HRP20110127T1 - Aksomadol za liječenje kod artritisa - Google Patents
Aksomadol za liječenje kod artritisa Download PDFInfo
- Publication number
- HRP20110127T1 HRP20110127T1 HR20110127T HRP20110127T HRP20110127T1 HR P20110127 T1 HRP20110127 T1 HR P20110127T1 HR 20110127 T HR20110127 T HR 20110127T HR P20110127 T HRP20110127 T HR P20110127T HR P20110127 T1 HRP20110127 T1 HR P20110127T1
- Authority
- HR
- Croatia
- Prior art keywords
- pain
- use according
- drug
- axomadol
- arthrosis
- Prior art date
Links
- 208000002193 Pain Diseases 0.000 title claims abstract 17
- LQJLLAOISDVBJM-FMKPAKJESA-N axomadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CC[C@@H](O)C2)CN(C)C)=C1 LQJLLAOISDVBJM-FMKPAKJESA-N 0.000 title claims abstract 4
- 229950005531 axomadol Drugs 0.000 title claims abstract 4
- 206010003246 arthritis Diseases 0.000 title 1
- 201000008482 osteoarthritis Diseases 0.000 claims abstract 5
- 239000003814 drug Substances 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 4
- 230000002269 spontaneous effect Effects 0.000 claims 2
- 206010006002 Bone pain Diseases 0.000 claims 1
- 208000007353 Hip Osteoarthritis Diseases 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 208000000112 Myalgia Diseases 0.000 claims 1
- 206010033425 Pain in extremity Diseases 0.000 claims 1
- 208000013465 muscle pain Diseases 0.000 claims 1
- 230000000284 resting effect Effects 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 201000005671 spondyloarthropathy Diseases 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Upotreba aksomadola za pripremu lijeka za liječenje boli u slučaju artroze. Patent sadrži još 8 patentnih zahtjeva.
Claims (9)
1. Upotreba aksomadola za pripremu lijeka za liječenje boli u slučaju artroze.
2. Upotreba prema prethodnom zahtjevu, naznačena time da je lijek u krutom obliku lijeka.
3. Upotreba prema zahtjevu 1 ili 2, naznačena time da je lijek prilagođen za oralnu primjenu.
4. Upotreba prema bilo kojem prethodnom zahtjevu, naznačena time da je lijek proizveden za primjenu dva puta dnevno (bid).
5. Upotreba prema bilo kojem prethodnom zahtjevu, naznačena time da lijek sadrži aksomadol u količini od 10 do 2000 mg.
6. Upotreba prema bilo kojem prethodnom zahtjevu, naznačena time da je aksomadol prisutan kao hidroklorid.
7. Upotreba prema bilo kojem prethodnom zahtjevu, naznačena time da je artroza odabrana iz grupe koja sadrži gonartrozu, koksartrozu i spondilartrozu.
