HK4288A - Sustained release theophylline tablet having reduced bulk - Google Patents

Sustained release theophylline tablet having reduced bulk

Info

Publication number
HK4288A
HK4288A HK42/88A HK4288A HK4288A HK 4288 A HK4288 A HK 4288A HK 42/88 A HK42/88 A HK 42/88A HK 4288 A HK4288 A HK 4288A HK 4288 A HK4288 A HK 4288A
Authority
HK
Hong Kong
Prior art keywords
sustained release
reduced bulk
release theophylline
theophylline tablet
theophylline
Prior art date
Application number
HK42/88A
Inventor
Stephen T David
Dana Brooks
Claude E Gallian
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of HK4288A publication Critical patent/HK4288A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Non-disintegrating tablets containing at least 95% by weight theophylline having a pair of opposing substantially planar surfaces and a very thin cross-section (i.e. 2.03-3.05 mm) have a high bioavailability on ingestion and a relatively steady release rate permitting a 12 hr. dosing interval for maintenance of non-toxic therapeutic blood theophylline concentrations. Excipients or tableting aids are not required, but trace amounts of a tableting lubricant are preferably included to facilitate continuous large scale production.
HK42/88A 1980-05-06 1988-01-21 Sustained release theophylline tablet having reduced bulk HK4288A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14742980A 1980-05-06 1980-05-06
US24978781A 1981-04-01 1981-04-01

Publications (1)

Publication Number Publication Date
HK4288A true HK4288A (en) 1988-01-29

Family

ID=26844921

Family Applications (1)

Application Number Title Priority Date Filing Date
HK42/88A HK4288A (en) 1980-05-06 1988-01-21 Sustained release theophylline tablet having reduced bulk

Country Status (17)

Country Link
AT (1) AT380789B (en)
AU (1) AU549299B2 (en)
CA (1) CA1165241A (en)
CY (1) CY1368A (en)
DE (1) DE3117756A1 (en)
DK (1) DK155976C (en)
FI (1) FI811356L (en)
FR (1) FR2484253A1 (en)
GB (1) GB2078518B (en)
HK (1) HK4288A (en)
IE (1) IE51157B1 (en)
IT (1) IT1209867B (en)
KE (1) KE3722A (en)
LU (1) LU83342A1 (en)
NL (1) NL8102168A (en)
SE (1) SE452550B (en)
SG (1) SG30987G (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4547358A (en) * 1980-05-06 1985-10-15 Mead Johnson & Company Sustained release tablet containing at least 95 percent theophylline
US4503031A (en) * 1982-12-17 1985-03-05 Glassman Jacob A Super-fast-starting-sustained release tablet
HU187215B (en) * 1983-01-26 1985-11-28 Egyt Gyogyszervegyeszeti Gyar Method for producing pharmaceutical product of high actor content and prolonged effect
US4753945A (en) * 1986-02-19 1988-06-28 Eye Research Institute Of Retina Foundation Stimulation of tear secretion with phosphodiesterase inhibitors
FR2595945B1 (en) * 1986-03-19 1990-01-19 Doms Laboratoires THEOPHYLLIN DELAY TABLET BASED ON P.V.C., AND PROCESS FOR PREPARING THE SAME

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL297088A (en) * 1961-01-31
DE1228029C2 (en) * 1964-05-09 1973-05-17 Merck Ag E Process for the production of tablets by pressing powder mixtures without prior granulation
US3723614A (en) * 1971-01-06 1973-03-27 Ciba Geigy Ag Maltese-cross scored tablet
US4264573A (en) * 1979-05-21 1981-04-28 Rowell Laboratories, Inc. Pharmaceutical formulation for slow release via controlled surface erosion

Also Published As

Publication number Publication date
FI811356L (en) 1981-11-07
GB2078518A (en) 1982-01-13
SE452550B (en) 1987-12-07
SE8102814L (en) 1981-11-07
DK200181A (en) 1981-11-07
FR2484253B1 (en) 1983-06-03
DE3117756A1 (en) 1982-04-29
DE3117756C2 (en) 1992-11-26
AU549299B2 (en) 1986-01-23
DK155976B (en) 1989-06-12
SG30987G (en) 1987-07-17
DK155976C (en) 1989-10-30
NL8102168A (en) 1981-12-01
IT8148406A0 (en) 1981-05-06
IE51157B1 (en) 1986-10-15
LU83342A1 (en) 1982-01-20
IT1209867B (en) 1989-08-30
AU7020581A (en) 1981-11-12
KE3722A (en) 1987-04-30
ATA202081A (en) 1985-12-15
FR2484253A1 (en) 1981-12-18
CY1368A (en) 1987-08-07
CA1165241A (en) 1984-04-10
GB2078518B (en) 1984-04-11
AT380789B (en) 1986-07-10
IE810989L (en) 1981-11-06

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Legal Events

Date Code Title Description
PE Patent expired