HK1257902A1 - 識別hla-cw8限制性突變kras的t細胞受體 - Google Patents
識別hla-cw8限制性突變kras的t細胞受體Info
- Publication number
- HK1257902A1 HK1257902A1 HK19100263.9A HK19100263A HK1257902A1 HK 1257902 A1 HK1257902 A1 HK 1257902A1 HK 19100263 A HK19100263 A HK 19100263A HK 1257902 A1 HK1257902 A1 HK 1257902A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- cell receptors
- mutated kras
- receptors recognizing
- recognizing hla
- restricted
- Prior art date
Links
- 108091008874 T cell receptors Proteins 0.000 title 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5748—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving oncogenic proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/82—Translation products from oncogenes
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562218688P | 2015-09-15 | 2015-09-15 | |
| PCT/US2016/050875 WO2017048593A1 (en) | 2015-09-15 | 2016-09-09 | T cell receptors recognizing hla-cw8 restricted mutated kras |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1257902A1 true HK1257902A1 (zh) | 2019-11-01 |
Family
ID=56985686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK19100263.9A HK1257902A1 (zh) | 2015-09-15 | 2019-01-08 | 識別hla-cw8限制性突變kras的t細胞受體 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10556940B2 (zh) |
| EP (2) | EP3901169A1 (zh) |
| JP (2) | JP7185524B2 (zh) |
| KR (1) | KR20180044428A (zh) |
| CN (2) | CN108350059B (zh) |
| AU (3) | AU2016323017B2 (zh) |
| CA (1) | CA2998869A1 (zh) |
| DK (1) | DK3350213T3 (zh) |
| ES (1) | ES2879287T3 (zh) |
| HK (1) | HK1257902A1 (zh) |
| IL (1) | IL257840B2 (zh) |
| MX (1) | MX2018003062A (zh) |
| SA (1) | SA518391109B1 (zh) |
| SG (1) | SG10201913868XA (zh) |
| WO (1) | WO2017048593A1 (zh) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL295616A (en) | 2015-07-31 | 2022-10-01 | Us Health | Adapted cells and treatment methods |
| PL3494133T3 (pl) | 2016-08-02 | 2022-11-21 | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services | Receptory limfocytów t anty-kras-g12d |
| GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
| WO2018183485A1 (en) * | 2017-03-31 | 2018-10-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of isolating neoantigen-specific t cell receptor sequences |
| WO2018213467A1 (en) * | 2017-05-16 | 2018-11-22 | The Johns Hopkins University | Manabodies and methods of using |
| JP2020530307A (ja) | 2017-06-30 | 2020-10-22 | インティマ・バイオサイエンス，インコーポレーテッド | 遺伝子治療のためのアデノ随伴ウイルスベクター |
| BR112020005469A2 (pt) * | 2017-09-20 | 2020-09-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | receptores de células t restritivas a hla classe ii contra ras mutado |
| CA3084246A1 (en) | 2017-12-04 | 2019-06-13 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Hla class i-restricted t cell receptors against mutated ras |
| WO2019246286A1 (en) * | 2018-06-19 | 2019-12-26 | Neon Therapeutics, Inc. | Neoantigens and uses thereof |
| SG11202101524RA (en) * | 2018-08-16 | 2021-03-30 | Biontech Us Inc | T cell receptor constructs and uses thereof |
| KR20210118865A (ko) * | 2019-01-22 | 2021-10-01 | 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 | G12r 돌연변이를 갖는 ras에 대한 hla 클래스 ii-제한된 t 세포 수용체 |
| GB2596461B (en) | 2019-02-20 | 2023-09-27 | Fred Hutchinson Cancer Center | Binding proteins specific for RAS neoantigens and uses thereof |
| WO2020210202A1 (en) * | 2019-04-11 | 2020-10-15 | The Board Of Trustees Of The Leland Stanford Junior University | Cytotoxic t lymphocytes specific for mutated forms of epidermal growth factor receptor for use in treating cancer |
| CN110172089B (zh) * | 2019-06-11 | 2020-01-07 | 北京鼎成肽源生物技术有限公司 | 一种kras突变多抗原组合、靶向kras突变肿瘤ctl及其应用 |
| CN112110995A (zh) * | 2019-06-19 | 2020-12-22 | 上海交通大学医学院 | 肿瘤新抗原多肽及其用途 |
| CN112759641B (zh) * | 2019-11-01 | 2023-01-20 | 香雪生命科学技术（广东）有限公司 | 一种识别Kras G12V的高亲和力TCR |
| IL294098A (en) | 2019-12-20 | 2022-08-01 | Instil Bio Uk Ltd | Devices and methods for isolating lymphocytes infiltrating tumors and their use |
| CN111574616B (zh) * | 2020-06-17 | 2021-02-02 | 深圳豪石生物科技有限公司 | 分离的t细胞受体和应用 |
| EP4298121A1 (en) | 2021-02-25 | 2024-01-03 | Alaunos Therapeutics, Inc. | Recombinant vectors comprising polycistronic expression cassettes and methods of use thereof |