8. Upotreba prema bilo kojem prethodnom zahtjevu, naznačena time da je bol umjerena do jaka.
9. Upotreba prema bilo kojem prethodnom zahtjevu, naznačena time da je bol odabrana iz grupe koja sadrži bol na dodir, bol kod nošenja tereta, zamorna bol, periartikularna bol nastala zbog pritiska, isijavajuća bol, bol kod mirovanja u istom položaju u dugom vremenskom razdoblju, neprekidna bol, spontana bol, bol prilikom kretanja, noćna bol, bol u mišićima, bol u ekstremitetima i bol u kostima kao spontana bol i bol kod mirovanja.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007022790A DE102007022790A1 (de) | 2007-05-11 | 2007-05-11 | Axomadol zur Schmerzbehandlung bei Arthrose |
| PCT/EP2008/003755 WO2008138558A1 (de) | 2007-05-11 | 2008-05-09 | Axomadol zur schmerzbehandlung bei arthrose |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110127T1 true HRP20110127T1 (hr) | 2011-03-31 |
Family
ID=39672675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110127T HRP20110127T1 (hr) | 2007-05-11 | 2011-02-23 | Aksomadol za liječenje kod artritisa |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US20080306161A1 (hr) |
| EP (1) | EP2155179B1 (hr) |
| JP (1) | JP2010526786A (hr) |
| KR (1) | KR20100017781A (hr) |
| CN (1) | CN101742993A (hr) |
| AT (1) | ATE489947T1 (hr) |
| AU (1) | AU2008250621A1 (hr) |
| CA (1) | CA2685379A1 (hr) |
| CY (1) | CY1111328T1 (hr) |
| DE (2) | DE102007022790A1 (hr) |
| DK (1) | DK2155179T3 (hr) |
| ES (1) | ES2357355T3 (hr) |
| HK (1) | HK1141436A1 (hr) |
| HR (1) | HRP20110127T1 (hr) |
| IL (1) | IL202001A0 (hr) |
| MX (1) | MX2009012096A (hr) |
| PL (1) | PL2155179T3 (hr) |
| PT (1) | PT2155179E (hr) |
| RU (1) | RU2009145804A (hr) |
| SI (1) | SI2155179T1 (hr) |
| WO (1) | WO2008138558A1 (hr) |
| ZA (1) | ZA200907646B (hr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110060053A1 (en) | 2002-09-09 | 2011-03-10 | Gruenenthal Gmbh | Crystalline Modifications of 6-Dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol |
| WO2011008298A2 (en) * | 2009-07-16 | 2011-01-20 | Nectid, Inc. | Novel axomadol dosage forms |
| WO2011023392A1 (en) | 2009-08-28 | 2011-03-03 | Grünenthal GmbH | Pharmaceutical combination comprising 6-dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol or 6-dimethylaminomethyl-1-(3-hydroxy-phenyl)-cyclohexane-1,3-diol and an antiepileptic |
| WO2012000667A1 (en) * | 2010-06-30 | 2012-01-05 | Grünenthal GmbH | Axomadol or metabolite thereof for use in the treatment of irritable bowel syndrome |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19525137C2 (de) * | 1995-07-11 | 2003-02-27 | Gruenenthal Gmbh | 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbin -dungen als Zwischenprodukte zur Herstellung pharmazeutischer Wirkstoffe |
| DE10004926A1 (de) * | 2000-02-04 | 2001-08-09 | Gruenenthal Gmbh | Verfahren zur enzymatischen Racematspaltung von Aminomethyl-Aryl-Cyclohexanol-Derivaten |
| DE10059413A1 (de) * | 2000-11-30 | 2002-06-20 | Gruenenthal Gmbh | Verwendung von substituierten 6-Dimethylaminomethyl-1-phenyl-cyclohexanverbindungen zur Therapie der Harninkontinenz |
| US20050176790A1 (en) * | 2001-02-28 | 2005-08-11 | Johannes Bartholomaus | Pharmaceutical salts |
| DE10109763A1 (de) | 2001-02-28 | 2002-09-05 | Gruenenthal Gmbh | Pharmazeutische Salze |
| DE10146275A1 (de) * | 2001-09-18 | 2003-04-24 | Gruenenthal Gmbh | Kombination ausgewählter Opioide mit Muscarin-Antagonisten zur Therapie der Harninkontinenz |
