HK1258800A1 - 用於修復心臟組織的心外膜衍生的旁分泌因子 - Google Patents

用於修復心臟組織的心外膜衍生的旁分泌因子

Info

Publication number
HK1258800A1
HK1258800A1 HK19101164.7A HK19101164A HK1258800A1 HK 1258800 A1 HK1258800 A1 HK 1258800A1 HK 19101164 A HK19101164 A HK 19101164A HK 1258800 A1 HK1258800 A1 HK 1258800A1
Authority
HK
Hong Kong
Prior art keywords
epicardial
cardiac tissue
paracrine factors
repairing cardiac
derived paracrine
Prior art date
Application number
HK19101164.7A
Other languages
English (en)
Inventor
P‧魯伊斯-洛扎諾
M.莫克拉
K.魏
Original Assignee
雷根科公司
桑福德伯納姆普雷比斯醫學研究所
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 雷根科公司, 桑福德伯納姆普雷比斯醫學研究所 filed Critical 雷根科公司
Publication of HK1258800A1 publication Critical patent/HK1258800A1/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1875Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007Drug-containing films, membranes or sheets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657Cardiomyocytes; Heart cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Developmental Biology & Embryology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
HK19101164.7A 2015-04-09 2019-01-23 用於修復心臟組織的心外膜衍生的旁分泌因子 HK1258800A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562145480P 2015-04-09 2015-04-09
US201562196766P 2015-07-24 2015-07-24
PCT/US2016/026809 WO2016164840A1 (en) 2015-04-09 2016-04-08 Epicardial-derived paracrine factors for repairing cardiac tissue

Publications (1)

Publication Number Publication Date
HK1258800A1 true HK1258800A1 (zh) 2019-11-22

Family

ID=57072385

Family Applications (1)

Application Number Title Priority Date Filing Date
HK19101164.7A HK1258800A1 (zh) 2015-04-09 2019-01-23 用於修復心臟組織的心外膜衍生的旁分泌因子

Country Status (10)

Country Link
US (2) US10682416B2 (zh)
EP (2) EP3280429B1 (zh)
JP (3) JP6839393B2 (zh)
CN (2) CN115417921A (zh)
AU (3) AU2016246070B2 (zh)
CA (1) CA2982179A1 (zh)
DK (1) DK3280429T3 (zh)
ES (1) ES2927176T3 (zh)
HK (1) HK1258800A1 (zh)
WO (1) WO2016164840A1 (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3280429B1 (en) * 2015-04-09 2022-06-01 Regencor, Inc. Fstl1 for use in repairing cardiac tissue
CN108486046B (zh) * 2018-02-09 2020-09-25 苏州大学 一种抗缺氧损伤的干细胞制剂及其制备方法与在制备治疗急性心梗药物中的应用
WO2023183933A1 (en) * 2022-03-25 2023-09-28 Regencor, Inc. Use of follistatin-like 1 (fstl1) in cardiometabolic heart failure
WO2023210713A1 (ja) * 2022-04-27 2023-11-02 国立大学法人京都大学 心外膜細胞再生促進剤および心外膜細胞の再生促進方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040253644A1 (en) * 1995-11-07 2004-12-16 Kaneka Corporation Rheumatoid arthritis autoantigen polypeptides
GB0611845D0 (en) * 2006-06-15 2006-07-26 Mcinerney Joseph G The utility hydration system
WO2009052478A1 (en) * 2007-10-19 2009-04-23 Trustees Of Boston University Metabolic and cardioprotection by the myokine follistatin-like 1 polypeptide
US20090326053A1 (en) * 2008-05-30 2009-12-31 Trustees Of Boston University Diagnostic uses of follistatin-like 1
US20100330044A1 (en) 2009-06-30 2010-12-30 Universite Libre De Bruxelles Mesp1 as a master regulator of multipotent cardiovascular progenitor specification and uses thereof
US20110104735A1 (en) 2009-11-01 2011-05-05 Zenbio, Inc. Human omental mesothelial cells, methods of isolation and uses thereof
WO2012019099A2 (en) 2010-08-05 2012-02-09 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Follistatin-like-protein-1 as a biomarker for inflammatory disorders
CA2814713A1 (en) 2010-10-14 2012-04-19 University Of Central Florida Research Foundation, Inc. Cardiac induced pluripotent stem cells and methods of use in repair and regeneration of myocardium
CN102648977B (zh) * 2011-02-25 2014-12-10 中国科学院上海生命科学研究院 滤泡素抑制素样蛋白1在调节钠钾atp酶活性中的用途
EP3280429B1 (en) * 2015-04-09 2022-06-01 Regencor, Inc. Fstl1 for use in repairing cardiac tissue

Also Published As

Publication number Publication date
DK3280429T3 (da) 2022-08-29
US20180092980A1 (en) 2018-04-05
ES2927176T3 (es) 2022-11-03
CN108601810B (zh) 2022-07-05
EP3280429A4 (en) 2018-12-19
AU2023214306A1 (en) 2023-08-31
CN108601810A (zh) 2018-09-28
JP2021046441A (ja) 2021-03-25
AU2020204541A1 (en) 2020-07-30
US10682416B2 (en) 2020-06-16
JP2023018119A (ja) 2023-02-07
EP4088733A1 (en) 2022-11-16
CN115417921A (zh) 2022-12-02
EP3280429A1 (en) 2018-02-14
JP2018512456A (ja) 2018-05-17
JP6839393B2 (ja) 2021-03-10
CA2982179A1 (en) 2016-10-13
JP7190711B2 (ja) 2022-12-16
AU2016246070A1 (en) 2017-11-02
AU2016246070B2 (en) 2020-04-09
WO2016164840A1 (en) 2016-10-13
US20200345851A1 (en) 2020-11-05
AU2020204541B2 (en) 2023-05-18
EP3280429B1 (en) 2022-06-01

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