HK1249138A1 - 治療具有tp53的半合子缺失的癌症的方法 - Google Patents

治療具有tp53的半合子缺失的癌症的方法

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Publication number
HK1249138A1
HK1249138A1 HK18108866.4A HK18108866A HK1249138A1 HK 1249138 A1 HK1249138 A1 HK 1249138A1 HK 18108866 A HK18108866 A HK 18108866A HK 1249138 A1 HK1249138 A1 HK 1249138A1
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HK
Hong Kong
Prior art keywords
methods
treating cancer
cancer harboring
hemizygous loss
harboring hemizygous
Prior art date
Application number
HK18108866.4A
Other languages
English (en)
Inventor
Xiongbin Lu
Yunhua Liu
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Publication of HK1249138A1 publication Critical patent/HK1249138A1/zh

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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HK18108866.4A 2015-03-04 2018-07-09 治療具有tp53的半合子缺失的癌症的方法 HK1249138A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562128480P 2015-03-04 2015-03-04
PCT/US2016/020687 WO2016141185A1 (en) 2015-03-04 2016-03-03 Methods of treating cancer harboring hemizygous loss of tp53

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HK1249138A1 true HK1249138A1 (zh) 2018-10-26

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HK18108866.4A HK1249138A1 (zh) 2015-03-04 2018-07-09 治療具有tp53的半合子缺失的癌症的方法

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US (2) US10563204B2 (zh)
EP (2) EP3741855A1 (zh)
JP (2) JP6811718B2 (zh)
KR (1) KR102697493B1 (zh)
CN (1) CN107847553A (zh)
AU (1) AU2016226133B2 (zh)
BR (1) BR112017018861A2 (zh)
CA (1) CA2978632C (zh)
CY (1) CY1123489T1 (zh)
DK (1) DK3265565T3 (zh)
ES (1) ES2831157T3 (zh)
HK (1) HK1249138A1 (zh)
HR (1) HRP20201791T1 (zh)
HU (1) HUE051776T2 (zh)
IL (2) IL284264B (zh)
LT (1) LT3265565T (zh)
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SI (1) SI3265565T1 (zh)
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IL284264B (en) 2015-03-04 2022-09-01 Univ Texas Methods for the treatment of cancer containing hemizygous loss of tp53
WO2017219029A2 (en) 2016-06-17 2017-12-21 Magenta Therapeutics, Inc. Compositions and methods for the depletion of cd117+cells
SG10202102897PA (en) 2017-01-20 2021-04-29 Magenta Therapeutics Inc Compositions and methods for the depletion of cd137+ cells
WO2020092602A1 (en) * 2018-10-30 2020-05-07 Ohio State Innovation Foundation Ph-activated nanoparticles
EP3917572A4 (en) * 2019-02-01 2022-11-09 Board of Regents, The University of Texas System MONOCLONAL ANTIBODIES AGAINST HUMAN MHC-RELATED DICKKOPF-1 PEPTIDES AND THEIR USES
CN111569076B (zh) * 2020-06-28 2022-05-17 中国农业科学院特产研究所 Polr2a抑制剂在制备药物中的应用
CN113702648B (zh) * 2021-09-13 2024-06-04 中南大学湘雅三医院 Polr2a在作为预测抗肿瘤药物的抗肿瘤疗效的生物标志物上的应用

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JP2021020952A (ja) 2021-02-18
IL284264B (en) 2022-09-01
KR102697493B1 (ko) 2024-08-23
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ZA201706459B (en) 2020-03-25
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