HRP20080598T3 - Combination of et-743 with 5-fluorouracil pro-drugs for the treatment of cancer - Google Patents

Combination of et-743 with 5-fluorouracil pro-drugs for the treatment of cancer

Info

Publication number
HRP20080598T3
HRP20080598T3 HR20080598T HRP20080598T HRP20080598T3 HR P20080598 T3 HRP20080598 T3 HR P20080598T3 HR 20080598 T HR20080598 T HR 20080598T HR P20080598 T HRP20080598 T HR P20080598T HR P20080598 T3 HRP20080598 T3 HR P20080598T3
Authority
HR
Croatia
Prior art keywords
combination
cancer
drugs
treatment
fluorouracil
Prior art date
Application number
HR20080598T
Other languages
English (en)
Croatian (hr)
Inventor
Ellen Rybak Mary
Original Assignee
Pharma Mar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar filed Critical Pharma Mar
Publication of HRP20080598T3 publication Critical patent/HRP20080598T3/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HR20080598T 2003-11-13 2008-12-02 Combination of et-743 with 5-fluorouracil pro-drugs for the treatment of cancer HRP20080598T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US51969003P 2003-11-13 2003-11-13
PCT/GB2004/050026 WO2005049031A1 (fr) 2003-11-13 2004-11-15 Combinaison

Publications (1)

Publication Number Publication Date
HRP20080598T3 true HRP20080598T3 (en) 2009-01-31

Family

ID=34619369

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20080598T HRP20080598T3 (en) 2003-11-13 2008-12-02 Combination of et-743 with 5-fluorouracil pro-drugs for the treatment of cancer

Country Status (15)

Country Link
US (1) US7622458B2 (fr)
EP (1) EP1689404B9 (fr)
JP (1) JP2007511499A (fr)
AT (1) ATE406897T1 (fr)
CA (1) CA2544320A1 (fr)
CY (1) CY1108629T1 (fr)
DE (1) DE602004016376D1 (fr)
DK (1) DK1689404T3 (fr)
ES (1) ES2314470T3 (fr)
HR (1) HRP20080598T3 (fr)
PL (1) PL1689404T3 (fr)
PT (1) PT1689404E (fr)
RS (1) RS50692B (fr)
SI (1) SI1689404T1 (fr)
WO (1) WO2005049031A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
DE60143911D1 (de) * 2000-11-06 2011-03-03 Pharma Mar Sa Antitumorzusammensetzungen welche ecteinascidin 743 enthalten
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0202544D0 (en) 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
EP1689404B9 (fr) 2003-11-13 2009-04-22 Pharma Mar, S.A.U. Combinaison du et-743 avec des pro-drugs du 5-fluorouracile pour le traitement du cancer
CA2545054A1 (fr) * 2003-11-14 2005-06-02 Pharma Mar, S.A. Therapie anticancer utilisant une combinaison de et-743 et de paclitaxel
UA87877C2 (en) * 2004-10-26 2009-08-25 Фарма Мар С.А., Сосьедад Униперсональ Pegylated liposomal doxorubicin in combination with ecteinescidin 743
PL1658848T3 (pl) 2004-10-29 2007-12-31 Pharma Mar Sa Preparaty zawierające ekteinascydynę i disacharyd
ATE546148T1 (de) * 2005-07-21 2012-03-15 Nuvo Res Ag Stabilisierte chlorit-lösungen in kombination mit fluorpyrimidinen zur krebsbehandlung
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
AU2008313634A1 (en) * 2007-10-19 2009-04-23 Pharma Mar, S.A. Prognostic molecular markers for ET-743 treatment
LT2786756T (lt) 2010-11-12 2020-05-11 Pharma Mar, S.A. Derinių terapija su topoizomerazės inhibitoriumi
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
EP3752154A4 (fr) * 2018-02-12 2021-12-29 Array Biopharma, Inc. Procédés et polythérapie pour traiter le cancer des voies biliaires

