HK1246784A1 - 用於治療脊髓性肌萎縮的化合物 - Google Patents

用於治療脊髓性肌萎縮的化合物

Info

Publication number
HK1246784A1
HK1246784A1 HK18106264.6A HK18106264A HK1246784A1 HK 1246784 A1 HK1246784 A1 HK 1246784A1 HK 18106264 A HK18106264 A HK 18106264A HK 1246784 A1 HK1246784 A1 HK 1246784A1
Authority
HK
Hong Kong
Prior art keywords
compounds
muscular atrophy
spinal muscular
treating spinal
treating
Prior art date
Application number
HK18106264.6A
Other languages
English (en)
Inventor
羅伯特‧杰克‧吉萊斯皮
哈薩內‧拉特尼
杰羅姆‧查爾斯‧沙利爾
Original Assignee
豪夫邁．羅氏有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 豪夫邁．羅氏有限公司 filed Critical 豪夫邁．羅氏有限公司
Publication of HK1246784A1 publication Critical patent/HK1246784A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK18106264.6A 2015-05-20 2018-05-15 用於治療脊髓性肌萎縮的化合物 HK1246784A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15168452 2015-05-20
PCT/EP2016/060952 WO2016184832A1 (en) 2015-05-20 2016-05-17 Compounds for treating spinal muscular atrophy

Publications (1)

Publication Number Publication Date
HK1246784A1 true HK1246784A1 (zh) 2018-09-14

Family

ID=53180664

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18106264.6A HK1246784A1 (zh) 2015-05-20 2018-05-15 用於治療脊髓性肌萎縮的化合物

Country Status (6)

Country Link
US (1) US10208067B2 (zh)
EP (1) EP3298017B1 (zh)
JP (1) JP6749343B2 (zh)
CN (1) CN107635999B (zh)
HK (1) HK1246784A1 (zh)
WO (1) WO2016184832A1 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2812004T3 (en) 2012-02-10 2018-10-15 Ptc Therapeutics Inc COMPOUNDS FOR TREATMENT OF SPINAL MUSCLE DROPHY
CN105392790B (zh) 2013-08-19 2019-04-19 豪夫迈·罗氏有限公司 4H-吡啶并[1,2-a]嘧啶-4-酮化合物制备用于预防或治疗癌症的药物的用途
EP3310169B1 (en) 2015-05-30 2023-05-17 PTC Therapeutics, Inc. Methods for modulating rna splicing
ES2879995T3 (es) 2015-12-10 2021-11-23 Ptc Therapeutics Inc Métodos para el tratamiento de la enfermedad de Huntington
WO2018098446A1 (en) 2016-11-28 2018-05-31 Ptc Therapeutics, Inc Methods for modulating rna splicing
AU2018282154B2 (en) 2017-06-05 2022-04-07 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
EA202090034A1 (ru) 2017-06-14 2020-04-16 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Способы модификации сплайсинга рнк
BR112019027719A2 (pt) 2017-06-28 2020-07-28 Ptc Therapeutics, Inc. métodos para tratar a doença de huntington
WO2019005980A1 (en) 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. METHODS OF TREATING HUNTINGTON'S DISEASE
KR20210005559A (ko) 2018-03-27 2021-01-14 피티씨 테라퓨틱스, 인크. 헌팅턴병 치료 화합물
AU2019294478B2 (en) 2018-06-27 2023-03-23 Ptc Therapeutics, Inc. Heterocyclic and heteroaryl compounds for treating Huntington's disease