| WO2023150562A1 (en) | 2022-02-01 | 2023-08-10 | Alaunos Therapeutics, Inc. | Methods for activation and expansion of t cells |
| CN114920824B (zh) * | 2022-05-27 | 2023-12-05 | 重庆医科大学 | Tcr或其抗原结合片段及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2497552C (en) | 2002-09-06 | 2014-05-27 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy |
| PT2327763T (pt) * | 2005-08-05 | 2018-05-11 | Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Gesundheit & Umwelt Gmbh | Geração de células t específicas de antigénios |
| US8383099B2 (en) | 2009-08-28 | 2013-02-26 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Adoptive cell therapy with young T cells |
| DK2618835T3 (en) * | 2010-09-20 | 2017-08-28 | Biontech Cell & Gene Therapies Gmbh | ANTIGEN-SPECIFIC T-CELL RECEPTORS AND T-CELL EPITOPES |
| WO2012129201A1 (en) | 2011-03-22 | 2012-09-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of growing tumor infiltrating lymphocytes in gas-permeable containers |
| EP2755997B1 (en) * | 2011-09-15 | 2018-07-04 | The United States of America, as represented by The Secretary, Department of Health and Human Services | T cell receptors recognizing hla-a1- or hla-cw7-restricted mage |
| GB201314404D0 (en) * | 2013-08-12 | 2013-09-25 | Immunocore Ltd | T Cell Receptors |
| AU2015353720B2 (en) | 2014-11-26 | 2020-02-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Anti-mutated KRAS T cell receptors |
-
2016
- 2016-09-09 CN CN201680058891.3A patent/CN108350059B/zh active Active
- 2016-09-09 WO PCT/US2016/050875 patent/WO2017048593A1/en active Application Filing
- 2016-09-09 EP EP21162567.8A patent/EP3901169A1/en active Pending
- 2016-09-09 KR KR1020187010326A patent/KR20180044428A/ko not_active Application Discontinuation
- 2016-09-09 DK DK16770408.9T patent/DK3350213T3/da active
- 2016-09-09 US US15/758,954 patent/US10556940B2/en active Active
- 2016-09-09 ES ES16770408T patent/ES2879287T3/es active Active
- 2016-09-09 JP JP2018513423A patent/JP7185524B2/ja active Active
- 2016-09-09 MX MX2018003062A patent/MX2018003062A/es unknown
- 2016-09-09 SG SG10201913868XA patent/SG10201913868XA/en unknown
- 2016-09-09 CN CN202111083392.9A patent/CN115073583A/zh active Pending
- 2016-09-09 EP EP16770408.9A patent/EP3350213B1/en active Active
- 2016-09-09 IL IL257840A patent/IL257840B2/en unknown
- 2016-09-09 AU AU2016323017A patent/AU2016323017B2/en active Active
- 2016-09-09 CA CA2998869A patent/CA2998869A1/en active Pending
-
2018
- 2018-03-13 SA SA518391109A patent/SA518391109B1/ar unknown
-
2019
- 2019-01-08 HK HK19100263.9A patent/HK1257902A1/zh unknown
-
2020
- 2020-01-10 US US16/739,310 patent/US11667692B2/en active Active
-
2021
- 2021-02-10 AU AU2021200833A patent/AU2021200833B2/en active Active
-
2022
- 2022-07-26 AU AU2022209229A patent/AU2022209229A1/en active Pending
- 2022-11-25 JP JP2022188263A patent/JP7461445B2/ja active Active
-
2023
- 2023-05-01 US US18/310,141 patent/US20230406904A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2021200833B2 (en) | 2022-04-28 |
| JP7185524B2 (ja) | 2022-12-07 |
| SA518391109B1 (ar) | 2022-02-14 |
| AU2016323017B2 (en) | 2020-11-12 |
| IL257840B2 (en) | 2023-10-01 |
| KR20180044428A (ko) | 2018-05-02 |
| IL257840B1 (en) | 2023-06-01 |
| US20200148739A1 (en) | 2020-05-14 |
| JP7461445B2 (ja) | 2024-04-03 |
| CN108350059A (zh) | 2018-07-31 |
| AU2021200833A1 (en) | 2021-03-04 |
| WO2017048593A1 (en) | 2017-03-23 |
| SG10201913868XA (en) | 2020-03-30 |
| MX2018003062A (es) | 2018-09-11 |
| EP3901169A1 (en) | 2021-10-27 |
| ES2879287T3 (es) | 2021-11-22 |
| AU2022209229A1 (en) | 2022-09-15 |
| JP2018535647A (ja) | 2018-12-06 |
| DK3350213T3 (da) | 2021-06-21 |
| IL257840A (en) | 2018-04-30 |
| EP3350213A1 (en) | 2018-07-25 |
| CN115073583A (zh) | 2022-09-20 |
| EP3350213B1 (en) | 2021-03-31 |
| CA2998869A1 (en) | 2017-03-23 |
| JP2023025108A (ja) | 2023-02-21 |
| US20190040111A1 (en) | 2019-02-07 |
| US10556940B2 (en) | 2020-02-11 |
| US20230406904A1 (en) | 2023-12-21 |
| US11667692B2 (en) | 2023-06-06 |
| AU2016323017A1 (en) | 2018-04-05 |
| CN108350059B (zh) | 2021-10-08 |
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