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5256663A (en) * 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5149804A (en) * 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
DE3635711A1 (de) * 1986-10-21 1988-04-28 Knoll Ag 5-nitrobenzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung
FR2697752B1 (fr) * 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
AU671491B2 (en) * 1992-12-18 1996-08-29 F. Hoffmann-La Roche Ag N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US20040059112A1 (en) * 1994-02-18 2004-03-25 Rinehart Kenneth L. Ecteinascidins
GB9508195D0 (en) * 1995-04-20 1995-06-07 Univ British Columbia Novel biologically active compounds and compositions,their use and derivation
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US5985876A (en) * 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
WO1999051238A1 (fr) * 1998-04-06 1999-10-14 The Board Of Trustees Of The University Of Illinois Ecteine-ascidines semi-synthetiques
KR100643092B1 (ko) 1998-05-11 2006-11-10 파르마 마르, 에스.에이. 엑테인아시딘 743의 대사산물
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
AR035842A1 (es) * 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
NZ520593A (en) * 2000-02-28 2004-10-29 Aventis Pharma S A composition comprising camptothecin and a pyrimidine derivative for the treatment of cancer
CN1436191B (zh) 2000-04-12 2011-09-14 法马马有限公司 抗肿瘤海鞘素衍生物
EP1356097A2 (fr) * 2000-08-11 2003-10-29 City of Hope Agent anti neoplasique et-743 inhibant la trans-activation par sxr
DE60143911D1 (de) * 2000-11-06 2011-03-03 Pharma Mar Sa Antitumorzusammensetzungen welche ecteinascidin 743 enthalten
WO2002064843A1 (fr) 2001-02-09 2002-08-22 The Regents Of The University Of California Composes de la famille de l'ecteinascidine: compositions et procedes
GB0121285D0 (en) 2001-09-03 2001-10-24 Cancer Res Ventures Ltd Anti-cancer combinations
CA2462502A1 (fr) 2001-10-19 2003-05-15 Pharma Mar, S.A. Utilisation amelioree de compose anti-tumoral dans le traitement des cancers
US20040019027A1 (en) * 2002-04-12 2004-01-29 Barry Forman Method of treating cerebrotendinous xanthomatosis
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
EP1689404B9 (fr) 2003-11-13 2009-04-22 Pharma Mar, S.A.U. Combinaison du et-743 avec des pro-drugs du 5-fluorouracile pour le traitement du cancer
CA2545054A1 (fr) 2003-11-14 2005-06-02 Pharma Mar, S.A. Therapie anticancer utilisant une combinaison de et-743 et de paclitaxel
GB0326486D0 (en) 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
WO2006035244A2 (fr) 2004-09-29 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Agents anti-inflammatoires
UA87877C2 (en) 2004-10-26 2009-08-25 Фарма Мар С.А., Сосьедад Униперсональ Pegylated liposomal doxorubicin in combination with ecteinescidin 743
PL1658848T3 (pl) * 2004-10-29 2007-12-31 Pharma Mar Sa Preparaty zawierające ekteinascydynę i disacharyd

Also Published As

Publication number Publication date
SI1689404T1 (sl) 2009-02-28
WO2005049031A1 (fr) 2005-06-02
JP2007511499A (ja) 2007-05-10
RS50692B (sr) 2010-06-30
CA2544320A1 (fr) 2005-06-02
PL1689404T3 (pl) 2009-02-27
EP1689404B9 (fr) 2009-04-22
EP1689404A1 (fr) 2006-08-16
US20070190164A1 (en) 2007-08-16
ES2314470T3 (es) 2009-03-16
DK1689404T3 (da) 2009-01-26
CY1108629T1 (el) 2014-04-09
ATE406897T1 (de) 2008-09-15
US7622458B2 (en) 2009-11-24
DE602004016376D1 (de) 2008-10-16
PT1689404E (pt) 2008-12-15
EP1689404B1 (fr) 2008-09-03

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