HK1251659A1 - 液滴微流控設備及感測其中的測定結果的方法 - Google Patents

液滴微流控設備及感測其中的測定結果的方法

Info

Publication number
HK1251659A1
HK1251659A1 HK18111159.4A HK18111159A HK1251659A1 HK 1251659 A1 HK1251659 A1 HK 1251659A1 HK 18111159 A HK18111159 A HK 18111159A HK 1251659 A1 HK1251659 A1 HK 1251659A1
Authority
HK
Hong Kong
Prior art keywords
assay
sensing
methods
result
microfluidic device
Prior art date
Application number
HK18111159.4A
Other languages
English (en)
Inventor
Benjamin James Hadwen
Adrian Marc Simon Jacobs
Jason Roderick Hector
Michael James Brownlow
Masahiro Adachi
Alison Mary Skinner
Mark Childs
Original Assignee
Sharp Life Science Eu Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sharp Life Science Eu Ltd filed Critical Sharp Life Science Eu Ltd
Publication of HK1251659A1 publication Critical patent/HK1251659A1/zh

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/148—Specific details about calibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B01L2300/1822—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks using Peltier elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427—Electrowetting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6095—Micromachined or nanomachined, e.g. micro- or nanosize
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/579—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving limulus lysate
HK18111159.4A 2015-08-28 2018-08-30 液滴微流控設備及感測其中的測定結果的方法 HK1251659A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14/838,781 US11061015B2 (en) 2015-08-28 2015-08-28 Droplet microfluidic device and methods of sensing the results of an assay therein

Publications (1)

Publication Number Publication Date
HK1251659A1 true HK1251659A1 (zh) 2019-02-01

Family

ID=58097861

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18111159.4A HK1251659A1 (zh) 2015-08-28 2018-08-30 液滴微流控設備及感測其中的測定結果的方法

Country Status (5)

Country Link
US (2) US11061015B2 (zh)
EP (1) EP3341740B1 (zh)
CN (1) CN107923927B (zh)
HK (1) HK1251659A1 (zh)
WO (1) WO2017038063A1 (zh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170056887A1 (en) * 2015-08-28 2017-03-02 Sharp Kabushiki Kaisha Droplet microfluidic device and methods of sensing the results of an assay therein
US11061015B2 (en) 2015-08-28 2021-07-13 Sharp Life Science (Eu) Limited Droplet microfluidic device and methods of sensing the results of an assay therein
US10926256B2 (en) * 2017-07-12 2021-02-23 Sharp Life Science (Eu) Limited Housing for simple assembly of an EWOD device
US11207686B2 (en) * 2018-08-21 2021-12-28 Sharp Life Science (Eu) Limited Microfluidic device and methods for digital assays in biological analyses
EP3623050A1 (en) 2018-09-12 2020-03-18 Sharp Life Science (EU) Limited Microfluidic device and a method of loading fluid therein
EP3623049A1 (en) 2018-09-12 2020-03-18 Sharp Life Science (EU) Limited Microfluidic device and a method of loading fluid therein
US20210033563A1 (en) * 2018-09-13 2021-02-04 Chun-Lung LIEN Nucleotide sequencing element and chip, and sequencing analysis method
WO2020079834A1 (ja) * 2018-10-19 2020-04-23 株式会社日立ハイテクノロジーズ 生化学用カートリッジ及び生化学分析装置
JP2022513138A (ja) * 2018-11-28 2022-02-07 オックスフォード ナノポール テクノロジーズ ピーエルシー 感知システムおよび動作方法
US10978007B2 (en) * 2018-12-03 2021-04-13 Sharp Life Science (Eu) Limited AM-EWOD circuit configuration with sensing column detection circuit
CN112649597A (zh) * 2019-10-10 2021-04-13 鸿富锦精密工业（深圳）有限公司 传感器和应用该传感器的检测装置
CN113340772B (zh) * 2021-06-11 2022-06-17 季华实验室 一种监测dna水凝胶凝胶化转变过程的方法
CN113747706B (zh) * 2021-08-11 2023-02-14 Oppo广东移动通信有限公司 装饰组件、壳体组件及电子设备
CN114177958B (zh) * 2021-12-09 2023-05-09 华南师范大学 一种高通量均匀液滴阵列制备方法及微结构阵列芯片

