HK1248147A1 - 布鲁顿氏酪氨酸激酶抑制剂的溶剂化形式 - Google Patents

布鲁顿氏酪氨酸激酶抑制剂的溶剂化形式 Download PDF

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Publication number
HK1248147A1
HK1248147A1 HK18107889.9A HK18107889A HK1248147A1 HK 1248147 A1 HK1248147 A1 HK 1248147A1 HK 18107889 A HK18107889 A HK 18107889A HK 1248147 A1 HK1248147 A1 HK 1248147A1
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HK
Hong Kong
Prior art keywords
crystalline form
solvate
same
xrpd
compound
Prior art date
Application number
HK18107889.9A
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English (en)
Chinese (zh)
Inventor
艾瑞克‧戈德曼
M‧S‧史密斯
蒂埃里‧伯诺德
阿尔贝托‧穆诺兹加西亚
克里斯多佛‧彼得‧沃洛
蒂埃裏‧伯諾德
阿爾貝托‧穆諾茲加西亞
克裏斯多佛‧彼得‧沃洛
Original Assignee
药品循环有限责任公司
藥品循環有限責任公司
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Publication of HK1248147A1 publication Critical patent/HK1248147A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/20—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by using diffraction of the radiation by the materials, e.g. for investigating crystal structure; by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materials; by using reflection of the radiation by the materials
    • G01N23/20075—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by using diffraction of the radiation by the materials, e.g. for investigating crystal structure; by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materials; by using reflection of the radiation by the materials by measuring interferences of X-rays, e.g. Borrmann effect

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK18107889.9A 2015-03-27 2016-03-25 布鲁顿氏酪氨酸激酶抑制剂的溶剂化形式 HK1248147A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562139594P 2015-03-27 2015-03-27
US62/139,594 2015-03-27
PCT/US2016/024305 WO2016160598A1 (en) 2015-03-27 2016-03-25 Solvated forms of a bruton's tyrosine kinase inhibitor

Publications (1)

Publication Number Publication Date
HK1248147A1 true HK1248147A1 (zh) 2018-10-12

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
HK18107889.9A HK1248147A1 (zh) 2015-03-27 2016-03-25 布鲁顿氏酪氨酸激酶抑制剂的溶剂化形式
HK18109251.5A HK1249737A1 (zh) 2015-03-27 2016-03-25 布鲁顿氏酪氨酸激酶抑制剂的溶剂化形式

Family Applications After (1)

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HK18109251.5A HK1249737A1 (zh) 2015-03-27 2016-03-25 布鲁顿氏酪氨酸激酶抑制剂的溶剂化形式

Country Status (11)

Country Link
US (4) US20180072738A1 (enExample)
EP (1) EP3273961A4 (enExample)
JP (2) JP2018509457A (enExample)
CN (1) CN107530346A (enExample)
AU (1) AU2016243116A1 (enExample)
BR (1) BR112017020744A2 (enExample)
CA (1) CA2981048A1 (enExample)
HK (2) HK1248147A1 (enExample)
MA (1) MA41827A (enExample)
MX (1) MX2017012430A (enExample)
WO (1) WO2016160598A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA37711A1 (fr) 2012-06-04 2017-05-31 Pharmacyclics Inc Formes cristallines d'un inhibiteur de tyrosine kinase de bruton
IL315294A (en) 2015-03-03 2024-10-01 Pharmacyclics Llc Pharmaceutical formulations of proton tyrosine kinase inhibitor
EP3337485B1 (en) * 2015-08-19 2021-03-17 Sun Pharmaceutical Industries Ltd Crystalline forms of ibrutinib
CZ2016276A3 (cs) * 2016-05-11 2017-11-22 Zentiva, K.S. Pevné formy volné báze ibrutinibu
US10183024B2 (en) 2016-12-02 2019-01-22 Apotex Inc. Crystalline forms of ibrutinib
CZ2017787A3 (cs) 2017-12-08 2019-06-19 Zentiva, K.S. Farmaceutické kompozice obsahující ibrutinib
EP3575300A1 (en) 2018-05-31 2019-12-04 Apotex Inc. Novel crystalline forms of ibrutinib
US10688050B1 (en) 2018-12-21 2020-06-23 Synthon B.V. Pharmaceutical composition comprising ibrutinib
EP3669867A1 (en) 2018-12-21 2020-06-24 Synthon B.V. Pharmaceutical composition comprising ibrutinib
CA3154566A1 (en) * 2019-09-18 2021-03-25 Prelude Therapeutics Incorporated Selective inhibitors of protein arginine methyltransferase 5 (prmt5)
CN114478547B (zh) * 2020-10-23 2026-01-23 上海润石医药科技有限公司 固体形式的布鲁顿酪氨酸激酶抑制剂化合物及其用途
WO2023242384A1 (en) 2022-06-17 2023-12-21 Krka, D.D., Novo Mesto Crystalline form of ibrutinib

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CO5210907A1 (es) * 1999-05-12 2002-10-30 Novartis Ag Solvatos de pometrozina, insecticidamente activos, composiciones que contienen estos compuestos y metodos tanto para producir dichos compuestos y composiciones como para controlar plagas animales con estas composiciones
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US20160287592A1 (en) 2013-04-08 2016-10-06 Pharmacyclics Llc Ibrutinib combination therapy
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Also Published As

Publication number Publication date
US20180072738A1 (en) 2018-03-15
MA41827A (fr) 2018-01-30
JP2022033783A (ja) 2022-03-02
CN107530346A (zh) 2018-01-02
CA2981048A1 (en) 2016-10-06
BR112017020744A2 (pt) 2018-07-17
MX2017012430A (es) 2018-07-06
AU2016243116A1 (en) 2017-10-19
JP2018509457A (ja) 2018-04-05
US20200347063A1 (en) 2020-11-05
US20220106317A1 (en) 2022-04-07
WO2016160598A1 (en) 2016-10-06
EP3273961A1 (en) 2018-01-31
EP3273961A4 (en) 2018-10-31
HK1249737A1 (zh) 2018-11-09
US20190367519A1 (en) 2019-12-05

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