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1383409A (en) 1972-09-09 1974-02-12 Pfizer Ltd Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them
US4122274A (en) * 1977-05-25 1978-10-24 Bristol-Myers Company 3-Tetrazolo-5,6,7,8-substituted-pyrido[1,2-a]pyrimidin-4-ones
EP1257537B1 (en) * 2000-01-24 2007-05-30 AstraZeneca AB Therapeutic morpholino-substituted compounds
US6774134B2 (en) 2000-12-20 2004-08-10 Bristol-Myers Squibb Company Heterocyclic substituted 2-methyl-benzimidazole antiviral agents
DE10218592A1 (de) * 2002-04-26 2003-11-06 Bayer Cropscience Ag Triazolopyrimidine
KR20060069356A (ko) * 2003-06-20 2006-06-21 카이론 코포레이션 항암제로서 피리디노[1,2-α]피리미딘-4-온 화합물
CN101723949B (zh) 2003-12-24 2013-10-23 生物区科学管理控股有限公司 用于治疗呼吸道合胞体病毒感染的多环试剂
WO2009151546A2 (en) 2008-05-27 2009-12-17 Ptc Therapeutics, Inc. Methods for treating spinal muscular atrophy
WO2010019243A1 (en) 2008-08-13 2010-02-18 Ptc Therapeutics, Inc. Methods for treating viral infections
US8126566B2 (en) 2008-08-14 2012-02-28 Cardiac Pacemakers, Inc. Performance assessment and adaptation of an acoustic communication link
US8871756B2 (en) 2011-08-11 2014-10-28 Hoffmann-La Roche Inc. Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease
GB201119538D0 (en) 2011-11-10 2011-12-21 Viral Ltd Pharmaceutical compounds
DK2812004T3 (en) * 2012-02-10 2018-10-15 Ptc Therapeutics Inc COMPOUNDS FOR TREATMENT OF SPINAL MUSCLE DROPHY
US9649317B2 (en) * 2012-09-19 2017-05-16 The Trustees Of The University Of Pennsylvania Heterocyclic compounds and their use for the treatment of neurodegenerative tauopathies
EP2997028A1 (en) 2013-05-14 2016-03-23 F.Hoffmann-La Roche Ag Aza-oxo-indoles for the treatment and prophylaxis of respiratory syncytial virus infection
PL3027600T3 (pl) * 2013-07-31 2022-08-08 Novartis Ag 1,4-dwupodstawione pochodne pirydazyny i ich zastosowanie do leczenia stanów związanych z niedoborem smn
AR099134A1 (es) 2014-01-24 2016-06-29 Hoffmann La Roche Procedimiento para la preparación de n-[(3-aminooxetán-3-il)metil]-2-(1,1-dioxo-3,5-dihidro-1,4-benzotiazepín-4-il)-6-metil-quinazolín-4-amina
AU2015261046C1 (en) 2014-05-15 2019-07-25 F. Hoffmann-La Roche Ag Compounds for treating spinal muscular atrophy

Also Published As

Publication number Publication date
WO2016184832A1 (en) 2016-11-24
US10208067B2 (en) 2019-02-19
EP3298017B1 (en) 2019-08-14
CN107635999A (zh) 2018-01-26
JP6749343B2 (ja) 2020-09-02
EP3298017A1 (en) 2018-03-28
JP2018519273A (ja) 2018-07-19
CN107635999B (zh) 2020-09-25
US20180194781A1 (en) 2018-07-12

Similar Documents

Publication Publication Date Title
HUS2100037I1 (hu) Vegyületek gerinc eredetû izomsorvadás kezelésére
HK1256089A1 (zh) 用於治療脊髓性肌萎縮的組合物
HK1246784A1 (zh) 用於治療脊髓性肌萎縮的化合物
HK1215399A1 (zh) 用於治療脊髓性肌萎縮的化合物
SG11201705093UA (en) Composition for treating il-6-related diseases
HK1258823A1 (zh) 用於治療肌營養不良的方法
HK1244217A1 (zh) 用於治療蛋白質病的方法
IL262830A (en) Preparations and methods for the treatment of spinal muscular atrophy
IL272791A (en) Methods for treating muscular dystrophy
EP3302695B8 (en) Devices for treating muscles
HK1248130A1 (zh) 用於治療疼痛的組合物
IL231816A (en) Bone fracture treatment devices
GB201604658D0 (en) Treatment for pain
PT3250218T (pt) Péptido natkide para o tratamento da obesidade
ZA201800752B (en) Improved prosthesis for osteosynthesis
PL3129031T3 (pl) Kompozycja do terapii zaburzeń żołądkowych
ZA201805215B (en) Preparation for nasal-nasopharyngeal treatment
SG11201708378TA (en) Bone screw
GB201505205D0 (en) Treatment for pain
GB201504688D0 (en) Treatment for pain