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4221865A (en) 1978-10-06 1980-09-09 Baxter Travenol Laboratories, Inc. Method for determining endotoxin concentration
US4221866A (en) 1978-10-06 1980-09-09 Baxter Travenol Laboratories, Inc. Method for determining endotoxin concentration
US4276050A (en) 1980-01-10 1981-06-30 Abbott Laboratories Method for systemic endotoxin detection
US4273557A (en) 1980-03-31 1981-06-16 Mallinckrodt, Inc. Limulus lysate procedure for determining endotoxins
JPS5885162A (ja) 1981-11-16 1983-05-21 Seikagaku Kogyo Co Ltd エンドトキシン測定法
GB9220564D0 (en) 1992-09-29 1992-11-11 Univ London The method of rheological investigation
US6565727B1 (en) 1999-01-25 2003-05-20 Nanolytics, Inc. Actuators for microfluidics without moving parts
CA2472029C (en) 2001-11-26 2014-04-15 Keck Graduate Institute Method, apparatus and article for microfluidic control via electrowetting, for chemical, biochemical and biological assays and the like
US6911132B2 (en) 2002-09-24 2005-06-28 Duke University Apparatus for manipulating droplets by electrowetting-based techniques
CA2479452C (en) * 2003-08-30 2008-11-04 F.Hoffmann-La Roche Ag Method and device for determining analytes in a liquid
US8613889B2 (en) * 2006-04-13 2013-12-24 Advanced Liquid Logic, Inc. Droplet-based washing
US7816121B2 (en) * 2006-04-18 2010-10-19 Advanced Liquid Logic, Inc. Droplet actuation system and method
FR2909293B1 (fr) * 2006-12-05 2011-04-22 Commissariat Energie Atomique Micro-dispositif de traitement d'echantillons liquides
WO2008101194A2 (en) 2007-02-15 2008-08-21 Advanced Liquid Logic, Inc. Capacitance detection in a droplet actuator
WO2009135205A2 (en) 2008-05-02 2009-11-05 Advanced Liquid Logic, Inc. Droplet actuator techniques using coagulatable samples
WO2011020011A2 (en) * 2009-08-13 2011-02-17 Advanced Liquid Logic, Inc. Droplet actuator and droplet-based techniques
US8653832B2 (en) 2010-07-06 2014-02-18 Sharp Kabushiki Kaisha Array element circuit and active matrix device
US8339711B2 (en) 2011-04-22 2012-12-25 Sharp Kabushiki Kaisha Active matrix device and method of driving the same
US9458543B2 (en) 2012-12-04 2016-10-04 Sharp Kabushiki Kaisha Active matrix electrowetting-on-dielectric device
US9492824B2 (en) * 2013-01-16 2016-11-15 Sharp Kabushiki Kaisha Efficient dilution method, including washing method for immunoassay
US9169573B2 (en) 2013-01-23 2015-10-27 Sharp Kabushiki Kaisha AM-EWOD device and method of driving with variable voltage AC driving
US20150060272A1 (en) 2013-03-15 2015-03-05 Nanomix, Inc. Amperometric detection of limulus amebocyte lysate activation by endotoxin and/or 1-3-beta-d-glucan
US11061015B2 (en) 2015-08-28 2021-07-13 Sharp Life Science (Eu) Limited Droplet microfluidic device and methods of sensing the results of an assay therein
US20170056887A1 (en) 2015-08-28 2017-03-02 Sharp Kabushiki Kaisha Droplet microfluidic device and methods of sensing the results of an assay therein

Also Published As

Publication number Publication date
US20170059523A1 (en) 2017-03-02
WO2017038063A1 (en) 2017-03-09
CN107923927B (zh) 2021-07-27
EP3341740A4 (en) 2018-09-12
EP3341740A1 (en) 2018-07-04
US11536710B2 (en) 2022-12-27
US20210148890A1 (en) 2021-05-20
EP3341740B1 (en) 2020-09-30
CN107923927A (zh) 2018-04-17
US11061015B2 (en) 2021-07-13

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