HK1258984A1 - 尿苷類磷醯胺前藥、其製備方法及其在醫藥上的應用 - Google Patents

尿苷類磷醯胺前藥、其製備方法及其在醫藥上的應用

Info

Publication number
HK1258984A1
HK1258984A1 HK19101469.9A HK19101469A HK1258984A1 HK 1258984 A1 HK1258984 A1 HK 1258984A1 HK 19101469 A HK19101469 A HK 19101469A HK 1258984 A1 HK1258984 A1 HK 1258984A1
Authority
HK
Hong Kong
Prior art keywords
preparation
method therefor
medicinal uses
uridine
phosphoramide prodrug
Prior art date
Application number
HK19101469.9A
Other languages
English (en)
Inventor
王國成
吳會敏
Original Assignee
江蘇天士力帝益藥業有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 江蘇天士力帝益藥業有限公司 filed Critical 江蘇天士力帝益藥業有限公司
Publication of HK1258984A1 publication Critical patent/HK1258984A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
HK19101469.9A 2016-03-25 2019-01-28 尿苷類磷醯胺前藥、其製備方法及其在醫藥上的應用 HK1258984A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201610180475 2016-03-25
PCT/CN2017/077693 WO2017162169A1 (zh) 2016-03-25 2017-03-22 尿苷类磷酰胺前药、其制备方法及其在医药上的应用

Publications (1)

Publication Number Publication Date
HK1258984A1 true HK1258984A1 (zh) 2019-11-22

Family

ID=59899318

Family Applications (1)

Application Number Title Priority Date Filing Date
HK19101469.9A HK1258984A1 (zh) 2016-03-25 2019-01-28 尿苷類磷醯胺前藥、其製備方法及其在醫藥上的應用

Country Status (12)

Country Link
US (1) US10745434B2 (zh)
EP (1) EP3434685B1 (zh)
JP (1) JP6890132B2 (zh)
KR (1) KR20180122333A (zh)
CN (2) CN109071588B (zh)
AU (1) AU2017239338B2 (zh)
CA (1) CA3010462A1 (zh)
HK (1) HK1258984A1 (zh)
IL (1) IL261193B (zh)
RU (1) RU2740760C2 (zh)
TW (1) TW201733596A (zh)
WO (1) WO2017162169A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105983016B (zh) 2015-03-23 2023-08-11 天士力医药集团股份有限公司 一种含有水飞蓟宾的药物组合
CN114262348A (zh) * 2020-09-16 2022-04-01 上海本仁科技有限公司 环状核苷磷酸酯类化合物及其应用
CN113234102A (zh) * 2021-05-18 2021-08-10 宁波大学 一种三配位磷衍生物及中间体及制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2466729C2 (ru) 2006-12-28 2012-11-20 Айденикс Фармасьютикалз, Инк. Соединения и фармацевтические композиции для лечения вирусных инфекций
US7964580B2 (en) * 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US8053186B2 (en) 2007-06-15 2011-11-08 The Ohio State University Research Foundation Oncogenic ALL-1 fusion proteins for targeting Drosha-mediated microRNA processing
TWI576352B (zh) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 核苷磷醯胺
US9156874B2 (en) * 2011-01-03 2015-10-13 Nanjing Molecular Research, Inc. Double-liver-targeting phosphoramidate and phosphonoamidate prodrugs
EP2697242B1 (en) * 2011-04-13 2018-10-03 Merck Sharp & Dohme Corp. 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
WO2013187978A1 (en) * 2012-06-16 2013-12-19 Nanjing Molecular Research, Inc. Double-liver-targeting phosphoramidate and phosphonoamidate prodrugs
CN103224530B (zh) * 2012-08-13 2014-10-29 洛阳聚慧投资股份有限公司 一组替诺福韦酯化合物、制备方法及其在抗病毒方面的应用
CN107312039B (zh) 2012-08-30 2019-06-25 江苏豪森药业集团有限公司 一种替诺福韦前药的制备方法
CN103435672A (zh) * 2013-04-25 2013-12-11 刘沛 含有取代苄基的新型核苷磷酸酯前药的结构与合成
CN105307661A (zh) * 2013-05-16 2016-02-03 里博科学有限责任公司 4’-叠氮基,3’-脱氧基-3’-氟取代的核苷衍生物

Also Published As

Publication number Publication date
US10745434B2 (en) 2020-08-18
CN109071588A (zh) 2018-12-21
RU2018125748A3 (zh) 2020-04-23
CN107226831A (zh) 2017-10-03
RU2740760C2 (ru) 2021-01-20
AU2017239338A1 (en) 2018-07-19
JP6890132B2 (ja) 2021-06-18
AU2017239338B2 (en) 2020-08-27
JP2019514843A (ja) 2019-06-06
IL261193A (en) 2018-10-31
CA3010462A1 (en) 2017-09-28
WO2017162169A1 (zh) 2017-09-28
EP3434685B1 (en) 2021-06-16
US20180371004A1 (en) 2018-12-27
EP3434685A1 (en) 2019-01-30
KR20180122333A (ko) 2018-11-12
RU2018125748A (ru) 2020-01-13
IL261193B (en) 2020-10-29
TW201733596A (zh) 2017-10-01
CN109071588B (zh) 2021-07-06
EP3434685A4 (en) 2019-11-13

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