HK37392A - New morpholino derivatives of daunorubicin and doxorubicin - Google Patents

New morpholino derivatives of daunorubicin and doxorubicin

Info

Publication number
HK37392A
HK37392A HK373/92A HK37392A HK37392A HK 37392 A HK37392 A HK 37392A HK 373/92 A HK373/92 A HK 373/92A HK 37392 A HK37392 A HK 37392A HK 37392 A HK37392 A HK 37392A
Authority
HK
Hong Kong
Prior art keywords
daunorubicin
doxorubicin
new
morpholino derivatives
hydrogen
Prior art date
Application number
HK373/92A
Other languages
English (en)
Inventor
Bargiotti Alberto
Zini Pierangelo
Penco Sergio
Giuliani Fernando
Original Assignee
Farmitalia Carlo Erba S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba S.R.L. filed Critical Farmitalia Carlo Erba S.R.L.
Publication of HK37392A publication Critical patent/HK37392A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
HK373/92A 1985-03-22 1992-05-28 New morpholino derivatives of daunorubicin and doxorubicin HK37392A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB08507577A GB2172594B (en) 1985-03-22 1985-03-22 New morpholino derivatives of daunorubicin and doxorubicin

Publications (1)

Publication Number Publication Date
HK37392A true HK37392A (en) 1992-06-04

Family

ID=10576503

Family Applications (1)

Application Number Title Priority Date Filing Date
HK373/92A HK37392A (en) 1985-03-22 1992-05-28 New morpholino derivatives of daunorubicin and doxorubicin

Country Status (10)

