient qui en a besoin | |
| SK14612003A3 (sk) | Použitie enantiomérne čistého escitalopramu a farmaceutický prostriedok s obsahom escitalopramu | |
| RU2007120690A (ru) | Комбинации антагонистов никотинового ацетилхолинового альфа-7-рецептора | |
| NZ587202A (en) | Methods for measuring a patient response upon administration of a drug and compositions thereof | |
| RU2004135563A (ru) | Лекарственное средство для лечения повышенной активности мочевого пузыря | |
| RU2020125170A (ru) | Композиции и способы улучшения биодоступности 5-гидрокситриптофана | |
| CO6430439A2 (es) | Agonistas del receptor de esfingosina -1- fosfato | |
| RU2008110933A (ru) | Применение амброксола для лечения риновирусных инфекций | |
| AR073265A1 (es) | Uso de dronedarona para la preparacion de un medicamento para la prevencion de ictus o ataque isquemico transitorio | |
| AR046036A1 (es) | Composiciones de risedronato y metodos para su uso | |
| RU2009131745A (ru) | Лекарственное средство для профилактического и/или терапевтического лечения деменции по типу альцгеймера | |
| JP2016505050A5 (sr) | ||
| HRP20110225T1 (hr) | Nova kombinacija lijekova kao antidepresivi | |
| RU2008134143A (ru) | Фармацевтическая композиция цитиколина, холина альфосцерата и l-карнитина (или ацетил-l-карнитина) для лечения и профилактики заболеваний центральной нервной системы и способ лечения | |
| WO2012056246A1 (en) | Combination treatment of major depressive disorder |