HK5495A - New use of 1,4-dihydropyridine derivatives - Google Patents

New use of 1,4-dihydropyridine derivatives

Info

Publication number
HK5495A
HK5495A HK5495A HK5495A HK5495A HK 5495 A HK5495 A HK 5495A HK 5495 A HK5495 A HK 5495A HK 5495 A HK5495 A HK 5495A HK 5495 A HK5495 A HK 5495A
Authority
HK
Hong Kong
Prior art keywords
formula
compound
blood
calcium
preparation
Prior art date
Application number
HK5495A
Other languages
English (en)
French (fr)
Original Assignee
Sandoz Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag. filed Critical Sandoz Ag.
Publication of HK5495A publication Critical patent/HK5495A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Claims (4)

1. Verwendung einer Verbindung der Formel worin
R1 Wasserstoff
R2 und R5 unabhängig voneinander Alkyl mit 1 bis 6 Kohlenstoffatomen
R3 und R4 unabhängig voneinander Alkoxy mit 1 bis 6 Kohlenstoffatomen
R6 Wasserstoff und
X Sauerstoff bedeuten zur Herstellung eines Arzneimittels das zur Behandlung von Atherosclerose geeignet ist.
2. Verwendung einer Verbindung der Formel I gemäss Anspruch 1 zur Herstellung eines Arzneimittels das zur Vorbeugung oder Hemmung der Plaquebildung bei der Atherosclerose geeignet ist.
3. Verwendung von 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3-methoxycarbonyl-pyridin-5-carbonsäure isopropyl ester als Verbindung der Formel 1 zur Herstellung eines Medikamentes gemäss den Ansprüchen 1 oder 2.
4. Verwendung von 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-pyridin-3,5-dicarbonsäure diethylester als Verbindung der Formel I zur Herstellung eines Medikamentes gemäss den Ansprüchen 1 oder 2.
HK5495A 1984-11-12 1995-01-12 New use of 1,4-dihydropyridine derivatives HK5495A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848428552A GB8428552D0 (en) 1984-11-12 1984-11-12 Organic compounds
PCT/EP1985/000597 WO1986002836A1 (en) 1984-11-12 1985-11-08 New use of 1,4-dihydropyridine derivatives and combinations thereof with calcitonins

Publications (1)

Publication Number Publication Date
HK5495A true HK5495A (en) 1995-01-20

Family

ID=10569606

Family Applications (1)

Application Number Title Priority Date Filing Date
HK5495A HK5495A (en) 1984-11-12 1995-01-12 New use of 1,4-dihydropyridine derivatives

Country Status (14)

Country Link
EP (1) EP0202282B1 (de)
JP (1) JPH0627069B2 (de)
AT (1) ATE77952T1 (de)
AU (1) AU586455B2 (de)
CY (1) CY1794A (de)
DE (1) DE3586321T2 (de)
DK (1) DK332786A (de)
GB (1) GB8428552D0 (de)
HK (1) HK5495A (de)
MY (1) MY102063A (de)
PH (1) PH22606A (de)
SG (1) SG79394G (de)
WO (1) WO1986002836A1 (de)
ZA (1) ZA858672B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103613584B (zh) * 2013-11-27 2016-04-27 沈阳药科大学 一种伊拉地平合成产物后处理的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2210667A1 (de) * 1972-03-06 1973-09-20 Bayer Ag Kondensiert aromatisch substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2335466A1 (de) * 1973-07-12 1975-01-30 Bayer Ag Alkoxyalkyl-1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DK149855C (da) * 1977-06-20 1987-04-21 Sandoz Ag Analogifremgangsmaade til fremstilling af 1,4-dihydropyridinderivater
BE886259A (fr) * 1979-11-23 1981-05-20 Sandoz Sa Nouveaux medicament a base de derives de la 1,4-dihydropyridine, pour le traitement de l'insuffisance cerebrovasculaire ou a action spamolytique
DE3015219A1 (de) * 1980-04-19 1981-10-22 Bayer Ag, 5090 Leverkusen 6-amino-4,5-dihydropyridin-3-carbonsaeureester, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4442112A (en) * 1981-09-02 1984-04-10 Sandoz Ltd. Dihydropyridine derivatives useful in treating vascular headaches
DE3222367A1 (de) * 1982-06-15 1983-12-15 Bayer Ag, 5090 Leverkusen Verwendung von 1,4-dihydropyridinen in antiarteriosklerotika und deren herstellung
FR2528431B1 (fr) * 1982-06-15 1986-01-10 Sandoz Sa Nouveaux derives de la 1,4-dihydropyridine, leur preparation et leur utilisation comme medicaments
JPS597163A (ja) * 1982-07-02 1984-01-14 Yamanouchi Pharmaceut Co Ltd 抗動脈硬化剤
US4656181A (en) * 1982-11-24 1987-04-07 Cermol S.A. Esters of 1,4-dihydropyridines, processes for the preparation of the new esters, and medicaments containing the same
DE3307422A1 (de) * 1983-03-03 1984-09-06 Bayer Ag, 5090 Leverkusen Fluessigzubereitungen von dihydropyridinen, ein verfahren zu ihrer herstellung, sowie ihre verwendung bei der bekaempfung von erkrankungen
EP0125803A3 (de) * 1983-04-27 1987-01-21 FISONS plc Pharmazeutisch aktive Dihydropyridine

Also Published As

Publication number Publication date
AU5199286A (en) 1986-06-03
WO1986002836A1 (en) 1986-05-22
DK332786D0 (da) 1986-07-11
DE3586321D1 (de) 1992-08-13
SG79394G (en) 1994-10-14
ZA858672B (en) 1987-06-24
PH22606A (en) 1988-10-17
GB8428552D0 (en) 1984-12-19
DE3586321T2 (de) 1992-12-10
MY102063A (en) 1992-03-31
EP0202282A1 (de) 1986-11-26
JPH0627069B2 (ja) 1994-04-13
AU586455B2 (en) 1989-07-13
DK332786A (da) 1986-07-11
ATE77952T1 (de) 1992-07-15
CY1794A (en) 1995-02-17
JPS62500785A (ja) 1987-04-02
EP0202282B1 (de) 1992-07-08

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)