| ES2819854T3 (es) * | 2002-11-22 | 2021-04-19 | Gruenenthal Gmbh | Uso de (1R,2R)-3-(3-dimetilamino-1-etil-2-metil-propil)-fenol para tratar el dolor inflamatorio |
| DE10333835A1 (de) * | 2003-07-24 | 2005-03-10 | Gruenenthal Gmbh | 6-Dimethylaminomethyl-1-(3-methoxy-phenyl)-cyclohexane-1,3-diol enthaltendes Arzneimittel mit verzögerter Wirkstofffreisetzung |
| AU2005259476B2 (en) * | 2004-07-01 | 2010-07-29 | Gruenenthal Gmbh | Oral dosage form safeguarded against abuse |
| DE102005009217A1 (de) * | 2005-02-25 | 2006-08-31 | Grünenthal GmbH | Phosphatsalze der 6-Dimethylaminomethyl-1-(3-methoxyphenyl)-1,3-dihydroxy-cyclohexanverbindungen |
| NZ560204A (en) * | 2005-02-25 | 2011-01-28 | Gruenenthal Chemie | Crystalline forms of (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxy- phenyl)cyclohexane-1,3-diol hydrochloride |
-
2007
- 2007-05-11 DE DE102007022790A patent/DE102007022790A1/de not_active Withdrawn
-
2008
- 2008-05-09 RU RU2009145804/15A patent/RU2009145804A/ru not_active Application Discontinuation
- 2008-05-09 MX MX2009012096A patent/MX2009012096A/es active IP Right Grant
- 2008-05-09 PT PT08758440T patent/PT2155179E/pt unknown
- 2008-05-09 DK DK08758440.5T patent/DK2155179T3/da active
- 2008-05-09 DE DE502008001951T patent/DE502008001951D1/de active Active
- 2008-05-09 ES ES08758440T patent/ES2357355T3/es active Active
- 2008-05-09 KR KR1020097025938A patent/KR20100017781A/ko not_active Application Discontinuation
- 2008-05-09 AU AU2008250621A patent/AU2008250621A1/en not_active Abandoned
- 2008-05-09 WO PCT/EP2008/003755 patent/WO2008138558A1/de active Application Filing
- 2008-05-09 CA CA002685379A patent/CA2685379A1/en not_active Abandoned
- 2008-05-09 US US12/118,231 patent/US20080306161A1/en not_active Abandoned
- 2008-05-09 SI SI200830139T patent/SI2155179T1/sl unknown
- 2008-05-09 CN CN200880015678A patent/CN101742993A/zh active Pending
- 2008-05-09 AT AT08758440T patent/ATE489947T1/de active
- 2008-05-09 JP JP2010506858A patent/JP2010526786A/ja active Pending
- 2008-05-09 PL PL08758440T patent/PL2155179T3/pl unknown
- 2008-05-09 EP EP08758440A patent/EP2155179B1/de not_active Not-in-force
-
2009
- 2009-10-30 ZA ZA200907646A patent/ZA200907646B/xx unknown
- 2009-11-09 IL IL202001A patent/IL202001A0/en unknown
-
2010
- 2010-08-12 HK HK10107704.0A patent/HK1141436A1/xx not_active IP Right Cessation
- 2010-09-10 US US12/879,562 patent/US20100331424A1/en not_active Abandoned
-
2011
- 2011-02-16 CY CY20111100191T patent/CY1111328T1/el unknown
- 2011-02-23 HR HR20110127T patent/HRP20110127T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2009012096A (es) | 2009-11-23 |
| PL2155179T3 (pl) | 2011-05-31 |
| CA2685379A1 (en) | 2008-11-20 |
| KR20100017781A (ko) | 2010-02-16 |
| WO2008138558A1 (de) | 2008-11-20 |
| EP2155179A1 (de) | 2010-02-24 |
| IL202001A0 (en) | 2010-06-16 |
| EP2155179B1 (de) | 2010-12-01 |
| US20080306161A1 (en) | 2008-12-11 |
| PT2155179E (pt) | 2011-03-07 |
| ATE489947T1 (de) | 2010-12-15 |
| RU2009145804A (ru) | 2011-06-20 |
| US20100331424A1 (en) | 2010-12-30 |
| CY1111328T1 (el) | 2015-08-05 |
| ZA200907646B (en) | 2010-07-28 |
| HK1141436A1 (en) | 2010-11-12 |
| DE502008001951D1 (de) | 2011-01-13 |
| ES2357355T3 (es) | 2011-04-25 |
| DK2155179T3 (da) | 2011-03-07 |
| AU2008250621A1 (en) | 2008-11-20 |
| SI2155179T1 (sl) | 2011-03-31 |
| CN101742993A (zh) | 2010-06-16 |
| DE102007022790A1 (de) | 2008-11-20 |
| JP2010526786A (ja) | 2010-08-05 |
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