Country Link
US (1) US4672057A (cs)
JP (1) JPS61221194A (cs)
BE (1) BE904431A (cs)
BG (1) BG60535B2 (cs)
BR (1) BR1100255A (cs)
CZ (1) CZ419591A3 (cs)
DE (1) DE3609052C2 (cs)
GB (1) GB2172594B (cs)
HK (1) HK37392A (cs)
MX (1) MX9203114A (cs)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3823224A1 (de) * 1988-07-08 1990-01-11 Behringwerke Ag Morpholino-derivate der rhodomycine, verfahren zu ihrer herstellung und ihre verwendung
GB8905668D0 (en) * 1989-03-13 1989-04-26 Erba Carlo Spa New 3'-(4-morpholinyl)-and 3'-(2-methoxy-4-morpholinyl)-anthracycline derivatives
US5304687A (en) * 1989-12-19 1994-04-19 Farmitalia Carlo Erba S.R.L. Morpholinyl derivatives of doxorubicin and process for their preparation
ES2094136T3 (es) * 1989-12-19 1997-01-16 Pharmacia Spa Intermediarios quirales de 1,5-diyodo-2-metoxi o benciloxi.
GB9019933D0 (en) * 1990-09-12 1990-10-24 Erba Carlo Spa 13-dihydro-3'-(2-alkoxy-4-morphlinyl)anthracyclines
GB9019934D0 (en) * 1990-09-12 1990-10-24 Erba Carlo Spa 2-hydroxy-and 2-acyloxy-4-morpholinyl anthracyclines
US5776458A (en) * 1990-12-05 1998-07-07 Pharmacia & Upjohn S.P.A. Anthracycline-conjugates
GB9026491D0 (en) * 1990-12-05 1991-01-23 Erba Carlo Spa Anthracycline-conjugates
GB9028105D0 (en) * 1990-12-27 1991-02-13 Erba Carlo Spa Process for the preparation of substituted benzofuran derivatives
GB9216962D0 (en) * 1992-08-11 1992-09-23 Erba Carlo Spa Therapeutically active naphthalenesulfonic-pyrrolecarboxamido derivatives
GB9909925D0 (en) 1999-04-29 1999-06-30 Pharmacia & Upjohn Spa Combined preparations comprising anthracycline derivatives
ATE344801T1 (de) 1999-12-29 2006-11-15 Immunogen Inc Doxorubicin- und daunorubicin-enthaltende, zytotoxische mittel und deren therapeutische anwendung
US20040038904A1 (en) * 2002-05-21 2004-02-26 Angela Ogden Method of treating multiple sclerosis
RU2005132175A (ru) * 2003-03-18 2006-01-27 Фармация Италия С.П.А. (It) Комбинированное лечение опухолей, включающее неморубицин и лучевую терапию
US20060198882A1 (en) * 2003-03-21 2006-09-07 Yechezkel Barenholz Stable liposomes or micelles comprising a sphinolipid and a peg-lipopolymer
JP2008520560A (ja) * 2004-11-15 2008-06-19 イッスム・リサーチ・ディベロップメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシティ・オブ・エルサレム 組合せ治療
JP4513765B2 (ja) * 2005-04-15 2010-07-28 日本ビクター株式会社 電気音響変換器
EA200970116A1 (ru) * 2006-07-12 2009-08-28 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. Кристаллический гидрохлорид неморубицина
WO2008092796A1 (en) * 2007-01-29 2008-08-07 Nerviano Medical Sciences S.R.L. Antitumor combination comprising a morpholinyl anthracycline and an antibody
WO2008138758A1 (en) 2007-05-11 2008-11-20 Nerviano Medical Sciences S.R.L. Pharmaceutical composition of an anthracycline
US20100190736A1 (en) * 2007-08-02 2010-07-29 Nerviano Medical Sciences S.R.L. Morpholinyl anthracycline derivative combined with protein kinase inhibitors
EP2240495B1 (en) 2008-02-01 2015-07-15 Genentech, Inc. Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
EP2257310A2 (en) * 2008-02-26 2010-12-08 Nerviano Medical Sciences S.r.l. Antitumor combination comprising a morpholinyl anthracycline derivative and demethylating agents
AR072804A1 (es) 2008-07-15 2010-09-22 Genentech Inc Conjugados derivados de antraciclina,proceso para su preparacion,composiciones farmaceuticas que los contienen y su uso como agentes antitumorales.
AU2011274229A1 (en) 2010-07-02 2013-01-10 Angiochem Inc. Short and D-amino acid-containing polypeptides for therapeutic conjugates and uses thereof
WO2012064627A2 (en) 2010-11-08 2012-05-18 Genentech, Inc. Subcutaneously administered anti-il-6 receptor antibody
BR112013013127B1 (pt) 2010-12-02 2021-06-22 Nerviano Medical Sciences S.R.L. Processo para a preparação de derivados de morfolinil antraciclina, compostos derivados de morfolinil antraciclina e composição farmacêutica compreendendo estes compostos
HK1206270A1 (en) 2012-03-16 2016-01-08 The Johns Hopkins University Controlled release formulations for the delivery of hif-1 inhibitors
KR101640912B1 (ko) * 2014-07-03 2016-07-20 현대자동차주식회사 고온 저마찰성 코팅층 및 이의 제조방법
US10149913B2 (en) 2014-09-12 2018-12-11 Genentech, Inc. Anthracycline disulfide intermediates, antibody-drug conjugates and methods
EP4180061A1 (en) 2021-11-10 2023-05-17 Nerviano Medical Sciences S.r.l. Anthracycline derivative linker reagents, antibody-drug conjugates and methods
WO2025168481A1 (en) 2024-02-05 2025-08-14 Nerviano Medical Sciences S.R.L. Imino-anthracycline derivatives and methods

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE639897A (cs) *
US4464529A (en) * 1982-07-20 1984-08-07 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin

Also Published As

Publication number Publication date
DE3609052A1 (de) 1986-09-25
BG60535B2 (bg) 1995-07-28
CZ419591A3 (en) 1993-03-17
GB8507577D0 (en) 1985-05-01
BE904431A (fr) 1986-07-16
GB2172594A (en) 1986-09-24
MX9203114A (es) 1992-07-01
DE3609052C2 (de) 1994-10-27
GB2172594B (en) 1988-06-08
JPS61221194A (ja) 1986-10-01
US4672057A (en) 1987-06-09
BR1100255A (pt) 2002-04-02
JPH0482160B2 (cs) 1992-12-25

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Legal Events

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PE Patent expired

Effective date: 20050321